Transcriptomic evaluation of tau and TDP-43 synergism shows tauopathy predominance and reveals potential modulating targets

Authors: Jadhav, Vaishnavi S., Stair, Jade G., Eck, Randall J., Smukowski, Samuel N., Currey, Heather N., Toscano, Laura Garcia, Hincks, Joshua C., Latimer, Caitlin S., Valdmanis, Paul N., Kraemer, Brian C., Liachko, Nicole F.

Source: In Neurobiology of Disease April 2024 193

mRNA and circRNA mislocalization to synapses are key features of Alzheimer's disease.

Authors: Smukowski, Samuel N.^1,2 (AUTHOR), Danyko, Cassidy^1,3 (AUTHOR), Somberg, Jenna^1,4 (AUTHOR), Kaufman, Eli J.¹ (AUTHOR), Course, Meredith M.^1,5 (AUTHOR), Postupna, Nadia⁴ (AUTHOR), Barker-Haliski, Melissa⁶ (AUTHOR), Keene, C. Dirk^4,7 (AUTHOR), Valdmanis, Paul N.^1,2,4 (AUTHOR) paulnv@uw.edu

Source: PLoS Genetics. 7/29/2024, Vol. 20 Issue 7, p1-35. 35p.

Subject Terms: *CIRCULAR RNA, *ALZHEIMER'S disease, *IMMOBILIZED proteins, *NEUROFIBRILLARY tangles, *AMPA receptors, *NEUROPLASTICITY, *MESSENGER RNA, *SYNAPSES

Evolution of a Human-Specific Tandem Repeat Associated with ALS

Authors: Course, Meredith M., Gudsnuk, Kathryn, Smukowski, Samuel N., Winston, Kosuke, Desai, Nitin, Ross, Jay P., Sulovari, Arvis, Bourassa, Cynthia V., Spiegelman, Dan, Couthouis, Julien, Yu, Chang-En, Tsuang, Debby W., Jayadev, Suman, Kay, Mark A., Gitler, Aaron D., Dupre, Nicolas, Eichler, Evan E., Dion, Patrick A., Rouleau, Guy A., Valdmanis, Paul N.

Source: In The American Journal of Human Genetics 3 September 2020 107(3):445-460

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Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer’s Disease-like Pathology

Authors: Savas, Jeffrey N., Wang, Yi-Zhi, DeNardo, Laura A., Martinez-Bartolome, Salvador, McClatchy, Daniel B., Hark, Timothy J., Shanks, Natalie F., Cozzolino, Kira A., Lavallée-Adam, Mathieu, Smukowski, Samuel N., Park, Sung Kyu, Kelly, Jeffery W., Koo, Edward H., Nakagawa, Terunaga, Masliah, Eliezer, Ghosh, Anirvan, Yates, John R., III

Source: In Cell Reports 28 November 2017 21(9):2614-2627

Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins

Authors: Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J., Heroven, Christina, Vennekens, Kristel M., Smukowski, Samuel N., Regan, Michael C., Jia, Wanyi, Smith, Alexandra C., Furukawa, Hiro, Savas, Jeffrey N., de Wit, Joris, Begbie, Jo, Craig, Ann Marie, Aricescu, A. Radu

Source: In Neuron 16 August 2017 95(4):896-913

Progress in Amyotrophic Lateral Sclerosis Gene Discovery

Authors: Smukowski, Samuel N., Maioli, Heather, Latimer, Caitlin S., Bird, Thomas D., Jayadev, Suman, Valdmanis, Paul N.

Source: Neurology.Genetics. 8(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153009929.0x000001&indx=1&recIds=ETOCvdc_100153009929.0x000001

Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer

Authors: Apóstolo, Nuno, Smukowski, Samuel N., Vanderlinden, Jeroen, Condomitti, Giuseppe, Rybakin, Vasily, ten Bos, Jolijn, Trobiani, Laura, Portegies, Sybren, Vennekens, Kristel M., Gounko, Natalia V., Comoletti, Davide, Wierda, Keimpe D., Savas, Jeffrey N., de Wit, Joris

Source: Nature communications. 11(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174470464.0x000001&indx=1&recIds=ETOCvdc_100174470464.0x000001

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Structural Mechanism for Modulation of Synaptic Neuroligin-Neurexin Signaling by MDGA Proteins

Authors: Elegheert, Jonathan, Cvetkovska, Vedrana, Clayton, Amber J., Heroven, Christina, Vennekens, Kristel M., Smukowski, Samuel N., Regan, Michael C., Jia, Wanyi, Smith, Alexandra C., Furukawa, Hiro, Savas, Jeffrey N., de Wit, Joris, Begbie, Jo, Craig, Ann Marie, Aricescu, A. Radu

Source: Neuron. 109(1):189-190

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121107194.0x000001&indx=1&recIds=ETOCvdc_100121107194.0x000001

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