Functional evaluation of novel variants of B4GALNT1 in a patient with hereditary spastic paraplegia and the general population

Authors: Kei-ichiro Inamori, Katsuya Nakamura, Fumi Shishido, Jia-Chen Hsu, Masakazu Nagafuku, Takahiro Nitta, Junji Ikeda, Hidekane Yoshimura, Minori Kodaira, Naomi Tsuchida, Naomichi Matsumoto, Satoshi Uemura, Shiho Ohno, Noriyoshi Manabe, Yoshiki Yamaguchi, Akira Togayachi, Kiyoko F. Aoki-Kinoshita, Shoko Nishihara, Jun-ichi Furukawa, Tadashi Kaname, Masahiko Nakamura, Takayoshi Shimohata, Shu Tadaka, Matsuyuki Shirota, Kengo Kinoshita, Yutaka Nakamura, Isao Ohno, Yoshiki Sekijima, Jin-ichi Inokuchi

Source: Frontiers in Neuroscience, Vol 18 (2024)

Subject Terms: hereditary spastic paraplegia, gangliosides, B4GALNT1, GM2/GD2 synthase, glycosyltransferase, missense variant, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnins.2024.1437668/full; https://doaj.org/toc/1662-453X

Access URL: https://doaj.org/article/71c917f9d2d54bdf92d9ba2611dfc30c

Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment

Authors: Hideo Hagihara, Hirotaka Shoji, Satoko Hattori, Giovanni Sala, Yoshihiro Takamiya, Mika Tanaka, Masafumi Ihara, Mihiro Shibutani, Izuho Hatada, Kei Hori, Mikio Hoshino, Akito Nakao, Yasuo Mori, Shigeo Okabe, Masayuki Matsushita, Anja Urbach, Yuta Katayama, Akinobu Matsumoto, Keiichi I Nakayama, Shota Katori, Takuya Sato, Takuji Iwasato, Haruko Nakamura, Yoshio Goshima, Matthieu Raveau, Tetsuya Tatsukawa, Kazuhiro Yamakawa, Noriko Takahashi, Haruo Kasai, Johji Inazawa, Ikuo Nobuhisa, Tetsushi Kagawa, Tetsuya Taga, Mohamed Darwish, Hirofumi Nishizono, Keizo Takao, Kiran Sapkota, Kazutoshi Nakazawa, Tsuyoshi Takagi, Haruki Fujisawa, Yoshihisa Sugimura, Kyosuke Yamanishi, Lakshmi Rajagopal, Nanette Deneen Hannah, Herbert Y Meltzer, Tohru Yamamoto, Shuji Wakatsuki, Toshiyuki Araki, Katsuhiko Tabuchi, Tadahiro Numakawa, Hiroshi Kunugi, Freesia L Huang, Atsuko Hayata-Takano, Hitoshi Hashimoto, Kota Tamada, Toru Takumi, Takaoki Kasahara, Tadafumi Kato, Isabella A Graef, Gerald R Crabtree, Nozomi Asaoka, Hikari Hatakama, Shuji Kaneko, Takao Kohno, Mitsuharu Hattori, Yoshio Hoshiba, Ryuhei Miyake, Kisho Obi-Nagata, Akiko Hayashi-Takagi, Léa J Becker, Ipek Yalcin, Yoko Hagino, Hiroko Kotajima-Murakami, Yuki Moriya, Kazutaka Ikeda, Hyopil Kim, Bong-Kiun Kaang, Hikari Otabi, Yuta Yoshida, Atsushi Toyoda, Noboru H Komiyama, Seth GN Grant, Michiru Ida-Eto, Masaaki Narita, Ken-ichi Matsumoto, Emiko Okuda-Ashitaka, Iori Ohmori, Tadayuki Shimada, Kanato Yamagata, Hiroshi Ageta, Kunihiro Tsuchida, Kaoru Inokuchi, Takayuki Sassa, Akio Kihara, Motoaki Fukasawa, Nobuteru Usuda, Tayo Katano, Teruyuki Tanaka, Yoshihiro Yoshihara, Michihiro Igarashi, Takashi Hayashi, Kaori Ishikawa, Satoshi Yamamoto, Naoya Nishimura, Kazuto Nakada, Shinji Hirotsune, Kiyoshi Egawa, Kazuma Higashisaka, Yasuo Tsutsumi, Shoko Nishihara, Noriyuki Sugo, Takeshi Yagi, Naoto Ueno, Tomomi Yamamoto, Yoshihiro Kubo, Rie Ohashi, Nobuyuki Shiina, Kimiko Shimizu, Sayaka Higo-Yamamoto, Katsutaka Oishi, Hisashi Mori, Tamio Furuse, Masaru Tamura, Hisashi Shirakawa, Daiki X Sato, Yukiko U Inoue, Takayoshi Inoue, Yuriko Komine, Tetsuo Yamamori, Kenji Sakimura, Tsuyoshi Miyakawa

