From periphery immunity to central domain through clinical interview as a new insight on schizophrenia

Authors: Wirginia Krzyściak, Marta Szwajca, Natalia Śmierciak, Robert Chrzan, Aleksander Turek, Paulina Karcz, Amira Bryll, Maciej Pilecki, Eva Morava, Anna Ligęzka, Tamas Kozicz, Paulina Mazur, Bogna Batko, Anna Skalniak, Tadeusz Popiela

Source: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6fc6575b49cd45cbbd81461c46d34f95

Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors

Authors: Ważyńska, Marta A., Butera, Roberto, Requesens, Marta, Plat, Annechien, Zarganes-Tzitzikas, Tryfon, Neochoritis, Constantinos G., Plewka, Jacek, Skalniak, Lukasz, Kocik-Krol, Justyna, Musielak, Bogdan

Source: Journal of medicinal chemistry. 66(14):9577-9591

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633257682&indx=1&recIds=ETOCRN633257682

Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies

Authors: Ismael Rodriguez, Justyna Kocik-Krol, Lukasz Skalniak, Bogdan Musielak, Aneta Wisniewska, Agnieszka Ciesiołkiewicz, Łukasz Berlicki, Jacek Plewka, Przemyslaw Grudnik, Malgorzata Stec, Maciej Siedlar, Tad A. Holak, Katarzyna Magiera-Mularz

Source: Molecular Cancer, Vol 22, Iss 1, Pp 1-8 (2023)

Subject Terms: PD-1, Programmed death 1, PD-L1, Programmed death ligand 1, CD80, Immune checkpoint blockade, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://doaj.org/toc/1476-4598

Access URL: https://doaj.org/article/4d89b666a61e477c85c3abb086044bda

C2-Symmetrical Terphenyl Derivatives as Small Molecule Inhibitors of Programmed Cell Death 1/Programmed Death Ligand 1 Protein–Protein Interaction

Authors: Joanna Klimek, Oskar Kruc, Joanna Ceklarz, Beata Kamińska, Bogdan Musielak, Robin van der Straat, Alexander Dӧmling, Tad A. Holak, Damian Muszak, Justyna Kalinowska-Tłuścik, Łukasz Skalniak, Ewa Surmiak

Source: Molecules, Vol 29, Iss 11, p 2646 (2024)

Subject Terms: PD-L1, immune checkpoint, small molecule inhibitor, cancer, C2-symmetrical ligands, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/11/2646; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/a5d831ce94ba4f578f5a3ee0930719c2

Substrate Affinity Is Not Crucial for Therapeutic L-Asparaginases: Antileukemic Activity of Novel Bacterial Enzymes

Authors: Anna Ściuk, Kinga Wątor, Izabela Staroń, Paulina Worsztynowicz, Kinga Pokrywka, Joanna Sliwiak, Marta Kilichowska, Kamila Pietruszewska, Zofia Mazurek, Anna Skalniak, Krzysztof Lewandowski, Mariusz Jaskolski, Joanna I. Loch, Marcin Surmiak

Source: Molecules, Vol 29, Iss 10, p 2272 (2024)

Subject Terms: L-asparaginase, substrate affinity, leukemia, cell proliferation, cell apoptosis, Organic chemistry, QD241-441

File Description: electronic resource

Relation: https://www.mdpi.com/1420-3049/29/10/2272; https://doaj.org/toc/1420-3049

Access URL: https://doaj.org/article/ff44c9002d474bcc824bc0e7d2ea15b1

A study of the interactions between human osteoblast-like cells and polymer composites with functionalized graphene derivatives using 2D correlation spectroscopy (2D-COS)

Authors: Kołodziej, Anna, Wesełucha-Birczyńska, Aleksandra, Długoń, Elżbieta, Świętek, Małgorzata, Gubernat, Maciej, Skalniak, Łukasz, Błażewicz, Marta

Source: In Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 15 January 2023 285

Whole-Exome Screening and Analysis of Signaling Pathways in Multiple Endocrine Neoplasia Type 1 Patients with Different Outcomes: Insights into Cellular Mechanisms and Possible Functional Implications.

