Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis

Authors: Dalapati, Trisha ^{1, 2}, Wang, Liuyang ², Jones, Angela G. ^{2, 3}, Cardwell, Jonathan ⁴, Konigsberg, Iain R. ⁴, Bossé, Yohan ⁵, Sin, Don D. ⁶, Timens, Wim ⁷, Hao, Ke ⁸, Yang, Ivana ⁴, Ko, Dennis C. ^{2, 3, 9, 10, ∗}

Source: In Human Genetics and Genomics Advances 10 April 2025 6(2)

Identifying Abnormal Exertional Breathlessness in COPD: Comparing Modified Medical Research Council and COPD Assessment Test With Cardiopulmonary Exercise Testing

Authors: FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus ^{a, ∗}, Lewthwaite, Hayley ^{b, c}, Bourbeau, Jean ^{d, e}, Tan, Wan C. ^g

Source: In Chest March 2025 167(3):697-711

Granzyme B May Act as an Effector Molecule to Control the Inflammatory Process in COPD.

Authors: Kim, Won-Dong¹ (AUTHOR) wdkim2@naver.com, Sin, Don D.² (AUTHOR)

Source: COPD: Journal of Chronic Obstructive Pulmonary Disease. Dec2024, Vol. 21 Issue 1, p1-11. 11p.

Subject Terms: *REGULATORY B cells, *REGULATORY T cells, *CHRONIC obstructive pulmonary disease, *ENZYME-linked immunosorbent assay, *IMMUNOSTAINING

Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies

Authors: Moll, Matthew, Hecker, Julian, Platig, John, Zhang, Jingzhou, Ghosh, Auyon J., Pratte, Katherine A., Wang, Rui-Sheng, Hill, Davin, Konigsberg, Iain R., Chiles, Joe W., III, Hersh, Craig P., Castaldi, Peter J., Glass, Kimberly, Dy, Jennifer G., Sin, Don D., Tal-Singer, Ruth, Mouded, Majd, Rennard, Stephen I., Anderson, Gary P., Kinney, Gregory L., Bowler, Russell P., Curtis, Jeffrey L., McDonald, Merry-Lynn, Silverman, Edwin K., Hobbs, Brian D., Cho, Michael H.

Source: In eBioMedicine December 2024 110

Younger epigenetic age is associated with higher cardiorespiratory fitness in individuals with airflow limitation

Authors: Hernandez Cordero, Ana I. ^{1, 2, 11}, Peters, Carli ^{1, 11}, Li, Xuan ¹, Yang, Chen Xi ¹, Ambalavanan, Amirthagowri ³, MacIsaac, Julie L. ^{2, 4}, Kobor, Michael S. ^{2, 4}, Fonseca, Gregory J. ⁵, Doiron, Dany ⁵, Tan, Wan ¹, Bourbeau, Jean ⁵, Jensen, Dennis ^{5, 6}, Sin, Don D. ^{1, 2, 7}, Koelwyn, Graeme J. ^{1, 8}, Stickland, Michael K. ⁹, Duan, Qingling ^{3, 10}, Leung, Janice M. ^{1, 2, 10, 12, ∗}

Source: In iScience 18 October 2024 27(10)

Interleukin-1α inhibits transforming growth factor-β1 and β2-induced extracellular matrix production, remodeling and signaling in human lung fibroblasts: Master regulator in lung mucosal repair

Authors: Usman, Kauna, Fouadi, May, Nwozor, Kingsley Okechukwu, Aminazadeh, Fatemeh, Nair, Parameswaran, Luo, Honglin, Sin, Don D., Osei, Emmanuel Twumasi, Hackett, Tillie-Louise

Source: In Matrix Biology September 2024 132:47-58

Abnormal Exertional Breathlessness on Cardiopulmonary Cycle Exercise Testing in Relation to Self-Reported and Physiologic Responses in Chronic Airflow Limitation

Authors: Bourbeau, Jean, Tan, Wan C., FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Samet, Jonathon, Puhan, Milo, Hamid, Qutayba, Hogg, James C., Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Sadatsafavi, Mohsen, To, Teresa, Gershon, Andrea, Li, Pei-Zhi, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candice, Ekström, Magnus, Lewthwaite, Hayley

Source: In Chest July 2024 166(1):81-94

2023 Canadian Thoracic Society Guideline on Pharmacotherapy in Patients With Stable COPD

Authors: Bourbeau, Jean, Bhutani, Mohit, Hernandez, Paul, Aaron, Shawn D., Beauchesne, Marie-France, Kermelly, Sophie B., D’Urzo, Anthony, Lal, Avtar, Maltais, François, Marciniuk, Jeffrey D., Mulpuru, Sunita, Penz, Erika, Sin, Don D., Van Dam, Anne, Wald, Joshua, Walker, Brandie L., Marciniuk, Darcy D.

