Design and characterization of protective pan-ebolavirus and pan-filovirus bispecific antibodies.

Authors: Wirchnianski, Ariel S.^1,2, Nyakatura, Elisabeth K.¹, Herbert, Andrew S.^3,4, andrew.s.herbert4.civ@health.mil, Kuehne, Ana I.³, Abbasi, Shawn A.^3,4, Florez, Catalina^3,4, Storm, Nadia⁵, McKay, Lindsay G. A.⁵, Dailey, Leandrew¹, Kuang, Erin⁴, Abelson, Dafna M.⁴, Wec, Anna Z.², Chakraborti, Srinjoy¹, Holtsberg, Frederick W.⁶, Shulenin, Sergey⁶, Bornholdt, Zachary A.⁷, Aman, M. Javad⁷, Honko, Anna N.⁴, Griffiths, Anthony⁴, Dye, John M.³

Source: PLoS Pathogens; 4/11/2024, Vol. 20 Issue 4, p1-25, 25p

Role of Antibodies in Protection Against Ebola Virus in Nonhuman Primates Immunized With Three Vaccine Platforms

Authors: Warfield, Kelly L., Howell, Katie A., Vu, Hong, Geisbert, Joan, Wong, Gary, Shulenin, Sergey, Sproule, Stephanie, Holtsberg, Frederick W., Leung, Daisy W., Amarasinghe, Gaya K., Swenson, Dana L., Bavari, Sina, Kobinger, Gary P., Geisbert, Thomas W., Aman, M. Javad

Source: The Journal of Infectious Diseases, 2018 Dec . 218, S553-S564.

Access URL: https://www.jstor.org/stable/26576226

Design and evaluation of bi- and trispecific antibodies targeting multiple filovirus glycoproteins

Authors: Nyakatura, Elisabeth K., Zak, Samantha E., Wec, Anna Z., Hofmann, Daniel, Shulenin, Sergey, Bakken, Russell R., Aman, M. Javad, Chandran, Kartik, Dye, John M., Lai, Jonathan R.

Source: In Journal of Biological Chemistry 20 April 2018 293(16):6201-6211

Post-exposure immunotherapy for two ebolaviruses and Marburg virus in nonhuman primates

Authors: Brannan, Jennifer, He, Shihua, Howell, Katie, Prugar, Laura, Zhu, Wenjun, Vu, Hong, Shulenin, Sergey, Kailasan, Shweta, Raina, Henna, Wong, Gary, Rahim, Md, Banadyga, Logan, Tierney, Kevin, Zhao, Xuelian, Li, Yuxing, Holtsberg, Frederick, Dye, John, Qiu, Xiangguo, Aman, M.

Source: Nature communications. 10(1):1-10

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100103849102.0x000001&indx=1&recIds=ETOCvdc_100103849102.0x000001

Immunization-Elicited Broadly Protective Antibody Reveals Ebolavirus Fusion Loop as a Site of Vulnerability

Authors: Zhao, Xuelian, Howell, Katie A., He, Shihua, Brannan, Jennifer M., Wec, Anna Z., Davidson, Edgar, Turner, Hannah L., Chiang, Chi-I., Lei, Lin, Fels, J. Maximilian, Vu, Hong, Shulenin, Sergey, Turonis, Ashley N., Kuehne, Ana I., Liu, Guodong, Ta, Mi, Wang, Yimeng, Sundling, Christopher, Xiao, Yongli, Spence, Jennifer S., Doranz, Benjamin J., Holtsberg, Frederick W., Ward, Andrew B., Chandran, Kartik, Dye, John M., Qiu, Xiangguo, Li, Yuxing, Aman, M. Javad

Source: In Cell 18 May 2017 169(5):891-904

Antigenic landscapes on Staphylococcus aureus pore-forming toxins reveal insights into specificity and cross-neutralization

Authors: Kailasan, Shweta, Kant, Ravi, Noonan-Shueh, Madeleine, Kanipakala, Tulasikumari, Liao, Grant, Shulenin, Sergey, Leung, Daisy W., Alm, Richard A., Adhikari, Rajan P., Amarasinghe, Gaya K., Gross, Michael L., Aman, M. Javad

