Infiltrating lipid-rich macrophage subpopulations identified as a regulator of increasing prostate size in human benign prostatic hyperplasia

Authors: Nadia Atallah Lanman, Era Meco, Philip Fitchev, Andree K. Kolliegbo, Meaghan M. Broman, Yana Filipovich, Harish Kothandaraman, Gregory M. Cresswell, Pooja Talaty, Malgorzata Antoniak, Svetlana Brumer, Alexander P. Glaser, Andrew M. Higgins, Brian T. Helfand, Omar E. Franco, Chi-Hsiung Wang, Susan E. Crawford, Timothy L. Ratliff, Simon W. Hayward, Renee E. Vickman

Source: Frontiers in Immunology, Vol 15 (2025)

Subject Terms: benign prostatic hyperplasia, ScRNA-seq, inflammation, macrophages, lipids, urinary symptoms, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2024.1494476/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/f57dcc2b2163436596de62492451300c

Shared Inherited Genetics of Benign Prostatic Hyperplasia and Prostate Cancer

Authors: Alexander Glaser, Zhuqing Shi, Jun Wei, Nadia A. Lanman, Skylar Ladson-Gary, Renee E. Vickman, Omar E. Franco, Susan E. Crawford, S. Lilly Zheng, Simon W. Hayward, William B. Isaacs, Brian T. Helfand, Jianfeng Xu

Source: European Urology Open Science, Vol 43, Iss , Pp 54-61 (2022)

Subject Terms: Benign prostatic hyperplasia, Prostate cancer, Heritability, Genetic correlation, Single nucleotide polymorphisms, Genetic risk score, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666168322007364; https://doaj.org/toc/2666-1683

Access URL: https://doaj.org/article/b38eb71cdebd4aa9be17d3bfc70b3177

TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease

Authors: Renee E. Vickman, LaTayia Aaron-Brooks, Renyuan Zhang, Nadia A. Lanman, Brittany Lapin, Victoria Gil, Max Greenberg, Takeshi Sasaki, Gregory M. Cresswell, Meaghan M. Broman, J. Sebastian Paez, Jacqueline Petkewicz, Pooja Talaty, Brian T. Helfand, Alexander P. Glaser, Chi-Hsiung Wang, Omar E. Franco, Timothy L. Ratliff, Kent L. Nastiuk, Susan E. Crawford, Simon W. Hayward

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/572e6df1a2f4471bb53b3a820ff54a37

Could TNF-antagonists be a novel treatment strategy for BPH patients?

Authors: Renee E. Vickman, Omar E. Franco, Simon W. Hayward

Source: Cell Stress, Vol 6, Iss 6, Pp 65-67 (2022)

Subject Terms: benign prostatic hyperplasia, inflammation, autoimmune disease, tumor necrosis factor, therapy, Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.cell-stress.com/researcharticles/2022a-vickman-cell-stress/; https://doaj.org/toc/2523-0204

Access URL: https://doaj.org/article/e70ffa74350b4e9f8db72367028bdcda

Genetic Susceptibility for Low Testosterone in Men and Its Implications in Biology and Screening: Data from the UK Biobank

Authors: Richard J. Fantus, Rong Na, Jun Wei, Zhuqing Shi, W. Kyle Resurreccion, Joshua A. Halpern, Omar Franco, Simon W. Hayward, William B. Isaacs, S. Lilly Zheng, Jianfeng Xu, Brian T. Helfand

Source: European Urology Open Science, Vol 29, Iss , Pp 36-46 (2021)

Subject Terms: Testosterone, Genome-wide association study, Expression quantitative trait locus, Genetic risk score, Diseases of the genitourinary system. Urology, RC870-923, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2666168321000847; https://doaj.org/toc/2666-1683

Access URL: https://doaj.org/article/88312c2d3ce94fd6934d0ef0ec8ab4ab

Propagation of human prostate tissue from induced pluripotent stem cells

Authors: Anastasia C. Hepburn, Emma L. Curry, Mohammad Moad, Rebecca E. Steele, Omar E. Franco, Laura Wilson, Parmveer Singh, Adriana Buskin, Susan E. Crawford, Luke Gaughan, Ian G. Mills, Simon W. Hayward, Craig N. Robson, Rakesh Heer

Source: Stem Cells Translational Medicine, Vol 9, Iss 7, Pp 734-745 (2020)

Subject Terms: androgen receptor, differentiation, induced pluripotent stem cells, organoids, prostate, prostate cancer, Medicine (General), R5-920, Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2157-6564; https://doaj.org/toc/2157-6580

Access URL: https://doaj.org/article/1a016c78ab2e4635979543ad1a0a990f

The role of the androgen receptor in prostate development and benign prostatic hyperplasia: A review

Authors: Renee E. Vickman, Omar E. Franco, Daniel C. Moline, Donald J. Vander Griend, Praveen Thumbikat, Simon W. Hayward

Source: Asian Journal of Urology, Vol 7, Iss 3, Pp 191-202 (2020)

Subject Terms: Prostate development, Benign prostatic hyperplasia, Androgen receptor, Prostate stroma, Inflammation, Diseases of the genitourinary system. Urology, RC870-923

