Overall Adverse Event Profile of Vadadustat versus Darbepoetin Alfa for the Treatment of Anemia Associated with Chronic Kidney Disease in Phase 3 Trials

Authors: Agarwal, Rajiv, Anand, Sanjeev, Eckardt, Kai-Uwe, Luo, Wenli, Parfrey, Patrick S., Sarnak, Mark J., Solinsky, Christine M., Vargo, Dennis L., Winkelmayer, Wolfgang C., Chertow, Glenn M.

Source: American journal of nephrology. 53(10):701-710

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100172703696.0x000001&indx=1&recIds=ETOCvdc_100172703696.0x000001

Development of a unified clinical trial database for Alzheimer's disease

Authors: Neville, Jon, Kopko, Steve, Broadbent, Steve, Avilés, Enrique, Stafford, Robert, Solinsky, Christine M., Bain, Lisa J., Cisneroz, Martin, Romero, Klaus, Stephenson, Diane

Source: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association October 2015 11(10):1212-1221

Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial

Authors: Hernandez, Gerson D., Solinsky, Christine M., Mack, Wendy J., Kono, Naoko, Rodgers, Kathleen E., Wu, Chun‐Yi, Mollo, Ana R., Lopez, Claudia M., Pawluczyk, Sonia, Bauer, Gerhard, Matthews, Dawn, Shi, Yonggang, Law, Meng, Rogawski, Michael A., Schneider, Lon S., Brinton, Roberta D.

Source: Alzheimer's & dementia.Translational research & clinical interventions. 6(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100140147504.0x000001&indx=1&recIds=ETOCvdc_100140147504.0x000001

Overall Adverse Event Profile of Vadadustat for the Treatment of Anemia Associated With Chronic Kidney Disease in Phase 3 Trials.

Authors: Agarwal, Rajiv, Anand, Sanjeev, Eckardt, Kai-Uwe, Luo, Wenli, Parfrey, Patrick S., Sarnak, Mark J., Solinsky, Christine M., Vargo, Dennis L., Winkelmayer, Wolfgang C., Chertow, Glenn M.

Source: American Journal of Nephrology; 2022, Vol. 53 Issue 10, p701-710, 10p

Subject Terms: CLINICAL trials, CHRONIC kidney failure, ANEMIA treatment, HYPOXIA-inducible factors, CHRONICALLY ill

MITOCHONDRIAL HAPLOGROUP IN COMBINATION WITH APOE GENOTYPE AS POTENTIAL PREDICTIVE BIOMARKER TO IDENTIFY RESPONDERS TO REGENERATIVE THERAPEUTIC ALLOPREGNANOLONE FOR ALZHEIMER'S DISEASE

Authors: Wang, Yiwei, Solinsky, Christine M., Hernandez, Gerson D., Schneider, Lon S., Brinton, Roberta Diaz

Source: Alzheimer's & dementia. 14(7):P271-P272

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069568775.0x000001&indx=1&recIds=ETOCvdc_100069568775.0x000001

P1‐018: MITOCHONDRIAL HAPLOGROUP IN COMBINATION WITH APOE GENOTYPE AS POTENTIAL PREDICTIVE BIOMARKER TO IDENTIFY RESPONDERS TO REGENERATIVE THERAPEUTIC ALLOPREGNANOLONE FOR ALZHEIMER'S DISEASE

Authors: Wang, Yiwei, Solinsky, Christine M., Hernandez, Gerson D., Schneider, Lon S., Brinton, Roberta Diaz

Source: Alzheimer's & dementia. 14(7):P271-P272

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174809881.0x000001&indx=1&recIds=ETOCvdc_100174809881.0x000001

Allopregnanolone Preclinical Acute Pharmacokinetic and Pharmacodynamic Studies to Predict Tolerability and Efficacy for Alzheimer’s Disease.

Authors: Irwin, Ronald W.¹, Solinsky, Christine M.², Loya, Carlos M.³, Salituro, Francesco G.³, Rodgers, Kathleen E.⁴, Bauer, Gerhard⁵, Rogawski, Michael A.⁶, Brinton, Roberta Diaz^1,7 rbrinton@usc.edu

Source: PLoS ONE. Jun2015, Vol. 10 Issue 6, p1-31. 31p.

