Immunotherapy-activated T cells recruit and skew late-stage activated M1-like macrophages that are critical for therapeutic efficacy

Authors: van Elsas, Marit J., Middelburg, Jim, Labrie, Camilla, Roelands, Jessica, Schaap, Gaby, Sluijter, Marjolein, Tonea, Ruxandra, Ovcinnikovs, Vitalijs, Lloyd, Katy, Schuurman, Janine, Riesenfeld, Samantha J., Gajewski, Thomas F., de Miranda, Noel F.C.C., van Hall, Thorbald, van der Burg, Sjoerd H.

Source: In Cancer Cell 10 June 2024 42(6):1032-1050

The MHC-E peptide ligands for checkpoint CD94/NKG2A are governed by inflammatory signals, whereas LILRB1/2 receptors are peptide indifferent

Authors: Middelburg, Jim, Ghaffari, Soroush, Schoufour, Tom A.W., Sluijter, Marjolein, Schaap, Gaby, Göynük, Büsra, Sala, Benedetta M., Al-Tamimi, Lejla, Scheeren, Ferenc, Franken, Kees L.M.C., Akkermans, Jimmy J.L.L., Cabukusta, Birol, Joosten, Simone A., Derksen, Ian, Neefjes, Jacques, van der Burg, Sjoerd H., Achour, Adnane, Wijdeven, Ruud H.M., Weidanz, Jon, van Hall, Thorbald

Source: In Cell Reports 26 December 2023 42(12)

A Single-Domain TCR-like Antibody Selective for the Qa-1^b/Qdm Peptide Complex Enhances Tumoricidal Activity of NK Cells via Blocking the NKG2A Immune Checkpoint

Authors: Ghaffari, Soroush, Upchurch-Ange, Katherine, Gimlin, Susanne, Tripathi, Trivendra, Sluijter, Marjolein, Middelburg, Jim, van Hall, Thorbald, Weidanz, Jon

Source: Journal of immunology. 208(9):2246-2255

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN629332118&indx=1&recIds=ETOCRN629332118

NKG2A is a late immune checkpoint on CD8 T cells and marks repeated stimulation and cell division

Authors: Borst, Linda, Sluijter, Marjolein, Sturm, Gregor, Charoentong, Pornpimol, Santegoets, Saskia J., Gulijk, Mandy, Elsas, Marit J., Groeneveldt, Christianne, Montfoort, Nadine, Finotello, Francesca, Trajanoski, Zlatko, Kiełbasa, Szymon M., Burg, Sjoerd H., Hall, Thorbald

Source: International journal of cancer. 150(4):688-704

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100147447908.0x000001&indx=1&recIds=ETOCvdc_100147447908.0x000001

NKG2A Blockade Potentiates CD8 T Cell Immunity Induced by Cancer Vaccines

Authors: van Montfoort, Nadine, Borst, Linda, Korrer, Michael J., Sluijter, Marjolein, Marijt, Koen A., Santegoets, Saskia J., van Ham, Vanessa J., Ehsan, Ilina, Charoentong, Pornpimol, André, Pascale, Wagtmann, Nicolai, Welters, Marij J.P., Kim, Young J., Piersma, Sytse J., van der Burg, Sjoerd H., van Hall, Thorbald

Source: In Cell 13 December 2018 175(7):1744-1755

Metabolic stress in cancer cells induces immune escape through a PI3K-dependent blockade of IFNγ receptor signaling

Authors: Marijt, Koen, Sluijter, Marjolein, Blijleven, Laura, Tolmeijer, Sofie, Scheeren, Ferenc, Burg, Sjoerd, Hall, Thorbald

Source: Journal for immunotherapy of cancer. 7(1):1-12

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190706462.0x000001&indx=1&recIds=ETOCvdc_100190706462.0x000001

High FcγR Expression on Intratumoral Macrophages Enhances Tumor-Targeting Antibody Therapy

Authors: Benonisson, Hreinn, Sow, Heng Sheng, Breukel, Cor, Claassens, Jill, Brouwers, Conny, Linssen, Margot M., Fransen, Marieke F., Sluijter, Marjolein, Ossendorp, Ferry, van Hall, Thorbald

Source: Journal of immunology. 201(12):3741-3749

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN618442315&indx=1&recIds=ETOCRN618442315

The Immunogenicity of a Proline-Substituted Altered Peptide Ligand toward the Cancer-Associated TEIPP Neoepitope Trh4 Is Unrelated to Complex Stability

Authors: Hafstrand, Ida, Doorduijn, Elien M., Sun, Renhua, Talyzina, Anna, Sluijter, Marjolein, Pellegrino, Sara, Sandalova, Tatyana, Duru, Adil Doganay, van Hall, Thorbald, Achour, Adnane

