A novel whole blood assay to quantify the release of T cell associated cytokines in response to Bordetella pertussis antigens

Authors: Diavatopoulos, Dimitri A., Mills, Kingston H.G., Kester, Kent E., Kampmann, Beate, Silerova, Marcela, Heininger, Ulrich, van Dongen, Jacques J.M., van der Most, Robbert G., Huijnen, Martijn A., Siena, Emilio, Mielcarek, Nathalie, Ochs, Martina M., Denoël, Philippe, Berbers, Guy, Buisman, Annemarie M., de Jonge, Marien I., Fenwick, Craig, Gorringe, Andrew, He, Qiushui, Kelly, Dominic, Le Grand, Roger, Locht, Camille, Mascart, Françoise, Mertsola, Jussi, Orfao, Alberto, Pantaleo, Giuseppe, Pollard, Andrew J., Preston, Andrew, Read, Robert, Sebo, Peter, van Els, Cecile, Vecerek, Branislav, Londoño-Hayes, Patricia, de Groot, Ronald, Pinto, Marta Valente, Barkoff, Alex-Mikael, Bibi, Sagida, Knuutila, Aapo, Teräsjärvi, Johanna, Clutterbuck, Elizabeth, Gimenez-Fourage, Sophie, Pagnon, Anke, van Gaans-van den Brink, Jacqueline A.M., Corbiere, Veronique, De Montfort, Aymeric, Saso, Anja, Jobe, Haddijatou, Roetynck, Sophie, Simonetti, Elles, Diavatopoulos, Dimitri, Lambert, Eleonora E., Blanc, Pascal, van Els, Cécile A.C.M.

Source: In Journal of Immunological Methods November 2024 534

Intradermal administration of the pneumococcal conjugate vaccine in mice results in lower antibody responses as compared to intramuscular administration

Authors: Uijen, Rienke F., van Beek, Lucille F., van Opzeeland, Fred, Simonetti, Elles, van Selm, Saskia, Bonduelle, Olivia, Combadière, Behazine, Langereis, Jeroen D., de Jonge, Marien I.

Source: Vaccine. 41(1):10-14

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100194887754.0x000001&indx=1&recIds=ETOCvdc_100194887754.0x000001

The impact of Bacillus Calmette-Guérin vaccination on antibody response after COVID-19 vaccination

Authors: Taks, Esther J.M., Moorlag, Simone J.C.F.M., Föhse, Konstantin, Simonetti, Elles, van der Gaast-de Jongh, Christa E., van Werkhoven, Cornelis H., Bonten, Marc J.M., Oever, Jaap ten, de Jonge, Marien I., van de Wijgert, Janneke H.H.M., Netea, Mihai G.

Source: In iScience 17 November 2023 26(11)

The impact of BNT162b2 mRNA vaccine on adaptive and innate immune responses

Authors: Föhse, Konstantin, Geckin, Büsra, Zoodsma, Martijn, Kilic, Gizem, Liu, Zhaoli, Röring, Rutger J., Overheul, Gijs J., van de Maat, Josephine, Bulut, Ozlem, Hoogerwerf, Jacobien J., ten Oever, Jaap, Simonetti, Elles, Schaal, Heiner, Adams, Ortwin, Müller, Lisa, Ostermann, Philipp Niklas, van de Veerdonk, Frank L., Joosten, Leo A.B., Haagmans, Bart L., van Crevel, Reinout, van Rij, Ronald P., GeurtsvanKessel, Corine, de Jonge, Marien I., Li, Yang, Domínguez-Andrés, Jorge, Netea, Mihai G.

Source: In Clinical Immunology October 2023 255

TLR-Induced IL-12 and CCL2 Production by Myeloid Cells Is Dependent on Adenosine A3 Receptor—Mediated Signaling

Authors: van der Putten, Céline, Veth, Jennifer, Sukurova, Lejla, Zuiderwijk-Sick, Ella A., Simonetti, Elles, Koenen, Hans J. P. M., Burm, Saskia M., van Noort, Johannes M., IJzerman, Ad P., van Hijum, Sacha A. F. T.

Source: Journal of immunology. 202(8):2421-2430

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN619748164&indx=1&recIds=ETOCRN619748164

Role of antibodies and IL17-mediated immunity in protection against pneumococcal otitis media

Authors: Habets, Marrit N., van Selm, Saskia, van Opzeeland, Fred J., Simonetti, Elles, Hermans, Peter W.M., de Jonge, Marien I., Diavatopoulos, Dimitri A.

Source: In Vaccine 21 November 2016 34(48):5968-5974

Antigen-Independent Restriction of Pneumococcal Density by Mucosal Adjuvant Cholera Toxin Subunit B

Authors: Kuipers, Kirsten, Diavatopoulos, Dimitri A., van Opzeeland, Fred, Simonetti, Elles, van den Kieboom, Corné H., Kerstholt, Mariska, Borczyk, Malgorzata, van IngenSchenau, D., Brandsma, Eelke T., Netea, Mihai G., de Jonge, Marien I.