Source: MAbs. 14(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100168255968.0x000001&indx=1&recIds=ETOCvdc_100168255968.0x000001

Antibody Treatment of Ebola and Sudan Virus Infection via a Uniquely Exposed Epitope within the Glycoprotein Receptor-Binding Site

Authors: Howell, Katie A., Qiu, Xiangguo, Brannan, Jennifer M., Bryan, Christopher, Davidson, Edgar, Holtsberg, Frederick W., Wec, Anna Z., Shulenin, Sergey, Biggins, Julia E., Douglas, Robin, Enterlein, Sven G., Turner, Hannah L., Pallesen, Jesper, Murin, Charles D., He, Shihua, Kroeker, Andrea, Vu, Hong, Herbert, Andrew S., Fusco, Marnie L., Nyakatura, Elisabeth K., Lai, Jonathan R., Keck, Zhen-Yong, Foung, Steven K.H., Saphire, Erica Ollmann, Zeitlin, Larry, Ward, Andrew B., Chandran, Kartik, Doranz, Benjamin J., Kobinger, Gary P., Dye, John M., Aman, M. Javad

Source: In Cell Reports 17 May 2016 15(7):1514-1526

A "Trojan horse" bispecific-antibody strategy for broad protection against ebolaviruses

Authors: Wec, Anna Z., Nyakatura, Elisabeth K., Herbert, Andrew S., Howell, Katie A., Holtsberg, Frederick W., Bakken, Russell R., Mittler, Eva, Christin, John R., Shulenin, Sergey, Jangra, Rohit K., Bharrhan, Sushma, Kuehne, Ana I., Bornholdt, Zachary A., Flyak, Andrew I., Saphire, Erica Ollmann, Crowe, James E., Aman, M. Javad, Dye, John M., Lai, Jonathan R., Chandran, Kartik

Source: Science, 2016 Oct . 354(6310), 350-354.

Access URL: https://www.jstor.org/stable/44710847

Quantitative serology assays for determination of antibody responses to Ebola virus glycoprotein and matrix protein in nonhuman primates and humans

Authors: Vu, Hong, Shulenin, Sergey, Grolla, Allen, Audet, Jonathan, He, Shihua, Kobinger, Gary, Unfer, Robert C., Warfield, Kelly L., Aman, M. Javad, Holtsberg, Frederick W.

Source: In Antiviral Research February 2016 126:55-61

Cooperativity Enables Non-neutralizing Antibodies to Neutralize Ebolavirus

Authors: Howell, Katie A., Brannan, Jennifer M., Bryan, Christopher, McNeal, Andrew, Davidson, Edgar, Turner, Hannah L., Vu, Hong, Shulenin, Sergey, He, Shihua, Kuehne, Ana, Herbert, Andrew S., Qiu, Xiangguo, Doranz, Benjamin J., Holtsberg, Frederick W., Ward, Andrew B., Dye, John M., Aman, M. Javad

Source: Cell reports. 19(2):413-424

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100070129367.0x000001&indx=1&recIds=ETOCvdc_100070129367.0x000001

Synthetic Human Monoclonal Antibodies toward Staphylococcal Enterotoxin B (SEB) Protective against Toxic Shock Syndrome

Authors: Karauzum, Hatice, Chen, Gang, Abaandou, Laura, Mahmoudieh, Mahta, Boroun, Atefeh R., Shulenin, Sergey, Devi, V. Sathya, Stavale, Eric, Warfield, Kelly L., Zeitlin, Larry, Roy, Chad J., Sidhu, Sachdev S., Aman, M. Javad

Source: In Journal of Biological Chemistry 20 July 2012 287(30):25203-25215

Biophysical Characterization and Conformational Stability of Ebola and Marburg Virus-Like Particles

