Species-specific NLRP3 regulation and its role in CNS autoinflammatory diseases

Authors: Koller, Beverly H. ^{1, 2, 6, ∗}, Nguyen, MyTrang ^{1, 2}, Snouwaert, John N. ^{1, 2}, Gabel, Christopher A. ⁵, Ting, Jenny P.-Y. ^{1, 2, 3, 4, ∗∗}

Source: In Cell Reports 26 March 2024 43(3)

Target Cell Activation of a Structurally Novel NOD-Like Receptor Pyrin Domain-Containing Protein 3 Inhibitor NT-0796 Enhances Potency

Authors: Smolak, Pamela, Nguyen, MyTrang, Diamond, Christine, Wescott, Heather, Doedens, John R., Schooley, Kenneth, Snouwaert, John N., Bock, Mark G., Harrison, David, Watt, Alan P., Koller, Beverly H., Gabel, Christopher A. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics March 2024 388(3):798-812

Elarekibep (PRS-060/AZD1402), a new class of inhaled Anticalin medicine targeting IL-4Ra for type 2 endotype asthma

Authors: Matschiner, Gabriele, Fitzgerald, Mary F., Moebius, Ulrich, Hohlbaum, Andreas M., Gille, Hendrik, Jensen, Kristian, Kirchfeld, Klaus, Rattenstetter, Barbara, Laforge, Alice, Bel Aiba, Rachida S., Ciccotosto, Joe, Nyugen, Hong, Foster, Martyn L., Snouwaert, John N., Nguyen, MyTrang, Koller, Beverly H., Matis, Louis, Anderson, Gary P., Olwill, Shane A.

Source: Journal of allergy and clinical immunology. 151(4):966-975

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187208695.0x000001&indx=1&recIds=ETOCvdc_100187208695.0x000001

Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements.

Authors: Snouwaert, John N.^1,2 (AUTHOR), Jania, Leigh A.^1,2 (AUTHOR), Nguyen, Trang^1,2 (AUTHOR), Martinez, David R.³ (AUTHOR), Schäfer, Alexandra³ (AUTHOR), Catanzaro, Nicholas J.³ (AUTHOR), Gully, Kendra L.³ (AUTHOR), Baric, Ralph S.^3,4 (AUTHOR), Heise, Mark^1,4 (AUTHOR), Ferris, Martin T.^1,4 (AUTHOR), Anderson, Elizabeth^1,4 (AUTHOR), Pressey, Katia^1,4 (AUTHOR), Dillard, Jacob A.^1,4 (AUTHOR), Taft-Benz, Sharon^1,4 (AUTHOR), Baxter, Victoria K.⁵ (AUTHOR), Ting, Jenny P-Y^1,2,4,6 (AUTHOR), Koller, Beverly H.^1,2 (AUTHOR) bkoller@email.unc.edu

Source: PLoS Pathogens. 2/22/2023, Vol. 18 Issue 2, p1-31. 31p.

Subject Terms: *ANGIOTENSIN converting enzyme, *VIRAL tropism, *SARS-CoV-2, *RENIN-angiotensin system, *HUMAN DNA, *COVID-19 pandemic

A Mutation in the Borcs7 Subunit of the Lysosome Regulatory BORC Complex Results in Motor Deficits and Dystrophic Axonopathy in Mice

Authors: Snouwaert, John N., Church, Rachel J., Jania, Leigh, Nguyen, MyTrang, Wheeler, Matthew L., Saintsing, Andrew, Mieczkowski, Piotr, Manuel de Villena, Fernando Pardo, Armao, Diane, Moy, Sheryl S., Lorenzo, Damaris N., Koller, Beverly H.

Source: In Cell Reports 31 July 2018 24(5):1254-1265

Mice Lacking Three Loci Encoding 14 Glutathione Transferase Genes: A Novel Tool for Assigning Function to the GSTP, GSTM, and GSTT Families

Authors: Xiang, Zhidan, Snouwaert, John N., Kovarova, Martina, Nguyen, MyTrang, Repenning, Peter W., Latour, Anne M., Cyphert, Jaime M., Koller, Beverly H. ^*

Source: In Drug Metabolism and Disposition June 2014 42(6):1074-1083

Arsenic Metabolism in Mice Carrying a BORCS7/AS3MT Locus Humanized by Syntenic Replacement.

Authors: Koller, Beverly H.¹, Snouwaert, John N.¹, Douillet, Christelle², Jania, Leigh A.¹, El-Masri, Hisham³, Thomas, David J.³, Stýblo, Miroslav² styblo@med.unc.edu

Source: Environmental Health Perspectives. Aug2020, Vol. 128 Issue 8, p087003-1-087003-15. 15p. 1 Illustration, 1 Chart, 9 Graphs.

Subject Terms: *ARSENIC metabolism, *ANALYSIS of variance, *ANIMAL experimentation, *BIOTECHNOLOGY, *GENE expression, *GENES, *GENETIC polymorphisms, *MICE, *GENETIC mutation, *POLYMERASE chain reaction, *T-test (Statistics), *DETOXIFICATION (Alternative medicine), *ENVIRONMENTAL exposure, *DESCRIPTIVE statistics

An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice

Authors: Snouwaert, John N., Nguyen, MyTrang, Repenning, Peter W., Dye, Rebecca, Livingston, Eric W., Kovarova, Martina, Moy, Sheryl S., Brigman, Brian E., Bateman, Ted A., Ting, Jenny P.-Y., Koller, Beverly H.

