KAT6B overexpression in mice causes aggression, anxiety, and epilepsy

Authors: Bergamasco, Maria I. ^{1, 2}, Ozturk, Ezgi ^{3, 4, 5}, Casillas-Espinosa, Pablo M. ^{3, 4, 5}, Garnham, Alexandra L. ^{1, 2}, Abeysekera, Waruni ^{1, 2}, Wimmer, Verena C. ^{1, 2}, Rajasekhar, Pradeep ^{1, 2}, Vanyai, Hannah K. ^{1, 2}, Whitehead, Lachlan ^{1, 2}, Blewitt, Marnie E. ^{1, 2}, Rogers, Kelly ^{1, 2}, Vogel, Adam P. ^{6, 7}, Hannan, Anthony J. ^{8, 9}, Smyth, Gordon K. ^{1, 10}, Jones, Nigel C. ^{3, 4, 5}, Thomas, Tim ^{1, 2, 11, 12, ∗}, Voss, Anne K. ^{1, 2, 11, 12, 13, ∗∗}

Source: In iScience 21 March 2025 28(3)

Self-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries

Authors: Ang, Chow Hiang ¹, Arandjelovic, Philip ^{2, 3}, Cheng, Jinming ^{2, 3, 4}, Yang, Jicheng ^{1, 2, 3}, Guo, Fusheng ¹, Yu, Yuanquan ⁵, Nelameham, Sarmilla ¹, Whitehead, Lachlan ^{3, 6}, Li, Jiangtao ⁵, Silver, David L. ⁷, Barker, Nick ^{8, 9}, Visvader, Jane E. ^{2, 3}, Chow, Pierce K.H. ^{10, 12}, Smyth, Gordon K. ^{4, 11}, Chen, Yunshun ^{2, 3, 4}, Virshup, David M. ¹, Fu, Nai Yang ^{1, 2, 3, 9, 13, ∗}

Source: In Cell Reports 28 January 2025 44(1)

Loss of KAT6B causes premature ossification and promotes osteoblast differentiation during development

Authors: Bergamasco, Maria I. ^{a, b}, Ogier, Jacqueline M. ^c, Garnham, Alexandra L. ^{a, b}, Whitehead, Lachlan ^{a, b}, Rogers, Kelly ^{a, b}, Smyth, Gordon K. ^{a, d}, Burt, Rachel A. ^e, Voss, Anne K. ^{a, b, ⁎⁎, 1}, Thomas, Tim ^{a, b, ⁎, 1}

Source: In Developmental Biology April 2025 520:141-154

Hormone-responsive progenitors have a unique identity and exhibit high motility during mammary morphogenesis

Authors: Dawson, Caleb A. ^{1, 2, 3, 10}, Milevskiy, Michael J.G. ^{1, 3, 10}, Capaldo, Bianca D. ^{1, 3}, Yip, Raymond K.H. ^{3, 4}, Song, Xiaoyu ^{1, 2}, Vaillant, François ^{1, 3}, Prokopuk, Lexie ^{1, 3, 9}, Jackling, Felicity C. ¹, Smyth, Gordon K. ^{5, 6}, Chen, Yunshun ^{1, 3, 5}, Lindeman, Geoffrey J. ^{1, 7, 8}, Visvader, Jane E. ^{1, 2, 11, ∗}

Source: In Cell Reports 24 December 2024 43(12)

The histone acetyltransferase KAT6B is required for hematopoietic stem cell development and function

Authors: Bergamasco, Maria I., Ranathunga, Nishika, Abeysekera, Waruni, Li-Wai-Suen, Connie S N, Garnham, Alexandra L., Willis, Simon N., McRae, Helen M., Yang, Yuqing, D’Amico, Angela, Di Rago, Ladina, Wilcox, Stephen, Nutt, Stephen L., Alexander, Warren S., Smyth, Gordon K., Voss, Anne K., Thomas, Tim

Source: In Stem Cell Reports 9 April 2024 19(4):469-485

Systemic inflammatory response syndrome triggered by blood-borne pathogens induces prolonged dendritic cell paralysis and immunosuppression

Authors: Ashayeripanah, Mitra, Vega-Ramos, Javier, Fernandez-Ruiz, Daniel, Valikhani, Shirin, Lun, Aaron T.L., White, Jason T., Young, Louise J., Yaftiyan, Atefeh, Zhan, Yifan, Wakim, Linda, Caminschi, Irina, Lahoud, Mireille H., Lew, Andrew M., Shortman, Ken, Smyth, Gordon K., Heath, William R., Mintern, Justine D., Roquilly, Antoine, Villadangos, Jose A.

