ZNF251 haploinsufficiency confers PARP inhibitors resistance in BRCA1-mutated cancer cells through activation of homologous recombination

Authors: Li, Huan ^{a, 1, 3}, Chatla, Srinivas ^{b, 3}, Liu, Xiaolei ^{c, 4}, Tian, Zhen ^{a, 4}, Vekariya, Umeshkumar ^b, Wang, Peng ^a, Kim, Dongwook ^a, Octaviani, Stacia ^a, Lian, Zhaorui ^a, Morton, George ^d, Feng, Zijie ^e, Yang, Dan ^a, Sullivan-Reed, Katherine ^b, Childers, Wayne ^d, Yu, Xiang ^f, Chitrala, Kumaraswamy Naidu ^{b, 2}, Madzo, Jozef ^a, Skorski, Tomasz ^{b, g, h, ⁎⁎}, Huang, Jian ^{a, i, j, ⁎}

Source: In Cancer Letters 31 March 2025 613

Epigenetic balance ensures mechanistic control of MLL amplification and rearrangement

Authors: Gray, Zach H., Chakraborty, Damayanti, Duttweiler, Reuben R., Alekbaeva, Gulnaz D., Murphy, Sedona E., Chetal, Kashish, Ji, Fei, Ferman, Benjamin I., Honer, Madison A., Wang, Zhentian, Myers, Cynthia, Sun, Renhong, Kaniskan, H. Ümit, Toma, Monika Maria, Bondarenko, Elena A., Santoro, John N., Miranda, Christopher, Dillingham, Megan E., Tang, Ran, Gozani, Or, Jin, Jian, Skorski, Tomasz, Duy, Cihangir, Lee, Hayan, Sadreyev, Ruslan I., Whetstine, Johnathan R.

Source: In Cell 12 October 2023 186(21):4528-4545

DNA polymerase θ protects leukemia cells from metabolically induced DNA damage

Authors: Vekariya, Umeshkumar, Toma, Monika, Nieborowska-Skorska, Margaret, Le, Bac Viet, Caron, Marie-Christine, Kukuyan, Anna-Mariya, Sullivan-Reed, Katherine, Podszywalow-Bartnicka, Paulina, Chitrala, Kumaraswamy N., Atkins, Jessica, Drzewiecka, Malgorzata, Feng, Wanjuan, Chan, Joe, Chatla, Srinivas, Golovine, Konstantin, Jelinek, Jaroslav, Sliwinski, Tomasz, Ghosh, Jayashri, Matlawska-Wasowska, Ksenia, Chandramouly, Gurushankar, Nejati, Reza, Wasik, Mariusz, Sykes, Stephen M., Piwocka, Katarzyna, Hadzijusufovic, Emir, Valent, Peter, Pomerantz, Richard T., Morton, George, Childers, Wayne, Zhao, Huaqing, Paietta, Elisabeth M., Levine, Ross L., Tallman, Martin S., Fernandez, Hugo F., Litzow, Mark R., Gupta, Gaorav P., Masson, Jean-Yves, Skorski, Tomasz ^∗

Source: In Blood 11 May 2023 141(19):2372-2389

TIAR and FMRP shape pro-survival nascent proteome of leukemia cells in the bone marrow microenvironment

Authors: Wolczyk, Magdalena ¹, Serwa, Remigiusz ^{2, 3}, Kominek, Agata ¹, Klejman, Agata ⁴, Milek, Jacek ⁵, Chwałek, Marta ¹, Turos-Korgul, Laura ¹, Charzyńska, Agata ⁶, Dabrowski, Michal ⁶, Dziembowska, Magdalena ⁵, Skorski, Tomasz ⁷, Piwocka, Katarzyna ¹, Podszywalow-Bartnicka, Paulina ^{1, 8, ∗}

Source: In iScience 21 April 2023 26(4)

4-1BBL–containing leukemic extracellular vesicles promote immunosuppressive effector regulatory T cells

Authors: Swatler, Julian, Turos-Korgul, Laura, Brewinska-Olchowik, Marta, De Biasi, Sara, Dudka, Wioleta, Le, Bac Viet, Kominek, Agata, Cyranowski, Salwador, Pilanc, Paulina, Mohammadi, Elyas, Cysewski, Dominik, Kozlowska, Ewa, Grabowska-Pyrzewicz, Wioleta, Wojda, Urszula, Basak, Grzegorz, Mieczkowski, Jakub, Skorski, Tomasz, Cossarizza, Andrea, Piwocka, Katarzyna ^*

