Nature or nurture: genetic and environmental predictors of adiposity gain in adults

Authors: Peruchet-Noray, Laia ^{a, b}, Dimou, Niki ^a, Cordova, Reynalda ^{a, c}, Fontvieille, Emma ^a, Jansana, Anna ^a, Gan, Quan ^a, Breeur, Marie ^a, Baurecht, Hansjörg ^d, Bohmann, Patricia ^d, Konzok, Julian ^d, Stein, Michael J. ^d, Dahm, Christina C. ^e, Zilhão, Nuno R. ^e, Mellemkjær, Lene ^f, Tjønneland, Anne ^{f, g}, Kaaks, Rudolf ^h, Katzke, Verena ^h, Inan-Eroglu, Elif ⁱ, Schulze, Matthias B. ^{i, j}, Masala, Giovanna ^k, Sieri, Sabina ^l, Simeon, Vittorio ^m, Matullo, Giuseppe ^{n, o}, Molina-Montes, Esther ^{p, q, r, s}, Amiano, Pilar ^{q, t, u}, Chirlaque, María-Dolores ^{q, v}, Gasque, Alba ^w, Atkins, Joshua ^x, Smith-Byrne, Karl ^x, Ferrari, Pietro ^a, Viallon, Vivian ^a, Agudo, Antonio ^y, Gunter, Marc J. ^{a, z}, Bonet, Catalina ^y, Freisling, Heinz ^{a, ∗∗}, Carreras-Torres, Robert ^{aa, ∗}

Source: In eBioMedicine January 2025 111

Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics

Authors: Desai, Trishna A., Hedman, Åsa K., Dimitriou, Marios, Koprulu, Mine, Figiel, Sandy, Yin, Wencheng, Johansson, Mattias, Watts, Eleanor L., Atkins, Joshua R., Sokolov, Aleksandr V., Schiöth, Helgi B., Gunter, Marc J., Tsilidis, Konstantinos K., Martin, Richard M., Pietzner, Maik, Langenberg, Claudia, Mills, Ian G., Lamb, Alastair D., Mälarstig, Anders, Key, Tim J., Travis, Ruth C., Smith-Byrne, Karl

Source: In eBioMedicine July 2024 105

Association between circulating inflammatory markers and adult cancer risk: a Mendelian randomization analysis

Authors: Landi, Maria Teresa, Stevens, Victoria, Wang, Ying, Albanes, Demetrios, Caporaso, Neil, Brennan, Paul, Amos, Christopher I., Shete, Sanjay, Hung, Rayjean J., Bickeböller, Heike, Risch, Angela, Houlston, Richard, Lam, Stephen, Tardon, Adonina, Chen, Chu, Bojesen, Stig E., Johansson, Mattias, Wichmann, H-Erich, Christiani, David, Rennert, Gadi, Arnold, Susanne, Field, John K., Le Marchand, Loic, Melander, Olle, Brunnström, Hans, Liu, Geoffrey, Andrew, Angeline, Kiemeney, Lambertus A., Shen, Hongbing, Zienolddiny, Shan, Grankvist, Kjell, Johansson, Mikael, Teare, M. Dawn, Hong, Yun-Chul, Yuan, Jian-Min, Lazarus, Philip, Schabath, Matthew B., Aldrich, Melinda C., Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia, Schumacher, Fredrick R., Benlloch, Sara, Al Olama, Ali Amin, Muir, Kenneth R., Berndt, Sonja I., Conti, David V., Wiklund, Fredrik, Chanock, Stephen, Tangen, Catherine M., Batra, Jyotsna, Clements, Judith A., Grönberg, Henrik, Pashayan, Nora, Schleutker, Johanna, Albanes, Demetrius, Weinstein, Stephanie J., Wolk, Alicja, West, Catharine M.L., Mucci, Lorelei A., Cancel-Tassin, Géraldine, Koutros, Stella, Sørensen, Karina Dalsgaard, Grindedal, Eli Marie, Neal, David E., Hamdy, Freddie C., Donovan, Jenny L., Travis, Ruth C., Hamilton, Robert J., Ingles, Sue Ann, Rosenstein, Barry S., Lu, Yong-Jie, Giles, Graham G., MacInnis, Robert J., Kibel, Adam S., Vega, Ana, Kogevinas, Manolis, Penney, Kathryn L., Park, Jong Y., Stanfrod, Janet L., Cybulski, Cezary, Nordestgaard, Børge G., Nielsen, Sune F., Brenner, Hermann, Maier, Christiane, Logothetis, Christopher J., John, Esther M., Teixeira, Manuel R., Neuhausen, Susan L., De Ruyck, Kim, Razack, Azad, Newcomb, Lisa F., Lessel, Davor, Kaneva, Radka, Usmani, Nawaid, Claessens, Frank, Townsend, Paul A., Castelao, Jose Esteban, Roobol, Monique J., Menegaux, Florence, Khaw, Kay-Tee, Cannon-Albright, Lisa, Pandha, Hardev, Thibodeau, Stephen N., Hunter, David J., Kraft, Peter, Blot, William J., Riboli, Elio, Yarmolinsky, James, Robinson, Jamie W., Mariosa, Daniela, Karhunen, Ville, Huang, Jian, Dimou, Niki, Murphy, Neil, Burrows, Kimberley, Bouras, Emmanouil, Smith-Byrne, Karl, Lewis, Sarah J., Galesloot, Tessel E., Vermeulen, Sita, Martin, Paul, Hou, Lifang, Newcomb, Polly A., White, Emily, Wu, Anna H., Le Marchand, Loïc, Phipps, Amanda I., Buchanan, Daniel D., Zhao, Sizheng Steven, Gill, Dipender, Chanock, Stephen J., Purdue, Mark P., Davey Smith, George, Herzig, Karl-Heinz, Järvelin, Marjo-Riitta, Amos, Chris I., Dehghan, Abbas, Gunter, Marc J., Tsilidis, Kostas K., Martin, Richard M.