Source: In Chest November 2023 164(5):1159-1183

Impaired Spirometry and COPD Increase the Risk of Cardiovascular Disease: A Canadian Cohort Study

Authors: FitzGerald, J. Mark, Sin, Don D., Marciniuk, Darcy D., O’Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn, Maltais, François, Doiron, Dany, Mancino, Palmina, Li, Pei Zhi, Jensen, Dennis, Baglole, Carolyn, Fortier, Yvan, Sin, Don, Yang, Julia, Road, Jeremy, Comeau, Joe, Png, Adrian, Johnson, Kyle, Coxson, Harvey, Leipsic, Jonathon, Hague, Cameron, Kirby, Miranda, Song, Zhi, Benedetti, Andrea, Lo, Christine, Cheng, Sarah, Un, Elena, Fung, Cynthia, Wang, Wen Tiang, Zheng, Liyun, Faroon, Faize, Radivojevic, Olga, Chung, Sally, Zou, Carl, Bourbeau, Jean, Baril, Jacinthe, Labonte, Laura, Chapman, Kenneth, McClean, Patricia, Audisho, Nadeen, Dumonceaux, Curtis, Machado, Lisette, Fulton, Scott, Osterling, Kristen, Wigerius, Denise, Vandemheen, Kathy, Pratt, Gay, Bergeron, Amanda, O’Donnell, Denis, McNeil, Matthew, Whelan, Kate, Brouillard, Cynthia, Marciniuk, Darcy, Clemens, Ron, Baran, Janet, Leuschen, Candace, Krishnan, Suurya, Tan, Wan C., Farias, Raquel, Aaron, Shawn D.

Source: In Chest September 2023 164(3):637-649

Global Initiative for Chronic Obstructive Lung Disease 2023 Report: GOLD Executive Summary

Authors: Agustí, Alvar, Celli, Bartolome R., Criner, Gerard J., Halpin, David, Anzueto, Antonio, Barnes, Peter, Bourbeau, Jean, Han, MeiLan K., Martinez, Fernando J., Montes de Oca, Maria, Mortimer, Kevin, Papi, Alberto, Pavord, Ian, Roche, Nicolas, Salvi, Sundeep, Sin, Don D., Singh, Dave, Stockley, Robert, López Varela, M. Victorina, Wedzicha, Jadwiga A., Vogelmeier, Claus F.

Source: In Archivos de Bronconeumología April 2023 59(4):232-248

Generalizability of Risk Stratification Algorithms for Exacerbations in COPD

Authors: Bansback, Nick, Bottorff, Joan L., Bryan, Stirling, Burns, Paloma, Carlsten, Chris, Conklin, Annalijn I., De Vera, Mary, Gershon, Andrea, Gupta, Samir, Gustafson, Paul, Harvard, Stephanie, Hoens, Alison M., Mokhtaran, Mehrshad, Johnson, Jim, Joshi, Phalgun, Leung, Janice, Lynd, Larry D., Metcalfe, Rebecca K., Michaux, Kristina D., Sadatsafavi, Mohsen, Simmers, Brian, Sin, Don D., Smith, Daniel, Struik, Laura, Vinay, Dhingra, Ho, Joseph Khoa, Safari, Abdollah, Adibi, Amin, Johnson, Kate

Source: In Chest April 2023 163(4):790-798

Losartan metabolite EXP3179 is a unique blood pressure-lowering AT1R antagonist with direct, rapid endothelium-dependent vasoactive properties

Authors: Sauge, Elodie, Pechkovsky, Dmitri, Atmuri, N.D. Prasad, Tehrani, Arash Y., White, Zoe, Dong, Ying, Cait, Jessica, Hughes, Michael, Tam, Anthony, Donen, Graham, Yuen, Christopher, Walker, Michael J.A., McNagny, Kelly M., Sin, Don D., Ciufolini, Marco A., Bernatchez, Pascal

Source: In Vascular Pharmacology December 2022 147

Cigarette Smoking and Asthma

Authors: Thomson, Neil C., Polosa, Riccardo, Sin, Don D.