Authors: Skalniak, Anna¹ (AUTHOR) anna.skalniak@uj.edu.pl, Trofimiuk-Müldner, Małgorzata² (AUTHOR) malgorzata.trofimiuk@uj.edu.pl, Surmiak, Marcin¹ (AUTHOR) marcin.surmiak@uj.edu.pl, Totoń-Żurańska, Justyna³ (AUTHOR) justyna.toton-zuranska@uj.edu.pl, Jabrocka-Hybel, Agata² (AUTHOR) agata.jabrocka-hybel@uj.edu.pl, Hubalewska-Dydejczyk, Alicja² (AUTHOR) alicja.hubalewska-dydejczyk@uj.edu.pl

Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 2, p1065. 11p.

Subject Terms: *MEDICAL screening, *PITUITARY tumors, *CELLULAR signal transduction, *TUMORS, *CELL adhesion

Immunological routine laboratory parameters at admission influence the improvement of positive symptoms in schizophrenia patients after pharmacological treatment

Authors: Anna Skalniak, Wirginia Krzyściak, Natalia Śmierciak, Marta Szwajca, Paulina Donicz, Tamas Kozicz, Maciej Pilecki

Source: Frontiers in Psychiatry, Vol 14 (2023)

Subject Terms: schizophrenia, inflammation, laboratory diagnostic tests, outcome of a patient’s treatment, cost optimization in psychiatry, Psychiatry, RC435-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fpsyt.2023.1082135/full; https://doaj.org/toc/1664-0640

Access URL: https://doaj.org/article/b587d6a8a48c4f78a5df45a67259fc46

AIP gene germline variants in adult Polish patients with apparently sporadic pituitary macroadenomas

Authors: Małgorzata Trofimiuk-Müldner, Bartosz Domagała, Grzegorz Sokołowski, Anna Skalniak, Alicja Hubalewska-Dydejczyk

Source: Frontiers in Endocrinology, Vol 14 (2023)

Subject Terms: aryl hydrocarbon receptor-interacting protein, AIP, pituitary, adenoma, mutation, Diseases of the endocrine glands. Clinical endocrinology, RC648-665

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fendo.2023.1098367/full; https://doaj.org/toc/1664-2392

Access URL: https://doaj.org/article/26f06a2d69ae4944b63e7930eaae99b7

Human and mouse PD-L1: similar molecular structure, but different druggability profiles

Authors: Magiera-Mularz, Katarzyna, Kocik, Justyna, Musielak, Bogdan, Plewka, Jacek, Sala, Dominik, Machula, Monika, Grudnik, Przemyslaw, Hajduk, Malgorzata, Czepiel, Marcin, Siedlar, Maciej, Holak, Tad A., Skalniak, Lukasz

Source: In iScience 22 January 2021 24(1)

Application of bioorthogonal hetero-Diels–Alder cycloaddition of 5-arylidene derivatives of 1, 3-dimethylbarbituric acid and vinyl thioether for imaging inside living cellsElectronic supplementary information (ESI) available. See DOI: 10.1039/d1ob00697e

Authors: Bazan, Bartłomiej, Pałasz, Aleksandra, Skalniak, Łukasz, Cież, Dariusz, Buda, Szymon, Jędrzejowska, Katarzyna, Głomb, Sonia, Kamzol, Daniel, Czarnota, Kinga, Latos, Krystian, Kozieł, Krzysztof, Musielak, Bogdan

Source: Organic & biomolecular chemistry. 19(27):6045-6058

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123178140.0x000001&indx=1&recIds=ETOCvdc_100123178140.0x000001

Software Quality Improvement by Application of a Component-Based Software Meta-Architecture
Computational collective intelligence (International conference)

Authors: Skalniak, Tomasz, Rot, Artur, Gryncewicz, Wieslawa

Source: Lecture notes in computer science. 11684:428-442

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCCN605434744&indx=1&recIds=ETOCCN605434744

Systematic ‘foldamerization’ of peptide inhibiting p53-MDM2/X interactions by the incorporation of trans- or cis-2-aminocyclopentanecarboxylic acid residues

Authors: Fortuna, Paulina, Twarda-Clapa, Aleksandra, Skalniak, Lukasz, Ożga, Katarzyna, Holak, Tad A., Berlicki, Łukasz

Source: In European Journal of Medicinal Chemistry 15 December 2020 208

Does 2D correlation Raman spectroscopy distinguish polymer nanomaterials due to the nanoaddition?

