Pembrolizumab with or without radiotherapy for metastatic non-small-cell lung cancer: a pooled analysis of two randomised trials

Authors: Theelen, Willemijn S M E ^*, Chen, Dawei ^{*, *}, Verma, Vivek, Hobbs, Brian P, Peulen, Heike M U, Aerts, Joachim G J V, Bahce, Idris, Niemeijer, Anna Larissa N, Chang, Joe Y, de Groot, Patricia M, Nguyen, Quynh-Nhu, Comeaux, Nathan I, Simon, George R, Skoulidis, Ferdinandos, Lin, Steven H, He, Kewen, Patel, Roshal, Heymach, John, Baas, Paul, Welsh, James W

Source: In The Lancet Respiratory Medicine May 2021 9(5):467-475

SPACEWALK: A Remote Participation Study of ALK Resistance Leveraging Plasma Cell-Free DNA Genotyping

Authors: Lawrence, Marissa N., Tamen, Rubii M., Martinez, Pablo, Sable-Hunt, Alicia, Addario, Tony, Barbour, Pete, Shaffer, Tristan, Hosseini, Seyed Ali, Bertucci, Caterina, Lim, Lee P., Hong, Fangxin, Michael, Kesi, Simon, George R., Riess, Jonathan W., Awad, Mark M., Oxnard, Geoffrey R.

Source: In JTO Clinical and Research Reports April 2021 2(4)

Real-World and Clinical Trial Validation of a Deep Learning Radiomic Biomarker for PD-(L)1 Immune Checkpoint Inhibitor Response in Advanced Non–Small Cell Lung Cancer.

Authors: Sako, Chiharu, Duan, Chong, Maresca, Kevin, Kent, Sean, Schmidt, Taly Gilat, Aerts, Hugo J.W.L., Parikh, Ravi B., Simon, George R., Jordan, Petr

Source: JCO Clinical Cancer Informatics; 12/13/2024, Vol. 8, p1-17, 17p

Subject Terms: POSITRON emission tomography, IMMUNE checkpoint inhibitors, DEEP learning, COMPUTED tomography, OVERALL survival, BIOMARKERS

Real-World Impact of Comprehensive Genomic Profiling on Biomarker Detection, Receipt of Therapy, and Clinical Outcomes in Advanced Non–Small Cell Lung Cancer.

Authors: Wallenta Law, Jeanna, Bapat, Bela, Sweetnam, Connor, Mohammed, Hina, McBratney, Ashleigh, Izano, Monika A., Scannell Bryan, Molly, Spencer, Scott, Schroeder, Brock, Hostin, Damon, Simon, George R., Berry, Anna B.

Source: JCO Precision Oncology; 12/1/2024, Vol. 8, p1-13, 13p

Subject Terms: PATIENT decision making, GENETIC testing, OVERALL survival, LUNG cancer, ODDS ratio

Phase 1/2 Trial of Pembrolizumab and Concurrent Chemoradiation Therapy for Limited-Stage SCLC

Authors: Welsh, James W., Heymach, John V., Guo, Chunxiao, Menon, Hari, Klein, Katherine, Cushman, Taylor R., Verma, Vivek, Hess, Kenneth R., Shroff, Girish, Tang, Chad, Skoulidis, Ferdinandos, Jeter, Melenda, Comeaux, Nathan, Patel, Roshal R., Chen, Dawei, Ozgen, Tugce, Nguyen, Quynh-Nhu, Chang, Joe Y., Altan, Mehmet, Zhang, Jianjun, Papadimitrakopoulou, Vassiliki A., Simon, George R., Byers, Lauren A., Glisson, Bonnie

Source: In Journal of Thoracic Oncology December 2020 15(12):1919-1927

Programmed Death-Ligand 1 Heterogeneity and Its Impact on Benefit From Immune Checkpoint Inhibitors in NSCLC