Subject Terms: *PREGNANOLONE, *PHARMACOKINETICS, *PHARMACODYNAMICS, *DRUG tolerance, *ALZHEIMER'S disease treatment, *DRUG efficacy

DEVELOPMENT OF IPSC-BASED BIOMARKERS TO IDENTIFY THE PATIENT POPULATION RESPONSIVE TO ALLOPREGNANOLONE

Authors: Solinsky, Christine M., Hennes, Valerie, Blurton-Jones, Mathew, Park, Jenny Ayoung, Chui, Helena C., Ichida, Justin K., Brinton, Roberta Diaz

Source: Alzheimer's & dementia. 15(7):P871-P871

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093003059.0x000001&indx=1&recIds=ETOCvdc_100093003059.0x000001

COMBINING SEX, APOE GENOTYPE, AND MITOCHONDRIAL GENETIC VARIANCE AS PREDICTIVE RESPONDER IDENTIFIER TO REGENERATIVE THERAPEUTIC ALLOPREGNANOLONE FOR ALZHEIMER'S DISEASE

Authors: Wang, Yiwei, Solinsky, Christine M., Hernandez, Gerson D., Schneider, Lon S., Brinton, Roberta Diaz

Source: Alzheimer's & dementia. 15(7):P938-P938

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091208064.0x000001&indx=1&recIds=ETOCvdc_100091208064.0x000001

CLINICAL TRIAL RECRUITMENT FRAMEWORK FOR EARLY ALZHEIMER'S DISEASE

Authors: Irwin, Ronald W., Hernandez, Gerson, Solinsky, Christine M., Lopez, Claudia M., Kono, Naoko, Mack, Wendy J., Schneider, Lon S., Brinton, Roberta Diaz

Source: Alzheimer's & dementia. 13(7):P1262-P1262

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061741842.0x000001&indx=1&recIds=ETOCvdc_100061741842.0x000001

DEVELOPMENT OF AN IPSC-BASED BIOMARKER STRATEGY TO IDENTIFY NEUROREGENERATIVE RESPONDERS TO ALLOPREGNANOLONE

Authors: Solinsky, Christine M., Park, Jenny Ayoung, Chui, Helena C., Blurton-Jones, Mathew, Ichida, Justin K., Brinton, Roberta Diaz

Source: Alzheimer's & dementia. 13(7):P998-P998

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100061736752.0x000001&indx=1&recIds=ETOCvdc_100061736752.0x000001

COMPARATIVE PHARMACOKINETIC ASSESSMENT OF ALLOPREGNANOLONE TO DEVELOP A REGENERATIVE THERAPEUTIC FOR MILD COGNITIVE IMPAIRMENT AND EARLY ALZHEIMER'S DISEASE

Authors: Irwin, Ronald W., Solinsky, Christine M., Rodgers, Kathleen E., Bauer, Gerhard, Rogawski, Michael A., Brinton, Roberta Diaz

Source: Alzheimer's & dementia. 12(7):P430-P430

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093207871.0x000001&indx=1&recIds=ETOCvdc_100093207871.0x000001

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DEVELOPMENT OF IPSC-BASED BIOMARKERS TO IDENTIFY THE PATIENT POPULATION RESPONSIVE TO ALLOPREGNANOLONE

Authors: Solinsky, Christine M., Hennes, Valerie, Blurton-Jones, Mathew, Park, Jenny Ayoung, Chui, Helena C., Ichida, Justin K., Brinton, Roberta Diaz

Source: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2016 12(7) Supplement:P871-P871

Early-stage development of ips-based biomarkers to identify patient population with a regenerative profile responsive to allopregnanolone

Authors: Solinsky, Christine M., Desai, Maunil K., Yao, Jia, Hennes, Valerie, Chang Chui, Helena, Ichida, Justin K., Diaz-Brinton, Roberta

Source: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2015 11(7) Supplement:P633-P634

Allopregnanolone chronic exposure using regenerative treatment regimen: Preclinical ind enabling toxicology indicating safety

Authors: Irwin, Ronald W., Kim, Kyuri, Green, Carol E., Solinsky, Christine M., Bauer, Gerhard, Rogawski, Michael A., Rodgers, Kathleen E., Brinton, Roberta Diaz

Source: In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2015 11(7) Supplement:P472-P473

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Transforming growth factor-β signaling alters substrate permeability and tight junction protein expression at the blood–brain barrier during inflammatory pain.

Authors: Ronaldson, Patrick T., DeMarco, Kristin M., Sanchez-Covarrubias, Lucy, Solinsky, Christine M., Davis, Thomas P.

Source: Journal of Cerebral Blood Flow & Metabolism; Jun2009, Vol. 29 Issue 6, p1084-1098, 15p, 1 Diagram, 1 Chart, 6 Graphs

Subject Terms: BLOOD-brain barrier, BRAIN blood-vessels, BLOOD flow, BLOOD circulation, TRANSFORMING growth factors-beta

P3‐032: COMBINING SEX, APOE GENOTYPE, AND MITOCHONDRIAL GENETIC VARIANCE AS PREDICTIVE RESPONDER IDENTIFIER TO REGENERATIVE THERAPEUTIC ALLOPREGNANOLONE FOR ALZHEIMER'S DISEASE.

Authors: Wang, Yiwei, Solinsky, Christine M., Hernandez, Gerson D., Schneider, Lon S., Brinton, Roberta Diaz

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Jul2019 7S Part 18, Vol. 15, pP938-P938, 1p