The direct impact of mandatory PCV10 vaccination on invasive pneumococcal disease in Polish children

Authors: Skoczyńska, Anna ^{a, ⁎}, Gołębiewska, Agnieszka ^a, Wróbel-Pawelczyk, Izabela ^a, Ronkiewicz, Patrycja ^a, Kiedrowska, Marlena ^a, Błaszczyk, Kinga ^a, Czerwiński, Michał ^b, Waśko, Izabela ^{a, 1}, Sadkowska-Todys, Małgorzata ^b, Kuch, Alicja ^a, Hryniewicz, Waleria ^a

Source: In Vaccine 30 April 2025 54

PPARs in Clinical Experimental Medicine after 35 Years of Worldwide Scientific Investigations and Medical Experiments.

Authors: Skoczyńska, Anna¹ (AUTHOR) anna.skoczynska@umw.edu.pl, Ołdakowska, Monika² (AUTHOR) monika.oldakowska@umw.edu.pl, Dobosz, Agnieszka³ (AUTHOR) agnieszka.dobosz@umw.edu.pl, Adamiec, Rajmund^4,5 (AUTHOR) rajmund.adamiec@umw.edu.pl, Gritskevich, Sofya² (AUTHOR) anna.jonkisz@umw.edu.pl, Jonkisz, Anna² (AUTHOR) arleta.lebioda@umw.edu.pl, Lebioda, Arleta² (AUTHOR) malgorzata.malodobra-mazur@umw.edu.pl, Adamiec-Mroczek, Joanna⁶ (AUTHOR) joanna.adamiec-mroczek@umw.edu.pl, Małodobra-Mazur, Małgorzata² (AUTHOR) tadeusz.dobosz@umw.edu.pl, Dobosz, Tadeusz² (AUTHOR)

Source: Biomolecules (2218-273X). Jul2024, Vol. 14 Issue 7, p786. 34p.

Subject Terms: *NUCLEAR receptors (Biochemistry), *PEROXISOME proliferator-activated receptors, *PERIODICAL editors, *EXPERIMENTAL medicine, *NUCLEAR families

Global impact of ten-valent and 13-valent pneumococcal conjugate vaccines on invasive pneumococcal disease in all ages (the PSERENADE project): a global surveillance analysis

