Alterations in bile acid kinetics after bariatric surgery in patients with obesity with or without type 2 diabetes

Authors: Wahlström, Annika, Aydin, Ömrüm, Olsson, Lisa M., Sjöland, Wilhelm, Henricsson, Marcus, Lundqvist, Annika, Marschall, Hanns-Ulrich, Franken, Rutger, van de Laar, Arnold, Gerdes, Victor, Meijnikman, Abraham S., Hofsø, Dag, Groen, Albert K., Hjelmesæth, Jøran, Nieuwdorp, Max, Bäckhed, Fredrik

Source: In eBioMedicine August 2024 106

Long‐term hypercaloric diet exacerbates metabolic liver disease in PNPLA3 I148M animals

Authors: Su, Huan, Haque, Madhuri, Becker, Svea, Edlund, Karolina, Duda, Julia, Wang, Qingbi, Reißing, Johanna, Marschall, Hanns‐Ulrich, Candels, Lena S., Mohamed, Mohamed, Sjöland, Wilhelm, Liao, Lijun, Drexler, Stephan A., Strowig, Till, Rahnenführer, Jörg, Hengstler, Jan G., Hatting, Maximilian, Trautwein, Christian

Source: Liver international. 43(8):1699-1713

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187930552.0x000001&indx=1&recIds=ETOCvdc_100187930552.0x000001

GLP-2 Improves Hepatic Inflammation and Fibrosis in Mdr2-/- Mice Via Activation of NR4a1/Nur77 in Hepatic Stellate Cells and Intestinal FXR Signaling

Authors: Fuchs, Claudia D., Claudel, Thierry, Mlitz, Veronika, Riva, Alessandra, Menz, Moritz, Brusilovskaya, Ksenia, Haller, Felix, Baumgartner, Maximilian, Königshofer, Philipp, Unger, Lukas W., Sjöland, Wilhelm, Scharnagl, Hubert, Stojakovic, Tatjana, Busslinger, Georg, Reiberger, Thomas, Marschall, Hanns-Ulrich, Trauner, Michael

Source: In Cellular and Molecular Gastroenterology and Hepatology 2023 16(5):847-856

An integrated analysis of bile acid metabolism in humans with severe obesity.

Authors: Aydin, Ömrüm, Wahlström, Annika, de Jonge, Patrick A., Meijnikman, Abraham S., Sjöland, Wilhelm, Olsson, Lisa, Henricsson, Marcus, de Goffau, Marcus C., Oonk, Stijn, Bruin, Sjoerd C., Acherman, Yair I.Z., Marschall, Hanns-Ulrich, Gerdes, Victor E.A., Nieuwdorp, Max, Bäckhed, Fredrik, Groen, Albert K.

Source: Hepatology (02709139); Jan2025, Vol. 81 Issue 1, p19-31, 13p

Production of deoxycholic acid by lowabundant microbial species is associated with impaired glucose metabolism.

Authors: Wahlström, Annika, Brumbaugh, Ariel, Sjöland, Wilhelm, Olsson, Lisa, Hao Wu, Henricsson, Marcus, Lundqvist, Annika, Makki, Kassem, Hazen, Stanley L., Bergström, Göran, Marschall, Hanns-Ulrich, Fischbach, Michael A., Bäckhed, Fredrik

Source: Nature Communications; 5/20/2024, Vol. 15 Issue 1, p1-11, 11p, 1 Chart, 3 Graphs

PNPLA3 I148M substitution excerbate NAFLD under a long-term high fat diet

Authors: Su, Huan, Haque, Madhuri, Becker, Svea, Edlund, Karolina, Duda, Julia, Wang, Qingbi, Reißing, Johanna, Marschall, Hanns-Ulrich, Candels, Lena Susanna, Mohamed, Mohamed Ramadan, Sjöland, Wilhelm, Strowig, Till, Rahnenführer, Jörg, Hengstler, Jan G., Hatting, Maximilian, Trautwein, Christian

Source: Journal of hepatology. 78(S1):S778-S778

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194689358.0x000001&indx=1&recIds=ETOCvdc_100194689358.0x000001

Absence of gut microbiota reduces neonatal survival and exacerbates liver disease in Cyp2c70-deficient mice with a human-like bile acid composition.

Authors: Sjöland, Wilhelm¹, Wahlström, Annika¹, Makki, Kassem¹, Schöler, Marc¹, Molinaro, Antonio^1,2, Olsson, Lisa¹, Greiner, Thomas Uwe¹, Caesar, Robert¹, de Boer, Jan Freark^3,4, Kuipers, Folkert^3,5, Bäckhed, Fredrik^1,6,7 Fredrik.Backhed@wlab.gu.se, Marschall, Hanns-Ulrich^1,6 hanns-ulrich.marschall@gu.se

Source: Clinical Science. Jul2023, Vol. 137 Issue 13, p995-1011. 17p.

Subject Terms: *GUT microbiome, *BILE acids, *LIVER diseases, *HEPATIC fibrosis, *HUMAN microbiota, *EPICATECHIN, *NONNUTRITIVE sweeteners

WED-470 - PNPLA3 I148M substitution excerbate NAFLD under a long-term high fat diet

Authors: Su, Huan, Haque, Madhuri, Becker, Svea, Edlund, Karolina, Duda, Julia, Wang, Qingbi, Reißing, Johanna, Marschall, Hanns-Ulrich, Candels, Lena Susanna, Mohamed, Mohamed Ramadan, Sjöland, Wilhelm, Strowig, Till, Rahnenführer, Jörg, Hengstler, Jan G., Hatting, Maximilian, Trautwein, Christian

Source: In Journal of Hepatology June 2023 78 Supplement 1:S778-S778