On a Divergence Penalized Landau-de Gennes Model

Authors: Bronsard, Lia, Chen, Jinqi, Mazzouza, Léa, McDonald, Daniel, Singh, Nathan, Stantejsky, Dominik, van Brussel, Lee

Subject Terms: Mathematics - Analysis of PDEs, Mathematics - Classical Analysis and ODEs, 35C15, 35E05, 35J50, 49S05, 76A15

Access URL: http://arxiv.org/abs/2410.09930

Intrinsic tumor resistance to CAR T cells is a dynamic transcriptional state that is exploitable with low-dose radiation

Authors: Kim, Alexander B., Chou, Ssu-Yu, Kang, Solomon, Kwon, Eric, Inkman, Matthew, Szymanski, Jeff, Andruska, Neal, Colgan, Cian, Zhang, Jin, Yang, Joanna C., Singh, Nathan, DeSelm, Carl J.

Source: In Blood Advances 26 September 2023 7(18):5396-5408

Efficacy of checkpoint inhibition after CAR-T failure in aggressive B-cell lymphomas: outcomes from 15 US institutions

Authors: Major, Ajay, Yu, Jovian, Shukla, Navika, Che, Yan, Karrison, Theodore G., Treitman, Rachel, Kamdar, Manali K., Haverkos, Bradley M., Godfrey, James, Babcook, Melissa A., Voorhees, Timothy J., Carlson, Sophie, Gaut, Daria, Oliai, Caspian, Romancik, Jason T., Winter, Allison M., Hill, Brian T., Bansal, Radhika, Villasboas Bisneto, Jose C., Nizamuddin, Imran A., Karmali, Reem, Fitzgerald, Lindsey A., Stephens, Deborah M., Pophali, Priyanka A., Trabolsi, Asaad, Schatz, Jonathan H., Hu, Marie, Bachanova, Veronika, Slade, Michael J., Singh, Nathan, Ahmed, Nausheen, McGuirk, Joseph P., Bishop, Michael R., Riedell, Peter A., Kline, Justin

Source: In Blood Advances 22 August 2023 7(16):4528-4538

Costimulatory domains direct distinct fates of CAR-driven T-cell dysfunction

Authors: Selli, Mehmet Emrah, Landmann, Jack H., Terekhova, Marina, Lattin, John, Heard, Amanda, Hsu, Yu-Sung, Chang, Tien-Ching, Chang, Jufang, Warrington, John, Ha, Helen, Kingston, Natalie, Hogg, Graham, Slade, Michael, Berrien-Elliott, Melissa M., Foster, Mark, Kersting-Schadek, Samantha, Gruszczynska, Agata, DeNardo, David, Fehniger, Todd A., Artyomov, Maxim, Singh, Nathan

Source: In Blood 29 June 2023 141(26):3153-3165

An NK-like CAR T cell transition in CAR T cell dysfunction

Authors: Good, Charly R., Aznar, M. Angela, Kuramitsu, Shunichiro, Samareh, Parisa, Agarwal, Sangya, Donahue, Greg, Ishiyama, Kenichi, Wellhausen, Nils, Rennels, Austin K., Ma, Yujie, Tian, Lifeng, Guedan, Sonia, Alexander, Katherine A., Zhang, Zhen, Rommel, Philipp C., Singh, Nathan, Glastad, Karl M., Richardson, Max W., Watanabe, Keisuke, Tanyi, Janos L., O’Hara, Mark H., Ruella, Marco, Lacey, Simon F., Moon, Edmund K., Schuster, Stephen J., Albelda, Steven M., Lanier, Lewis L., Young, Regina M., Berger, Shelley L., June, Carl H.

Source: In Cell 9 December 2021 184(25):6081-6100

Advances in CAR design

Authors: Heard, Amanda, Chang, Jufang, Warrington, John M., Singh, Nathan

Source: In Best Practice & Research Clinical Haematology September 2021 34(3)

Mechanisms of resistance to CAR T cell therapies

Authors: Singh, Nathan, Orlando, Elena, Xu, Jun, Xu, Jie, Binder, Zev, Collins, McKensie A., O’Rourke, Donald M., Melenhorst, J. Joseph ^*

Source: In Seminars in Cancer Biology October 2020 65:91-98

Boosting engineered T cells

Authors: Singh, Nathan, June, Carl H.

Source: Science, 2019 Jul 01. 365(6449), 119-120.

Access URL: https://www.jstor.org/stable/26745347

Overview of Hematopoietic Cell Transplantation for the Treatment of Hematologic Malignancies

Authors: Singh, Nathan, Loren, Alison W.

Source: In Clinics in Chest Medicine December 2017 38(4):575-593

Monocyte lineage–derived IL-6 does not affect chimeric antigen receptor T-cell function

Authors: Singh, Nathan ^*, Hofmann, Ted J., Gershenson, Zachary, Levine, Bruce L., Grupp, Stephan A., Teachey, David T., Barrett, David M.