Source: In Blood Advances 22 March 2022 6(6):1879-1894

ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia

Authors: Di Marcantonio, Daniela, Martinez, Esteban, Kanefsky, Joice S., Huhn, Jacklyn M., Gabbasov, Rashid, Gupta, Anushk, Krais, John J., Peri, Suraj, Tan, YinFei, Skorski, Tomasz, Dorrance, Adrienne, Garzon, Ramiro, Goldman, Aaron R., Tang, Hsin-Yao, Johnson, Neil, Sykes, Stephen M.

Source: In Molecular Cell 1 July 2021 81(13):2752-2764

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Authors: Le, Bac Viet, Podszywalow-Bartnicka, Paulina, Maifrede, Silvia, Sullivan-Reed, Katherine, Nieborowska-Skorska, Margaret, Golovine, Konstantin, Yao, Juo-Chin, Nejati, Reza, Cai, Kathy Q., Caruso, Lisa Beatrice, Swatler, Julian, Dabrowski, Michal, Lian, Zhaorui, Valent, Peter, Paietta, Elisabeth M., Levine, Ross L., Fernandez, Hugo F., Tallman, Martin S., Litzow, Mark R., Huang, Jian, Challen, Grant A., Link, Daniel, Tempera, Italo, Wasik, Mariusz A., Piwocka, Katarzyna, Skorski, Tomasz

Source: In Cell Reports 6 October 2020 33(1)

Inhibition of the mutated c-KIT kinase in AML1-ETO–positive leukemia cells restores sensitivity to PARP inhibitor

Authors: Nieborowska-Skorska, Margaret, Paietta, Elisabeth M., Levine, Ross L., Fernandez, Hugo F., Tallman, Martin S., Litzow, Mark R., Skorski, Tomasz

Source: In Blood Advances 10 December 2019 3(23):4050-4054

Non-NAD-like PARP-1 inhibitors in prostate cancer treatment

Authors: Karpova, Yaroslava, Wu, Chao, Divan, Ali, McDonnell, Mark E., Hewlett, Elizabeth, Makhov, Peter, Gordon, John, Ye, Min, Reitz, Allen B., Childers, Wayne E., Skorski, Tomasz, Kolenko, Vladimir, Tulin, Alexei V.

Source: In Biochemical Pharmacology September 2019 167:149-162

Clonal composition of karyotypically normal AML at diagnosis is not affected by the microenvironment

Authors: Toma, Monika M., Karami, Adam, Nieborowska-Skorska, Margaret, Skorski, Tomasz ^∗

Source: In Blood Neoplasia May 2025 2(2)

Star wars against leukemia: attacking the clones

Authors: Toma, Monika M., Skorski, Tomasz

Source: Leukemia; November 2024, Vol. 38 Issue: 11 p2293-2302, 10p

Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells.

Authors: Barszczewska-Pietraszek, Gabriela, Czarny, Piotr, Drzewiecka, Małgorzata, Błaszczyk, Maciej, Radek, Maciej, Synowiec, Ewelina, Wigner-Jeziorska, Paulina, Sitarek, Przemysław, Szemraj, Janusz, Skorski, Tomasz, Śliwiński, Tomasz

Source: International Journal of Molecular Sciences; Sep2024, Vol. 25 Issue 17, p9134, 17p

Subject Terms: DNA damage, DNA polymerases, CELL cycle, GENE expression, CELL analysis, POLY ADP ribose

Tyrosine kinase inhibitor–induced defects in DNA repair sensitize FLT3(ITD)-positive leukemia cells to PARP1 inhibitors

Authors: Maifrede, Silvia, Nieborowska-Skorska, Margaret, Sullivan-Reed, Katherine, Dasgupta, Yashodhara, Podszywalow-Bartnicka, Paulina, Le, Bac Viet, Solecka, Martyna, Lian, Zhaorui, Belyaeva, Elizaveta A., Nersesyan, Alina, Machnicki, Marcin M., Toma, Monika, Chatain, Nicolas, Rydzanicz, Malgorzata, Zhao, Huaqing, Jelinek, Jaroslav, Piwocka, Katarzyna, Sliwinski, Tomasz, Stoklosa, Tomasz, Ploski, Rafal, Fischer, Thomas, Sykes, Stephen M., Koschmieder, Steffen, Bullinger, Lars, Valent, Peter, Wasik, Mariusz A., Huang, Jian, Skorski, Tomasz

