Lysine-specific demethylase 1 (LSD1) suppresses cellular senescence by riboflavin uptake-dependent demethylation activity

Authors: Taiichi Osumi, Taiki Nagano, Tetsushi Iwasaki, Jotaro Nakanishi, Kazuyuki Miyazawa, Shinji Kamada

Source: Scientific Reports, Vol 15, Iss 1, Pp 1-13 (2025)

Subject Terms: LSD1, Demethylation, Cellular senescence, Riboflavin, Flavin adenine dinucleotide (FAD), DNA damage, Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/6ba6ab05044941d49471ce30ab7f0a7a

Nectin-4 regulates cellular senescence-associated enlargement of cell size

Authors: Ryoko Katasho, Taiki Nagano, Tetsushi Iwasaki, Shinji Kamada

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/29318c9ac0144953bd14b72dff83a2a5

Fission yeast arrestin-related trafficking adaptor, Arn1/Any1, is ubiquitinated by Pub1 E3 ligase and regulates endocytosis of Cat1 amino acid transporter

Authors: Akio Nakashima, Shinji Kamada, Fuyuhiko Tamanoi, Ushio Kikkawa

Source: Biology Open, Vol 3, Iss 6, Pp 542-552 (2014)

Subject Terms: Arrestin-related trafficking adaptor, ART, Arn1/Any1, Amino acid uptake, Endocytosis of transporter, Ubiquitination, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://bio.biologists.org/content/3/6/542; https://doaj.org/toc/2046-6390

Access URL: https://doaj.org/article/25d65b306dcc47bcbf7f1231c3b2dc30

Branched-chain amino acids enhance premature senescence through mammalian target of rapamycin complex I-mediated upregulation of p21 protein.

Authors: Masayuki Nakano, Akio Nakashima, Taiki Nagano, Shintaro Ishikawa, Ushio Kikkawa, Shinji Kamada

Source: PLoS ONE, Vol 8, Iss 11, p e80411 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3819289?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/e42ff7eee4094d95bab0ee587934ecc2

Contribution of caspase(s) to the cell cycle regulation at mitotic phase.

Authors: Toshiaki Hashimoto, Ushio Kikkawa, Shinji Kamada

Source: PLoS ONE, Vol 6, Iss 3, p e18449 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3068168?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/c72b71b4789642a89ae725b79085a757

Structural insights into the action mechanisms of artificial electron acceptors in photosystem II.

Authors: Shinji Kamada¹, Yoshiki Nakajima² yoshi-n@okayama-u.ac.jp, Jian-Ren Shen² shen@cc.okayama-u.ac.jp

Source: Journal of Biological Chemistry. Jul2023, Vol. 299 Issue 7, p1-11. 11p.

Subject Terms: *ELECTROPHILES, *MOLECULAR structure, *PHOTOSYSTEMS, *BINDING sites, *WATER transfer

Reprogramming of somatic cells and nuclei by Xenopus oocyte and egg extracts.

Authors: TOKMAKOV, ALEXANDER A., TETSUSHI IWASAKI, KEN-ICHI SATO, SHINJI KAMADA

Source: International Journal of Developmental Biology; 2016, Vol. 60 Issue 7-9, p289-296, 8p

Subject Terms: XENOPUS eggs, SOMATIC cells, OVUM physiology, PLURIPOTENT stem cells, CELL differentiation, TRANSCRIPTION factors

Midostaurin preferentially attenuates proliferation of triple-negative breast cancer cell lines through inhibition of Aurora kinase family.

Authors: Masaaki Kawai, Akio Nakashima, Shinji Kamada, Ushio Kikkawa

Source: Journal of Biomedical Science; Jul2015, Vol. 22 Issue 1, p1-10, 10p, 1 Color Photograph, 2 Diagrams, 5 Graphs

Subject Terms: BREAST cancer, CANCER cell proliferation, BIOMARKERS, HORMONE receptors, EPIDERMAL growth factor receptors, PROTEIN kinase inhibitors, AURORA kinases

Cyclin I is involved in the regulation of cell cycle progression.

Authors: Taiki Nagano, Toshiaki Hashimoto, Akio Nakashima, Shin-Ichi Hisanaga, Ushio Kikkawa, Shinji Kamada

Source: Cell Cycle; 08/15/2013, Vol. 12 Issue 16, p2617-2724, 8p

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Proline dehydrogenase promotes senescence through the generation of reactive oxygen species.

Authors: Taiki Nagano, Akio Nakashima, Kengo Onishi, Kosuke Kawai, Yuto Awai, Mizuki Kinugasa, Tetsushi Iwasaki, Ushio Kikkawa, Shinji Kamada

Source: Journal of Cell Science; 4/15/2017, Vol. 130 Issue 8, p1-1, 1p

Subject Terms: PROLINE, DEHYDROGENASES, CELLULAR aging

LY6D-induced macropinocytosis as a survival mechanism of senescent cells.

Authors: Taiki Nagano¹, Tetsushi Iwasaki^1,2,3, Kengo Onishi², Yuto Awai³, Anju Terachi², Shione Kuwaba³, Shota Asano², Ryoko Katasho², Kiyoko Nagai¹, Akio Nakashima^1,4, Ushio Kikkawa^1,4, Shinji Kamada^1,2,3 skamada@kobe-u.ac.jp

Source: Journal of Biological Chemistry. Jan-Jun2021, Vol. 296, p1-15. 15p.

Subject Terms: *LIPID rafts, *MEMBRANE lipids, *CELL membranes, *AMINO acids, *GLUTAMINE

Phosphorylation of Cyclin-dependent Kinase 5 (Cdk5) at Tyr-15 Is Inhibited by Cdk5 Activators and Does Not Contribute to the Activation of Cdk5.

Authors: Hiroyuki Kobayashi¹, Taro Saito¹, Ko Sato¹, Kotaro Furusawa¹, Tomohisa Hosokawa¹, Koji Tsutsumi¹, Akiko Asada¹, Shinji Kamada², Toshio Ohshima³, Shin-ichi Hisanaga¹ hisanaga-shinichi@tmu.ac.jp

Source: Journal of Biological Chemistry. 7/11/2014, Vol. 289 Issue 28, p19627-19636. 10p.

Subject Terms: *PHOSPHORYLATION, *CYCLIN-dependent kinases, *CELL proliferation, *PROTEIN-tyrosine kinases, *NEURONS