Authors: Hong, Lingzhi, Negrao, Marcelo V., Dibaj, Seyedeh S., Chen, Runzhe, Reuben, Alexandre, Bohac, Jadi M., Liu, Xiaoke, Skoulidis, Ferdinandos, Gay, Carl M., Cascone, Tina, Mitchell, Kyle G., Tran, Hai T., Le, Xiuning, Byers, Lauren A., Sepesi, Boris, Altan, Mehmet, Elamin, Yasir Y., Fossella, Frank V., Kurie, Jonathan M., Lu, Charles, Mott, Frank E., Tsao, Anne S., Rinsurongkawong, Waree, Lewis, Jeff, Gibbons, Don L., Glisson, Bonnie S., Blumenschein, George R., Jr., Roarty, Emily B., Futreal, P. Andrew, Wistuba, Ignacio I., Roth, Jack A., Swisher, Stephen G., Papadimitrakopoulou, Vassiliki A., Heymach, John V., Lee, J. Jack, Simon, George R., Zhang, Jianjun

Source: In Journal of Thoracic Oncology September 2020 15(9):1449-1459

Phase I Trial of Pembrolizumab and Radiation Therapy after Induction Chemotherapy for Extensive-Stage Small Cell Lung Cancer

Authors: Welsh, James W., Heymach, John V., Chen, Dawei, Verma, Vivek, Cushman, Taylor R., Hess, Kenneth R., Shroff, Girish, Tang, Chad, Skoulidis, Ferdinandos, Jeter, Melenda, Menon, Hari, Nguyen, Quynh-Nhu, Chang, Joe Y., Altan, Mehmet, Papadimitrakopoulou, Vassiliki A., Simon, George R., Raju, Uma, Byers, Lauren, Glisson, Bonnie

Source: In Journal of Thoracic Oncology February 2020 15(2):266-273

Responsiveness to immune checkpoint inhibitors versus other systemic therapies in RET-aberrant malignancies

Authors: Hegde, Aparna, Andreev-Drakhlin, Alexander Y., Roszik, Jason, Huang, Le, Liu, Shuang, Hess, Kenneth, Cabanillas, Maria, Hu, Mimi I., Busaidy, Naifa L., Sherman, Steven I., Dadu, Ramona, Grubbs, Elizabeth G., Ali, Siraj M., Lee, Jessica, Elamin, Yasir Y., Simon, George R., Blumenschein, George R., Jr, Papadimitrakopoulou, Vassiliki A., Hong, David, Meric-Bernstam, Funda, Heymach, John, Subbiah, Vivek

Source: In ESMO Open 2020 5(5)

A Phase II Trial of Alisertib (MLN8237) in Salvage Malignant Mesothelioma

Authors: Gay, Carl M., Zhou, Yanhong, Lee, J. Jack, Tang, Xi Ming, Lu, Wei, Wistuba, Ignacio I., Ferrarotto, Renata, Gibbons, Don L., Glisson, Bonnie S., Kies, Merrill S., Simon, George R., Heymach, John V., Tsao, Anne S.

Source: Oncologist. 25(10):e1457-e1463

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108181076.0x000001&indx=1&recIds=ETOCvdc_100108181076.0x000001

Silicon photonic crystal microcavity biosensors for label free highly sensitive and specific lung cancer detection

Authors: Lai, Wei-Cheng, Chakravarty, Swapnajit, Zou, Yi, Drabkin, Harry A., Gemmill, Robert M., Simon, George R., Chin, Steve H., Chen, Ray T.

Source: IEEE Photonics Conference 2012 Photonics Conference (IPC), 2012 IEEE. :443-444 Sep, 2012

Relation: 2012 IEEE Photonics Conference (IPC)

Pembrolizumab plus chemotherapy for first-line treatment of metastatic nonsquamous non-small-cell lung cancer: a network meta-analysis

Authors: Frederickson, Andrew M, Arndorfer, Stella, Zhang, Ina, Lorenzi, Maria, Insinga, Ralph, Arunachalam, Ashwini, Burke, Thomas A, Simon, George R

Source: Immunotherapy. 11(5):407-428

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100188378675.0x000001&indx=1&recIds=ETOCvdc_100188378675.0x000001

Utilization Patterns and Trends in Epidermal Growth Factor Receptor (EGFR) Mutation Testing Among Patients With Newly Diagnosed Metastatic Lung Cancer

Authors: Shen, Chan, Kehl, Kenneth L., Zhao, Bo, Simon, George R., Zhou, Shouhao, Giordano, Sharon H.