Source: Cell reports. 17(11):3077-3088

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063108011.0x000001&indx=1&recIds=ETOCvdc_100063108011.0x000001

AT1A Angiotensin Receptors in the Renal Proximal Tubule Regulate Blood Pressure

Authors: Gurley, Susan B., Riquier-Brison, Anne D.M., Schnermann, Jurgen, Sparks, Matthew A., Allen, Andrew M., Haase, Volker H., Snouwaert, John N., Le, Thu H., McDonough, Alicia A., Koller, Beverley H., Coffman, Thomas M.

Source: Cell metabolism. 13(4):469-475

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100069980753.0x000001&indx=1&recIds=ETOCvdc_100069980753.0x000001

An Animal Model for Cystic Fibrosis Made by Gene Targeting

Authors: Snouwaert, John N., Brigman, Kristen K., Latour, Anne M., Malouf, Nadia N., Boucher, Richard C., Smithies, Oliver, Koller, Beverly H.

Source: Science, 1992 Aug . 257(5073), 1083-1088.

Access URL: https://www.jstor.org/stable/2879836

Altered Inflammatory Responses in Leukotriene-Deficient Mice

Authors: Goulet, Jennifer L., Snouwaert, John N., Latour, Anne M., Coffman, Thomas M., Koller, Beverly H.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1994 Dec . 91(26), 12852-12856.

Access URL: https://www.jstor.org/stable/2366441

High-Level Expression of a Bioengineered, Cysteine-Free Hepatocyte-Stimulating Factor (Interleukin 6)-Like Protein

Authors: Jambou, Robert C., Snouwaert, John N., Bishop, Gail Abendroth, Stebbins, John R., Frelinger, Jeffrey A., Fowlkes, Dana M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 1988 Dec . 85(24), 9426-9430.

Access URL: https://www.jstor.org/stable/32646

Deficits in sensorimotor gating and tests of social behavior in a genetic model of reduced NMDA receptor function

Authors: Duncan, Gary E, Moy, Sheryl S, Perez, Antonio, Eddy, Dawn M, Zinzow, Wendy M, Lieberman, Jeffrey A, Snouwaert, John N, Koller, Beverly H

Source: In Behavioural Brain Research 2004 153(2):507-519

Method of making cysteine depleted IL-6 muteins

Cysteine depleted IL-6 muteins

Oxysterols Modify NLRP2 in Epithelial Cells, Identifying a Mediator of Ozone-induced Inflammation.

Authors: Perryman, Alexia, Speen, Adam M., Kim, Hye-Young H., Hoffman, Jessica R., Clapp, Phillip W., Martin, William Rivera, Snouwaert, John N., Koller, Beverly H., Porter, Ned A., Jaspers, Ilona

Source: American Journal of Respiratory Cell & Molecular Biology; Nov2021, Vol. 65 Issue 5, p500-512, 31p

Subject Terms: OZONE, OXYSTEROLS, AIR pollutants, LUNG diseases, INFLAMMATION, LIPIDS

The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth.

Authors: Nguyen, MyTrang, Camenisch, Todd, Snouwaert, John N.

Source: Nature; November 6 1997, Vol. 390, p78-81, 4p

Alterations in regional brain metabolism in genetic and pharmacological models of reduced NMDA receptor function

Authors: Duncan, Gary E ^∗, Miyamoto, Seiya, Gu, Hongbin, Lieberman, Jeffrey A, Koller, Beverly H, Snouwaert, John N

Source: In Brain Research 2002 951(2):166-176

Dual vaccination against IL-4 and IL-13 protects against chronic allergic asthma in mice.

Authors: Conde, Eva, Bertrand, Romain, Balbino, Bianca, Bonnefoy, Jonathan, Stackowicz, Julien, Caillot, Noémie, Colaone, Fabien, Hamdi, Samir, Houmadi, Raïssa, Loste, Alexia, Kamphuis, Jasper B. J., Huetz, François, Guilleminault, Laurent, Gaudenzio, Nicolas, Mougel, Aurélie, Hardy, David, Snouwaert, John N., Koller, Beverly H., Serra, Vincent, Bruhns, Pierre

Source: Nature Communications; 5/11/2021, Vol. 12 Issue 1, p1-14, 14p

Subject Terms: MUCUS, IMMUNOGLOBULIN E, ASTHMA, HUMORAL immunity, VACCINATION, MONOCLONAL antibodies, VACCINE development, GENETIC translation

BRCA1 deficient embryonic stem cells display a decreased homologous recombination frequency and an increased frequency of non-homologous recombination that is corrected by expression of a Brca1 transgene.

Authors: Snouwaert, John N, Gowen, Lori C, Latour, Anne M, Mohn, Amy R, Xiao, Andrew, DiBiase, Lauren, Koller, Beverly H

Source: Oncogene. 12/20/99 Review, Vol. 18 Issue 55, p7900. 8p.

Subject Terms: *EMBRYONIC stem cells, *HOMOLOGY (Biology), *DNA repair, *TRANSGENES