Differential risk assessment in persons at risk of type 2 diabetes using urinary peptidomics

Authors: Schork, Anja ^{a, b, c, ⁎}, Fritsche, Andreas ^{a, b, c}, Schleicher, Erwin D. ^d, Peter, Andreas ^d, Heni, Martin ^{a, b, c, e}, Stefan, Norbert ^{a, b, c}, von Schwartzenberg, Reiner Jumpertz ^{a, b, c}, Guthoff, Martina ^{a, b, c}, Mischak, Harald ^f, Siwy, Justyna ^f, Birkenfeld, Andreas L. ^{a, b, c}, Wagner, Robert ^{a, b, c, g, h}

Source: In Metabolism June 2025 167

Randomized Trial of SGLT2 Inhibitor Identifies Target Proteins in Diabetic Kidney Disease

Authors: Ahluwalia, Tarunveer S., Rönkkö, Teemu K.E., Eickhoff, Mie K., Curovic, Viktor Rotbain, Siwy, Justyna, Eder, Susanne, Denicolò, Sara, Mayer, Gert, Mischak, Harald, Rossing, Peter, Persson, Frederik

Source: In Kidney International Reports February 2024 9(2):334-346

Presence of retinopathy and incident kidney and cardiovascular events in type 2 diabetes with normoalbuminuria – A post-hoc analysis of the PRIORITY randomized clinical trial

Authors: Rotbain Curovic, Viktor, Tofte, Nete, Lindhardt, Morten, Adamova, Katarina, Bakker, Stephan J.L., Beige, Joachim, Beulens, Joline W.J., Birkenfeld, Andreas L., Currie, Gemma, Delles, Christian, Dimos, Ingo, Francová, Lidmila, Frimodt-Møller, Marie, Girman, Peter, Göke, Rüdiger, Hansen, Tine W., Havrdova, Tereza, Kooy, Adriaan, Laverman, Gozewijnw D., Mischak, Harald, Navis, Gerjan, Nijpels, Giel, Noutsou, Marina, Ortiz, Alberto, Parvanova, Aneliya, Persson, Frederik, Petrie, John R., Ruggenenti, Piero L., Rutters, Femke, Rychlík, Ivan, Siwy, Justyna, Spasovski, Goce, Speeckaert, Marijn, Trillini, Matias, Zürbig, Petra, von der Leyen, Heiko, Rossing, Peter

Source: In Journal of Diabetes and Its Complications April 2023 37(4)

Machine Learning-Based Urine Peptidome Analysis to Predict and Understand Mechanisms of Progression to Kidney Failure

Authors: ALENCAR DE PINHO, Natalia, AYAV, Carole, CANNET, Dorothée, COMBE, Christian, DELEUZE, Jean-François, FOUQUE, Denis, FRIMAT, Luc, HERPE, Yves-Edouard, JACQUELINET, Christian, LAVILLE, Maurice, LIABEUF, Sophie, MASSY, Ziad A., PASCAL, Christophe, ROBINSON, Bruce, PECOITS-FILHO, Roberto, SCHANSTRA, Joost, STENGEL, Bénédicte, LANGE, Céline, METZGER, Marie, SPEYER, Elodie, Massy, Ziad A., Lambert, Oriane, Metzger, Marie, Sedki, Mohammed, Chaubet, Adeline, Breuil, Benjamin, Jaafar, Acil, Tack, Ivan, Nguyen-Khoa, Thao, Alves, Melinda, Siwy, Justyna, Mischak, Harald, Verbeke, Francis, Glorieux, Griet, Herpe, Yves-Edouard, Schanstra, Joost P., Stengel, Bénédicte, Klein, Julie

