Antiangiogenic Pterocarpan and Flavonoid Constituents of Erythrina lysistemon

Authors: Nassief, Sarah M., Amer, Masouda E., Shawky, Eman, Sishtla, Kamakshi, Mas-Claret, Eduard, Muniyandi, Anbukkarasi, Corson, Timothy W., Mulholland, Dulcie A., El-Masry, Sawsan

Source: Journal of natural products. 86(4):759-766

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN632440545&indx=1&recIds=ETOCRN632440545

Synthesis and Structure Revision of Naturally Occurring Homoisoflavane (+)-Dracaeconolide B

Authors: Kwon, Sangil, Lee, Sanha, Hur, Joonseong, Ko, Keebeom, Fei, Xiang, Jeong, Kwang Won, Sishtla, Kamakshi, Muniyandi, Anbukkarasi, Bae, Munhyung, Corson, Timothy W.

Source: Journal of natural products. 86(1):149-156

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631555419&indx=1&recIds=ETOCRN631555419

Ref-1 is overexpressed in neovascular eye disease and targetable with a novel inhibitor.

Authors: Muniyandi, Anbukkarasi, Hartman, Gabriella D., Sishtla, Kamakshi, Rai, Ratan, Gomes, Cátia, Day, Kristina, Song, Yang, Masters, Andi R., Quinney, Sara K., Qi, Xiaoping, Woods, Hailey, Boulton, Michael E., Meyer, Jason S., Vilseck, Jonah Z., Georgiadis, Millie M., Kelley, Mark R., Corson, Timothy W.

Source: Angiogenesis; Mar2025, Vol. 28 Issue 1, p1-29, 29p

Ref‐1 redox activity regulates retinal neovascularization by modulating transcriptional activation of HIF‐1α.

Authors: Hartman, Gabriella D., Muniyandi, Anbukkarasi, Sishtla, Kamakshi, Kpenu, Eyram K., Miller, William P., Kaplan, Bryan A., Kim, Leo A., Liu, Sheng, Wan, Jun, Qi, Xiaoping, Boulton, Michael E., Kelley, Mark R., Corson, Timothy W.

Source: FASEB Journal; Feb2025, Vol. 39 Issue 3, p1-22, 22p

Small-molecule inhibitors of ferrochelatase are antiangiogenic agents

Authors: Sishtla, Kamakshi, Lambert-Cheatham, Nathan, Lee, Bit, Han, Duk Hee, Park, Jaehui, Sardar Pasha, Sheik Pran Babu, Lee, Sanha, Kwon, Sangil, Muniyandi, Anbukkarasi, Park, Bomina, Odell, Noa, Waller, Sydney, Park, Il Yeong, Lee, Soo Jae, Seo, Seung-Yong, Corson, Timothy W.

Source: In Cell Chemical Biology 16 June 2022 29(6):1010-1023

Heme Synthesis Inhibition Blocks Angiogenesis via Mitochondrial Dysfunction

Authors: Shetty, Trupti, Sishtla, Kamakshi, Park, Bomina, Repass, Matthew J., Corson, Timothy W.

Source: In iScience 21 August 2020 23(8)

Phenotypic Screening of Chemical Libraries Enriched by Molecular Docking to Multiple Targets Selected from Glioblastoma Genomic Data

Authors: Xu, David, Zhou, Donghui, Bum-Erdene, Khuchtumur, Bailey, Barbara J., Sishtla, Kamakshi, Liu, Sheng, Wan, Jun, Aryal, Uma K., Lee, Jonathan A., Wells, Clark D.

Source: ACS chemical biology. 15(6):1424-1444

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624170451&indx=1&recIds=ETOCRN624170451

Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization

Authors: Sardar Pasha, Sheik Pran Babu ¹, Sishtla, Kamakshi ¹, Sulaiman, Rania S., Park, Bomina, Shetty, Trupti, Shah, Fenil, Fishel, Melissa L., Wikel, James H., Kelley, Mark R., Corson, Timothy W. ^*

Source: In The Journal of Pharmacology and Experimental Therapeutics October 2018 367(1):108-118

Antiangiogenic Activity and Cytotoxicity of Triterpenoids and Homoisoflavonoids from Massonia pustulata and Massonia bifolia

Authors: Schwikkard, Sianne, Whitmore, Hannah, Corson, Timothy, Sishtla, Kamakshi, Langat, Moses, Carew, Mark, Mulholland, Dulcie

Source: Planta medica. 84(9/10):638-644

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100185144349.0x000001&indx=1&recIds=ETOCvdc_100185144349.0x000001

Long‐Acting Microparticle Formulation of Griseofulvin for Ocular Neovascularization Therapy.