Source: In Cell Reports 27 February 2024 43(2)

Survey of activation‐induced genome architecture reveals a novel enhancer of Myc

Authors: Chan, Wing Fuk, Coughlan, Hannah D, Ruhle, Michelle, Iannarella, Nadia, Alvarado, Carolina, Groom, Joanna R, Keenan, Christine R, Kueh, Andrew J, Wheatley, Adam K, Smyth, Gordon K, Allan, Rhys S, Johanson, Timothy M

Source: Immunology and cell biology. 101(4):345-357

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182147850.0x000001&indx=1&recIds=ETOCvdc_100182147850.0x000001

Three-dimensional genome architecture coordinates key regulators of lineage specification in mammary epithelial cells

Authors: Milevskiy, Michael J.G., Coughlan, Hannah D., Kane, Serena R., Johanson, Timothy M., Kordafshari, Somayeh, Chan, Wing Fuk, Tsai, Minhsuang, Surgenor, Elliot, Wilcox, Stephen, Allan, Rhys S., Chen, Yunshun, Lindeman, Geoffrey J., Smyth, Gordon K., Visvader, Jane E.

Source: In Cell Genomics 8 November 2023 3(11)

Loss of PHF6 causes spontaneous seizures, enlarged brain ventricles and altered transcription in the cortex of a mouse model of the Börjeson–Forssman–Lehmann intellectual disability syndrome.

Authors: McRae, Helen M.^1,2, Leong, Melody P. Y.^1,2, Bergamasco, Maria I.^1,2, Garnham, Alexandra L.^1,2, Hu, Yifang¹, Corbett, Mark A.³, Whitehead, Lachlan^1,2, El-Saafin, Farrah^1,2, Sheikh, Bilal N.^1,2, Wilcox, Stephen^1,2, Hannan, Anthony J.^4,5, Gécz, Jozef^3,6, Smyth, Gordon K.^1,7, Thomas, Tim^1,2, tthomas@wehi.edu.au, Voss, Anne K.^1,2, tthomas@wehi.edu.au

Source: PLoS Genetics; 10/15/2024, Vol. 20 Issue 10, p1-35, 35p

Stem cell plasticity, acetylation of H3K14, and de novo gene activation rely on KAT7

Authors: Kueh, Andrew J., Bergamasco, Maria I., Quaglieri, Anna, Phipson, Belinda, Li-Wai-Suen, Connie S.N., Lönnstedt, Ingrid M., Hu, Yifang, Feng, Zhi-Ping, Woodruff, Chris, May, Rose E., Wilcox, Stephen, Garnham, Alexandra L., Snyder, Michael P., Smyth, Gordon K., Speed, Terence P., Thomas, Tim, Voss, Anne K.

Source: In Cell Reports 31 January 2023 42(1)

The histone lysine acetyltransferase HBO1 (KAT7) regulates hematopoietic stem cell quiescence and self-renewal

Authors: Yang, Yuqing, Kueh, Andrew J., Grant, Zoe L., Abeysekera, Waruni, Garnham, Alexandra L., Wilcox, Stephen, Hyland, Craig D., Di Rago, Ladina, Metcalf, Don, Alexander, Warren S., Coultas, Leigh, Smyth, Gordon K., Voss, Anne K., Thomas, Tim

Source: Blood. 139(6):845-858

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100183249487.0x000001&indx=1&recIds=ETOCvdc_100183249487.0x000001

In vivo genome‐editing screen identifies tumor suppressor genes that cooperate with Trp53 loss during mammary tumorigenesis

Authors: Heitink, Luuk, Whittle, James R., Vaillant, François, Capaldo, Bianca D., Dekkers, Johanna F., Dawson, Caleb A., Milevskiy, Michael J. G., Surgenor, Elliot, Tsai, Minhsuang, Chen, Huei‐Rong, Christie, Michael, Chen, Yunshun, Smyth, Gordon K., Herold, Marco J., Strasser, Andreas, Lindeman, Geoffrey J., Visvader, Jane E.