Authors: Hu, Lei, Trefethen, Jared M., Zeng, Yuhong, Yee, Luisa, Ohtake, Satoshi, Lechuga‐Ballesteros, David, Warfield, Kelly L., Aman, M. Javad, Shulenin, Sergey, Unfer, Robert, Enterlein, Sven G., Truong‐Le, Vu, Volkin, David B., Joshi, Sangeeta B., Middaugh, C. Russell

Source: In Journal of Pharmaceutical Sciences December 2011 100(12):5156-5173

Evolution of the vertebrate ABC gene family: Analysis of gene birth and death

Authors: Annilo, Tarmo, Chen, Zhang-Qun, Shulenin, Sergey, Costantino, Julie, Thomas, Lauren, Lou, Hong, Stefanov, Stefan, Dean, Michael

Source: In Genomics 2006 88(1):1-11

Characterization of human immunodeficiency virus type 1 (HIV-1) containing mutations in the nucleocapsid protein at a putative HIV-1 protease cleavage site

Authors: Thomas, James A., Shulenin, Sergey, Coren, Lori V., Bosche, William J., Gagliardi, Tracy D., Gorelick, Robert J., Oroszlan, Stephen

Source: In Virology 2006 354(2):261-270

Effects of human TRIM5α polymorphisms on antiretroviral function and susceptibility to human immunodeficiency virus infection

Authors: Javanbakht, Hassan, An, Ping, Gold, Bert, Petersen, Desiree C., O'Huigin, Colm, Nelson, George W., O'Brien, Stephen J., Kirk, Gregory D., Detels, Roger, Buchbinder, Susan, Donfield, Sharyne, Shulenin, Sergey, Song, Byeongwoon, Perron, Michel J., Stremlau, Matthew, Sodroski, Joseph, Dean, Michael, Winkler, Cheryl

Source: In Virology 2006 354(1):15-27

Human monoclonal antibodies against chikungunya virus target multiple distinct epitopes in the E1 and E2 glycoproteins.

Authors: Quiroz, Jose A.¹, Malonis, Ryan J.¹, Thackray, Larissa B.², Cohen, Courtney A.³, Pallesen, Jesper⁴, Jangra, Rohit K.⁵, Brown, Rebecca S.⁶, Hofmann, Daniel¹, Holtsberg, Frederick W.⁷, Shulenin, Sergey⁷, Nyakatura, Elisabeth K.¹, Durnell, Lorellin A.², Rayannavar, Vinayak¹, Daily, Johanna P.⁸, Ward, Andrew B.⁴, Aman, M. Javad⁷, Dye, John M.³, Chandran, Kartik⁵, Diamond, Michael S.^2,9,10, Kielian, Margaret⁶

Source: PLoS Pathogens; 11/7/2019, Vol. 15 Issue 11, p1-30, 30p

Bioanalysis Young Investigator: Sathyadevi Venkataramani

Authors: Venkataramani, Sathyadevi, Shulenin, Sergey

Source: Bioanalysis. 4(9):999-1001

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100115839438.0x000001&indx=1&recIds=ETOCvdc_100115839438.0x000001

In Vitro Processing of HIV-1 Nucleocapsid Protein by the Viral Proteinase: Effects of Amino Acid Substitutions at the Scissile Bond in the Proximal Zinc Finger Sequence.

Authors: Tözsér, József, Shulenin, Sergey, Louis, John M.

Source: Biochemistry; April 13 2004, Vol. 43 Issue 14, p4304-4312, 9p

ABCA3 Gene Mutations in Newborns with Fatal Surfactant Deficiency.

Authors: Shulenin, Sergey, Nogee, Lawrence M., Annilo, Tarmo

Source: New England Journal of Medicine; March 25 2004, Vol. 350 Issue 13, p1296-1303, 8p

Human immunodeficiency virus type 1 capsid protein is a substrate of the retroviral proteinase while integrase is resistant toward proteolysis.

Authors: Tözsér, József, Shulenin, Sergey, Kádas, János

Source: Virology; May 25 2003, Vol. 310 Issue 1, p16-23, 8p