Design and preparation of pH-sensitive cytotoxic liposomal formulations containing antitumor colchicine analogues for target release.

Authors: Shchegravina, Ekaterina S., Tretiakova, Daria S., Sitdikova, Alsu R., Usova, Sofia D., Boldyrev, Ivan A., Alekseeva, Anna S., Svirshchevskaya, Elena V., Vodovozova, Elena L., Fedorov, Alexey Yu.

Source: Journal of Liposome Research; Sep2024, Vol. 34 Issue 3, p399-410, 12p

Subject Terms: PRODRUGS, COLCHICINE, COLLOIDAL stability, LIPOSOMES, TUMOR microenvironment, ANTINEOPLASTIC agents

Design, Synthesis and In Vitro Biological Activity of Novel C-7 Methylene Congeners of Furanoallocolchicinoids.

Authors: Gracheva, Iuliia A., Svirshchevskaya, Elena V., Shchegravina, Ekaterina S., Malysheva, Yulia B., Sitdikova, Alsu R., Fedorov, Alexey Yu.

Source: Pharmaceutics; Apr2023, Vol. 15 Issue 4, p1034, 10p

Subject Terms: BIOSYNTHESIS, DOUBLE bonds, CELL cycle, METHYLENE group, SPATIAL orientation