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221438821930102X; https://doaj.org/toc/2214-3882

Access URL: https://doaj.org/article/2c4de903b2b744cc811de8dfd81c5e39

Pathomimetic avatars reveal divergent roles of microenvironment in invasive transition of ductal carcinoma in situ

Authors: Mansoureh Sameni, Dora Cavallo-Medved, Omar E. Franco, Anita Chalasani, Kyungmin Ji, Neha Aggarwal, Arulselvi Anbalagan, Xuequn Chen, Raymond R. Mattingly, Simon W. Hayward, Bonnie F. Sloane

Source: Breast Cancer Research, Vol 19, Iss 1, Pp 1-19 (2017)

Subject Terms: Ductal carcinoma in situ, Myoepithelial cells, Fibroblasts, Tumor microenvironment, Proteolysis, 3D pathomimetic model, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s13058-017-0847-0; https://doaj.org/toc/1465-542X

Access URL: https://doaj.org/article/218cebe31a514f969dddcd8dfafa13cd

Reduction of pro-tumorigenic activity of human prostate cancer-associated fibroblasts using Dlk1 or SCUBE1

Authors: Brigid Orr, O. Cathal Grace, Pam Brown, Antony C. P. Riddick, Grant D. Stewart, Omar E. Franco, Simon W. Hayward, Axel A. Thomson

Source: Disease Models & Mechanisms, Vol 6, Iss 2, Pp 530-536 (2013)

Subject Terms: Medicine, Pathology, RB1-214

File Description: electronic resource

Relation: http://dmm.biologists.org/content/6/2/530; https://doaj.org/toc/1754-8403; https://doaj.org/toc/1754-8411

Access URL: https://doaj.org/article/dbdb5fb3732b445f97114d602a98b0c6

Bladder tissue formation from cultured bladder urothelium.

Authors: Siam Oottamasathien, Karin Williams, Omar E. Franco, John C. Thomas, Katrina Saba, Neil A. Bhowmick, Andrea Staack, Romano T. Demarco, John W. Brock, Simon W. Hayward, John C. Pope

Source: Developmental Dynamics; Oct2006, Vol. 235 Issue 10, p2795-2801, 7p

Development and characterization of efficient xenograft models for benign and malignant human prostate tissue.

Authors: Yuzhuo Wang, Monica P. Revelo, Daniel Sudilovsky, Mei Cao, Wilfred G. Chen, Lester Goetz, Hui Xue, Marianne Sadar, Scott B. Shappell, Gerald R. Cunha, Simon W. Hayward

Source: Prostate; Jul2005, Vol. 64 Issue 2, p149-159, 11p

Unopposed c-MYC expression in benign prostatic epithelium causes a cancer phenotype.

Authors: Karin Williams, Suzanne Fernandez, Xavier Stien, Kenichiro Ishii, Harold D. Love, Yun-Fai (Chris) Lau, Richard L. Roberts, Simon W. Hayward

Source: Prostate; Jun2005, Vol. 63 Issue 4, p369-384, 16p

Role of the stromal microenvironment in carcinogenesis of the prostate.

Authors: Gerald R. Cunha, Simon W. Hayward, Y.Z. Wang

Source: International Journal of Cancer; 10/20/2003, Vol. 107 Issue 1, p1, 10p

Subject Terms: ANDROGENS, PROSTATITIS, ENDOCRINOLOGY, PROSTATE diseases

Glucocorticoids suppress renal cell carcinoma progression by enhancing Na,K-ATPase beta-1 subunit expression.

Authors: Thu P Huynh, Sonali P Barwe, Seung J Lee, Ryan McSpadden, Omar E Franco, Simon W Hayward, Robert Damoiseaux, Stephen S Grubbs, Nicholas J Petrelli, Ayyappan K Rajasekaran

Source: PLoS ONE, Vol 10, Iss 4, p e0122442 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC4383530?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a8ce098a8e1c4231a254c1dbbadf5d65

TGF-β1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.

Authors: David A Barron, Douglas W Strand, Steven J Ressler, Truong D Dang, Simon W Hayward, Feng Yang, Gustavo E Ayala, Michael Ittmann, David R Rowley

Source: PLoS ONE, Vol 5, Iss 10, p e13751 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2966419?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/23b07d2dbd7a46c98479cbd626a896cd

Androgen regulated genes in human prostate xenografts in mice: relation to BPH and prostate cancer.

Authors: Harold D Love, S Erin Booton, Braden E Boone, Joan P Breyer, Tatsuki Koyama, Monica P Revelo, Scott B Shappell, Jeffrey R Smith, Simon W Hayward

Source: PLoS ONE, Vol 4, Iss 12, p e8384 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2793011?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/19661fe217ef4cf3accda41dedb736f1

A role for polyploidy in the tumorigenicity of Pim-1-expressing human prostate and mammary epithelial cells.

Authors: Meejeon Roh, Omar E Franco, Simon W Hayward, Riet van der Meer, Sarki A Abdulkadir

Source: PLoS ONE, Vol 3, Iss 7, p e2572 (2008)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/18596907/pdf/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f7c3d302cc6643d9942ab3d9f8a02b8d