Source: eLife, Vol 12 (2024)

Subject Terms: brain pH, lactate, metabolism, neuropsychiatric disorders, animal models, working memory, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/89376; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/15de117935204a21a8487997042e8094

Switching mechanism from AR to EGFR signaling via 3-O-sulfated heparan sulfate in castration-resistant prostate cancer

Authors: Hayato Ota, Hirokazu Sato, Shuji Mizumoto, Ken Wakai, Kei Yoneda, Kazuo Yamamoto, Hayao Nakanishi, Jun-Ichiro Ikeda, Shinichi Sakamoto, Tomohiko Ichikawa, Shuhei Yamada, Satoru Takahashi, Yuzuru Ikehara, Shoko Nishihara

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-16 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/aa8c11582cf6481ba26e4b14fd87cada

Predicting the pathogenicity of missense variants based on protein instability to support diagnosis of patients with novel variants of ARSL

Authors: Eriko Aoki, Noriyoshi Manabe, Shiho Ohno, Taiga Aoki, Jun-Ichi Furukawa, Akira Togayachi, Kiyoko Aoki-Kinoshita, Jin-Ichi Inokuchi, Kenji Kurosawa, Tadashi Kaname, Yoshiki Yamaguchi, Shoko Nishihara

Source: Molecular Genetics and Metabolism Reports, Vol 37, Iss , Pp 101016- (2023)

Subject Terms: Arylsulfatase L, Rare disease, Missense variant, Stabilization energy, Sulfatase activity, Protein instability, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2214426923000629; https://doaj.org/toc/2214-4269

Access URL: https://doaj.org/article/9a483fec4a0e4c73898ecb681d86b97e

A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition

Authors: Federico Pecori, Ikuko Yokota, Hisatoshi Hanamatsu, Taichi Miura, Chika Ogura, Hayato Ota, Jun-ichi Furukawa, Shinya Oki, Kazuo Yamamoto, Osamu Yoshie, Shoko Nishihara

Source: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/c2bda6e3df6349d5b749d60c512ff8ee

Disaccharide-tag for highly sensitive identification of O-GlcNAc-modified proteins in mammalian cells.

Authors: Hirohito Abo, Masahiko Kume, Federico Pecori, Taichi Miura, Naoki Matsumoto, Shoko Nishihara, Kazuo Yamamoto

Source: PLoS ONE, Vol 17, Iss 5, p e0267804 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/21f1c918c7484818bb887fdb1c5f04b3

Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9).

Authors: Tomoko Honda, Norihito Kawasaki, Rei Yanagihara, Ryo Tamura, Karin Murakami, Tomomi Ichimiya, Naoki Matsumoto, Shoko Nishihara, Kazuo Yamamoto

Source: PLoS ONE, Vol 17, Iss 7, p e0268485 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/98cfc8b13c4f48dca977f42fc66133a4

Mucin-Type O-Glycosylation in the Drosophila Nervous System

Authors: Kazuyoshi Itoh, Shoko Nishihara

Source: Frontiers in Neuroanatomy, Vol 15 (2021)

Subject Terms: mucin-type O-glycans, mucin-type O-glycosylation, T antigen, Drosophila, nervous system, neuromuscular junction, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Human anatomy, QM1-695

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fnana.2021.767126/full; https://doaj.org/toc/1662-5129

Access URL: https://doaj.org/article/db67f63866794dc8bbcb0dee048dddad

Dermatan-4-O-Sulfotransferase-1 Contributes to the Undifferentiated State of Mouse Embryonic Stem Cells

Authors: Chika Ogura, Shoko Nishihara

Source: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Subject Terms: mouse embryonic stem cells, D4ST1, self-renewal, Cdx2, endodermal differentiation, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fcell.2021.733964/full; https://doaj.org/toc/2296-634X

Access URL: https://doaj.org/article/94b14dea14d849a6ba955536c9efe763

Site-specific O-GlcNAcylation of Psme3 maintains mouse stem cell pluripotency by impairing P-body homeostasis

Authors: Federico Pecori, Nanako Kondo, Chika Ogura, Taichi Miura, Masahiko Kume, Youhei Minamijima, Kazuo Yamamoto, Shoko Nishihara

Source: Cell Reports, Vol 36, Iss 2, Pp 109361- (2021)

Subject Terms: Ddx6, embryonic stem cells, glycosylation, O-GlcNAc, P-bodies, pluripotency, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124721007592; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/951224586e5242feb28111d701e109ec

O-GlcNAc on PKCζ Inhibits the FGF4-PKCζ-MEK-ERK1/2 Pathway via Inhibition of PKCζ Phosphorylation in Mouse Embryonic Stem Cells

Authors: Taichi Miura, Masahiko Kume, Takeshi Kawamura, Kazuo Yamamoto, Takao Hamakubo, Shoko Nishihara

Source: Stem Cell Reports, Vol 10, Iss 1, Pp 272-286 (2018)