Source: The Journal of Infectious Diseases, 2016 Nov . 214(10), 1588-1596.

Access URL: https://www.jstor.org/stable/26166831

Antiviral responses induced by Tdap-IPV vaccination are associated with persistent humoral immunity to Bordetella pertussis.

Authors: Gillard, Joshua, Suffiotti, Madeleine, Brazda, Peter, Venkatasubramanian, Prashanna B., Versteegen, Pauline, de Jonge, Marien I., Kelly, Dominic, Bibi, Sagida, Pinto, Marta Valente, Simonetti, Elles, Babiceanu, Mihaela, Kettring, Andrew, Teodosio, Cristina, de Groot, Ronald, Berbers, Guy, Stunnenberg, Hendrik G., Schanen, Brian, Fenwick, Craig, Huynen, Martijn A., Diavatopoulos, Dimitri A.

Source: Nature Communications; 3/8/2024, Vol. 15 Issue 1, p1-17, 17p

Subject Terms: BORDETELLA pertussis, HUMORAL immunity, TYPE I interferons, BOOSTER vaccines, VACCINATION

Geographic Terms: UNITED Kingdom, NETHERLANDS

Salmonella outer membrane vesicles displaying high densities of pneumococcal antigen at the surface offer protection against colonization

Authors: Kuipers, Kirsten, Daleke-Schermerhorn, Maria H., Jong, Wouter S.P., ten Hagen-Jongman, Corinne M., van Opzeeland, Fred, Simonetti, Elles, Luirink, Joen, de Jonge, Marien I.

Source: In Vaccine 21 April 2015 33(17):2022-2029

Reduced Expression of HLA-DR on Monocytes During Severe Respiratory Syncytial Virus Infections

Authors: Ahout, Inge M. L., Jans, Jop, Haroutiounian, Lilid, Simonetti, Elles R., van der Gaast-de Jongh, Christa, Diavatopoulos, Dimitri A., de Jonge, Marien I., de Groot, Ronald, Ferwerda, Gerben

Source: Pediatric infectious disease journal. 35(3):e89-e96

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100037314366.0x000001&indx=1&recIds=ETOCvdc_100037314366.0x000001

Chloroquine Modulates the Fungal Immune Response in Phagocytic Cells From Patients With Chronic Granulomatous Disease

Authors: Henriet, Stefanie S. V., Jans, Jop, Simonetti, Elles, Kwon-Chung, Kyung J., Rijs, Antonius J. M. M., Hermans, Peter W. M., Holland, Steve M., de Jonge, Marien I., Warris, Adilia

Source: The Journal of Infectious Diseases, 2013 Jun . 207(12), 1932-1939.

Access URL: http://dx.doi.org/10.1093/infdis/jit103

Umbilical cord-mesenchymal stem cells induce a memory phenotype in CD4⁺ T cells.

Authors: Ezgi Sengun, Wolfs, Tim G. A. M., van Bruggen, Valéry L. E., van Cranenbroek, Bram, Simonetti, Elles R., Ophelders, Daan, de Jonge, Marien I., Joosten, Irma, van der Molen, Renate G.

Source: Frontiers in Immunology; 2023, p1-16, 16p

Subject Terms: T cells, STEM cells, MONONUCLEAR leukocytes, MESENCHYMAL stem cells, HUMAN stem cells

A semi high-throughput whole blood-based flow cytometry assay to detect and monitor Bordetella pertussis-specific Th1, Th2 and Th17 responses.

Authors: Corbière, Véronique, Lambert, Eleonora E., Rodesch, Marine, van Gaans-van den Brink, Jacqueline A. M., Misiak, Alicja, Simonetti, Elles, Van Praet, Anne, Godefroid, Audrey, Diavatopoulos, Dimitri A., van Els, Cécile A. C. M., Mascart, Françoise

Source: Frontiers in Immunology; 2/6/2023, Vol. 14, p1-15, 15p

Subject Terms: FLOW cytometry, PERTUSSIS toxin, T cells, CRYOPRESERVATION of cells, WHOOPING cough vaccines

Quantitative Assessment of Human T Lymphocytes in RAG2 −/−γc −/− Mice: The Impact of Ex Vivo Manipulation on In Vivo Functionality

Authors: van Rijn, Rozemarijn S., Simonetti, Elles R., Hagenbeek, Anton, Bonyhadi, Mark, Storm, Gert, Martens, Anton C.M., Ebeling, Saskia B.

Source: In Experimental Hematology 2007 35(1):117-127

Efficacy of BCG Vaccination Against Respiratory Tract Infections in Older Adults During the Coronavirus Disease 2019 Pandemic.