Authors: Pennington, Kate, Krause, Vicki, Rahman, Hafizur, Almeida, Samanta, Kellner, James, Deceuninck, Geneviève, Lefebvre, Brigitte, Hormazabal, Juan, Valenzuela, Maria Teresa, Krizova, Pavla, Sahu Khan, Aalisha, Toropainen, Maija, Varon, Emmanuelle, Ploy, Marie-Cecile, Hossain, Ilias, Magaziotou, Ioanna, Tzanakaki, Georgina, Chow, Kin-Hung, Erlendsdottir, Helga, Corcoran, Mary, Riccardo, Flavia, Oishi, Kazunori, Verani, Jennifer, Dimina, Elina, Swarthout, Todd, Mungun, Tuya, Zerouali, Khalid, van Sorge, Nina, Gilkison, Charlotte, Vestrheim, Didrik, Kuch, Alicja, Thoon, Koh Cheng, Ang, Michelle, Avdičová, Mária, Kleynhans, Jackie, de Gouveia, Linda, Muñoz-Almagro, Carmen, de Miguel, Sara, Castilla, Jesús, Morfeldt, Eva, Amin-Chowdhury, Zahin, Smith, Andrew, Pilishvili, Tamara, Kobayashi, Miwako, Reasonover, Alisa, Pelton, Stephen, Sutcliffe, Catherine, Aukes, Laurie, Byington, Carrie, Dalby, Tine, Celentano, Lucia, Hanquet, Germaine, Bennett, Julia C ^{a, *, *}, Deloria Knoll, Maria ^{a, *, **}, Kagucia, Eunice W ^b, Garcia Quesada, Maria ^a, Zeger, Scott L ^a, Hetrich, Marissa K ^a, Yang, Yangyupei ^a, Herbert, Carly ^c, Ogyu, Anju ^a, Cohen, Adam L ^{d, e}, Yildirim, Inci ^f, Winje, Brita A ^g, von Gottberg, Anne ^{h, i}, Viriot, Delphine ^k, van der Linden, Mark ^l, Valentiner-Branth, Palle ^m, Suga, Shigeru ⁿ, Steens, Anneke ^o, Skoczynska, Anna ^p, Sinkovec Zorko, Nadja ^q, Scott, J Anthony ^b, Savulescu, Camelia ^r, Savrasova, Larisa ^s, Sanz, Juan Carlos ^t, Russell, Fiona ^{u, w}, Ricketson, Leah J ^x, Puentes, Rodrigo ^y, Nuorti, J Pekka ^{z, aa}, Mereckiene, Jolita ^ab, McMahon, Kimberley ^ac, McGeer, Allison ^ad, Mad'arová, Lucia ^ae, Mackenzie, Grant A ^{v, af, ag, ah}, MacDonald, Laura ^ai, Lepp, Tiia ^aj, Ladhani, Shamez N ^ak, Kristinsson, Karl G ^al, Kozakova, Jana ^am, Klein, Nicola P ^an, Jayasinghe, Sanjay ^ao, Ho, Pak-Leung ^ap, Hilty, Markus ^aq, Heyderman, Robert S ^{ar, as}, Hasanuzzaman, Md ^at, Hammitt, Laura L ^{a, b}, Guevara, Marcela ^{au, av}, Grgic-Vitek, Marta ^q, Gierke, Ryan ^e, Georgakopoulou, Theano ^aw, Galloway, Yvonne ^ax, Diawara, Idrissa ^{ay, az}, Desmet, Stefanie ^{ba, bb}, De Wals, Philippe ^bc, Dagan, Ron ^bd, Colzani, Edoardo ^be, Cohen, Cheryl ^{h, j}, Ciruela, Pilar ^{au, bf}, Chuluunbat, Urtnasan ^bg, Chan, Guanhao ^bh, Camilli, Romina ^bi, Bruce, Michael G ^bj, Brandileone, Maria-Cristina C ^bk, Bigogo, Godfrey ^bl, Ampofo, Krow ^bm, O'Brien, Katherine L ^a, Feikin, Daniel R ^{d, †}, Hayford, Kyla ^{a, †}

Source: In The Lancet Infectious Diseases

Adult pneumococcal vaccination — new opportunities

Authors: Kuchar, Ernest, Chorostowska-Wynimko, Joanna, Czupryniak, Leszek, Fal, Andrzej, Flisiak, Robert, Mamcarz, Artur, Nitsch-Osuch, Aneta, Skoczyńska, Anna, Stajszczyk, Marcin, Wysocki, Jacek

Source: Family medicine & primary care review. 25(1):93-101

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632183597&indx=1&recIds=ETOCRN632183597

Trends in invasive bacterial diseases during the first 2 years of the COVID-19 pandemic: analyses of prospective surveillance data from 30 countries and territories in the IRIS Consortium

