Transcriptomic analysis of the immune response to in vivo gene electrotransfer in colorectal cancer

Authors: De Robertis, Mariangela ^{1, 2, 8}, Bozic, Tim ^{3, 8}, Santek, Iva ^{3, 4}, Marzano, Flaviana ², Markelc, Bostjan ^{3, 5}, Silvestris, Domenico Alessandro ¹, Tullo, Apollonia ², Pesole, Graziano ^{1, 2}, Cemazar, Maja ^{3, 6, ∗}, Signori, Emanuela ^{7, ∗∗}

Source: In Molecular Therapy - Nucleic Acids 11 March 2025 36(1)

SARS-CoV-2 infection of thymus induces loss of function that correlates with disease severity

Authors: Rosichini, Marco, Bordoni, Veronica, Silvestris, Domenico Alessandro, Mariotti, Davide, Matusali, Giulia, Cardinale, Antonella, Zambruno, Giovanna, Condorelli, Angelo Giuseppe, Flamini, Sara, Genah, Shirley, Catanoso, Marialuigia, Del Nonno, Franca, Trezzi, Matteo, Galletti, Lorenzo, De Stefanis, Cristiano, Cicolani, Nicolò, Petrini, Stefania, Quintarelli, Concetta, Agrati, Chiara, Locatelli, Franco, Velardi, Enrico

Source: Journal of allergy and clinical immunology. 151(4):911-921

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100187208613.0x000001&indx=1&recIds=ETOCvdc_100187208613.0x000001

Differential RNA editing landscapes in host cell versus the SARS-CoV-2 genome

Authors: Kurkowiak, Małgorzata, Fletcher, Sarah, Daniels, Alison, Mozolewski, Paweł, Silvestris, Domenico Alessandro, Król, Ewelina, Marek-Trzonkowska, Natalia, Hupp, Ted, Tait-Burkard, Christine

Source: In iScience 17 November 2023 26(11)

The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation

Authors: Gatsiou, Aikaterini, Tual-Chalot, Simon, Napoli, Matteo, Ortega-Gomez, Almudena, Regen, Tommy, Badolia, Rachit, Cesarini, Valeriana, Garcia-Gonzalez, Claudia, Chevre, Raphael, Ciliberti, Giorgia, Silvestre-Roig, Carlos, Martini, Maurizio, Hoffmann, Jedrzej, Hamouche, Rana, Visker, Joseph R., Diakos, Nikolaos, Wietelmann, Astrid, Silvestris, Domenico Alessandro, Georgiopoulos, Georgios, Moshfegh, Ali, Schneider, Andre, Chen, Wei, Guenther, Stefan, Backs, Johannes, Kwak, Shin, Selzman, Craig H., Stamatelopoulos, Kimon, Rose-John, Stefan, Trautwein, Christian, Spyridopoulos, Ioakim, Braun, Thomas, Waisman, Ari, Gallo, Angela, Drakos, Stavros G., Dimmeler, Stefanie, Sperandio, Markus, Soehnlein, Oliver, Stellos, Konstantinos

Source: In Immunity 9 May 2023 56(5):979-997

The CD64/CD28/CD3ζ chimeric receptor reprograms T-cell metabolism and promotes T-cell persistence and immune functions while triggering antibody-independent and antibody-dependent cytotoxicity.

Authors: Caratelli, Sara, De Paolis, Francesca, Silvestris, Domenico Alessandro, Baldari, Silvia, Salvatori, Illari, Tullo, Apollonia, Lanzilli, Giulia, Gurtner, Aymone, Ferri, Alberto, Valle, Cristiana, Padovani, Simona, Cesarini, Valeriana, Sconocchia, Tommaso, Cifaldi, Loredana, Arriga, Roberto, Spagnoli, Giulio Cesare, Ferrone, Soldano, Venditti, Adriano, Rossi, Piero, Pesole, Graziano

Source: Experimental Hematology & Oncology; 2/17/2025, Vol. 14 Issue 1, p1-21, 21p

Subject Terms: ANTIBODY-dependent cell cytotoxicity, CYTOLOGY, MEDICAL sciences, LIFE sciences, T cells

REDIportal: toward an integrated view of the A-to-I editing.