Authors: Chobisa, Dhawal, Muniyandi, Anbukkarasi, Sishtla, Kamakshi, Corson, Timothy W., Yeo, Yoon

Source: Small; p1-14, 14p

Ferrochelatase is a therapeutic target for ocular neovascularization

Authors: Basavarajappa, Halesha D, Sulaiman, Rania S, Qi, Xiaoping, Shetty, Trupti, Sheik Pran Babu, Sardar, Sishtla, Kamakshi L, Lee, Bit, Quigley, Judith, Alkhairy, Sameerah, Briggs, Christian M, Gupta, Kamna, Tang, Buyun, Shadmand, Mehdi, Grant, Maria B, Boulton, Michael E, Seo, Seung‐Yong, Corson, Timothy W

Source: EMBO molecular medicine. 9(6):786-801

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186098933.0x000001&indx=1&recIds=ETOCvdc_100186098933.0x000001

Bufadienolides and anti-angiogenic homoisoflavonoids from Rhodocodon cryptopodus, Rhodocodon rotundus and Rhodocodon cyathiformis

Authors: Whitmore, Hannah, Sishtla, Kamakshi, Knirsch, Walter, Andriantiana, Jacky L., Schwikkard, Sianne, Mas-Claret, Eduard, Nassief, Sarah M., Isyaka, Sani M., Corson, Timothy W., Mulholland, Dulcie A.

Source: Fitoterapia. 141

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098034950.0x000001&indx=1&recIds=ETOCvdc_100098034950.0x000001

Cover Image.

Authors: Hartman, Gabriella D., Muniyandi, Anbukkarasi, Sishtla, Kamakshi, Kpenu, Eyram K., Miller, William P., Kaplan, Bryan A., Kim, Leo A., Liu, Sheng, Wan, Jun, Qi, Xiaoping, Boulton, Michael E., Kelley, Mark R., Corson, Timothy W.

Source: FASEB Journal; Feb2025, Vol. 39 Issue 3, p1-1, 1p

Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14

Authors: Sishtla, Kamakshi, Pitt, Natalie, Shadmand, Mehdi, O'Hare, Michael N., Sulaiman, Rania S., Sinn, Anthony L., Condon, Keith, Pollok, Karen E., Sandusky, George E., Corson, Timothy W.

Source: Scientific reports. 8(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100130975854.0x000001&indx=1&recIds=ETOCvdc_100130975854.0x000001

PRMT5 is a therapeutic target in choroidal neovascularization.

Authors: Muniyandi, Anbukkarasi, Martin, Matthew, Sishtla, Kamakshi, Motolani, Aishat, Sun, Mengyao, Jensen, Nathan R., Qi, Xiaoping, Boulton, Michael E., Prabhu, Lakshmi, Lu, Tao, Corson, Timothy W.

Source: Scientific Reports; 1/31/2023, Vol. 13 Issue 1, p1-18, 18p

Subject Terms: NF-kappa B, MACULAR degeneration, VASCULAR endothelial growth factors, RETINAL ganglion cells, NEOVASCULARIZATION, PROTEIN arginine methyltransferases, ENDOSTATIN, METHYLTRANSFERASES

Identification of Novel Pathways Regulated by APE1/Ref-1 in Human Retinal Endothelial Cells.

Authors: Mijit, Mahmut, Liu, Sheng, Sishtla, Kamakshi, Hartman, Gabriella D., Wan, Jun, Corson, Timothy W., Kelley, Mark R.

Source: International Journal of Molecular Sciences; Jan2023, Vol. 24 Issue 2, p1101, 15p

Subject Terms: ENDONUCLEASES, DNA repair, SCHWANNOMAS, ENDOTHELIAL cells, RNA metabolism

Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization.

Authors: Park, Bomina, Sardar Pasha, Sheik Pran Babu, Sishtla, Kamakshi L., Hartman, Gabriella D., Qi, Xiaoping, Boulton, Michael E., Corson, Timothy W.

Source: International Journal of Molecular Sciences; Dec2022, Vol. 23 Issue 24, p15595, 21p

Subject Terms: EPOXIDE hydrolase, GENE expression, MACULAR degeneration, ENDOTHELIAL growth factors, NEOVASCULARIZATION

An improved method for murine laser-induced choroidal neovascularization lesion quantification from optical coherence tomography images

Authors: Jensen, Nathan R., Lambert-Cheatham, Nathan, Hartman, Gabriella D., Muniyandi, Anbukkarasi, Park, Bomina, Sishtla, Kamakshi, Corson, Timothy W.

Source: In MethodsX 2022 9

Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids

Authors: Lee, Bit, Sun, Wei, Lee, Hyungjun, Basavarajappa, Halesha, Sulaiman, Rania S., Sishtla, Kamakshi, Fei, Xiang, Corson, Timothy W., Seo, Seung-Yong

Source: In Bioorganic & Medicinal Chemistry Letters 1 September 2016 26(17):4277-4281

Enantioselective Synthesis of Homoisoflavanones by Asymmetric Transfer Hydrogenation and Their Biological Evaluation for Antiangiogenic Activity.

Authors: Heo, Myunghoe, Lee, Bit, Sishtla, Kamakshi, Fei, Xiang, Lee, Sanha, Park, Soojun, Yuan, Yue, Lee, Seul, Kwon, Sangil, Lee, Jungeun, Kim, Sanghee, Corson, Timothy W., Seo, Seung-Yong

Source: Journal of Organic Chemistry; 8/16/2019, Vol. 84 Issue 16, p9995-10011, 17p