Authors: Shaw, David, Abad, Raquel, Amin-Chowdhury, Zahin, Bautista, Adriana, Bennett, Desiree, Broughton, Karen, Cao, Bin, Casanova, Carlo, Choi, Eun Hwa, Chu, Yiu-Wai, Claus, Heike, Coelho, Juliana, Corcoran, Mary, Cottrell, Simon, Cunney, Robert, Cuypers, Lize, Dalby, Tine, Davies, Heather, de Gouveia, Linda, Deghmane, Ala-Eddine, Demczuk, Walter, Desmet, Stefanie, Domenech, Mirian, Drew, Richard, du Plessis, Mignon, Duarte, Carolina, Erlendsdóttir, Helga, Fry, Norman K, Fuursted, Kurt, Hale, Thomas, Henares, Desiree, Henriques-Normark, Birgitta, Hilty, Markus, Hoffmann, Steen, Humphreys, Hilary, Ip, Margaret, Jacobsson, Susanne, Johnson, Christopher, Johnston, Jillian, Jolley, Keith A, Kawabata, Aníbal, Kozakova, Jana, Kristinsson, Karl G, Krizova, Pavla, Kuch, Alicja, Ladhani, Shamez, Lâm, Thiên-Trí, León, María Eugenia, Lindholm, Laura, Litt, David, Maiden, Martin C J, Martin, Irene, Martiny, Delphine, Mattheus, Wesley, McCarthy, Noel D, Meehan, Mary, Meiring, Susan, Mölling, Paula, Morfeldt, Eva, Morgan, Julie, Mulhall, Robert, Muñoz-Almagro, Carmen, Murdoch, David, Murphy, Joy, Musilek, Martin, Mzabi, Alexandre, Novakova, Ludmila, Oftadeh, Shahin, Perez-Argüello, Amaresh, Pérez-Vázquez, Maria, Perrin, Monique, Perry, Malorie, Prevost, Benoit, Roberts, Maria, Rokney, Assaf, Ron, Merav, Sanabria, Olga Marina, Scott, Kevin J, Sheppard, Carmen, Siira, Lotta, Sintchenko, Vitali, Skoczyńska, Anna, Sloan, Monica, Slotved, Hans-Christian, Smith, Andrew J, Steens, Anneke, Taha, Muhamed-Kheir, Toropainen, Maija, Tzanakaki, Georgina, Vainio, Anni, van der Linden, Mark P G, van Sorge, Nina M, Varon, Emmanuelle, Vohrnova, Sandra, von Gottberg, Anne, Yuste, Jose, Zanella, Rosemeire, Zhou, Fei, Brueggemann, Angela B ^*

Source: In The Lancet Digital Health September 2023 5(9):e582-e593

Emergence of a multidrug-resistant and virulent Streptococcus pneumoniae lineage mediates serotype replacement after PCV13: an international whole-genome sequencing study

Authors: Brooks, Abdullah, Corso, Alejandra, Davydov, Alexander, Maguire, Alison, Kiran, Anmol, Moiane, Benild, Beall, Bernard, Zhao, Chunjiang, Aanensen, David, Everett, Dean, Faccone, Diego, Foster-Nyarko, Ebenezer, Bojang, Ebrima, Egorova, Ekaterina, Voropaeva, Elena, Sampane-Donkor, Eric, Sadowy, Ewa, Nagaraj, Geetha, Mucavele, Helio, Belabbès, Houria, Elmdaghri, Naima, Verani, Jennifer, Keenan, Jeremy, Lees, John, N Nair Thulasee Bhai, Jyothish, Ndlangisa, Kedibone, Zerouali, Khalid, Bentley, Leon, Titov, Leonid, De Gouveia, Linda, Alaerts, Maaike, Ip, Margaret, de Cunto Brandileone, Maria Cristina, Hasanuzzaman, Md, Paragi, Metka, Nurse-Lucas, Michele, du Plessis, Mignon, Ali, Mushal, Croucher, Nicholas, Wolter, Nicole, Givon-Lavi, Noga, Porat, Nurit, Köseoglu Eser, Özgen, Ho, Pak-Leung, Eberechi Akpaka, Patrick, Gagetti, Paula, Tientcheu, Peggy-Estelle, Law, Pierra, Benisty, Rachel, Mostowy, Rafal, Malaker, Roly, Grassi Almeida, Samanta Cristine, Doiphode, Sanjay, Madhi, Shabir, Devi Sekaran, Shamala, Clarke, Stuart, Srifuengfung, Somporn, Nzenze, Susan, Kastrin, Tamara, Ochoa, Theresa, Hryniewicz, Waleria, Urban, Yulia, Lo, Stephanie W ^*, Mellor, Kate, Cohen, Robert, Alonso, Alba Redin, Belman, Sophie, Kumar, Narender, Hawkins, Paulina A, Gladstone, Rebecca A, von Gottberg, Anne, Veeraraghavan, Balaji, Ravikumar, K L, Kandasamy, Rama, Pollard, Sir Andrew J, Saha, Samir K, Bigogo, Godfrey, Antonio, Martin, Kwambana-Adams, Brenda, Mirza, Shaper, Shakoor, Sadia, Nisar, Imran, Cornick, Jennifer E, Lehmann, Deborah, Ford, Rebecca L, Sigauque, Betuel, Turner, Paul, Moïsi, Jennifer, Obaro, Stephen K, Dagan, Ron, Diawara, Idrissa, Skoczyńska, Anna, Wang, Hui, Carter, Philip E, Klugman, Keith P, Rodgers, Gail, Breiman, Robert F, McGee, Lesley, Bentley, Stephen D ^*, Muñoz-Almagro, Carmen ^*, Varon, Emmanuelle ^*