Source: In The Journal of Allergy and Clinical Immunology: In Practice November 2022 10(11):2783-2797

Towards the elimination of chronic obstructive pulmonary disease: a Lancet Commission

Authors: Stolz, Daiana, Mkorombindo, Takudzwa, Schumann, Desiree M, Agusti, Alvar, Ash, Samuel Y, Bafadhel, Mona, Bai, Chunxue, Chalmers, James D, Criner, Gerard J, Dharmage, Shyamali C, Franssen, Frits M E, Frey, Urs, Han, MeiLan, Hansel, Nadia N, Hawkins, Nathaniel M, Kalhan, Ravi, Konigshoff, Melanie, Ko, Fanny W, Parekh, Trisha M, Powell, Pippa, Rutten-van Mölken, Maureen, Simpson, Jodie, Sin, Don D, Song, Yuanlin, Suki, Bela, Troosters, Thierry, Washko, George R, Welte, Tobias, Dransfield, Mark T ^*

Source: In The Lancet 17-23 September 2022 400(10356):921-972

ACCEPT 2·0: Recalibrating and externally validating the Acute COPD exacerbation prediction tool (ACCEPT)

Authors: Safari, Abdollah, Adibi, Amin, Sin, Don D., Lee, Tae Yoon, Ho, Joseph Khoa, Sadatsafavi, Mohsen

Source: In eClinicalMedicine September 2022 51

The relationship between the epigenetic aging biomarker “grimage” and lung function in both the airway and blood of people living with HIV: An observational cohort study

Authors: Baker, J.V., Duprez, D., Carr, A., Hoy, J., Dolan, M., Telenti, A., Grady, C., Matthews, G., Rockstroh, J., Belloso, W.H., Kagan, J.M., Wright, E., Brew, B., Price, R.W., Robertson, K., Cysique, L., Kunisaki, K.M., Connett, J.E., Niewoehner, D.E., Endpoint Review Committee, Lifson, A., Davey, R.T., Jr., Gatell, J.M., Pedersen, C., Prineas, R., Worley, J., Hernández Cordero, Ana I, Yang, Chen Xi, Yang, Julia, Li, Xuan, Horvath, Steve, Shaipanich, Tawimas, MacIsaac, Julia, Lin, David, McEwen, Lisa, Kobor, Michael S., Guillemi, Silvia, Harris, Marianne, Lam, Wan, Lam, Stephen, Obeidat, Ma'en, Novak, Richard M., Hudson, Fleur, Klinker, Hartwig, Dharan, Nila, Montaner, Julio, Man, S.F. Paul, Kunisaki, Ken, Sin, Don D., Leung, Janice M.

Source: In eBioMedicine September 2022 83

Cannabis smoking is associated with persistent epigenome-wide disruptions despite smoking cessation.

Authors: Cordero, Ana I. Hernandez, Li, Xuan, Yang, Chen Xi, Ambalavanan, Amirtha, MacIsaac, Julie L., Kobor, Michael S., Doiron, Dany, Tan, Wan, Bourbeau, Jean, Sin, Don D., Duan, Qingling, Leung, Janice M., Tan, Wan C., FitzGerald, JMark, Marciniuk, Darcy D., O'Donnell, Denis E., Hernandez, Paul, Chapman, Kenneth R., Walker, Brandie, Aaron, Shawn

Source: BMC Pulmonary Medicine; 4/9/2025, Vol. 25 Issue 1, p1-11, 11p

Subject Terms: SMOKING cessation, MEDICAL sciences, OBSTRUCTIVE lung diseases, FALSE discovery rate, SMOKING

Should all patients with COPD be treated with inhaled triple therapy?

Authors: Sin, Don D., Sadatsafavi, Mohsen

Source: ERJ Open Research; Mar2025, Vol. 11 Issue 2, p1-4, 4p

COPD Exacerbations, Air Pollutant Fluctuations, and Individual-Level Factors in the Pandemic Era.

Authors: Mikaeeli, Sahar, Doiron, Dany, Bourbeau, Jean, Li, Pei Zhi, Aaron, Shawn D, Chapman, Kenneth R, Hernandez, Paul, Maltais, François, Marciniuk, Darcy D, O'Donnell, Denis E, Sin, Don D, Walker, Brandie L, Tan, Wan C, Rousseau, Simon, Ross, Bryan A

Source: International Journal of COPD; Mar2025, Vol. 20, p735-751, 17p

Food for thought: optimal diet in patients with asthma and chronic obstructive pulmonary disease.

Authors: Vameghestahbanati, Motahareh, Wang, Carolyn J., Sin, Don D.

Source: Current Opinion in Pulmonary Medicine; Mar2025, Vol. 31 Issue 2, p106-116, 11p