Authors: D'Addabbo, Pietro, Cohen-Fultheim, Roni, Twersky, Itamar, Fonzino, Adriano, Silvestris, Domenico Alessandro, Prakash, Ananth, Mazzacuva, Pietro Luca, Vizcaino, Juan Antonio, Green, Andrew, Sweeney, Blake, Yates, Andy, Lussi, Yvonne, Luo, Jie, Martin, Maria-Jesus, Eisenberg, Eli, Levanon, Erez Y, Pesole, Graziano, Picardi, Ernesto

Source: Nucleic Acids Research; 1/6/2025, Vol. 53 Issue D1, pD233-D242, 10p

Donor-derived GD2-specific CAR T cells in relapsed or refractory neuroblastoma

Authors: Quintarelli, Concetta, Del Bufalo, Francesca, De Ioris, Maria Antonietta, Guercio, Marika, Algeri, Mattia, Pagliara, Daria, Silvestris, Domenico Alessandro, Di Nardo, Matteo, Sinibaldi, Matilde, Di Cecca, Stefano, Iaffaldano, Laura, Manni, Simona, Fustaino, Valentina, Garganese, Maria Carmen, Colafati, Giovanna Stefania, Bertaina, Valentina, Becilli, Marco, Mastronuzzi, Angela, Fabozzi, Francesco, Gunetti, Monica, Iacovelli, Stefano, Bugianesi, Rossana, Macchia, Stefania, Li Pira, Giuseppina, Cefalo, Maria Giuseppina, Leone, Giovanna, Del Baldo, Giada, De Angelis, Biagio, Locatelli, Franco

Source: Nature Medicine; March 2025, Vol. 31 Issue: 3 p849-860, 12p

MicroRNA Editing Detection and Function: A Combined In Silico and Experimental Approach for the Identification and Validation of Putative Oncogenic Targets

Authors: Tassinari, Valentina, Cesarini, Valeriana, Silvestris, Domenico Alessandro, Scafidi, Andrea, Cucina, Lorenzo, Gallo, Angela

Source: Methods in molecular biology. 2181:253-268

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN624603951&indx=1&recIds=ETOCRN624603951

The Interplay between CD27dull and CD27bright B Cells Ensures the Flexibility, Stability, and Resilience of Human B Cell Memory

Authors: Grimsholm, Ola, Piano Mortari, Eva, Davydov, Alexey N., Shugay, Mikhail, Obraztsova, Anna S., Bocci, Chiara, Marasco, Emiliano, Marcellini, Valentina, Aranburu, Alaitz, Farroni, Chiara, Silvestris, Domenico Alessandro, Cristofoletti, Cristina, Giorda, Ezio, Scarsella, Marco, Cascioli, Simona, Barresi, Sabina, Lougaris, Vassilios, Plebani, Alessandro, Cancrini, Caterina, Finocchi, Andrea, Moschese, Viviana, Valentini, Diletta, Vallone, Cristina, Signore, Fabrizio, de Vincentiis, Giovanni, Zaffina, Salvatore, Russo, Giandomenico, Gallo, Angela, Locatelli, Franco, Tozzi, Alberto E., Tartaglia, Marco, Chudakov, Dmitriy M., Carsetti, Rita

Source: In Cell Reports 3 March 2020 30(9):2963-2977

Increased adenosine-to-inosine RNA editing in rheumatoid arthritis

Authors: Vlachogiannis, Nikolaos I., Gatsiou, Aikaterini, Silvestris, Domenico Alessandro, Stamatelopoulos, Kimon, Tektonidou, Maria G., Gallo, Angela, Sfikakis, Petros P., Stellos, Konstantinos

Source: In Journal of Autoimmunity January 2020 106

The adaptive potential of RNA editing-mediated miRNA-retargeting in cancer

Authors: Tassinari, Valentina, Cesarini, Valeriana, Silvestris, Domenico Alessandro, Gallo, Angela

Source: In BBA - Gene Regulatory Mechanisms March 2019 1862(3):291-300

ADAR2 Protein Is Associated with Overall Survival in GBM Patients and Its Decrease Triggers the Anchorage-Independent Cell Growth Signature.

