LMK235 ameliorates inflammation and fibrosis after myocardial infarction by inhibiting LSD1-related pathway

Authors: Fangzhou Lv, Laidi Xie, Lei Li, Jiafeng Lin

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Myocardial infarction, HDAC4, HDAC5, LSD1, NF-κB pathway, Smad2/3 pathway, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6cfadd4f34824f219325a01672b312d5

Bicyclol attenuates pulmonary fibrosis with silicosis via both canonical and non-canonical TGF-β1 signaling pathways

Authors: Tong-Tong Liu, Hai-Fei Sun, Ming-Ze Tang, Hao-Ran Shen, Zhen Shen, Yan-Xing Han, Yun Zhan, Jian-Dong Jiang

Source: Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-19 (2024)

Subject Terms: Bicyclol, Silicosis, Pulmonary fibrosis, TGF-β1, JAK2/STAT3, SMAD2/3, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/1479-5876

Access URL: https://doaj.org/article/2b118b10efc04e819d2449e7e07a98e0

Phytochemicals and Chronic Diseases Prevention

Contributors: Yang, Haixia, Deng, Jianjun

Subject Terms: ginsenoside Rh4, SIX1, TGF-?/Smad2/3 pathway, gastric cancer, affinity ultrafiltration, molecular docking, preparative isolation, Saxifraga atrata, 11-O-(4?-O-methylgalloyl)-bergenin, flaxseed, soy, red clover, lipid profile, meta-analysis, cardiovascular disease, botanical supplements, postmenopausal woman, metastasis, ESCC, Wnt/?-catenin, c-Myc, antioxidants, bilberry, by-products, food supplement, HPLC, phenolic compounds, polyphenols, pomace, red currant, clarified apple juices, food processing degree, gut microbiota, metabolomics, rats, rosmarinic acid, Parkinson’s disease, mitochondrial function, Abl tyrosine kinase, rotenone, Mitragyna speciosa, kratom, glucosidase, pancreatic lipase, anti-diabetes mellitus, A. tenuissimum flower flavonoids, network pharmacology, type 2 diabetes mellitus, zerumbone, microglial cells, macrophage polarization, neuroinflammation, redox homeostasis, lycopene, fasting blood glucose, diabetes mellitus, systematic review, DNMTs, HDACs, flavonoids, fruit extract, CD1 mice, qRT-PCR, gene expression, alcoholic liver disease, liver fibrosis, hepatic encephalopathy, Schisandrin B, dietary phytochemical index, obesity, preschooler, child, Korea National Health and Nutrition Examination Survey (KNHANES), Mathematics and Science, Biology, life sciences

File Description: application/octet-stream

Access URL: https://directory.doabooks.org/handle/20.500.12854/139308
https://mdpi.com/books/pdfview/book/9304

Dexmedetomidine protects against sepsis-induced lung injury through autophagy and Smad2/3 signaling pathway

Authors: Zhanli Liu, Jiqing Xu, Yanqiu Zhao, Yanbin Wan, Rui Guo, Canling Long, Jia Liu, Xinhuang Yao, Wenchao Yin

Source: Iranian Journal of Basic Medical Sciences, Vol 27, Iss 4, Pp 453-460 (2024)

Subject Terms: acute lung injury, autophagy, dexmedetomidine, sepsis, smad2/3, Medicine

File Description: electronic resource

Relation: https://ijbms.mums.ac.ir/article_23432_58bbcd054e1c852fb5be487df6f06eb2.pdf; https://doaj.org/toc/2008-3866; https://doaj.org/toc/2008-3874

Access URL: https://doaj.org/article/55e028745aa14aa5b59ab39dcb166ade

SIRT7 protects against liver fibrosis by suppressing stellate cell activation via TGF-β/SMAD2/3 pathway

Authors: Ding, Cong, Liu, Bohao, Yu, Tingzi, Wang, Zhiqiang, Peng, Jinying, Gu, Yiying, Li, Zhuan ^⁎

Source: In Biomedicine & Pharmacotherapy November 2024 180

TGF-β and TNF-α interaction promotes the expression of MMP-9 through H3K36 dimethylation: implications in breast cancer metastasis

Authors: Shihab Kochumon, Amnah Al-Sayyar, Texy Jacob, Fatemah Bahman, Nadeem Akhter, Ajit Wilson, Sardar Sindhu, Yusuf A. Hannun, Rasheed Ahmad, Fahd Al-Mulla

Source: Frontiers in Immunology, Vol 15 (2024)

Subject Terms: histone methylation, H3K36me2, MMP-9, Smad2/3, TNF-α, TGF-β, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1430187/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/696c9cb63bb64aa6870c452bff928f5f

