Discovery, Optimization, and Preclinical Pharmacology of EP652, a METTL3 Inhibitor with Efficacy in Liquid and Solid Tumor Models.

Authors: Dutheuil, Guillaume, Oukoloff, Killian, Korac, Julien, Lenoir, François, El Bousmaqui, Mohamed, Probst, Nicolas, Lapin, Alexey, Nakhabina, Galina, Sorlet, Catherine, Parmentier, Nicolas, Karila, Delphine, Ghavtadze, Nugzar, Casault, Paméla, Claridge, Stephen, Sapmaz, Selma, Slater, Martin J., Fraser, Graeme L.

Source: Journal of Medicinal Chemistry; 2/13/2025, Vol. 68 Issue 3, p2981-3003, 23p

F901318 represents a novel class of antifungal drug that inhibits dihydroorotate dehydrogenase

Authors: Oliver, Jason D., Sibley, Graham E. M., Beckmann, Nicola, Dobb, Katharine S., Slater, Martin J., McEntee, Laura, du Pré, Saskia, Livermore, Joanne, Bromley, Michael J., Wiederhold, Nathan P., Hope, William W., Kennedy, Anthony J., Law, Derek, Birch, Mike

Source: Proceedings of the National Academy of Sciences of the United States of America, 2016 Nov 01. 113(45), 12809-12814.

Access URL: https://www.jstor.org/stable/26472391

X [dbnd]Y [dbnd]ZH systems as potential 1,3-dipoles. Part 62: 1,3-Dipolar cycloaddition reactions of metallo-azomethine ylides derived from α-iminophosphonates

Authors: Dondas, H. Ali, Durust, Yasar, Grigg, Ronald, Slater, Martin J., Sarker, Mohammed Abul Basher

Source: In Tetrahedron 2005 61(45):10667-10682

Evaluation of neomycin analogues for HIV-1 RRE RNA recognition identifies enhanced activity simplified neamine analogues

Authors: Simon, Binto, Walmsley, Claire, Jackson, Victoria J., Garvey, Edward P., Slater, Martin J., Berrisford, David J., Gardiner, John M.

Source: In Bioorganic & Medicinal Chemistry Letters 15 January 2019 29(2):339-341

Virtual Screening Strategies for Identifying Novel Chemotypes.

Authors: Lang, Stuart, Slater, Martin J.

Source: Journal of Medicinal Chemistry; 5/9/2024, Vol. 67 Issue 9, p6897-6898, 2p

Antiviral dibenzothiazepinone derivatives

Dibenzothiazepinthione as antiviral agents

Further indole derivatives with antiviral activity

Method for the treatment of protoza infections with 2.sup.1 -deoxy-2.sup.1 -fluoropurine nucleosides

Stereospecific dicobalt octacarbonyl mediated enyne cyclization for the synthesis of methyl deoxynorpentalenolactone H.

Authors: Magnus, Philip, Slater, Martin J., Principe, Lawrence M.

Source: Journal of Organic Chemistry; October 13 1989, Vol. 54, p5148-5153, 6p

Stereospecific dicobalt octacarbonyl mediated enyne cyclization for the synthesis of the cytotoxic sesquiterpene (±)-quadrone.

Authors: Magnus, Philip, Principe, Lawrence M., Slater, Martin J.

Source: Journal of Organic Chemistry; April 17 1987, Vol. 52, p1483-1486, 4p

The Relative Catalytic Efficiency of β-Lactamase Catalyzed Acyl and Phosphyl Transfer

Authors: Slater, Martin J., Laws, Andrew P., Page, Michael I.

Source: In Bioorganic Chemistry April 2001 29(2):77-95

Indolocarbazoles: potent, selective inhibitors of human cytomegalovirus replication

Authors: Slater, Martin J. ^*, Cockerill, Stuart, Baxter, Robert, Bonser, Robert W., Gohil, Kam, Gowrie, Clare, Robinson, J.Edward, Littler, Edward, Parry, Nigel, Randall, Roger, Snowden, Wendy

Source: In Bioorganic & Medicinal Chemistry 1999 7(6):1067-1074

2-Chloro-3-substituted-1,4-naphthoquinone inactivators of human cytomegalovirus protease

Authors: Ertl, Peter, Cooper, David, Allen, Geoffrey, Slater, Martin J.

Source: In Bioorganic & Medicinal Chemistry Letters 1999 9(19):2863-2866

Synthesis of neamine libraries for RNA recognition using solution phase chemistry

Authors: Nunns, Claire L., Spence, Lee A., Slater, Martin J., Berrisford, David J.

Source: In Tetrahedron Letters 1999 40(52):9341-9345

The Regiospecific One-Pot Phosphorylation of Either the 5′- or 2′-Hydroxyl in 3′-Deoxycytidines Without Protection: Critical Role of the Base.

Authors: Howes, Peter D.^1,2 (AUTHOR) pdh4343@gsk.com, Slater, Martin J.¹ (AUTHOR), Wareing, Katrina¹ (AUTHOR)

Source: Nucleosides, Nucleotides & Nucleic Acids. May2003, Vol. 22 Issue 5-8, p687-689. 3p.

Subject Terms: *PHOSPHORYLATION, *HYDROXYL group, *CYTIDINE diphosphate choline, *PYRIDINE, *MAGNESIUM compounds

Synthesis and evaluation of novel α-amino cyclic boronates as inhibitors of HCV NS3 protease

Authors: Li, Xianfeng, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z., Li, Qun, Zhou, Yasheen, Plattner, Jacob J., Baker, Stephen J., Qian, Xuelei, Fan, Dazhong, Liao, Liang, Ni, Zhi-Jie, White, Gemma V., Mordaunt, Jackie E., Lazarides, Linos X., Slater, Martin J., Jarvest, Richard L., Thommes, Pia, Ellis, Malcolm, Edge, Colin M., Hubbard, Julia A., Somers, Don, Rowland, Paul, Nassau, Pamela, McDowell, Bill, Skarzynski, Tadeusz J., Kazmierski, Wieslaw M., Grimes, Richard M., Wright, Lois L., Smith, Gary K., Zou, Wuxin, Wright, Jon, Pennicott, Lewis E.

Source: In Bioorganic & Medicinal Chemistry Letters 15 June 2010 20(12):3550-3556

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates

Authors: Li, Xianfeng, Zhang, Yong-Kang, Liu, Yang, Ding, Charles Z., Zhou, Yasheen, Li, Qun, Plattner, Jacob J., Baker, Stephen J., Zhang, Suoming, Kazmierski, Wieslaw M., Wright, Lois L., Smith, Gary K., Grimes, Richard M., Crosby, Renae M., Creech, Katrina L., Carballo, Luz H., Slater, Martin J., Jarvest, Richard L., Thommes, Pia, Hubbard, Julia A., Convery, Maire A., Nassau, Pamela M., McDowell, William, Skarzynski, Tadeusz J., Qian, Xuelei, Fan, Dazhong, Liao, Liang, Ni, Zhi-Jie, Pennicott, Lewis E., Zou, Wuxin, Wright, Jon

Source: In Bioorganic & Medicinal Chemistry Letters 2010 20(19):5695-5700

Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

Authors: Burton, George, Ku, Thomas W., Carr, Thomas J., Kiesow, Terry, Sarisky, Robert T., Lin-Goerke, Juili, Hofmann, Glenn A., Slater, Martin J., Haigh, David, Dhanak, Dashyant, Johnson, Victor K., Parry, Nigel R., Thommes, Pia

Source: In Bioorganic & Medicinal Chemistry Letters 2007 17(7):1930-1933

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