Source: In The Lancet Microbe October 2022 3(10):e735-e743

Pneumococcal vaccination among adults — updated Polish recommendations

Authors: Kuchar, Ernest, Antczak, Adam, Skoczyńska, Anna, Fal, Andrzej, Wysocki, Jacek, Walusiak-Skorupa, Jolanta, Czajkowska-Malinowska, Małgorzata, Mastalerz-Migas, Agnieszka, Flisiak, Robert, Nitsch-Osuch, Aneta

Source: Family medicine & primary care review. 24(3):285-291

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630611245&indx=1&recIds=ETOCRN630611245

Lack of berberine effect on bone mechanical properties in rats with experimentally induced diabetes

Authors: Londzin, Piotr, Kocik, Sonia, Kisiel-Nawrot, Ewa, Janas, Aleksandra, Skoczyńska, Anna, Krivošíková, Zora, Štefíková, Kornélia, Gajdoš, Martin, Cegieła, Urszula, Folwarczna, Joanna

Source: In Biomedicine & Pharmacotherapy February 2022 146

Changes in the incidence of invasive disease due to Streptococcus pneumoniae, Haemophilus influenzae, and Neisseria meningitidis during the COVID-19 pandemic in 26 countries and territories in the Invasive Respiratory Infection Surveillance Initiative: a prospective analysis of surveillance data

Authors: Brueggemann, Angela B ^*, Jansen van Rensburg, Melissa J, Shaw, David, McCarthy, Noel D, Jolley, Keith A, Maiden, Martin C J, van der Linden, Mark P G, Amin-Chowdhury, Zahin, Bennett, Désirée E, Borrow, Ray, Brandileone, Maria-Cristina C, Broughton, Karen, Campbell, Ruth, Cao, Bin, Casanova, Carlo, Choi, Eun Hwa, Chu, Yiu Wai, Clark, Stephen A, Claus, Heike, Coelho, Juliana, Corcoran, Mary, Cottrell, Simon, Cunney, Robert J, Dalby, Tine, Davies, Heather, de Gouveia, Linda, Deghmane, Ala-Eddine, Demczuk, Walter, Desmet, Stefanie, Drew, Richard J, du Plessis, Mignon, Erlendsdottir, Helga, Fry, Norman K, Fuursted, Kurt, Gray, Steve J, Henriques-Normark, Birgitta, Hale, Thomas, Hilty, Markus, Hoffmann, Steen, Humphreys, Hilary, Ip, Margaret, Jacobsson, Susanne, Johnston, Jillian, Kozakova, Jana, Kristinsson, Karl G, Krizova, Pavla, Kuch, Alicja, Ladhani, Shamez N, Lâm, Thiên-Trí, Lebedova, Vera, Lindholm, Laura, Litt, David J, Martin, Irene, Martiny, Delphine, Mattheus, Wesley, McElligott, Martha, Meehan, Mary, Meiring, Susan, Mölling, Paula, Morfeldt, Eva, Morgan, Julie, Mulhall, Robert M, Muñoz-Almagro, Carmen, Murdoch, David R, Murphy, Joy, Musilek, Martin, Mzabi, Alexandre, Perez-Argüello, Amaresh, Perrin, Monique, Perry, Malorie, Redin, Alba, Roberts, Richard, Roberts, Maria, Rokney, Assaf, Ron, Merav, Scott, Kevin J, Sheppard, Carmen L, Siira, Lotta, Skoczyńska, Anna, Sloan, Monica, Slotved, Hans-Christian, Smith, Andrew J, Song, Joon Young, Taha, Muhamed-Kheir, Toropainen, Maija, Tsang, Dominic, Vainio, Anni, van Sorge, Nina M, Varon, Emmanuelle, Vlach, Jiri, Vogel, Ulrich, Vohrnova, Sandra, von Gottberg, Anne, Zanella, Rosemeire C, Zhou, Fei

