Creation of mouse TNFR2-selective agonistic TNF mutants using a phage display technique

Authors: Daisuke Ando, Masaki Inoue, Haruhiko Kamada, Shintaro Taki, Takeshi Furuya, Yasuhiro Abe, Kazuya Nagano, Yasuo Tsutsumi, Shin-ichi Tsunoda

Source: Biochemistry and Biophysics Reports, Vol 7, Iss 2, Pp 309-315 (2016)

Subject Terms: Tumor necrosis factor-α, TNF, TNFR2, Phage display technique, Cytokine, Mutant, Biology (General), QH301-705.5, Biochemistry, QD415-436

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2405580816300929; https://doaj.org/toc/2405-5808

Access URL: https://doaj.org/article/b58a039dae444976bcc2955198f7fb09

A Novel Bispecific Antibody against Human CD3 and Ephrin Receptor A10 for Breast Cancer Therapy.

Authors: Shintaro Taki, Haruhiko Kamada, Masaki Inoue, Kazuya Nagano, Yohei Mukai, Kazuma Higashisaka, Yasuo Yoshioka, Yasuo Tsutsumi, Shin-ichi Tsunoda

Source: PLoS ONE, Vol 10, Iss 12, p e0144712 (2015)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0144712&type=printable; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/9ef01f1527f44aeebc145b68518034c4

Domain order of a bispecific diabody dramatically enhances its antitumor activity beyond structural format conversion: the case of the hEx3 diabody.

Authors: Ryutaro Asano¹, Takashi Kumagai¹, Keisuke Nagai¹, Shintaro Taki¹, Ippei Shimomura¹, Kyoko Arai¹, Hiromi Ogata¹, Mai Okada¹, Fumitaka Hayasaka¹, Hideaki Sanada¹, Takeshi Nakanishi¹, Teemu Karvonen¹, Hiroki Hayashi², Yu Katayose², Michiaki Unno², Toshio Kudo³, Mitsuo Umetsu¹, Izumi Kumagai¹, kmiz@kuma.che.tohoku.ac.jp

Source: PEDS: Protein Engineering, Design & Selection; May2013, Vol. 26 Issue 5, p359-367, 9p

A trimeric structural fusion of an antagonistic tumor necrosis factor-α mutant enhances molecular stability and enables facile modification.

Authors: Masaki Inoue^1,2,3, Daisuke Ando^1,4, Haruhiko Kamada^1,2,5, Shintaro Taki^1,4, Mayumi Niiyama¹, Yohei Mukai¹, Takashi Tadokoro⁶, Katsumi Maenaka⁶, Taisuke Nakayama^1,7, Yuji Kado^1,7, Tsuyoshi Inoue^1,7, Yasuo Tsutsumi^2,6,8, Shin-ichi Tsunoda^1,2,3,4,8 tsunoda@pharm.kobegakuin.ac.jp

Source: Journal of Biological Chemistry. Apr2017, Vol. 292 Issue 16, p6438-6451. 14p.

Subject Terms: *TUMOR necrosis factors, *TUMOR necrosis factor receptors, *AUTOIMMUNE diseases, *POLYETHYLENE glycol, *MUTANT proteins