Subject Terms: O-GlcNAc, embryonic stem cell, PKCζ, MEK-ERK1/2 pathway, FGF4 signaling, Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213671117305143; https://doaj.org/toc/2213-6711

Access URL: https://doaj.org/article/c0cd61de082b4e72af90d2b34493aa99

Strong radioprotective FGF1 signaling down-regulates proliferative and metastatic capabilities of the angiosarcoma cell line, ISOS-1, through the dual inhibition of EGFR and VEGFR pathways

Authors: Taichi Miura, Mayumi Fujita, Mitsuko Kawano, Kaori Imadome, Takeshi Yasuda, Shoko Nishihara, Toru Imamura, Mikio Masuzawa, Takashi Imai, Fumiaki Nakayama

Source: Clinical and Translational Radiation Oncology, Vol 7, Iss , Pp 83-90 (2017)

Subject Terms: Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405630817300356; https://doaj.org/toc/2405-6308

Access URL: https://doaj.org/article/cafa6260ed84448db63d923f6577f822

3-O-sulfated heparan sulfate recognized by the antibody HS4C3 contributes [corrected] to the differentiation of mouse embryonic stem cells via fas signaling.

Authors: Kazumi Hirano, Norihiko Sasaki, Tomomi Ichimiya, Taichi Miura, Toin H Van Kuppevelt, Shoko Nishihara

Source: PLoS ONE, Vol 7, Iss 8, p e43440 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3420900?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/3b1993f4d78d4606a993457d0cb5698b

Correction: 3--Sulfated Heparan Sulfate Recognized by the Antibody HS4C3 Contribute to the Differentiation of Mouse Embryonic Stem Cells via Fas Signaling.

Authors: Kazumi Hirano, Norihiko Sasaki, Tomomi Ichimiya, Taichi Miura, Toin H. Van Kuppevelt, Shoko Nishihara

Source: PLoS ONE, Vol 7, Iss 10 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3502339; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a270a215b8e24e0ea98faee4f24d14e8

Identification of genes required for neural-specific glycosylation using functional genomics.

Authors: Miki Yamamoto-Hino, Yoshimi Kanie, Wakae Awano, Kiyoko F Aoki-Kinoshita, Hiroyuki Yano, Shoko Nishihara, Hideyuki Okano, Ryu Ueda, Osamu Kanie, Satoshi Goto

Source: PLoS Genetics, Vol 6, Iss 12, p e1001254 (2010)

Subject Terms: Genetics, QH426-470

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3009669?pdf=render; https://doaj.org/toc/1553-7390; https://doaj.org/toc/1553-7404

Access URL: https://doaj.org/article/391bfb5719154bb49d989a3f75a40ea0

Increased apoptosis of myoblasts in Drosophila model for the Walker-Warburg syndrome.

Authors: Morio Ueyama, Yoshihiro Akimoto, Tomomi Ichimiya, Ryu Ueda, Hayato Kawakami, Toshiro Aigaki, Shoko Nishihara

Source: PLoS ONE, Vol 5, Iss 7, p e11557 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2903483?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f166f719dbd24eb7a1270fe7e39f52ee

The 3'-phosphoadenosine 5'-phosphosulfate transporters, PAPST1 and 2, contribute to the maintenance and differentiation of mouse embryonic stem cells.

Authors: Norihiko Sasaki, Takuya Hirano, Tomomi Ichimiya, Masahiro Wakao, Kazumi Hirano, Akiko Kinoshita-Toyoda, Hidenao Toyoda, Yasuo Suda, Shoko Nishihara

Source: PLoS ONE, Vol 4, Iss 12, p e8262 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2788424?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/cf0fe00ab8b54f1493d15c90f64a6684

Insight into the regulation of glycan synthesis in Drosophila chaoptin based on mass spectrometry.

Authors: Yoshimi Kanie, Miki Yamamoto-Hino, Yayoi Karino, Hiroki Yokozawa, Shoko Nishihara, Ryu Ueda, Satoshi Goto, Osamu Kanie

Source: PLoS ONE, Vol 4, Iss 5, p e5434 (2009)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2672165?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/a51eef0325544b1ea31db7690c43aa23

The Functions of O-GlcNAc in Pluripotent Stem Cells

Authors: Taichi, Miura, Shoko, Nishihara

Source: Trends in glycoscience and glycotechnology. 31(178/180):E69-E76

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN622308860&indx=1&recIds=ETOCRN622308860

Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry.

Authors: Karin Murakami, Ryo Tamura, Sanae Ikehara, Hayato Ota, Tomomi Ichimiya, Naoki Matsumoto, Hisahiro Matsubara, Shoko Nishihara, Yuzuru Ikehara, Kazuo Yamamoto

Source: Biochemical Journal; Jan2023, Vol. 480 Issue 1, p41-56, 16p

Subject Terms: GLYCOSAMINOGLYCANS, CHONDROITIN sulfates, AMINO acid residues, HEPARAN sulfate, POLYSACCHARIDES, DISACCHARIDES