Source: In Kidney International Reports March 2023 8(3):544-555

Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study

Authors: Staessen, Jan A, Wendt, Ralph, Yu, Yu-Ling, Kalbitz, Sven, Thijs, Lutgarde, Siwy, Justyna, Raad, Julia, Metzger, Jochen, Neuhaus, Barbara, Papkalla, Armin, von der Leyen, Heiko, Mebazaa, Alexandre, Dudoignon, Emmanuel, Spasovski, Goce, Milenkova, Mimoza, Canevska-Taneska, Aleksandra, Lazo, Mercedes Salgueira, Psichogiou, Mina, Rajzer, Marek W, Fulawka, Lukasz, Dzitkowska-Zabielska, Magdalena, Weiss, Guenter, Feldt, Torsten, Stegemann, Miriam, Normark, Johan, Zoufaly, Alexander, Schmiedel, Stefan, Seilmaier, Michael, Rumpf, Benedikt, Banasik, Mirosław, Krajewska, Magdalena, Catanese, Lorenzo, Rupprecht, Harald, Czerwienska, Beata, Peters, Björn, Nilsson, Åsa, Rothfuss, Katja, Lübbert, Christoph, Mischak, Harald, Beige, Joachim, Ermisch, Jörg, Kellner, Nils, Peruth-Stutzmann, Lydia, Schroth, Stefanie, Schmidt, Jonathan, Schmidt, Ulrike, Breuer, Daniel, Abeud, Fariza, Fournier, Marie-Celine, Louadah, Badr, Molas, Rocio, Rojas, Fraile Loreto, García, Fabiola Alonso, Sánchez, Isabel Garcia, Hrom, Ioana Cezara, Więczek., Andrzej, Schwab, Matthias, K Asayama, Kei, Hansen, Tine W, Maestre, Gladys E, Basoulis, Dimitrios, Karamanakos., Georgios, Lis, Pawel, Olszanecka, Agnieszka, Bellmann-Weiler, Rosa, Lanser, Lucas, Edin, Alicia, Forsell, Matthias NE, Stegmayr, Bernd, Jensen, Björn-Erik Ole, Orth, Hans-Martin, Borstel, Sylke, Mikolajewska, Agata, Hecking, Manfred, Schmölz, Lukas, Hoffmann, Michał, Narkiewicz, Krzysztof, Matera-Witkiewicz, Agnieszka, Zachciał, Justyna, Litwin, Monika, Marciniak, Patrycja, Salgueira Lazo, Mercedes, Fuławka, Łukasz, Rupprecht, Harald D, Czerwieńska, Beata

Source: In The Lancet Digital Health October 2022 4(10):e727-e737

Urinary peptidomic profiles to address age-related disabilities: a prospective population study

Authors: Asayama, Kei, Bochud, Murielle, Boggia, José, Brguljan-Hitij, Jana, Feng, Ying-Mei, Gu, Yu-Mei, Hara, Azusa, Huang, Qi-Fang, Jin, Yu, Seidlerová, Jitka, Liu, Yan-Ping, Melgarejo, Jesus, Moliterno, Paula, Odili, Augustine N, Petit, Thibault, Raaijmakers, Anke, Schutte, Rudolph, Staessen, Jan A, Stolarz-Skrzypek, Katarzyna, Thijs, Lutgarde, Tikhonoff, Valérie, Wang, Ji-Guang, Wei, Fangfei, Wei, Dongmei, Yang, Wen-Yi, Yu, Yuling, Zhang, Zhenyu, Martens, Dries S, Nawrot, Tim S, Roels, Harry A, Wang, Congrong, Latosinska, Agnieszka, Mischak, Harald, Siwy, Justyna, Willum-Hansen, Tine, Maestre, Gladys E, Trenson, Sander, Zhang, Zhen-Yu, Beige, Joachim, Vlahou, Antonia, Janssens, Stefan

Source: In The Lancet Healthy Longevity November 2021 2(11):e690-e703

A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients

Authors: Wendt, Ralph, Thijs, Lutgarde, Kalbitz, Sven, Mischak, Harald, Siwy, Justyna, Raad, Julia, Metzger, Jochen, Neuhaus, Barbara, Leyen, Heiko von der, Dudoignon, Emmanuel, Mebazaa, Alexandre, Spasovski, Goce, Milenkova, Mimoza, Canevska-Talevska, Aleksandra, Czerwieńska, Beata, Wiecek, Andrzej, Peters, Björn, Nilsson, Åsa, Schwab, Matthias, Rothfuss, Katja, Lübbert, Christoph, Staessen, Jan A., Beige, Joachim

Source: In EClinicalMedicine June 2021 36

Exploratory Study Analyzing the Urinary Peptidome of T2DM Patients Suggests Changes in ECM but Also Inflammatory and Metabolic Pathways Following GLP-1R Agonist Treatment.