Source: In eBioMedicine February 2024 100

Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes

Authors: Bull, Caroline J., Hazelwood, Emma, Legge, Danny N., Corbin, Laura J., Richardson, Tom G., Lee, Matthew, Yarmolinsky, James, Smith-Byrne, Karl, Hughes, David A., Johansson, Mattias, Peters, Ulrike, Berndt, Sonja I., Brenner, Hermann, Burnett-Hartman, Andrea, Cheng, Iona, Kweon, Sun-Seog, Le Marchand, Loic, Li, Li, Newcomb, Polly A., Pearlman, Rachel, McConnachie, Alex, Welsh, Paul, Taylor, Roy, Lean, Mike E.J., Sattar, Naveed, Murphy, Neil, Gunter, Marc J., Timpson, Nicholas J., Vincent, Emma E.

Source: In eBioMedicine February 2024 100

Evaluation of pre-diagnostic blood protein measurements for predicting survival after lung cancer diagnosis

Authors: Feng, Xiaoshuang, Muller, David C., Zahed, Hana, Alcala, Karine, Guida, Florence, Smith-Byrne, Karl, Yuan, Jian-Min, Koh, Woon-Puay, Wang, Renwei, Milne, Roger L., Bassett, Julie K., Langhammer, Arnulf, Hveem, Kristian, Stevens, Victoria L., Wang, Ying, Johansson, Mikael, Tjønneland, Anne, Tumino, Rosario, Sheikh, Mahdi, Johansson, Mattias, Robbins, Hilary A.

Source: In eBioMedicine June 2023 92

Design and methodological considerations for biomarker discovery and validation in the Integrative Analysis of Lung Cancer Etiology and Risk (INTEGRAL) Program

Authors: Robbins, Hilary A., Alcala, Karine, Moez, Elham Khodayari, Guida, Florence, Thomas, Sera, Zahed, Hana, Warkentin, Matthew T., Smith-Byrne, Karl, Brhane, Yonathan, Muller, David, Feng, Xiaoshuang, Albanes, Demetrius, Aldrich, Melinda C., Arslan, Alan A., Bassett, Julie, Berg, Christine D., Cai, Qiuyin, Chen, Chu, Davies, Michael P.A., Diergaarde, Brenda, Field, John K., Freedman, Neal D., Huang, Wen-Yi, Johansson, Mikael, Jones, Michael, Koh, Woon-Puay, Lam, Stephen, Lan, Qing, Langhammer, Arnulf, Liao, Linda M., Liu, Geoffrey, Malekzadeh, Reza, Milne, Roger L., Montuenga, Luis M., Rohan, Thomas, Sesso, Howard D., Severi, Gianluca, Sheikh, Mahdi, Sinha, Rashmi, Shu, Xiao-Ou, Stevens, Victoria L., Tammemägi, Martin C., Tinker, Lesley F., Visvanathan, Kala, Wang, Ying, Wang, Renwei, Weinstein, Stephanie J., White, Emily, Wilson, David, Yuan, Jian-Min, Zhang, Xuehong, Zheng, Wei, Amos, Christopher I., Brennan, Paul, Johansson, Mattias, Hung, Rayjean J.