Source: In Cytotherapy July 2017 19(7):867-880

Relation of clinical culture method to T-cell memory status and efficacy in xenograft models of adoptive immunotherapy

Authors: Barrett, David M., Singh, Nathan, Liu, Xiaojun, Jiang, Shuguang, June, Carl H., Grupp, Stephan A., Zhao, Yangbing

Source: In Cytotherapy May 2014 16(5):619-630

Reduction of Radiation Exposure From C-Arm Fluoroscopy During Orthopaedic Trauma Operations With Introduction of Real-Time Dosimetry

Authors: Baumgartner, Rita, Libuit, Kiley, Ren, Dennis, Bakr, Omar, Singh, Nathan, Kandemir, Utku, Marmor, Meir Tibi, Morshed, Saam

Source: Journal of orthopaedic trauma. 30(2):e53-e58

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037064045.0x000001&indx=1&recIds=ETOCvdc_100037064045.0x000001

Synthetic manipulation of the cancer-immunity cycle: CAR-T cell therapy.

Authors: Singh, Nathan¹ (AUTHOR) nathan.singh@wustl.edu, Maus, Marcela V.^1,2 (AUTHOR) mvmaus@mgh.harvard.edu

Source: Immunity (10747613). Oct2023, Vol. 56 Issue 10, p2296-2310. 15p.

Subject Terms: *CHIMERIC antigen receptors, *CELLULAR therapy, *CELL cycle, *T cells, *SYNTHETIC genes

Poor Survival Outcomes of Checkpoint Inhibitors for B-Cell Lymphomas Relapsing after or Refractory to CAR T-Cell Therapy: A Real-World Cohort from 15 U.S. Academic Institutions

Authors: Major, Ajay, Yu, Jovian, Shukla, Navika D. ^*, Treitman, Rachel ^*, Kamdar, Manali K., Haverkos, Bradley M., Godfrey, James, Babcook, Melissa A., Voorhees, Timothy J., Carlson, Sophie G ^*, Gaut, Daria, Oliai, Caspian, Romancik, Jason T., Winter, Allison, Hill, Brian T., Bansal, Radhika ^*, Villasboas, Jose C., Nizamuddin, Imran A., Karmali, Reem, Fitzgerald, Lindsey A., Stephens, Deborah M., Pophali, Priyanka A., Trabolsi, Asaad ^*, Schatz, Jonathan H., Hu, Marie, Bachanova, Veronika, Slade, Michael J, Singh, Nathan, Ahmed, Nausheen, McGuirk, Joseph P., Bishop, Michael R., Riedell, Peter A. ^*, Kline, Justin

Source: In Blood 15 November 2022 140 Supplement 1:1328-1331

Discovery of a novel genomic alteration that renders leukemic cells resistant to CD19-targeted immunotherapies

Authors: Ghobadi, Armin, Landmann, Jack H., Carter, Alun, Cooper, Matthew L., Selli, Mehmet Emrah, Chang, Jufang, Baker, Matthew, Miller, Christopher A., Ferraro, Francesca, Chen, David Y., Smith, Amanda M., LaValle, Taylor A., Duncavage, Eric J., Chou, Justin, Tam, Victor, Benoun, Joseph M., Nater, Jenny, Scholler, Nathalie, Milletti, Francesca, Vezan, Remus, Bot, Adrian, Rossi, John M., Singh, Nathan

Source: In Blood Advances 25 October 2022 6(20):5634-5640

Donor-derived CD19 chimeric antigen receptor T cells

Authors: Singh, Nathan, Barrett, David M.

Source: Current opinion in hematology. 22(6):503-508

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037051250.0x000001&indx=1&recIds=ETOCvdc_100037051250.0x000001

The emergence of immunomodulation: Combinatorial immunochemotherapy opportunities for the next decade

Authors: Kandalaft, Lana E., Singh, Nathan, Liao, John B., Facciabene, Andrea, Berek, Jonathan S., Powell, Daniel J., Jr., Coukos, George

Source: In Gynecologic Oncology 2010 116(2):222-233

Antigen-specific depletion of CD4⁺ T cells by CAR T cells reveals distinct roles of higher- and lower-affinity TCRs during autoimmunity.

Authors: Yi, Jaeu, Miller, Aidan T., Archambault, Angela S., Jones, Andrew J., Bradstreet, Tara R., Bandla, Sravanthi, Hsu, Yu-Sung, Edelson, Brian T., Zhou, You W., Fremont, Daved H., Egawa, Takeshi, Singh, Nathan, Wu, Gregory F., Hsieh, Chyi-Song

Source: Science Immunology; 2022, Vol. 7 Issue 76, p1-14, 14p

Enhancing MHC-Independent T Cell Receptors Using Rational Protein Engineering

Authors: Chang, Jufang, Landmann, Jack, Tenzin, Yangdon, Warrington, John, Selli, Mehmet Emrah, Chang, Tien-Ching, Slade, Michael, Gupta, Deepesh, Singh, Nathan

Source: In Blood 28 November 2023 142 Supplement 1:354-354

Regulation of the Transcriptional Repressor BACH2 Overcomes Tonic Signaling-Driven CAR T Cell Dysfunction

Authors: Chang, Tien-Ching, Heard, Amanda, Warrington, John, Landmann, Jack, Afrin, Sadia, Chang, Jufang, Selli, Mehmet Emrah, Hsu, Yu-Sung, Singh, Nathan

Source: In Blood 2 November 2023 142 Supplement 1:2065-2065