Source: In The Lancet Digital Health June 2021 3(6):e360-e370

Biological properties of ruthenium(II)/(III) complexes with flavonoids as ligands

Authors: Małecka, Magdalena, Skoczyńska, Anna, Goodman, David M., Hartinger, Christian G., Budzisz, Elzbieta

Source: In Coordination Chemistry Reviews 1 June 2021 436

Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia? A hypothesis in the era of COVID-19

Authors: Kiedrowski, Miroslaw, Kapala, Przemyslaw, Kiedrowska, Marlena, Skoczynska, Anna, Czerw, Aleksandra, Deptała, Andrzej

Source: In Medical Hypotheses January 2021 146

New Zn(II) coordination polymer of indole-3-acetic acid, a plant-growth promoting hormone: Crystal structure, spectroscopic characterization, DFT calculations and microbiological activity

Authors: Szmigiel-Bakalarz, Ksenia, Skoczyńska, Anna, Lewańska, Monika, Günther, Daniel, Oeckler, Oliver, Malik-Gajewska, Magdalena, Michalska, Danuta, Morzyk-Ociepa, Barbara

Source: In Polyhedron 15 July 2020 185

Prevention and control of meningococcal disease: Updates from the Global Meningococcal Initiative in Eastern Europe

Authors: Bai, Xilian, Borrow, Ray, Bukovski, Suzana, Caugant, Dominique A., Culic, Davor, Delic, Snezana, Dinleyici, Ener Cagri, Eloshvili, Medeia, Erdősi, Tímea, Galajeva, Jelena, Křížová, Pavla, Lucidarme, Jay, Mironov, Konstantin, Nurmatov, Zuridin, Pana, Marina, Rahimov, Erkin, Savrasova, Larisa, Skoczyńska, Anna, Smith, Vinny, Taha, Muhamed-Kheir, Titov, Leonid, Vázquez, Julio, Yeraliyeva, Lyazzat

Source: In Journal of Infection December 2019 79(6):528-541

The cytotoxic effect of Ru(II) complexes with 5-(2-hydroxyphenyl)-3-methyl-1-(2-pyridyl)-1H-pyrazole-4-carboxylic acid methyl ester: Synthesis, X-ray structure and DNA damage potential

Authors: Skoczyńska, Anna, Pasternak, Beata, Małecka, Magdalena, Krajewska, Urszula, Mirowski, Marek, Merecz-Sadowska, Anna, Karwowski, Bolesław T., Kusz, Joachim, Budzisz, Elzbieta

Source: In Polyhedron 1 September 2019 169:228-238

Pneumococcal lineages associated with serotype replacement and antibiotic resistance in childhood invasive pneumococcal disease in the post-PCV13 era: an international whole-genome sequencing study

Authors: Brooks, Abdullah W, Corso, Alejandra, Davydov, Alexander, Maguire, Alison, Pollard, Andrew, Kiran, Anmol, Skoczynska, Anna, Moiane, Benild, Beall, Bernard, Sigauque, Betuel, Aanensen, David, Lehmann, Deborah, Faccone, Diego, Foster-Nyarko, Ebenezer, Bojang, Ebrima, Egorova, Ekaterina, Voropaeva, Elena, Sampane-Donkor, Eric, Sadowy, Ewa, Bigogo, Godfrey, Mucavele, Helio, Belabbès, Houria, Diawara, Idrissa, Moïsi, Jennifer, Verani, Jennifer, Keenan, Jeremy, Nair Thulasee Bhai, Jyothish N, Ndlangisa, Kedibone M, Zerouali, Khalid, Ravikumar, K L, Titov, Leonid, De Gouveia, Linda, Alaerts, Maaike, Ip, Margaret, de Cunto Brandileone, Maria Cristina, Hasanuzzaman, Md, Paragi, Metka, Nurse-Lucas, Michele, Ali, Mushal, Elmdaghri, Naima, Croucher, Nicholas, Wolter, Nicole, Porat, Nurit, Eser, Özgen Köseoglu, Akpaka, Patrick E, Turner, Paul, Gagetti, Paula, Tientcheu, Peggy-Estelle, Carter, Philip E, Mostowy, Rafal, Kandasamy, Rama, Ford, Rebecca, Henderson, Rebecca, Malaker, Roly, Shakoor, Sadia, Grassi Almeida, Samanta Cristine, Saha, Samir K, Doiphode, Sanjay, Madhi, Shabir A, Devi Sekaran, Shamala, Srifuengfung, Somporn, Obaro, Stephen, Clarke, Stuart C, Nzenze, Susan A, Kastrin, Tamara, Ochoa, Theresa J, Balaji, Veeraraghavan, Hryniewicz, Waleria, Urban, Yulia, Lo, Stephanie W ^{*, *}, Gladstone, Rebecca A ^*, van Tonder, Andries J, Lees, John A, du Plessis, Mignon, Benisty, Rachel, Givon-Lavi, Noga, Hawkins, Paulina A, Cornick, Jennifer E, Kwambana-Adams, Brenda, Law, Pierra Y, Ho, Pak Leung, Antonio, Martin, Everett, Dean B, Dagan, Ron, von Gottberg, Anne, Klugman, Keith P, McGee, Lesley, Breiman, Robert F, Bentley, Stephen D