Source: In Annals of Epidemiology January 2023 77:1-12

Blood pressure lowering and risk of new-onset type 2 diabetes: an individual participant data meta-analysis

Authors: Nazarzadeh, Milad, Bidel, Zeinab, Canoy, Dexter, Copland, Emma, Wamil, Malgorzata, Majert, Jeannette, Smith Byrne, Karl, Sundström, Johan, Teo, Koon, Davis, Barry R, Chalmers, John, Pepine, Carl J, Dehghan, Abbas, Bennett, Derrick A, Smith, George Davey, Rahimi, Kazem ^*

Source: In The Lancet 13 November 2021 398(10313):1803-1810

A proteogenomic analysis of the adiposity colorectal cancer relationship identifies GREM1 as a probable mediator.

Authors: Lee, Matthew A, Hatcher, Charlie A, Hazelwood, Emma, Goudswaard, Lucy J, Tsilidis, Konstantinos K, Vincent, Emma E, Martin, Richard M, Smith-Byrne, Karl, Brenner, Hermann, Cheng, Iona, Kweon, Sun-Seog, Marchand, Loic Le, Newcomb, Polly A, Schoen, Robert E, Peters, Ulrike, Gunter, Marc J, Guelpen, Bethany Van, Murphy, Neil

Source: International Journal of Epidemiology; Feb2025, Vol. 54 Issue 1, p1-13, 13p

Subject Terms: MENDELIAN randomization, DISEASE risk factors, BODY mass index, COLORECTAL cancer, OBESITY

Alcohol intake and endogenous sex hormones in women: Meta‐analysis of cohort studies and Mendelian randomization.

Authors: Tin Tin, Sandar¹ (AUTHOR) sandar.tintin@ndph.ox.ac.uk, Smith‐Byrne, Karl¹ (AUTHOR), Ferrari, Pietro² (AUTHOR), Rinaldi, Sabina² (AUTHOR), McCullough, Marjorie L.³ (AUTHOR), Teras, Lauren R.³ (AUTHOR), Manjer, Jonas⁴ (AUTHOR), Giles, Graham⁵ (AUTHOR), Le Marchand, Loïc⁶ (AUTHOR), Haiman, Christopher A.⁷ (AUTHOR), Wilkens, Lynne R.⁶ (AUTHOR), Chen, Yu⁸ (AUTHOR), Hankinson, Sue⁹ (AUTHOR), Tworoger, Shelley¹⁰ (AUTHOR), Eliassen, A. Heather^11,12 (AUTHOR), Willett, Walter C.^11,12 (AUTHOR), Ziegler, Regina G.¹³ (AUTHOR), Fuhrman, Barbara J.¹⁴ (AUTHOR), Sieri, Sabina¹⁵ (AUTHOR), Agnoli, Claudia¹⁵ (AUTHOR)

Source: Cancer (0008543X). Oct2024, Vol. 130 Issue 19, p3375-3386. 12p.

Subject Terms: *SEX hormones, *ALCOHOL dehydrogenase, *ALCOHOL drinking, *ESTRONE, *BREAST cancer

Smoking and alcohol by HPV status in head and neck cancer: a Mendelian randomization study.

Authors: Thakral, Abhinav, Lee, John JW., Hou, Tianzhichao, Hueniken, Katrina, Dudding, Tom, Gormley, Mark, Virani, Shama, Olshan, Andrew, Diergaarde, Brenda, Ness, Andrew R., Waterboer, Tim, Smith-Byrne, Karl, Brennan, Paul, Hayes, D. Neil, Sanderson, Eleanor, Brown, M. Catherine, Huang, Sophie, Bratman, Scott V., Spreafico, Anna, De Almeida, John

Source: Nature Communications; 9/10/2024, Vol. 15 Issue 1, p1-9, 9p

Subject Terms: HEAD & neck cancer, HUMAN papillomavirus, SQUAMOUS cell carcinoma, CARCINOGENESIS, SMOKING

Geographic variation of mutagenic exposures in kidney cancer genomes.