Source: Journal of immunology. 200(8):2860-2868

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615806259&indx=1&recIds=ETOCRN615806259

Dominant contribution of the proteasome and metalloproteinases to TAP-independent MHC-I peptide repertoire

Authors: Oliveira, Cláudia C., Sluijter, Marjolein, Querido, Bianca, Ossendorp, Ferry, van der Burg, Sjoerd H., van Hall, Thorbald

Source: In Molecular Immunology November 2014 62(1):129-136

Effectiveness of slow-release systems in CD40 agonistic antibody immunotherapy of cancer

Authors: Fransen, Marieke F., Cordfunke, Robert A., Sluijter, Marjolein, van Steenbergen, Mies J., Drijfhout, Jan W., Ossendorp, Ferry, Hennink, Wim E., Melief, Cornelis J.M.

Source: In Vaccine 26 March 2014 32(15):1654-1660

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2

Authors: Lampen, Margit H., Hassan, Chopie, Sluijter, Marjolein, Geluk, Annemieke, Dijkman, Karin, Tjon, Jennifer M., de Ru, Arnoud H., van der Burg, Sjoerd H., van Veelen, Peter A., van Hall, Thorbald

Source: In Molecular Immunology January-February 2013 53(1-2):126-131

T cells specific for a TAP-independent self-peptide remain naïve in tumor-bearing mice and are fully exploitable for therapy

Authors: Doorduijn, Elien M., Sluijter, Marjolein, Marijt, Koen A., Querido, Bianca J., van der Burg, Sjoerd H., van Hall, Thorbald

Source: Oncoimmunology. 7(3)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100063194144.0x000001&indx=1&recIds=ETOCvdc_100063194144.0x000001

In vivo modelling of cutaneous T-cell lymphoma: The role of SOCS1.

Authors: Luo, Yixin, Vermeer, Maarten H., de Gruijl, Frank R., Zoutman, Willem H., Sluijter, Marjolein, Hall, Thorbald van, Tensen, Cornelis P.

Source: Frontiers in Oncology; 11/24/2022, Vol. 12, p1-12, 12p

Subject Terms: CUTANEOUS T-cell lymphoma, SEZARY syndrome, MYCOSIS fungoides, TRANSGENIC mice, T cells, BLOOD testing, CELL cycle

Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model.

Authors: Kumar, Sumit, Schoonderwoerd, Mark J. A., Kroonen, Jessie S., de Graaf, Ilona J., Sluijter, Marjolein, Ruano, Dina, González-Prieto, Román, Vries, Matty Verlaan-de, Rip, Jasper, Arens, Ramon, de Miranda, Noel F. C. C., Hawinkels, Lukas J. A. C., van Hall, Thorbald, Vertegaal, Alfred C. O.

Source: Gut; Nov2022, Vol. 71 Issue 11, p2266-2283, 18p

Subject Terms: PANCREATIC intraepithelial neoplasia, CELL cycle, GRANZYMES, CANCER cells, IMMUNE system, PANCREATIC cancer, MOLECULAR biology

Limited Density of an Antigen Presented by RMA-S Cells Requires B7-1/CD28 Signaling to Enhance T-Cell Immunity at the Effector Phase.

Authors: Li, Xiao-Lin¹, Sluijter, Marjolein², Doorduijn, Elien M.², Kale, Shubha P.¹, McFerrin, Harris¹, Liu, Yong-Yu³, Li, Yan^1,4, Mottamal, Madhusoodanan¹, Yao, Xin¹, Du, Fengkun¹, Gu, Baihan¹, Hoang, Kim¹, Nguyen, Yen H.¹, Taylor, Nichelle¹, Stephens, Chelsea R.¹, van Hall, Thorbald², Zhang, Qian-Jin¹

Source: PLoS ONE. Nov2014, Vol. 9 Issue 11, p1-10. 10p.

Subject Terms: *CD28 antigen, *CELLULAR signal transduction, *ANTIGEN presenting cells, *CELLULAR immunity, *CANCER cells, *ANTINEOPLASTIC agents

Inhibition of CSF-1R Supports T-Cell Mediated Melanoma Therapy.

Authors: Sluijter, Marjolein¹, van der Sluis, Tetje C.² T.van_Hall@lumc.nl, van der Velden, Pieter A.³, Versluis, Mieke³, West, Brian L.⁴, van der Burg, Sjoerd H.¹, van Hall, Thorbald¹

Source: PLoS ONE. Aug2014, Vol. 9 Issue 8, p1-6. 6p.

Subject Terms: *MELANOMA treatment, *MACROPHAGE colony-stimulating factor, *CANCER immunotherapy, *T cells, *NEOVASCULARIZATION, *IMMUNOSUPPRESSION, *CANCER cell differentiation

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