Source: Molecular oncology. 16(5):1119-1131

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100144673745.0x000001&indx=1&recIds=ETOCvdc_100144673745.0x000001

MCL‑1 safeguards activated hair follicle stem cells to enable adult hair regeneration.

Authors: Chin, Hui San, Cheng, Jinming, Hsu, Shih Han, Lum, Guo Guang, Zaldivia, Maria TK, Nelameham, Sarmilla, Guo, Fusheng, Mallavarapu, Keerthana, Jackling, Felicity C., Yang, Jicheng, Tan, Jonathan S. L., Sampath, Prabha, Barker, Nick, Smyth, Gordon K., Lindeman, Geoffrey J., Strasser, Andreas, Visvader, Jane E., Chen, Yunshun, Chen, Ting, Fu, Nai Yang

Source: Nature Communications; 3/22/2025, Vol. 16 Issue 1, p1-20, 20p

KAT6B overexpression rescues embryonic lethality in homozygous null KAT6A mice restoring vitality and normal lifespan.

Authors: Bergamasco, Maria. I., Yang, Yuqing, Garnham, Alexandra L., Sheikh, Bilal N., Smyth, Gordon K., Voss, Anne. K., Thomas, Tim

Source: Nature Communications; 2/25/2025, Vol. 16 Issue 1, p1-16, 16p

KAT6B is required for histone 3 lysine 9 acetylation and SOX gene expression in the developing brain.

Authors: Bergamasco, Maria I., Abeysekera, Waruni, Garnham, Alexandra L., Yifang Hu, Li-Wai-Suen, Connie S. N., Sheikh, Bilal N., Smyth, Gordon K., Thomas, Tim, Voss, Anne K.

Source: Life Science Alliance; Feb2025, Vol. 8 Issue 2, p1-19, 19p

edgeR v4: powerful differential analysis of sequencing data with expanded functionality and improved support for small counts and larger datasets.

Authors: Chen, Yunshun, Chen, Lizhong, Lun, Aaron T L, Baldoni, Pedro L, Smyth, Gordon K

Source: Nucleic Acids Research; 1/27/2025, Vol. 53 Issue 2, p1-14, 14p

Benchmarking cell type annotation methods for 10x Xenium spatial transcriptomics data.

Authors: Cheng, Jinming, Jin, Xinyi, Smyth, Gordon K., Chen, Yunshun

Source: BMC Bioinformatics; 1/20/2025, Vol. 26 Issue 1, p1-15, 15p

Subject Terms: GENE expression profiling, TRANSCRIPTOMES, RNA sequencing, LIFE sciences, BREAST cancer

Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition

Authors: Hogg, Simon J., Motorna, Olga, Cluse, Leonie A., Johanson, Timothy M., Coughlan, Hannah D., Raviram, Ramya, Myers, Robert M., Costacurta, Matteo, Todorovski, Izabela, Pijpers, Lizzy, Bjelosevic, Stefan, Williams, Tobias, Huskins, Shannon N., Kearney, Conor J., Devlin, Jennifer R., Fan, Zheng, Jabbari, Jafar S., Martin, Ben P., Fareh, Mohamed, Kelly, Madison J., Dupéré-Richer, Daphné, Sandow, Jarrod J., Feran, Breon, Knight, Deborah, Khong, Tiffany, Spencer, Andrew, Harrison, Simon J., Gregory, Gareth, Wickramasinghe, Vihandha O., Webb, Andrew I., Taberlay, Phillippa C., Bromberg, Kenneth D., Lai, Albert, Papenfuss, Anthony T., Smyth, Gordon K., Allan, Rhys S., Licht, Jonathan D., Landau, Dan A., Abdel-Wahab, Omar, Shortt, Jake, Vervoort, Stephin J., Johnstone, Ricky W.

Source: In Molecular Cell 20 May 2021 81(10):2183-2200

statmod: Probability Calculations for the Inverse Gaussian Distribution

Authors: Giner, Göknur, Smyth, Gordon K.

Subject Terms: Statistics - Computation

Access URL: http://arxiv.org/abs/1603.06687

Permutation p-values should never be zero: calculating exact p-values when permutations are randomly drawn

Authors: Phipson, Belinda, Smyth, Gordon K.

Source: Stat. Appl. Genet. Molec. Biol., Volume 9 (2010), Issue 1, Article 39

Subject Terms: Statistics - Applications, 62G09, 62G10

Access URL: http://arxiv.org/abs/1603.05766