The key characteristics concept

Authors: Smith, Martyn T. ^⁎

Source: In Current Opinion in Toxicology March 2025 41

Mapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review

Authors: Rana, Iemaan, Nguyen, Patton K., Rigutto, Gabrielle, Louie, Allen, Lee, Jane, Smith, Martyn T., Zhang, Luoping

Source: In Chemosphere October 2023 339

Nonlinear low dose hematotoxicity of benzene; a pooled analyses of two studies among Chinese exposed workers

Authors: Vermeulen, Roel, Lan, Qing, Qu, Qingshan, Linet, Martha S., Zhang, Luoping, Li, Guilan, Portengen, Lutzen, Vlaanderen, Jelle, Sungkyoon, Kim, Hayes, Richard B., Yin, Songnian, Smith, Martyn T., Rappaport, Stephen M., Rothman, Nathaniel

Source: In Environment International July 2023 177

A systematic evidence map of chronic inflammation and immunosuppression related to per- and polyfluoroalkyl substance (PFAS) exposure

Authors: Zhang, Luoping ^{a, ∗}, Louie, Allen ^{a, b}, Rigutto, Gabrielle ^a, Guo, Helen ^a, Zhao, Yun ^a, Ahn, Stacy ^a, Dahlberg, Sarah ^a, Sholinbeck, Michael ^c, Smith, Martyn T. ^a

Source: In Environmental Research 1 March 2023 220

The vitamin D receptor as a potential target for the toxic effects of per- and polyfluoroalkyl substances (PFASs): An in-silico study

Authors: Azhagiya Singam, Ettayapuram Ramaprasad, Durkin, Kathleen A., La Merrill, Michele A., Furlow, J. David, Wang, Jen-Chywan, Smith, Martyn T.

Source: In Environmental Research 15 January 2023 217

Epigenome-wide association studies of occupational exposure to benzene and formaldehyde

Authors: Phillips, Rachael V., Wei, Linqing, Cardenas, Andres, Hubbard, Alan E., McHale, Cliona M., Vermeulen, Roel, Wei, Hu, Smith, Martyn T., Zhang, Luoping, Lan, Qing, Rothman, Nathaniel

Source: Epigenetics. 17(13):2259-2277

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182257215.0x000001&indx=1&recIds=ETOCvdc_100182257215.0x000001

Targeted proteomic scan identifies alteration of serum proteins among workers occupationally exposed to low levels of trichloroethylene

Authors: Hosgood, H. Dean, Rahman, Mohammad L., Blansky, Deanna, Hu, Wei, Davitt, Meghan, Wen, Cuiju, Huang, Yongshun, Tang, Xiaojiang, Li, Laiyu, Smith, Martyn T., Zhang, Luoping, Vermeulen, Roel, Rothman, Nathaniel, Bassig, Bryan A., Lan, Qing

Source: Environmental and molecular mutagenesis. 63(8-9):423-428

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100169405323.0x000001&indx=1&recIds=ETOCvdc_100169405323.0x000001

In Vitro characterization of the endocrine disrupting effects of per- and poly-fluoroalkyl substances (PFASs) on the human androgen receptor

Authors: Tachachartvanich, Phum, Singam, Ettayapuram Ramaprasad Azhagiya, Durkin, Kathleen A., Furlow, J. David, Smith, Martyn T., La Merrill, Michele A.

Source: In Journal of Hazardous Materials 5 May 2022 429

Epigenetic aging biomarkers and occupational exposure to benzene, trichloroethylene and formaldehyde

Authors: van der Laan, Lars, Cardenas, Andres, Vermeulen, Roel, Fadadu, Raj P., Hubbard, Alan E., Phillips, Rachael V., Zhang, Luoping, Breeze, Charles, Hu, Wei, Wen, Cuiju, Huang, Yongshun, Tang, Xiaojiang, Smith, Martyn T., Rothman, Nathaniel, Lan, Qing

Source: In Environment International January 2022 158

Consensus on the key characteristics of metabolism disruptors.

Authors: La Merrill, Michele A.¹ (AUTHOR) mlamerrill@ucdavis.edu, Smith, Martyn T.² (AUTHOR), McHale, Cliona M.² (AUTHOR), Heindel, Jerrold J.³ (AUTHOR), Atlas, Ella⁴ (AUTHOR), Cave, Matthew C.⁵ (AUTHOR), Collier, David⁶ (AUTHOR), Guyton, Kathryn Z.⁷ (AUTHOR), Koliwad, Suneil⁸ (AUTHOR), Nadal, Angel⁹ (AUTHOR), Rhodes, Christopher J.¹⁰ (AUTHOR), Sargis, Robert M.¹¹ (AUTHOR), Zeise, Lauren¹² (AUTHOR), Blumberg, Bruce¹³ (AUTHOR)

Source: Nature Reviews Endocrinology. Apr2025, Vol. 21 Issue 4, p245-261. 17p.