Isorhamnetin inhibits hypertrophic scar formation through TGF-β1/Smad and TGF-β1/CREB3L1 signaling pathways

Authors: Junzheng Wu, Yajuan Song, Jianzhang Wang, Tong Wang, Liu Yang, Yi Shi, Baoqiang Song, Zhou Yu

Source: Heliyon, Vol 10, Iss 13, Pp e33802- (2024)

Subject Terms: Isorhamnetin, Hypertrophic scar, TGF-β1, CREB3L1, Smad2/3, Science (General), Q1-390, Social sciences (General), H1-99

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405844024098335; https://doaj.org/toc/2405-8440

Access URL: https://doaj.org/article/c24b0f02223a4b2dbf9d81d40a15f5fa

USF1 transcriptionally activates USP14 to drive atherosclerosis by promoting EndMT through NLRC5/Smad2/3 axis

Authors: Zhiwen Zhang, Quan Guo, Chao Ma, Zhenzhou Zhao, Qingbo Shi, Haosen Yu, Lixin Rao, Muwei Li

Source: Molecular Medicine, Vol 30, Iss 1, Pp 1-13 (2024)

Subject Terms: Atherosclerosis, EndMT, USF1, USP14, NLRC5, Smad2/3, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

File Description: electronic resource

Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/a640c9e826a84eb8a1c678610505ec24

The silencing of NREP aggravates OA cartilage damage through the TGF-β1/Smad2/3 pathway in chondrocytes

Authors: Yang Liu, Mengrou Liu, Chengming Zhang, Xiaoke Li, Siyu Zheng, Le Wen, Peidong Liu, Pengcui Li, Ziquan Yang

Source: Journal of Orthopaedic Translation, Vol 44, Iss , Pp 26-34 (2024)

Subject Terms: Articular cartilage, Bioinformatics, NREP, Osteoarthritis, TGF-β1 /Smad2/3 pathway, Diseases of the musculoskeletal system, RC925-935

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214031X23000931; https://doaj.org/toc/2214-031X

Access URL: https://doaj.org/article/712954e8000249a6a56d241c7ccc452f

FBXO28 promotes cell proliferation, migration and invasion via upregulation of the TGF-beta1/SMAD2/3 signaling pathway in ovarian cancer

Authors: Gendi Song, Zhengwei Sun, Man Chu, Zihan Zhang, Jiajia Chen, Zhiwei Wang, Xueqiong Zhu

Source: BMC Cancer, Vol 24, Iss 1, Pp 1-13 (2024)

Subject Terms: FBXO28, TGF-b1, Ovarian cancer, Smad2/3, Migration, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1471-2407

Access URL: https://doaj.org/article/f65c8ce514fe45cf92a0a0169fc2c140

MiR-21 regulates skeletal muscle atrophy and fibrosis by targeting TGF-beta/SMAD7-SMAD2/3 signaling pathway

Authors: Song, Xianmin ^{a, 1}, Liu, Fei ^{a, 1}, Chen, Mengjie ^{a, 1}, Zhu, Minhui ^a, Zheng, Hongliang ^a, Wang, Wei ^a, Chen, Donghui ^{b, ⁎⁎}, Li, Meng ^{a, ⁎⁎⁎}, Chen, Shicai ^{a, ⁎}

Source: In Heliyon 30 June 2024 10(12)

Bone marrow mesenchymal stem cell transplantation alleviates radiation-induced myocardial fibrosis through inhibition of the TGF-β1/Smad2/3 signaling pathway in rabbit model

Authors: Jian Jun Gu, Hong Xiao Li, Wei Wei, Xiao Lin Sun, Bi Chun Li, Yong Chen, Jun Li, Xiang Gu

Source: Regenerative Therapy, Vol 24, Iss , Pp 1-10 (2023)

Subject Terms: RIMF, BMSCs, Cardiac function, TGF-β1, Smad2/3, Medicine (General), R5-920, Cytology, QH573-671

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2352320423000317; https://doaj.org/toc/2352-3204

Access URL: https://doaj.org/article/43feb8c2fd8048c99d023ad1648279e1

Exosomal circCOL1A1 promotes angiogenesis via recruiting EIF4A3 protein and activating Smad2/3 pathway in colorectal cancer

Authors: Gui Hu, Changwei Lin, Kai Gao, Miao Chen, Fei Long, Buning Tian

Source: Molecular Medicine, Vol 29, Iss 1, Pp 1-19 (2023)

