Protein kinase R and the integrated stress response drive immunopathology caused by mutations in the RNA deaminase ADAR1

Authors: Maurano, Megan, Snyder, Jessica M., Connelly, Caitlin, Henao-Mejia, Jorge, Sidrauski, Carmela, Stetson, Daniel B.

Source: In Immunity 14 September 2021 54(9):1948-1960

Substrate recruitment via eIF2γ enhances catalytic efficiency of a holophosphatase that terminates the integrated stress response.

Authors: Yahui Yan, Shetty, Maithili, Harding, Heather P., George, Ginto, Zyryanova, Alisa, Labbé, Katherine, Mafi, Amirhossein, Qi Hao, Sidrauski, Carmela, Ron, David

Source: Proceedings of the National Academy of Sciences of the United States of America; 4/2/2024, Vol. 121 Issue 14, p1-12, 42p

Subject Terms: PHOSPHOPROTEIN phosphatases, PEPTIDES, MOLECULAR dynamics, X-ray crystallography, DEEP learning

GDF15 is a dynamic biomarker of the integrated stress response in the central nervous system.

Authors: Asundi, Jyoti, Zhang, Chunlian, Donnelly‐Roberts, Diana, Solorio, Josè Zavala, Challagundla, Malleswari, Connelly, Caitlin, Boch, Christina, Chen, Jun, Richter, Mario, Maneshi, Mohammad Mehdi, Swensen, Andrew M., Lebon, Lauren, Schiffmann, Raphael, Sanyal, Subhabrata, Sidrauski, Carmela, Kolumam, Ganesh, Baruch, Amos

Source: CNS Neuroscience & Therapeutics; Feb2024, Vol. 30 Issue 2, p1-12, 12p

Subject Terms: CENTRAL nervous system, GROWTH differentiation factors, RETINAL ganglion cells, LEUKOENCEPHALOPATHIES, BIOMARKERS

A role for presenilin-1 in nuclear accumulation of Ire1 fragments and induction of the mammalian unfolded protein response.

Authors: Niwa, Maho, Sidrauski, Carmela, Kaufman, Randal J.

Source: Cell; December 23 1999, Vol. 99 Issue 7, p691-702, 12p

The transmembrane kinase Ire1p is a site-specific endonuclease that initiates mRNA splicing in the unfolded protein response.

Authors: Sidrauski, Carmela, Walter, Peter

Source: Cell; September 19 1997, Vol. 90, p1031-1039, 9p

tRNA ligase is required for regulated mRNA splicing in the unfolded protein response.

Authors: Sidrauski, Carmela, Cox, Jeffrey S., Walter, Peter

Source: Cell; November 1 1996, Vol. 87, p405-413, 9p

[1] Purification and activity assays of the catalytic domains of the kinase/endoribonuclease Ire 1p from Saccharomyces cerevisiae

Authors: Nock, Silke, Gonzalez, Tania N., Sidrauski, Carmela, Niwa, Maho, Walter, Peter

Source: In Methods in Enzymology 2001 342:3-10

Sugar phosphate activation of the stress sensor eIF2B.

Authors: Hao, Qi, Heo, Jin-Mi, Nocek, Boguslaw P., Hicks, Kevin G., Stoll, Vincent S., Remarcik, Clint, Hackett, Sean, LeBon, Lauren, Jain, Rinku, Eaton, Dan, Rutter, Jared, Wong, Yao Liang, Sidrauski, Carmela

Source: Nature Communications; 6/8/2021, Vol. 12 Issue 1, p1-12, 12p

Subject Terms: SUGAR phosphates, LEUKOENCEPHALOPATHIES, PROTEIN synthesis, ALLOSTERIC regulation, EIGENFUNCTIONS

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Intracellular signaling from the endoplasmic reticulum to the nucleus.

Alternate Title: review

Authors: Chapman, Rowan, Sidrauski, Carmela, Walter, Peter

Source: Annual Review of Cell & Developmental Biology; 1998, Vol. 14, p459-485, 27p

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The small molecule ISRIB rescues the stability and activity of Vanishing White Matter Disease eIF2B mutant complexes.

Authors: Yao Liang Wong, LeBon, Lauren, Edalji, Rohinton, Hock Ben Lim, Chaohong Sun, Sidrauski, Carmela

Source: eLife; 2018, p1-23, 23p

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Translational control by eIF2α phosphorylation regulates vulnerability to the synaptic and behavioral effects of cocaine.

Authors: Wei Huang, Placzek, Andon N., Di Prisco, Gonzalo Viana, Khatiwada, Sanjeev, Sidrauski, Carmela, Krnjević, Krešimir, Walter, Peter, Dani, John A., Costa-Mattioli, Mauro

Source: eLife; 2016, p1-18, 18p