Authors: Lohia, Sonnal^1,2 (AUTHOR), Siwy, Justyna³ (AUTHOR), Mavrogeorgis, Emmanouil^2,3 (AUTHOR), Eder, Susanne⁴ (AUTHOR) gert.mayer@i-med.ac.at, Thöni, Stefanie⁴ (AUTHOR), Mayer, Gert⁴ (AUTHOR), Mischak, Harald³ (AUTHOR), Vlahou, Antonia¹ (AUTHOR), Jankowski, Vera² (AUTHOR) vjankowski@ukaachen.de

Source: International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13540. 15p.

Subject Terms: *TYPE 2 diabetes, *GLUCAGON-like peptide-1 receptor, *TREATMENT effectiveness

Application of urinary peptide-biomarkers in trauma patients as a predictive tool for prognostic assessment, treatment and intervention timing.

Authors: Aktas, Gökmen, Keller, Felix, Siwy, Justyna, Latosinska, Agnieszka, Mischak, Harald, Mayor, Jorge, Clausen, Jan, Wilhelmi, Michaela, Brauckmann, Vesta, Sehmisch, Stephan, Pacha, Tarek Omar

Source: Scientific Reports; 1/6/2025, Vol. 14 Issue 1, p1-12, 12p

Subject Terms: INTENSIVE care patients, PEPTIDES, CAPILLARY electrophoresis, RESPIRATORY insufficiency, KIDNEY failure

Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study.

Authors: Yu-Ling Yu, Martens, Dries S., De-Wei An, Chori, Babangida, Latosinska, Agnieszka, Siwy, Justyna, Odili, Augustine N., Stolarz-Skrzypek, Katarzyna, Maestre, Gladys E., Kei Asayama, Yan Li, Verhamme, Peter, Allegaert, Karel, Mischak, Harald, Nawrot, Tim S., Staessen, Jan A.

Source: Aging & Disease; Jan2025, Vol. 16 Issue 1, p633-644, 12p

Subject Terms: BONE aging, OSTEOPOROSIS diagnosis, PROTEOMICS

Recent Advances in Urinary Peptide and Proteomic Biomarkers in Chronic Kidney Disease: A Systematic Review.

Authors: Catanese, Lorenzo^1,2,3 (AUTHOR) lorenzoriccardo.catanese@gmail.com, Siwy, Justyna⁴ (AUTHOR) siwy@mosaiques-diagnostics.com, Mischak, Harald⁴ (AUTHOR) mischak@mosaiques.de, Wendt, Ralph⁵ (AUTHOR) ralph.wendt@sanktgeorg.de, Beige, Joachim^5,6,7 (AUTHOR) joachim.beige@kfh.de, Rupprecht, Harald^1,2,3 (AUTHOR) harald.rupprecht@klinikum-bayreuth.de

Source: International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 11, p9156. 25p.