Subject Terms: CircCOL1A1, Exosomes, EIF4A3, Smad2/3, Colorectal cancer, Angiogenesis, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

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Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/63221a092d9744d6a74fae8ef8fabec6

CRTC2 activates the epithelial–mesenchymal transition of diabetic kidney disease through the CREB-Smad2/3 pathway

Authors: Yujie Li, Yufeng Zhang, Hongshuo Shi, Xuemei Liu, Zifa Li, Jiayi Zhang, Xiuge Wang, Wenbo Wang, Xiaolin Tong

Source: Molecular Medicine, Vol 29, Iss 1, Pp 1-12 (2023)

Subject Terms: Epithelial-to-mesenchymal transition, Diabetic kidney disease, CTRC2, CREB, Smad2/3, Therapeutics. Pharmacology, RM1-950, Biochemistry, QD415-436

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Relation: https://doaj.org/toc/1528-3658

Access URL: https://doaj.org/article/28e438e746094596913a3175c49c02d7

Cerebral protective effect of in situ and remote ischemic postconditioning on ischemic stroke rat via the TGFβ1-Smad2/3 signaling pathway

Authors: Ma, Wei ^{a, 1}, Yang, Jinwei ^{a, b, 1}, Zhang, Jinfen ^{a, 1}, He, Rui ^a, Luo, Yi ^a, Li, Chunyan ^{a, c}, Zhao, Feng ^a, Tao, Fengping ^a, Fan, Jingjing ^a, Yin, Luwei ^a, Zhu, Kewei ^a, Niu, Shourui ^a, Li, Liyan ^{a, ⁎}

Source: In Brain Research 1 February 2024 1824

Ellagic acid promotes osteoblasts differentiation via activating SMAD2/3 pathway and alleviates bone mass loss in OVX mice

Authors: Dong, Hui ^{a, b}, Cao, Yuxia ^{a, b}, Zou, Ke ^{a, b}, Shao, Qiang ^a, Liu, Ronghan ^b, Zhang, Ying ^b, Pan, Liuzhu ^b, Ning, Bin ^{a, b, ∗}

Source: In Chemico-Biological Interactions 25 January 2024 388

Therapeutic inhibition of miR-155 attenuates liver fibrosis via STAT3 signaling

Authors: Shashi Bala, Yuan Zhuang, Prashanth Thevkar Nagesh, Donna Catalano, Adam Zivny, Yanbo Wang, Jun Xie, Guangping Gao, Gyongyi Szabo

Source: Molecular Therapy: Nucleic Acids, Vol 33, Iss , Pp 413-427 (2023)

Subject Terms: MT: Non-coding RNAs, anti-miR-155 tough decoy, SMAD2/3, STAT3, CCl4, BDL, Therapeutics. Pharmacology, RM1-950

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2162253123001853; https://doaj.org/toc/2162-2531

Access URL: https://doaj.org/article/d75412b366fa4f0f89a90a39beefcc68

SMAD2/3 Phosphorylation is correlated with matrix metalloproteinase 9 expression in human periapical lesions

Authors: Wan, Chunyan ^{a, b, ⁎, 1}, Wang, Yongzheng ^{a, b, 1}, Li, Lei ^c, Liu, Lingshuang ^{a, b}, Guan, Qunli ^{a, b}

Source: In Archives of Oral Biology November 2023 155

Actin alpha 2, smooth muscle, a transforming growth factor-β1-induced factor, regulates collagen production in human periodontal ligament cells via Smad2/3 pathway

Authors: Naati Fakatava, Hiromi Mitarai, Asuka Yuda, Akira Haraguchi, Hiroko Wada, Daigaku Hasegawa, Hidefumi Maeda, Naohisa Wada

Source: Journal of Dental Sciences, Vol 18, Iss 2, Pp 567-576 (2023)

Subject Terms: ACTA2, Collagen production, Periodontal ligament, Smad2/3, TGF-β1, Dentistry, RK1-715

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S1991790222002136; https://doaj.org/toc/1991-7902

Access URL: https://doaj.org/article/d7b18929dd1b447aa50a9a8d52c67062

Repurposing of carvedilol to alleviate bleomycin-induced lung fibrosis in rats: Repressing of TGF-β1/α-SMA/Smad2/3 and STAT3 gene expressions

Authors: Abbas, Noha A.T. ^a, Nafea, Ola Elsayed ^{b, c, ⁎}, Mohammed, Heba Osama ^d, Samy, Walaa ^e, Abdelmageed, Amal Fawzy ^e, Afifi, Rofaida ^f, Hassan, Heba A. ^{a, g}

Source: In Life Sciences 1 July 2023 324