The ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis

Authors: Marco Losa, Marc Emmenegger, Pierre De Rossi, Patrick M Schürch, Tetiana Serdiuk, Niccolò Pengo, Danaëlle Capron, Dimitri Bieli, Niklas Bargenda, Niels J Rupp, Manfredi C Carta, Karl J Frontzek, Veronika Lysenko, Regina R Reimann, Petra Schwarz, Mario Nuvolone, Gunilla T Westermark, K Peter R Nilsson, Magdalini Polymenidou, Alexandre PA Theocharides, Simone Hornemann, Paola Picotti, Adriano Aguzzi

Source: EMBO Molecular Medicine, Vol 16, Iss 9, Pp 2024-2042 (2024)

Subject Terms: Innate Immunity, ASC, Serum Amyloid A (SAA), Inflammation, Amyloidosis, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/361701b3ccf5457e8ccf997a37e06f01

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region

Authors: Marc Emmenegger, Elena De Cecco, David Lamparter, Raphaël P.B. Jacquat, Julien Riou, Dominik Menges, Tala Ballouz, Daniel Ebner, Matthias M. Schneider, Itzel Condado Morales, Berre Doğançay, Jingjing Guo, Anne Wiedmer, Julie Domange, Marigona Imeri, Rita Moos, Chryssa Zografou, Leyla Batkitar, Lidia Madrigal, Dezirae Schneider, Chiara Trevisan, Andres Gonzalez-Guerra, Alessandra Carrella, Irina L. Dubach, Catherine K. Xu, Georg Meisl, Vasilis Kosmoliaptsis, Tomas Malinauskas, Nicola Burgess-Brown, Ray Owens, Stephanie Hatch, Juthathip Mongkolsapaya, Gavin R. Screaton, Katharina Schubert, John D. Huck, Feimei Liu, Florence Pojer, Kelvin Lau, David Hacker, Elsbeth Probst-Müller, Carlo Cervia, Jakob Nilsson, Onur Boyman, Lanja Saleh, Katharina Spanaus, Arnold von Eckardstein, Dominik J. Schaer, Nenad Ban, Ching-Ju Tsai, Jacopo Marino, Gebhard F.X. Schertler, Nadine Ebert, Volker Thiel, Jochen Gottschalk, Beat M. Frey, Regina R. Reimann, Simone Hornemann, Aaron M. Ring, Tuomas P.J. Knowles, Milo A. Puhan, Christian L. Althaus, Ioannis Xenarios, David I. Stuart, Adriano Aguzzi

Source: iScience, Vol 26, Iss 2, Pp 105928- (2023)

Subject Terms: Immunology, Microbiology, Virology, Biological database, Science

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2589004223000056; https://doaj.org/toc/2589-0042

Access URL: https://doaj.org/article/bea10cd3141c4742a1c82d8153f04eb2

LAG3 is not expressed in human and murine neurons and does not modulate α‐synucleinopathies

Authors: Marc Emmenegger, Elena De Cecco, Marian Hruska‐Plochan, Timo Eninger, Matthias M Schneider, Melanie Barth, Elena Tantardini, Pierre de Rossi, Mehtap Bacioglu, Rebekah G Langston, Alice Kaganovich, Nora Bengoa‐Vergniory, Andrès Gonzalez‐Guerra, Merve Avar, Daniel Heinzer, Regina Reimann, Lisa M Häsler, Therese W Herling, Naunehal S Matharu, Natalie Landeck, Kelvin Luk, Ronald Melki, Philipp J Kahle, Simone Hornemann, Tuomas P J Knowles, Mark R Cookson, Magdalini Polymenidou, Mathias Jucker, Adriano Aguzzi

Source: EMBO Molecular Medicine, Vol 13, Iss 9, Pp 1-20 (2021)

Subject Terms: LAG3, neurodegeneration, prionoids, α‐synuclein, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/7994f076bf964ea9bf26f7f4ba6a434a

Protective anti‐prion antibodies in human immunoglobulin repertoires

Authors: Assunta Senatore, Karl Frontzek, Marc Emmenegger, Andra Chincisan, Marco Losa, Regina Reimann, Geraldine Horny, Jingjing Guo, Sylvie Fels, Silvia Sorce, Caihong Zhu, Nathalie George, Stefan Ewert, Thomas Pietzonka, Simone Hornemann, Adriano Aguzzi

Source: EMBO Molecular Medicine, Vol 12, Iss 9, Pp 1-19 (2020)

Subject Terms: anti‐PrP antibodies, human immunological repertoires, next‐generation sequencing, phage display, prion disease, Medicine (General), R5-920, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1757-4676; https://doaj.org/toc/1757-4684

Access URL: https://doaj.org/article/c41b503363134ee683fd9afef525f6b5

Novel regulators of PrPC biosynthesis revealed by genome-wide RNA interference

Authors: Daniel Heinzer, Merve Avar, Daniel Patrick Pease, Ashutosh Dhingra, Jiang-An Yin, Elke Schaper, Berre Doğançay, Marc Emmenegger, Anna Spinelli, Kevin Maggi, Andra Chincisan, Simon Mead, Simone Hornemann, Peter Heutink, Adriano Aguzzi

Source: PLoS Pathogens, Vol 17, Iss 10 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8575309/?tool=EBI; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/0bb9cfda63ef41b79c0071537284dc38

The ultrastructure of infectious L-type bovine spongiform encephalopathy prions constrains molecular models.