Subject Terms: *CHRONIC kidney failure, *PEPTIDES, *MASS spectrometry, *PROTEOMICS, *BIOMARKERS

Early detection of diabetic kidney disease by urinary proteomics and subsequent intervention with spironolactone to delay progression (PRIORITY): a prospective observational study and embedded randomised placebo-controlled trial

Authors: Zimmermann, Silke, Rädisch, Brit, Hävemeier, Anika, Busmann, Annette, Wittkop, Ulrike, Neuhaus, Barbara, Ax-Smolarski, Regina, Zieglschmid, Veit, Bollweber, Eva, Wölk, Heidrun, Curovic, Viktor R., Tougaard, Ninna H., Eickhoff, Mie K., Pilemann-Lyberg, Sascha, Winther, Signe A., Rosenlund, Signe V., Hansen, Tine W., von Scholten, Bernt J., Hansen, Christian S., Zobel, Emilie H., Laursen, Jens C., Theilade, Simone, Jelstrup, Lone, Juhl, Tina R., Riis, Dorthe, Hermann, Jessie A., Lundgaard, Anne G., Halkjær, Maja L.D., Aabo, Lene, Frost Lerche, Therese, Lajer, Maria, Stefansen, Rikke J., Campbell, Maria A., Durban, Annika, Raad, Julia, Prigge, Michael, Schiemann, Marco, Wilson, Robbie, Kean, Sharon, Douglas, Elizabeth, Surtees, Pamela, Gant, Christina, Yeung, Stanley M.H., Hagedoorn, Ilse, Flynn, Joanne, Galloway, Joe, Brooksbank, Katriona, Aparicio, Carolina, Iliev, Ilian P., Nones, Francesco, Lo Bue, Francesca, Melacini, Daniela, Cugini, Daniela, Prandini, Silvia, Lecchi, Verusca, Yakymchuk, Svitlana, Gherardi, Giulia, Villa, Alessandro, Villa, Davide, Gaspari, Flavio, Cannata, Antonio N., Ferrari, Silvia, Stucchi, Nadia, Albrechtová, Šárka, Eldeik, Elina, Amanaki, Renata, Fernandez-Fernandez, Beatriz, Sanchez-Rodriguez, Jinny, Vázquez, Clotilde, Sanz, Ana B., Sanchez-Niño, Maria D., Ramos, Adrian M., Gonzalo, Maria Á., Schmidt, Ulrike, Selim, Gjulsen, Gjorgovski, Tatjana, Stratrova, Slavica S., Stojceva-Taneva, Olivera, Schutten-Westerneng, Petra, Wierbos, Brenda, Huvers, Frank, De Bruin, Anneke K., Lapauw, Bruno, de Man, Elsie, Rokegem, Kelly, Inion, Sabien, Kreutzmann, Kristin, Dewettinck, Isabelle, Boukens-de Graaf, Caroline, Clerc-de Jong, Ferrina, Entius, Jannet, Nannings, Marian, van Steenderen, Suzy, Petry, Friedrich W., Kilic, Ceyda, Tofte, Nete ^*, Lindhardt, Morten ^*, Adamova, Katarina, Bakker, Stephan J L, Beige, Joachim, Beulens, Joline W J, Birkenfeld, Andreas L, Currie, Gemma, Delles, Christian, Dimos, Ingo, Francová, Lidmila, Frimodt-Møller, Marie, Girman, Peter, Göke, Rüdiger, Havrdova, Tereza, Heerspink, Hiddo J L, Kooy, Adriaan, Laverman, Gozewijn D, Mischak, Harald, Navis, Gerjan, Nijpels, Giel, Noutsou, Marina, Ortiz, Alberto, Parvanova, Aneliya, Persson, Frederik, Petrie, John R, Ruggenenti, Piero L, Rutters, Femke, Rychlík, Ivan, Siwy, Justyna, Spasovski, Goce, Speeckaert, Marijn, Trillini, Matias, Zürbig, Petra, von der Leyen, Heiko, Rossing, Peter ^*

Source: In The Lancet Diabetes & Endocrinology April 2020 8(4):301-312

Peptides as "better biomarkers"? Value, challenges, and potential solutions to facilitate implementation.

Authors: Latosinska, Agnieszka, Frantzi, Maria, Siwy, Justyna

Source: Mass Spectrometry Reviews; Nov2024, Vol. 43 Issue 6, p1195-1236, 42p

Subject Terms: CEREBROSPINAL fluid, PEPTIDES, MASS spectrometry, BIOMARKERS, SAMPLE size (Statistics)

Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial.