Authors: Moorlag, Simone J C F M, Taks, Esther, Doesschate, Thijs ten, Vaart, Thomas W van der, Janssen, Axel B, Müller, Lisa, Ostermann, Philipp, Dijkstra, Helga, Lemmers, Heidi, Simonetti, Elles, Mazur, Marc, Schaal, Heiner, Heine, Rob ter, Veerdonk, Frank L van de, Bleeker-Rovers, Chantal P, Crevel, Reinout van, Oever, Jaap ten, Jonge, Marien I de, Bonten, Marc J, Werkhoven, Cornelis H van

Source: Clinical Infectious Diseases; Jul2022, Vol. 75 Issue 1, pe938-e946, 9p

Subject Terms: RESEARCH, CYTOKINES, CONFIDENCE intervals, RESPIRATORY infections, VACCINE effectiveness, PREVENTIVE health services, RANDOMIZED controlled trials, COMPARATIVE studies, PRE-tests & post-tests, PLACEBOS, BCG vaccines, DESCRIPTIVE statistics, STATISTICAL sampling, POLYMERASE chain reaction, COVID-19 pandemic, EVALUATION, OLD age

Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19.

Authors: Liu, Zhaoli, Kilic, Gizem, Li, Wenchao, Bulut, Ozlem, Gupta, Manoj Kumar, Zhang, Bowen, Qi, Cancan, Peng, He, Tsay, Hsin-Chieh, Soon, Chai Fen, Mekonnen, Yonatan Ayalew, Ferreira, Anaísa Valido, van der Made, Caspar I., van Cranenbroek, Bram, Koenen, Hans J. P. M., Simonetti, Elles, Diavatopoulos, Dimitri, de Jonge, Marien I., Müller, Lisa, Schaal, Heiner

Source: Frontiers in Immunology; 4/6/2022, Vol. 13, p1-15, 15p

Subject Terms: COVID-19, DISEASE complications, DNA methylation, INDUSTRIAL capacity, IMMUNE system

BCG-induced trained immunity enhances acellular pertussis vaccination responses in an explorative randomized clinical trial.

Authors: Gillard, Joshua, Blok, Bastiaan A., Garza, Daniel R., Venkatasubramanian, Prashanna Balaji, Simonetti, Elles, Eleveld, Marc J., Berbers, Guy A. M., van Gageldonk, Pieter G. M., Joosten, Irma, de Groot, Ronald, de Bree, L. Charlotte J., van Crevel, Reinout, de Jonge, Marien I., Huynen, Martijn A., Netea, Mihai G., Diavatopoulos, Dimitri A.

Source: NPJ Vaccines; 2/17/2022, Vol. 7 Issue 1, p1-9, 9p

Subject Terms: WHOOPING cough, WHOOPING cough vaccines, CLINICAL trials, BOOSTER vaccines, IMMUNOLOGIC memory, BCG vaccines, B cells

A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- γc-/- double-mutant mice

Authors: van Rijn, Rozemarijn S., Simonetti, Elles R., Hagenbeek, Anton, Hogenes, MariekeC.H., de Weger, Roel A., Canninga-van Dijk, Marijke R., Weijer, Kees, Spits, Hergen, Storm, Gert, van Bloois, Louis, Rijkers, Ger, Martens, AntonC.M., Ebeling, Saskia B. ^*

Source: In Blood 1 October 2003 102(7):2522-2531

Development and application of quantitative real time PCR and RT-PCR assays that discriminate between the full-length and truncated herpes simplex virus thymidine kinase gene

Authors: Ebeling, Saskia B. ^*, Eric Borst, H.P, Simonetti, Elles R., Hol, Samantha, Garin, Marina I., Slaper-Cortenbach, Ineke, Hagenbeek, Anton

Source: In Journal of Virological Methods 2003 109(2):177-186

SARS-CoV-2 mucosal antibody development and persistence and their relation to viral load and COVID-19 symptoms.

Authors: Fröberg, Janeri, Gillard, Joshua, Philipsen, Ria, Lanke, Kjerstin, Rust, Joyce, van Tuijl, Diana, Teelen, Karina, Bousema, Teun, Simonetti, Elles, van der Gaast-de Jongh, Christa E., Bos, Mariska, van Kuppeveld, Frank J., Bosch, Berend-Jan, Nabuurs-Franssen, Marrigje, van der Geest-Blankert, Nannet, van Daal, Charlotte, Huynen, Martijn A., de Jonge, Marien I., Diavatopoulos, Dimitri A.

Source: Nature Communications; 9/23/2021, Vol. 12 Issue 1, p1-11, 11p

Subject Terms: COVID-19, VIRAL load, SARS-CoV-2, SYMPTOMS, IMMUNOGLOBULINS, ANTIBODY formation