Authors: Cesarini, Valeriana^1,2 (AUTHOR), Silvestris, Domenico Alessandro¹ (AUTHOR), Galeano, Federica¹ (AUTHOR), Tassinari, Valentina^1,3 (AUTHOR), Martini, Maurizio^4,5 (AUTHOR), Locatelli, Franco^1,6 (AUTHOR), Gallo, Angela¹ (AUTHOR) angela.gallo@opbg.net

Source: Biomolecules (2218-273X). Aug2022, Vol. 12 Issue 8, p1142. 14p.

Subject Terms: *OVERALL survival, *CELL growth, *RNA editing, *PROTEINS, *GLIOBLASTOMA multiforme

ADAR1 is a new target of METTL3 and plays a pro-oncogenic role in glioblastoma by an editing-independent mechanism

Authors: Tassinari, Valentina, Cesarini, Valeriana, Tomaselli, Sara, Ianniello, Zaira, Silvestris, Domenico Alessandro, Ginistrelli, Lavinia Ceci, Martini, Maurizio, De Angelis, Biagio, De Luca, Gabriele, Vitiani, Lucia Ricci, Fatica, Alessandro, Locatelli, Franco, Gallo, Angela

Source: Genome biology. 22(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100193304084.0x000001&indx=1&recIds=ETOCvdc_100193304084.0x000001

Insight into immune profile associated with vitiligo onset and anti-tumoral response in melanoma patients receiving anti-PD-1 immunotherapy.

Authors: Carbone, Maria Luigia, Capone, Alessia, Guercio, Marika, Reddel, Sofia, Silvestris, Domenico Alessandro, Lulli, Daniela, Ramondino, Carmela, Peluso, Daniele, Quintarelli, Concetta, Volpe, Elisabetta, Failla, Cristina Maria

Source: Frontiers in Immunology; 2023, p01-14, 14p

Subject Terms: VITILIGO, T cell receptors, T helper cells, MELANOMA, T cells, CELL migration

Dynamic inosinome profiles reveal novel patient stratification and gender-specific differences in glioblastoma

Authors: Silvestris, Domenico Alessandro, Picardi, Ernesto, Cesarini, Valeriana, Fosso, Bruno, Mangraviti, Nicolò, Massimi, Luca, Martini, Maurizio, Pesole, Graziano, Locatelli, Franco, Gallo, Angela

Source: Genome biology. 20(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100129317473.0x000001&indx=1&recIds=ETOCvdc_100129317473.0x000001

Neutralizing IFNγ improves safety without compromising efficacy of CAR-T cell therapy in B-cell malignancies.

Authors: Manni, Simona, Del Bufalo, Francesca, Merli, Pietro, Silvestris, Domenico Alessandro, Guercio, Marika, Caruso, Simona, Reddel, Sofia, Iaffaldano, Laura, Pezzella, Michele, Di Cecca, Stefano, Sinibaldi, Matilde, Ottaviani, Alessio, Quadraccia, Maria Cecilia, Aurigemma, Mariasole, Sarcinelli, Andrea, Ciccone, Roselia, Abbaszadeh, Zeinab, Ceccarelli, Manuela, De Vito, Rita, Lodi, Maria Chiara

Source: Nature Communications; 6/9/2023, Vol. 14 Issue 1, p1-13, 13p

Subject Terms: B cells, CELLULAR therapy, B cell lymphoma, CYTOKINE release syndrome, MACROPHAGE activation syndrome, CHIMERIC antigen receptors

Genome-wide profiling of patient-derived glioblastoma stem-like cells reveals recurrent genetic and transcriptomic signatures associated with brain tumors.