Authors: Yu-Ling Yu, Siwy, Justyna, De-Wei An, González, Arantxa, Hansen, Tine, Latosinska, Agnieszka, Pellicori, Pierpaolo, Ravassa, Susana, Mariottoni, Beatrice, Verdonschot, Job A. J., Ahmed, Fozia, Petutschnigg, Johannes, Rossignol, Patrick, Heymans, Stephane, Cuthbert, Joe J., Girerd, Nicolas, Clark, Andrew L., Verhamme, Peter, Nawrot, Tim S., Janssens, Stefan

Source: Heart; Oct2024, Vol. 110 Issue 19, p1180-1187, 8p

Subject Terms: HEART failure, MOLECULAR biology, PROTEOMICS, MEDICAL sciences, MINERALOCORTICOID receptors, PEPTIDES, ALDOSTERONE antagonists, SODIUM-glucose cotransporters

Mortality Risk and Urinary Proteome Changes in Acute COVID-19 Survivors in the Multinational CRIT-COV-U Study.

Authors: Siwy, Justyna, Keller, Felix, Banasik, Mirosław, Peters, Björn, Dudoignon, Emmanuel, Mebazaa, Alexandre, Gülmez, Dilara, Spasovski, Goce, Lazo, Mercedes Salgueira, Rajzer, Marek W., Fuławka, Łukasz, Dzitkowska-Zabielska, Magdalena, Mischak, Harald, Hecking, Manfred, Beige, Joachim, Wendt, Ralph

Source: Biomedicines; Sep2024, Vol. 12 Issue 9, p2090, 14p

Subject Terms: POST-acute COVID-19 syndrome, APOLIPOPROTEIN A, IMMUNOGLOBULIN receptors, COVID-19, DEATH forecasting

Early detection of organ involvement in Fabry disease by biomarker assessment in conjunction with LGE cardiac MRI: results from the SOPHIA study

Authors: Weidemann, Frank, Beer, Meinrad, Kralewski, Martina, Siwy, Justyna, Kampmann, Christoph

Source: In Molecular Genetics and Metabolism February 2019 126(2):169-182

Multiple urinary peptides are associated with hypertension: a link to molecular pathophysiology.

Authors: Mavrogeorgis, Emmanouil, Kondyli, Margarita, Mischak, Harald, Vlahou, Antonia, Siwy, Justyna, Rossing, Peter, Campbell, Archie, Mels, Carina M. C., Delles, Christian, Staessen, Jan A., Latosinska, Agnieszka, Persu, Alexandre

Source: Journal of Hypertension; Aug2024, Vol. 42 Issue 8, p1331-1339, 9p

Integration of Urinary Peptidome and Fecal Microbiome to Explore Patient Clustering in Chronic Kidney Disease.

Authors: Mavrogeorgis, Emmanouil, Valkenburg, Sophie, Siwy, Justyna, Latosinska, Agnieszka, Glorieux, Griet, Mischak, Harald, Jankowski, Joachim

Source: Proteomes; Jun2024, Vol. 12 Issue 2, p11, 15p

Impact of Renal Denervation on Urinary Peptide-Based Biomarkers in Hypertension.

Authors: Lauder, Lucas, Siwy, Justyna, Mavrogeorgis, Emmanouil, Keller, Felix, Kunz, Michael, Wachter, Angelika, Emrich, Insa E., Böhm, Michael, Mischak, Harald, Mahfoud, Felix

Source: Hypertension (0194911X); Jun2024, Vol. 81 Issue 6, p1374-1382, 9p

Urinary peptidomics provides a noninvasive humanized readout of diabetic nephropathy in mice

Authors: Klein, Julie, Ramirez-Torres, Adela, Ericsson, Anette, Huang, Yufeng, Breuil, Benjamin, Siwy, Justyna, Mischak, Harald, Peng, Xiao-Rong, Bascands, Jean-Loup, Schanstra, Joost P.

Source: In Kidney International November 2016 90(5):1045-1055