Authors: Senkin, Sergey, Moody, Sarah, Díaz-Gay, Marcos, Abedi-Ardekani, Behnoush, Cattiaux, Thomas, Ferreiro-Iglesias, Aida, Wang, Jingwei, Fitzgerald, Stephen, Kazachkova, Mariya, Vangara, Raviteja, Le, Anh Phuong, Bergstrom, Erik N., Khandekar, Azhar, Otlu, Burçak, Cheema, Saamin, Latimer, Calli, Thomas, Emily, Atkins, Joshua Ronald, Smith-Byrne, Karl, Cortez Cardoso Penha, Ricardo

Source: Nature; May2024, Vol. 629 Issue 8013, p910-918, 9p

Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers.

Authors: Smith-Byrne, Karl, Hedman, Åsa, Dimitriou, Marios, Desai, Trishna, Sokolov, Alexandr V., Schioth, Helgi B., Koprulu, Mine, Pietzner, Maik, Langenberg, Claudia, Atkins, Joshua, Penha, Ricardo Cortez, McKay, James, Brennan, Paul, Sirui Zhou, Richards, Brent J., Yarmolinsky, James, Martin, Richard M., Borlido, Joana, Mu, Xinmeng J., Butterworth, Adam

Source: Nature Communications; 4/29/2024, Vol. 15 Issue 1, p1-11, 11p

Observational and genetic associations between cardiorespiratory fitness and cancer: a UK Biobank and international consortia study.

Authors: Watts, Eleanor L., Gonzales, Tomas I., Strain, Tessa, Saint-Maurice, Pedro F., Bishop, D. Timothy, Chanock, Stephen J., Johansson, Mattias, Keku, Temitope O., Le Marchand, Loic, Moreno, Victor, Newcomb, Polly A., Newton, Christina C., Pai, Rish K., Purdue, Mark P., Ulrich, Cornelia M., Smith-Byrne, Karl, Van Guelpen, Bethany, Eeles, Rosalind A., Haiman, Christopher A., Kote-Jarai, Zsofia

Source: British Journal of Cancer; Jan2024, Vol. 130 Issue 1, p114-124, 11p

Evaluation of circulating plasma proteins in breast cancer using Mendelian randomisation.

Authors: Mälarstig, Anders, Grassmann, Felix, Dahl, Leo, Dimitriou, Marios, McLeod, Dianna, Gabrielson, Marike, Smith-Byrne, Karl, Thomas, Cecilia E., Huang, Tzu-Hsuan, Forsberg, Simon K. G., Eriksson, Per, Ulfstedt, Mikael, Johansson, Mattias, Sokolov, Aleksandr V., Schiöth, Helgi B., Hall, Per, Schwenk, Jochen M., Czene, Kamila, Hedman, Åsa K.

Source: Nature Communications; 11/24/2023, Vol. 14 Issue 1, p1-9, 9p

Subject Terms: BLOOD proteins, BREAST cancer, EARLY detection of cancer, DRUG target, DISEASE risk factors

Kidney Function and Risk of Renal Cell Carcinoma.

Authors: Alcala, Karine¹, Zahed, Hana¹, Cardoso Penha, Ricardo Cortez¹, Alcala, Nicolas¹, Robbins, Hilary A.¹, Smith-Byrne, Karl², Martin, Richard M.^3,4,5, Muller, David C.⁶, Brennan, Paul¹, Johansson, Mattias¹ johanssonm@iarc.who.int

Source: Cancer Epidemiology, Biomarkers & Prevention. Nov2023, Vol. 32 Issue 11, p1644-1650. 7p.

Lung cancer risk discrimination of prediagnostic proteomics measurements compared with existing prediction tools.

Authors: Feng, Xiaoshuang, Wu, Wendy Yi-Ying, Onwuka, Justina Ucheojor, Haider, Zahra, Alcala, Karine, Smith-Byrne, Karl, Zahed, Hana, Guida, Florence, Wang, Renwei, Bassett, Julie K, Stevens, Victoria, Wang, Ying, Weinstein, Stephanie, Freedman, Neal D, Chen, Chu, Tinker, Lesley, Nøst, Therese Haugdahl, Koh, Woon-Puay, Muller, David, Colorado-Yohar, Sandra M

Source: JNCI: Journal of the National Cancer Institute; Sep2023, Vol. 115 Issue 9, p1050-1059, 10p

Subject Terms: LUNG cancer, DISEASE risk factors, RECEIVER operating characteristic curves, PROTEOMICS, EARLY detection of cancer

Genetic predisposition to metabolically unfavourable adiposity and prostate cancer risk: A Mendelian randomization analysis.