Authors: Razieh Kamali-Jamil, Ester Vázquez-Fernández, Brian Tancowny, Vineet Rathod, Sara Amidian, Xiongyao Wang, Xinli Tang, Andrew Fang, Assunta Senatore, Simone Hornemann, Sandor Dudas, Adriano Aguzzi, Howard S Young, Holger Wille

Source: PLoS Pathogens, Vol 17, Iss 6, p e1009628 (2021)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/85deff398ef147c1801b95f8303a4f6d

Genome-wide transcriptomics identifies an early preclinical signature of prion infection.

Authors: Silvia Sorce, Mario Nuvolone, Giancarlo Russo, Andra Chincisan, Daniel Heinzer, Merve Avar, Manuela Pfammatter, Petra Schwarz, Mirzet Delic, Micha Müller, Simone Hornemann, Despina Sanoudou, Claudia Scheckel, Adriano Aguzzi

Source: PLoS Pathogens, Vol 16, Iss 6, p e1008653 (2020)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/3378ce74ef8f40b7a548373f25fdab25

Enhanced detection of prion infectivity from blood by preanalytical enrichment with peptoid-conjugated beads.

Authors: Simone Hornemann, Petra Schwarz, Elisabeth J Rushing, Michael D Connolly, Ronald N Zuckermann, Alice Y Yam, Adriano Aguzzi

Source: PLoS ONE, Vol 14, Iss 9, p e0216013 (2019)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/b4b949759e0644ec8361656d65390e9d

Prion pathogenesis is unaltered in a mouse strain with a permeable blood-brain barrier.

Authors: Annika Keller, Mario Nuvolone, Irina Abakumova, Andra Chincisan, Regina Reimann, Merve Avar, Daniel Heinzer, Simone Hornemann, Josephin Wagner, Daniel Kirschenbaum, Fabian F Voigt, Caihong Zhu, Luca Regli, Fritjof Helmchen, Adriano Aguzzi

Source: PLoS Pathogens, Vol 14, Iss 11, p e1007424 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/154e8661ae744cb885de7f2073c95e14

A bispecific immunotweezer prevents soluble PrP oligomers and abolishes prion toxicity.

Authors: Marco Bardelli, Karl Frontzek, Luca Simonelli, Simone Hornemann, Mattia Pedotti, Federica Mazzola, Manfredi Carta, Valeria Eckhardt, Rocco D'Antuono, Tommaso Virgilio, Santiago F González, Adriano Aguzzi, Luca Varani

Source: PLoS Pathogens, Vol 14, Iss 10, p e1007335 (2018)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/b333e425dac04363bafbe5d00b152b89

Inhibition of group-I metabotropic glutamate receptors protects against prion toxicity.

Authors: Despoina Goniotaki, Asvin K K Lakkaraju, Amulya N Shrivastava, Pamela Bakirci, Silvia Sorce, Assunta Senatore, Rajlakshmi Marpakwar, Simone Hornemann, Fabrizio Gasparini, Antoine Triller, Adriano Aguzzi

Source: PLoS Pathogens, Vol 13, Iss 11, p e1006733 (2017)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/ebc3346a8fee4eca9efa320009cc3375

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein.

Authors: Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing, Kurt Wüthrich, Adriano Aguzzi

Source: PLoS ONE, Vol 12, Iss 2, p e0170503 (2017)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5313174?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/46cc397bf32a49668f77326a794fe0e2

Differential Toxicity of Antibodies to the Prion Protein.

Authors: Regina R Reimann, Tiziana Sonati, Simone Hornemann, Uli S Herrmann, Michael Arand, Simon Hawke, Adriano Aguzzi

Source: PLoS Pathogens, Vol 12, Iss 1, p e1005401 (2016)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4731068?pdf=render; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/76ecf16ee8974d819f2f80a8602d9b28

Neurotoxic Antibodies against the Prion Protein Do Not Trigger Prion Replication.

Authors: Karl Frontzek, Manuela Pfammatter, Silvia Sorce, Assunta Senatore, Petra Schwarz, Rita Moos, Katrin Frauenknecht, Simone Hornemann, Adriano Aguzzi

Source: PLoS ONE, Vol 11, Iss 9, p e0163601 (2016)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC5042507?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/375f6c4ea4064a5e80ebc999936eb25c

Prion infections and anti-PrP antibodies trigger converging neurotoxic pathways.

Authors: Uli S Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou, Adriano Aguzzi

Source: PLoS Pathogens, Vol 11, Iss 2, p e1004662 (2015)

Subject Terms: Immunologic diseases. Allergy, RC581-607, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004662&type=printable; https://doaj.org/toc/1553-7366; https://doaj.org/toc/1553-7374

Access URL: https://doaj.org/article/2f192076206246ed93ed98f65be2e327

Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification.

Authors: Michael Vanlandewijck, Thibaud Lebouvier, Maarja Andaloussi Mäe, Khayrun Nahar, Simone Hornemann, David Kenkel, Sara I Cunha, Johan Lennartsson, Andreas Boss, Carl-Henrik Heldin, Annika Keller, Christer Betsholtz

Source: PLoS ONE, Vol 10, Iss 11, p e0143407 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/fa59e83e7f19451c8403602659ddc266

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.

Authors: Magdalini Polymenidou, Rita Moos, Mike Scott, Christina Sigurdson, Yong-Zhong Shi, Bill Yajima, Iva Hafner-Bratkovic, Roman Jerala, Simone Hornemann, Kurt Wuthrich, Anne Bellon, Martin Vey, Graciela Garen, Michael N G James, Nat Kav, Adriano Aguzzi

Source: PLoS ONE, Vol 3, Iss 12, p e3872 (2008)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2592702?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/729d5a629adc4e109df2f2dba9164797

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