Source: In Clinical Lung Cancer July 2017 18(4):e233-e241

Randomized-controlled phase II trial of salvage chemotherapy after immunization with a TP53-transfected dendritic cell-based vaccine (Ad.p53-DC) in patients with recurrent small cell lung cancer

Authors: Chiappori, Alberto A., Williams, Charles C., Gray, Jhanelle E., Tanvetyanon, Tawee, Haura, Eric B., Creelan, Ben C., Thapa, Ram, Chen, Dung-Tsa, Simon, George R., Bepler, Gerold, Gabrilovich, Dmitry I., Antonia, Scott J.

Source: Cancer immunology, immunotherapy. 68(3):517-527

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100126866317.0x000001&indx=1&recIds=ETOCvdc_100126866317.0x000001

Perspective: rethinking therapeutic strategies in oncology.

Authors: Patz Jr., Edward F., Gottlin, Elizabeth B., Simon, George R.

Source: Frontiers in Oncology; 2024, p1-4, 4p

Subject Terms: ONCOLOGY, CANCER treatment, IMMUNE system, IMMUNE response, EXPERIMENTAL design

Molecularly Targeted Therapies in Non–Small-Cell Lung Cancer Annual Update 2014

Authors: Morgensztern, Daniel, Campo, Meghan J., Dahlberg, Suzanne E., Doebele, Robert C., Garon, Edward, Gerber, David E., Goldberg, Sarah B., Hammerman, Peter S., Heist, Rebecca S., Hensing, Thomas, Horn, Leora, Ramalingam, Suresh S., Rudin, Charles M., Salgia, Ravi, Sequist, Lecia V., Shaw, Alice T., Simon, George R., Somaiah, Neeta, Spigel, David R., Wrangle, John, Johnson, David, Herbst, Roy S., Bunn, Paul, Govindan, Ramaswamy

Source: In Journal of Thoracic Oncology January 2015 10(1) Supplement 1:S1-S63

nab-Paclitaxel for the Treatment of Advanced Squamous Non–Small-Cell Lung Cancer: A Comprehensive Update

Authors: Simon, George R.

Source: In Clinical Lung Cancer November 2014 15(6):391-397

Pemetrexed Use in the Adjuvant Setting for Completely Resectable Non–Small-Cell Lung Cancer

Authors: Simon, George R., Manegold, Christian, Barker, Scott S., Treat, Joseph A., Visseren-Grul, Carla, Obasaju, Coleman

Source: In Clinical Lung Cancer November 2013 14(6):601-608

Multiplexed specific label-free detection of NCI-H358 lung cancer cell line lysates with silicon based photonic crystal microcavity biosensors

Authors: Chakravarty, Swapnajit, Lai, Wei-Cheng, Zou, Yi, Drabkin, Harry A., Gemmill, Robert M., Simon, George R., Chin, Steve H., Chen, Ray T.

Source: In Biosensors and Bioelectronics 15 May 2013 43:50-55

The role of molecular analyses in the era of personalized therapy for advanced NSCLC

Authors: Tanner, Nichole T., Pastis, Nicholas J., Sherman, Carol, Simon, George R., Lewin, David, Silvestri, Gerard A.

Source: In Lung Cancer May 2012 76(2):131-137

Physician Preferences for Management of Patients with Stage IIIA NSCLC: Impact of Bulk of Nodal Disease on Therapy Selection

Authors: Tanner, Nichole T., Gomez, Mario, Rainwater, Chelsea, Nietert, Paul J., Simon, George R., Green, Mark R., Silvestri, Gerard A.

Source: In Journal of Thoracic Oncology February 2012 7(2):365-369