Authors: Perez‐Cornago, Aurora¹ (AUTHOR) aurora.perez‐cornago@ceu.ox.ac.uk, Smith‐Byrne, Karl¹ (AUTHOR), Hazelwood, Emma^2,3 (AUTHOR), Watling, Cody Z.¹ (AUTHOR), Martin, Susan⁴ (AUTHOR), Frayling, Timothy⁴ (AUTHOR), Lewis, Sarah^2,3 (AUTHOR), Martin, Richard M.^3,5 (AUTHOR), Yaghootkar, Hanieh^6,7 (AUTHOR), Travis, Ruth C.¹ (AUTHOR), Key, Timothy J.¹ (AUTHOR)

Source: Cancer Medicine. Aug2023, Vol. 12 Issue 15, p16482-16489. 8p.

Subject Terms: *PROSTATE cancer, *DISEASE risk factors, *OBESITY, *BODY mass index, *AGE of onset

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome.

Authors: Cardoso Penha, Ricardo Cortez¹ cortezr@iarc.who.int, Smith-Byrne, Karl², Atkins, Joshua R.¹, Haycock, Philip C.³, Kar, Siddhartha³, Codd, Veryan^4,5, Samani, Nilesh J.^4,5, Nelson, Christopher^4,5, Milojevic, Maja¹, Gabriel, Aurélie A. G.⁶, Amos, Christopher⁷, Brennan, Paul¹, Hung, Rayjean J.⁸, Kachuri, Linda⁹, Mckay, James D.¹ mckayj@iarc.who.int

Source: eLife. 4/20/2023, p1-20. 20p.

Subject Terms: *TELOMERES, *LUNG cancer, *GENETIC variation, *CANCER genes, *LUNGS, *GENE expression profiling

Company/Entity: NATIONAL Institutes of Health (U.S.)

Circulating insulin-like growth factors and risks of overall, aggressive and early-onset prostate cancer: a collaborative analysis of 20 prospective studies and Mendelian randomization analysis.

Authors: Watts, Eleanor L, Perez-Cornago, Aurora, Fensom, Georgina K, Smith-Byrne, Karl, Noor, Urwah, Andrews, Colm D, Gunter, Marc J, Holmes, Michael V, Martin, Richard M, Tsilidis, Konstantinos K, Albanes, Demetrius, Barricarte, Aurelio, Bueno-de-Mesquita, H Bas, Cohn, Barbara A, Deschasaux-Tanguy, Melanie, Dimou, Niki L, Ferrucci, Luigi, Flicker, Leon, Freedman, Neal D, Giles, Graham G

Source: International Journal of Epidemiology; Feb2023, Vol. 52 Issue 1, p71-86, 16p

Subject Terms: SOMATOMEDIN, PROSTATE cancer, RANDOMIZATION (Statistics), SOMATOMEDIN C, INSULIN-like growth factor-binding proteins, ANDROGEN receptors, LONGITUDINAL method, LINKAGE disequilibrium

Geographic Terms: UNITED Kingdom

Serum Extracellular Vesicle-Derived microRNAs as Potential Biomarkers for Pleural Mesothelioma in a European Prospective Study.

Authors: Casalone, Elisabetta, Birolo, Giovanni, Pardini, Barbara, Allione, Alessandra, Russo, Alessia, Catalano, Chiara, Mencoboni, Manlio, Ferrante, Daniela, Magnani, Corrado, Sculco, Marika, Dianzani, Irma, Grosso, Federica, Mirabelli, Dario, Filiberti, Rosa Angela, Rena, Ottavio, Sacerdote, Carlotta, Rodriguez-Barranco, Miguel, Smith-Byrne, Karl, Panico, Salvatore, Agnoli, Claudia

Source: Cancers; Jan2023, Vol. 15 Issue 1, p125, 15p

Subject Terms: BIOMARKERS, MESOTHELIOMA, MICRORNA, CASE-control method, RETROSPECTIVE studies, TREATMENT effectiveness, PLEURAL tumors, RESEARCH funding, SENSITIVITY & specificity (Statistics), EXTRACELLULAR vesicles, LONGITUDINAL method, EARLY medical intervention

Geographic Terms: EUROPE