Source: In Blood 5 July 2018 132(1):67-77

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms

Authors: Nieborowska-Skorska, Margaret, Maifrede, Silvia, Dasgupta, Yashodhara, Sullivan, Katherine, Flis, Sylwia, Le, Bac Viet, Solecka, Martyna, Belyaeva, Elizaveta A., Kubovcakova, Lucia, Nawrocki, Morgan, Kirschner, Martin, Zhao, Huaqing, Prchal, Josef T., Piwocka, Katarzyna, Moliterno, Alison R., Wasik, Mariusz, Koschmieder, Steffen, Green, Tony R., Skoda, Radek C., Skorski, Tomasz

Source: In Blood 28 December 2017 130(26):2848-2859

MLL-AF9 leukemias are sensitive to PARP1 inhibitors combined with cytotoxic drugs

Authors: Maifrede, Silvia, Martinez, Esteban, Nieborowska-Skorska, Margaret, Di Marcantonio, Daniela, Hulse, Michael, Le, Bac Viet, Zhao, Huaqing, Piwocka, Katarzyna, Tempera, Italo, Sykes, Stephen M., Skorski, Tomasz

Source: In Blood Advances 22 August 2017 1(19):1467-1472

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks.

Authors: Vekariya, Umeshkumar, Minakhin, Leonid, Chandramouly, Gurushankar, Tyagi, Mrityunjay, Kent, Tatiana, Sullivan-Reed, Katherine, Atkins, Jessica, Ralph, Douglas, Nieborowska-Skorska, Margaret, Kukuyan, Anna-Mariya, Tang, Hsin-Yao, Pomerantz, Richard T., Skorski, Tomasz

Source: Nature Communications; 7/10/2024, Vol. 15 Issue 1, p1-18, 18p

Subject Terms: DOUBLE-strand DNA breaks, DNA repair, DNA damage, DNA

Cooperative Action of Germ-Line Mutations in Decorin and p53 Accelerates Lymphoma Tumorigenesis

Authors: Iozzo, Renato V., Chakrani, Fatima, Perrotti, Danilo, McQuillan, David J., Skorski, Tomasz, Calabretta, Bruno, Eichstetter, Inge

Source: Proceedings of the National Academy of Sciences of the United States of America, 1999 Mar . 96(6), 3092-3097.

Access URL: https://www.jstor.org/stable/47494

BCR/ABL-Mediated Leukemogenesis Requires the Activity of the Small GTP-Binding Protein Rac

Authors: Skorski, Tomasz, Wlodarski, Pawel, Daheron, Laurence, Salomoni, Paolo, Nieborowska-Skorska, Malgorzata, Majewski, Miroslaw, Wasik, Mariusz, Calabretta, Bruno

Source: Proceedings of the National Academy of Sciences of the United States of America, 1998 Sep . 95(20), 11858-11862.

Access URL: https://www.jstor.org/stable/49277

Antileukemia Effect of c-myc N3 ′ → P5 ′ Phosphoramidate Antisense Oligonucleotides in vivo

Authors: Skorski, Tomasz, Perrotti, Danilo, Nieborowska-Skorska, Malgorzata, Gryaznov, Sergei, Calabretta, Bruno

Source: Proceedings of the National Academy of Sciences of the United States of America, 1997 Apr . 94(8), 3966-3971.

Access URL: https://www.jstor.org/stable/41939

Blastic Transformation of p53-Deficient Bone Marrow Cells by p210 bcr/abl Tyrosine Kinase

Authors: Skorski, Tomasz, Nieborowska-Skorska, Malgorzata, Wlodarski, Pawel, Perrotti, Danilo, Martinez, Robert, Wasik, Mariusz A., Calabretta, Bruno

Source: Proceedings of the National Academy of Sciences of the United States of America, 1996 Nov 01. 93(23), 13137-13142.

Access URL: https://www.jstor.org/stable/40760