Authors: Wesełucha-Birczyńska, Aleksandra, Kołodziej, Anna, Świętek, Małgorzata, Moskal, Paulina, Skalniak, Łukasz, Długoń, Elżbieta, Błażewicz, Marta

Source: In Journal of Molecular Structure 5 October 2020 1217

A 2D-Raman correlation spectroscopy study of the interaction of the polymer nanocomposites with carbon nanotubes and human osteoblast-like cells interface

Authors: Kołodziej, Anna, Wesełucha-Birczyńska, Aleksandra, Świętek, Małgorzata, Skalniak, Łukasz, Błażewicz, Marta

Source: In Journal of Molecular Structure 15 July 2020 1212

The Association of the Oral Microbiota with the Effects of Acid Stress Induced by an Increase of Brain Lactate in Schizophrenia Patients

Authors: Wirginia Krzyściak, Paulina Karcz, Beata Bystrowska, Marta Szwajca, Amira Bryll, Natalia Śmierciak, Anna Ligęzka, Aleksander Turek, Tamas Kozicz, Anna E. Skalniak, Paweł Jagielski, Tadeusz J. Popiela, Maciej Pilecki

Source: Biomedicines, Vol 11, Iss 2, p 240 (2023)

Subject Terms: brain lactate, schizophrenia, oral microbiota, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.mdpi.com/2227-9059/11/2/240; https://doaj.org/toc/2227-9059

Access URL: https://doaj.org/article/0833352cfcbf4d7c979f47c9f1479449

Hitting on the move: Targeting intrinsically disordered protein states of the MDM2-p53 interaction

Authors: Neochoritis, Constantinos G., Atmaj, Jack, Twarda-Clapa, Aleksandra, Surmiak, Ewa, Skalniak, Lukasz, Köhler, Lisa-Maria, Muszak, Damian, Kurpiewska, Katarzyna, Kalinowska-Tłuścik, Justyna, Beck, Barbara, Holak, Tad A., Dömling, Alexander

Source: In European Journal of Medicinal Chemistry 15 November 2019 182

Multicomponent Peptide Stapling as a Diversity‐Driven Tool for the Development of Inhibitors of Protein–Protein Interactions

Authors: Ricardo, Manuel G., Ali, Ameena M., Plewka, Jacek, Surmiak, Ewa, Labuzek, Beata, Neochoritis, Constantinos G., Atmaj, Jack, Skalniak, Lukasz, Zhang, Ran, Holak, Tad A., Groves, Matthew, Rivera, Daniel G., Dömling, Alexander

Source: Angewandte Chemie international edition. 59(13):5235-5241

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100102876002.0x000001&indx=1&recIds=ETOCvdc_100102876002.0x000001

Anti-CD44 DNA Aptamers Selectively Target Cancer Cells

Authors: Pęcak, Aleksandra, Skalniak, Łukasz, Pels, Katarzyna, Książek, Mirosław, Madej, Mariusz, Krzemień, Dobrosława, Malicki, Stanisław, Władyka, Benedykt, Dubin, Adam, Holak, Tad A., Dubin, Grzegorz

Source: Nucleic acid therapeutics. 30(5):289-298

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153501107.0x000001&indx=1&recIds=ETOCvdc_100153501107.0x000001

Miniprotein engineering for inhibition of PD‐1/PD‐L1 interaction.

Authors: Ciesiołkiewicz, Agnieszka, Lizandra Perez, Juan, Skalniak, Lukasz, Noceń, Paweł, Berlicki, Łukasz

Source: Protein Science: A Publication of the Protein Society; Aug2024, Vol. 33 Issue 8, p1-14, 14p