Synthesis of α-fluorocinnamate derivatives as novel cathepsin S inhibitors with in vitro antiproliferative activity against pancreatic cancer cells

Authors: Citarella, Andrea ^{a, ⁎}, Petrella, Serena ^b, Moi, Davide ^a, Dimasi, Alessandro ^a, Braga, Tommaso ^a, Ruberto, Lorenzo ^a, Pieraccini, Stefano ^a, Sironi, Maurizio ^a, Micale, Nicola ^c, Schirmeister, Tanja ^d, Damia, Giovanna ^b, Fasano, Valerio ^a, Silvani, Alessandra ^a, Giannini, Clelia ^a, Passarella, Daniele ^a

Source: In Bioorganic & Medicinal Chemistry 1 December 2024 115

Modular symmetric ligands for selective recognition of cancer-relevant G-quadruplexes

Authors: Platella, Chiara, Citarella, Andrea, Manenti, Marco, Spinelli, Guglielmo, Gaglione, Rosa, Arciello, Angela, Riccardi, Claudia, Musumeci, Domenica, Montesarchio, Daniela, Giannini, Clelia, Silvani, Alessandra

Source: In Journal of Molecular Structure 5 March 2024 1299

Computational Design, Synthesis, and Biological Evaluation of Diimidazole Analogues Endowed with Dual PCSK9/HMG-CoAR-Inhibiting Activity

Authors: Lammi, Carmen, Fassi, Enrico M. A., Manenti, Marco, Brambilla, Marta, Conti, Maria, Li, Jianqiang, Roda, Gabriella, Camera, Marina, Silvani, Alessandra, Grazioso, Giovanni

Source: Journal of medicinal chemistry. 66(12):7943-7958

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN633150173&indx=1&recIds=ETOCRN633150173

Mechanistic insights of the copper(i)-catalysed reaction between chlorohydrazones and terminal alkynesElectronic supplementary information (ESI) available: 1H and 13C NMR of all new compounds, IR and MS spectra of deuterated chlorohydrazone D-1a. See DOI: https://doi.org/10.1039/d3nj02712k

Authors: Ponti, Alessandro, Silvani, Alessandra, Molteni, Giorgio

Source: New journal of chemistry. 47(32):15261-15266

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190118762.0x000001&indx=1&recIds=ETOCvdc_100190118762.0x000001

Synthesis of SARS-CoV-2 Mpro inhibitors bearing a cinnamic ester warhead with in vitro activity against human coronavirusesElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d3ob00381g

Authors: Citarella, Andrea, Moi, Davide, Pedrini, Martina, Pérez-Peña, Helena, Pieraccini, Stefano, Dimasi, Alessandro, Stagno, Claudio, Micale, Nicola, Schirmeister, Tanja, Sibille, Giulia, Gribaudo, Giorgio, Silvani, Alessandra, Giannini, Clelia, Passarella, Daniele

Source: Organic & biomolecular chemistry. 21(18):3811-3824

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100182250364.0x000001&indx=1&recIds=ETOCvdc_100182250364.0x000001

Synthesis of potent and selective HDAC6 inhibitors led to unexpected opening of a quinazoline ringElectronic supplementary information (ESI) available. See https://doi.org/10.1039/d2ra01753a

Authors: Moi, Davide, Citarella, Andrea, Bonanni, Davide, Pinzi, Luca, Passarella, Daniele, Silvani, Alessandra, Giannini, Clelia, Rastelli, Giulio

Source: RSC advances. 12(18):11548-11556

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100147874395.0x000001&indx=1&recIds=ETOCvdc_100147874395.0x000001

DOX mediated synthesis of PLA-co-PS graft copolymers with matrix-driven self-assembly in PLA-based blends

Authors: Gazzotti, Stefano, Adolfsson, Karin H., Hakkarainen, Minna, Farina, Hermes, Silvani, Alessandra, Ortenzi, Marco Aldo

Source: In European Polymer Journal 5 May 2022 170

Highly diastereoselective entry to chiral oxindole-based β-amino boronic acids and spiro derivativesElectronic supplementary information (ESI) available: Experimental section, NMR studies, 1H, 13C and 11B NMR spectra for all new compounds. See DOI: 10.1039/d1ob01303c

Authors: Manenti, Marco, Gazzotti, Stefano, Lo Presti, Leonardo, Molteni, Giorgio, Silvani, Alessandra

Source: Organic & biomolecular chemistry. 19(33):7211-7216

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100128513911.0x000001&indx=1&recIds=ETOCvdc_100128513911.0x000001

Brown Allylation: Application to the Synthesis of Natural Products

Authors: Boiarska, Zlata, Braga, Tommaso, Silvani, Alessandra, Passarella, Daniele