Authors: Lazzarini, Elisabetta, Silvestris, Domenico Alessandro, Benvenuto, Giuseppe, Osti, Daniela, Fattore, Luigi, Paterra, Rosina, Finocchiaro, Gaetano, Malatesta, Paolo, Daga, Antonio, Gallotti, Alberto L., Galli, Rossella, Pelicci, Giuliana, Tesei, Anna, Bedeschi, Martina, Pallini, Roberto, Pasqualini, Lorenza, Romualdi, Chiara, Gallo, Angela, Ricci-Vitiani, Lucia, Indraccolo, Stefano

Source: Journal of Neuro-Oncology; May2023, Vol. 163 Issue 1, p47-59, 13p

Safe and effective off-the-shelf immunotherapy based on CAR.CD123-NK cells for the treatment of acute myeloid leukaemia.

Authors: Caruso, Simona, De Angelis, Biagio, Del Bufalo, Francesca, Ciccone, Roselia, Donsante, Samantha, Volpe, Gabriele, Manni, Simona, Guercio, Marika, Pezzella, Michele, Iaffaldano, Laura, Silvestris, Domenico Alessandro, Sinibaldi, Matilde, Di Cecca, Stefano, Pitisci, Angela, Velardi, Enrico, Merli, Pietro, Algeri, Mattia, Lodi, Mariachiara, Paganelli, Valeria, Serafini, Marta

Source: Journal of Hematology & Oncology; Dec2022, Vol. 15 Issue 1, p1-19, 19p

Subject Terms: ACUTE myeloid leukemia, STEM cell transplantation, BLAST injuries, INTERFERON gamma, KILLER cells, CHIMERIC antigen receptors, BONE marrow

CAR.CD123-NK Cells Have an Equally Effective but Safer Off-Tumor/on-Target Profile As Compared to CARCD123-T Cells for the Treatment of Acute Myeloid Leukaemia

Authors: Caruso, Simona ^*, Quintarelli, Concetta ^*, De Angelis, Biagio ^*, Del Bufalo, Francesca ^*, Ciccone, Roselia ^*, Donsante, Samantha ^*, Volpe, Gabriele ^*, Manni, Simona ^*, Guercio, Marika ^*, Pezzella, Michele ^*, Iaffaldano, Laura ^*, Silvestris, Domenico Alessandro ^*, Sinibaldi, Matilde ^*, Di Cecca, Stefano ^*, Pitisci, Angela ^*, Velardi, Enrico ^*, Merli, Pietro ^*, Algeri, Mattia ^*, Lodi, Mariachiara ^*, Paganelli, Valeria ^*, Serafini, Marta ^*, Riminucci, Mara ^*, Locatelli, Franco

Source: In Blood 15 November 2022 140 Supplement 1:7369-7370

ADAR-mediated RNA editing of DNA:RNA hybrids is required for DNA double strand break repair.

Authors: Jimeno, Sonia, Prados-Carvajal, Rosario, Fernández-Ávila, María Jesús, Silva, Sonia, Silvestris, Domenico Alessandro, Endara-Coll, Martín, Rodríguez-Real, Guillermo, Domingo-Prim, Judit, Mejías-Navarro, Fernando, Romero-Franco, Amador, Jimeno-González, Silvia, Barroso, Sonia, Cesarini, Valeriana, Aguilera, Andrés, Gallo, Angela, Visa, Neus, Huertas, Pablo

Source: Nature Communications; 9/17/2021, Vol. 12 Issue 1, p1-15, 15p

Subject Terms: DOUBLE-strand DNA breaks, RNA editing, DNA damage, DNA repair, CATALYTIC RNA