Metabolome-wide association study of occupational exposure to benzene

Authors: Rothman, Nathaniel, Vermeulen, Roel, Zhang, Luoping, Hu, Wei, Yin, Songnian, Rappaport, Stephen M, Smith, Martyn T, Jones, Dean P, Rahman, Mohammad, Lan, Qing, Walker, Douglas I

Source: Carcinogenesis. 42(11):1326-1336

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100138288662.0x000001&indx=1&recIds=ETOCvdc_100138288662.0x000001

Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity

Authors: Rusyn, Ivan, Arzuaga, Xabier, Cattley, Russell C., Corton, J. Christopher, Ferguson, Stephen S., Godoy, Patricio, Guyton, Kathryn Z., Kaplowitz, Neil, Khetani, Salman R., Roberts, Ruth A., Roth, Robert A., Smith, Martyn T.

Source: Hepatology. 74(6):3486-3496

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100135784514.0x000001&indx=1&recIds=ETOCvdc_100135784514.0x000001

Cell‐Based Bioassay to Screen Environmental Chemicals and Human Serum for Total Glucocorticogenic Activity

Authors: Rosa, Rosemarie, Vazquez, Sergio, Tachachartvanich, Phum, Daniels, Sarah I., Sillé, Fenna, Smith, Martyn T.

Source: Environmental toxicology and chemistry. 40(1):177-186

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116578113.0x000001&indx=1&recIds=ETOCvdc_100116578113.0x000001

Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands

Authors: de la Rosa, Rosemarie, Schlezinger, Jennifer J., Smith, Martyn T., Webster, Thomas F.

Source: In Toxicology in Vitro December 2020 69

Structure-based virtual screening of perfluoroalkyl and polyfluoroalkyl substances (PFASs) as endocrine disruptors of androgen receptor activity using molecular docking and machine learning

Authors: Azhagiya Singam, Ettayapuram Ramaprasad, Tachachartvanich, Phum, Fourches, Denis, Soshilov, Anatoly, Hsieh, Jennifer C.Y., La Merrill, Michele A., Smith, Martyn T., Durkin, Kathleen A.

Source: In Environmental Research November 2020 190

Structure-based discovery of the endocrine disrupting effects of hydraulic fracturing chemicals as novel androgen receptor antagonists

Authors: Tachachartvanich, Phum, Azhagiya Singam, Ettayapuram Ramaprasad, Durkin, Kathleen A., Smith, Martyn T., La Merrill, Michele A.

Source: In Chemosphere October 2020 257

Alterations in immune and renal biomarkers among workers occupationally exposed to low levels of trichloroethylene below current regulatory standards

Authors: Lee, Kyoung-Mu, Zhang, Luoping, Vermeulen, Roel, Hu, Wei, Bassig, Bryan A, Wong, Jason JJ, Qiu, Chuangyi, Purdue, Mark, Wen, Cuiju, Walker, Douglas I, Jones, Dean P, Li, Laiyu, Huang, Yongshun, Rothman, Nathaniel, Smith, Martyn T, Lan, Qing

Source: Occupational and Environmental Medicine, 2019 Jun 01. 76(6), 376-381.

Access URL: https://www.jstor.org/stable/26894766

Socioeconomic status and the association between arsenic exposure and type 2 diabetes

Authors: Eick, Stephanie M., Ferreccio, Catterina, Acevedo, Johanna, Castriota, Felicia, Cordero, José F., Roh, Taehyun, Smith, Allan H., Smith, Martyn T., Steinmaus, Craig

Source: In Environmental Research May 2019 172:578-585

Consensus on the key characteristics of endocrine-disrupting chemicals as a basis for hazard identification

Authors: La Merrill, Michele A., Vandenberg, Laura N., Smith, Martyn T., Goodson, William, Browne, Patience, Patisaul, Heather B., Guyton, Kathryn Z., Kortenkamp, Andreas, Cogliano, Vincent J., Woodruff, Tracey J., Rieswijk, Linda, Sone, Hideko, Korach, Kenneth S., Gore, Andrea C., Zeise, Lauren, Zoeller, R. Thomas

Source: Nature reviews.Endocrinology. 16(1):45-57

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193261810.0x000001&indx=1&recIds=ETOCvdc_100193261810.0x000001

Consensus on the Key Characteristics of Immunotoxic Agents as a Basis for Hazard Identification.

Authors: Germolec, Dori R.¹, Lebrec, Herve², Anderson, Stacey E.³, Burleson, Gary R.⁴, Cardenas, Andres⁵, Corsini, Emanuela⁶, Elmore, Sarah E.⁷, Kaplan, Barbara L. F.⁸, Lawrence, B. Paige^9,10, Lehmann, Geniece M.¹¹, Maier, Curtis C.¹², McHale, Cliona M.⁵, Myers, L. Peyton¹³, Pallardy, Marc¹⁴, Rooney, Andrew A.¹, Zeise, Lauren⁷, Luoping Zhang⁵, Smith, Martyn T.⁵, martynts@berkeley.edu

Source: Environmental Health Perspectives; Oct2022, Vol. 130 Issue 10, p105001-1-105001-16, 16p, 4 Diagrams