Source: European journal of organic chemistry. 2021(22):3214-3222

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100123657469.0x000001&indx=1&recIds=ETOCvdc_100123657469.0x000001

Spiro‐2‐oxindoles via 1, 3‐dipolar cycloadditions. A decade update

Authors: Molteni, Giorgio, Silvani, Alessandra

Source: European journal of organic chemistry. 2021(11):1653-1675

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100116937042.0x000001&indx=1&recIds=ETOCvdc_100116937042.0x000001

Eugenol-grafted aliphatic polyesters: Towards inherently antimicrobial PLA-based materials exploiting OCAs chemistry

Authors: Gazzotti, Stefano, Todisco, Simona Alessandra, Picozzi, Claudia, Ortenzi, Marco Aldo, Farina, Hermes, Lesma, Giordano, Silvani, Alessandra

Source: In European Polymer Journal May 2019 114:369-379

Nicotinic Acid Derivatives As Novel Noncompetitive α‑Amylase and α‑Glucosidase Inhibitors for Type 2 Diabetes Treatment.

Authors: Citarella, Andrea, Cavinato, Miriam, Rosini, Elena, Shehi, Haidi, Ballabio, Federico, Camilloni, Carlo, Fasano, Valerio, Silvani, Alessandra, Passarella, Daniele, Pollegioni, Loredano, Nardini, Marco

Source: ACS Medicinal Chemistry Letters; 9/12/2024, Vol. 15 Issue 9, p1474-1481, 8p

Cellulose nanofibrils as reinforcing agents for PLA-based nanocomposites: An in situ approach

Authors: Gazzotti, Stefano, Rampazzo, Riccardo, Hakkarainen, Minna, Bussini, Daniele, Ortenzi, Marco Aldo, Farina, Hermes, Lesma, Giordano, Silvani, Alessandra

Source: In Composites Science and Technology 8 February 2019 171:94-102

Exploitation of the Ugi–Joullié reaction in drug discovery and development

Authors: Gazzotti, Stefano, Rainoldi, Giulia, Silvani, Alessandra

Source: Expert opinion on drug discovery. 14(7):639-652

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100098595981.0x000001&indx=1&recIds=ETOCvdc_100098595981.0x000001

Exploiting Enantiopure β‐Amino Boronic Acids in Isocyanide‐Based Multicomponent Reactions

Authors: Manenti, Marco, Gusmini, Simone, Lo Presti, Leonardo, Silvani, Alessandra

Source: European journal of organic chemistry. 2022(25)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100154928414.0x000001&indx=1&recIds=ETOCvdc_100154928414.0x000001

Synthesis of Fluorine‐Containing, UV‐Responsive PLA‐Based Materials by Means of Functionalized DOX Monomer

Authors: Gazzotti, Stefano, Ortenzi, Marco Aldo, Farina, Hermes, Silvani, Alessandra

Source: Macromolecular chemistry and physics. 223(14)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100156101493.0x000001&indx=1&recIds=ETOCvdc_100156101493.0x000001

Polylactide/cellulose nanocrystals: The in situ polymerization approach to improved nanocomposites

Authors: Gazzotti, Stefano, Farina, Hermes, Lesma, Giordano, Rampazzo, Riccardo, Piergiovanni, Luciano, Ortenzi, Marco Aldo, Silvani, Alessandra

Source: In European Polymer Journal September 2017 94:173-184

Biocatalysed olefin reduction of 3-alkylidene oxindoles by baker's yeast

Authors: Rossetti, Arianna, Sacchetti, Alessandro, Bonfanti, Marta, Roda, Gabriella, Rainoldi, Giulia, Silvani, Alessandra

Source: In Tetrahedron 3 August 2017 73(31):4584-4590

Nirmatrelvir: From Discovery to Modern and Alternative Synthetic Approaches.

Authors: Galli, Michela, Migliano, Francesco, Fasano, Valerio, Silvani, Alessandra, Passarella, Daniele, Citarella, Andrea

Source: Processes; Jun2024, Vol. 12 Issue 6, p1242, 31p

Subject Terms: COVID-19 pandemic, COVID-19 treatment, FLOW chemistry, ORAL drug administration, SARS-CoV-2

Company/Entity: PFIZER Inc.

Poly(alditol sebacate)-PLA copolymers: enhanced degradability and tunable surface properties.

Authors: Gazzotti, Stefano, Hakkarainen, Minna, Pagnacco, Carlo Andrea, Manenti, Marco, Silvani, Alessandra, Farina, Hermes, Arnaboldi, Luca, Ortenzi, Marco Aldo

Source: Polymer Chemistry; 5/28/2024, Vol. 15 Issue 20, p2081-2093, 13p