Source: In The Lancet Infectious Diseases July 2019 19(7):759-769

Genetic variability of Polish serogroup B meningococci (2010–2016) including the 4CMenB vaccine component genes

Authors: Waśko, Izabela, Gołębiewska, Agnieszka, Kiedrowska, Marlena, Ronkiewicz, Patrycja, Wróbel-Pawelczyk, Izabela, Kuch, Alicja, Hong, Eva, Skoczyńska, Anna

Source: Vaccine. 38(8):1943-1952

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100097969857.0x000001&indx=1&recIds=ETOCvdc_100097969857.0x000001

Activity of temocillin against ESBL-, AmpC-, and/or KPC-producing Enterobacterales isolated in Poland

Authors: Kuch, Alicja, Zieniuk, Bartłomiej, Żabicka, Dorota, Van de Velde, Sebastien, Literacka, Elżbieta, Skoczyńska, Anna, Hryniewicz, Waleria

Source: European journal of clinical microbiology & infectious diseases. 39(6):1185-1191

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168187973.0x000001&indx=1&recIds=ETOCvdc_100168187973.0x000001

Relationships among streptococci from the mitis group, misidentified as Streptococcus pneumoniae

Authors: Sadowy, Ewa, Bojarska, Agnieszka, Kuch, Alicja, Skoczyńska, Anna, Jolley, Keith A., Maiden, Martin C. J., van Tonder, Andries J., Hammerschmidt, Sven, Hryniewicz, Waleria

Source: European journal of clinical microbiology & infectious diseases. 39(10):1865-1878

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168188649.0x000001&indx=1&recIds=ETOCvdc_100168188649.0x000001

Indole-3-Butyric Acid, a Natural Auxin, Protects against Fenton Reaction-Induced Oxidative Damage in Porcine Thyroid.

Authors: Skoczyńska, Anna K., Gładysz, Aleksandra K., Stępniak, Jan, Karbownik-Lewińska, Małgorzata

Source: Nutrients; Sep2024, Vol. 16 Issue 17, p3010, 10p

The effect of polyunsaturated fatty acids on cardiovascular risk factors and urinary mercury in workers employed at electrolytic production of chlorine.

Authors: SKOCZYŃSKA, ANNA¹ anna.skoczynska@umed.wroc.pl, CYRAN, MACIEJ², TURCZYN, BARBARA¹, WOJAKOWSKA, ANNA¹, SMYK, BEATA¹, SKOCZYŃSKA, MARTA³, Skoczyńska, Anna⁴ (AUTHOR), Skoczyńska, Marta⁵ (AUTHOR)

Source: International Journal of Occupational Medicine & Environmental Health. 2021, Vol. 34 Issue 4, p551-564. 14p.

Subject Terms: *MERCURY vapor, *MERCURY (Element), *UNSATURATED fatty acids, *CARDIOVASCULAR diseases risk factors, *HDL cholesterol, *SYSTOLIC blood pressure, *HEART beat