Research progress on the structural and anti-colorectal malignant tumor properties of Shikonin.

Authors: Chen, Jinghua^1,2 (AUTHOR), Liu, Jie³ (AUTHOR), Nie, Weiwei¹ (AUTHOR), Hou, Xingqin⁴ (AUTHOR), Zhang, Xi² (AUTHOR), Liu, Chao² (AUTHOR), Si, Linxin² (AUTHOR), Zhang, Mingzhu² (AUTHOR), Xu, Shutao² (AUTHOR), Xie, Qi¹ (AUTHOR) xieqi@sdfmu.edu.cn, Liang, Jing¹ (AUTHOR) liangjing0531@163.com, Li, Yan¹ (AUTHOR) liyan16766@163.com

Source: Journal of Cancer Research & Therapeutics. Dec2024, Vol. 20 Issue 7, p1957-1963. 7p.

Subject Terms: *SHIKONIN, *COLORECTAL cancer, *CANCER-related mortality, *NAPHTHOQUINONE, *COLON tumors

The Anti-tumor Function of Shikonin by Targeting EGFR/AKT/mTOR Signaling in Human Osteosarcoma Cells.

Authors: Zhu, Rui-Dan¹ (AUTHOR), Zhang, Jia-Jia² (AUTHOR), Yao, Xiao-Bin² (AUTHOR), Wang, Zhang-Jiao¹ (AUTHOR), Du, Zhi-Ling¹ (AUTHOR), Xu, Qing-Xia² (AUTHOR) zlyyxuqingxia0575@zzu.edu.cn

Source: Pharmacognosy Magazine. Jun2024, Vol. 20 Issue 2, p553-562. 10p.

Subject Terms: *SHIKONIN, *PROTEIN kinase B, *EPIDERMAL growth factor, *OSTEOSARCOMA, *EPIDERMAL growth factor receptors

Shikonin reduces M2 macrophage population in ovarian cancer by repressing exosome production and the exosomal galectin 3-mediated β-catenin activation.

Authors: Wang, Min¹ (AUTHOR), Sun, Yangyan² (AUTHOR), Gu, Rui¹ (AUTHOR), Tang, Yan¹ (AUTHOR), Han, Guorong³ (AUTHOR) hangr_322@163.com, Zhao, Shaojie¹ (AUTHOR) zsjie2005@163.com

Source: Journal of Ovarian Research. 5/14/2024, Vol. 17 Issue 1, p1-14. 14p.

Subject Terms: *SHIKONIN, *OVARIAN cancer, *MACROPHAGES, *EXOSOMES, *CANCER cells, *OVARIES

Natural Compounds Oridonin and Shikonin Exhibit Potentially Beneficial Regulatory Effects on Select Functions of Microglia.

Authors: Greuel, Bridget K.¹ (AUTHOR) victoriarobertgostlin@gmail.com, Da Silva, Dylan E.¹ (AUTHOR), Robert-Gostlin, Victoria N.¹ (AUTHOR), Klegeris, Andis¹ (AUTHOR) andis.klegeris@ubc.ca

Source: Brain Sciences (2076-3425). Apr2024, Vol. 14 Issue 4, p328. 14p.

Subject Terms: *SHIKONIN, *MICROGLIA, *LEUCINE, *TUMOR necrosis factors, *ALZHEIMER'S disease, *NEUROLOGICAL disorders

Preparation, in vitro anti-tumour activity and in vivo pharmacokinetics of RGD-decorated liposomes loaded with shikonin.

Authors: Li, Jiping¹ (AUTHOR), Zhang, Hao² (AUTHOR), Mao, Xinliang² (AUTHOR), Deng, Huilin² (AUTHOR), Fan, Li³ (AUTHOR), Yue, Liling³ (AUTHOR), Li, Chengchong⁴ (AUTHOR), Pan, Siwen⁵ (AUTHOR), Wen, Xianchun⁶ (AUTHOR) wen@qmu.edu.cn

Source: Pharmaceutical Development & Technology. Mar2024, Vol. 29 Issue 3, p153-163. 11p.

Subject Terms: Liposomes, Shikonin, Cytotoxins, Pharmacokinetics, Cell proliferation, Cancer cells, Breast cancer

The Role of miR-146a in the Anti-Inflammatory and Antioxidant Effects of Shikonin on Gingival Fibroblasts.

Authors: Fumimoto, Chihiro¹, fumimoto-c@cc.osaka-dent.ac.jp, Yamauchi, Nobuhiro¹, imai-k@cc.osaka-dent.ac.jpyamauchi@cc.osaka-dent.ac.jp, Imai, Kazutaka¹, nakamura-y@cc.osaka-dent.ac.jp, Nakamura, Yurika¹, azuma-h@cc.osaka-dent.ac.jp, Azuma, Hitoshi¹, kato-h@cc.osaka-dent.ac.jp, Kato, Hirohito¹, umeda-m@cc.osaka-dent.ac.jp, Taguchi, Yoichiro², odu.periodontist99@gmail.com, Umeda, Makoto¹

Source: Applied Sciences (2076-3417); Feb2025, Vol. 15 Issue 4, p2019, 11p

Shikonin Induces Glioma Necroptosis, Stemness Decline, and Impedes (Immuno)Proteasome Activity.

Authors: Qin, Xianyun¹ (AUTHOR), Zhang, Lu² (AUTHOR), Liu, Jilan¹ (AUTHOR), Lu, Yan³ (AUTHOR), Zhou, Fuyao² (AUTHOR), Jin, Feng⁴ (AUTHOR)

Source: Stem Cells International. 3/14/2024, Vol. 2024, p1-19. 19p.

Subject Terms: *SHIKONIN, *INTRACRANIAL tumors, *GLIOMAS, *CHINESE medicine, *DRUG development

Comparative Analysis of Shikonin and Alkannin Acyltransferases Reveals Their Functional Conservation in Boraginaceae.

Authors: Oshikiri, Haruka¹ (AUTHOR), Li, Hao² (AUTHOR), Manabe, Misaki¹ (AUTHOR), Yamamoto, Hirobumi³ (AUTHOR), Yazaki, Kazufumi² (AUTHOR), Takanashi, Kojiro¹ (AUTHOR) takanashi@shinshu-u.ac.jp

Source: Plant & Cell Physiology. Mar2024, Vol. 65 Issue 3, p362-371. 10p.

Subject Terms: *ACYLTRANSFERASES, *SHIKONIN, *BORAGINACEAE, *ENZYME specificity, *COMPARATIVE studies, *PLANT species, *NICOTIANA benthamiana, *NICOTIANA

The interaction mechanisms analysis of shikonin with α-glucosidase by multi-spectroscopic and molecular docking methods.

Authors: Liu, Dan¹ (AUTHOR), Cheng, Ye¹ (AUTHOR), Li, Yan-jun¹ (AUTHOR), Miao, Jing-yi¹ (AUTHOR), Cao, Xiang-yu¹ (AUTHOR) caoxiangyu@lnu.edu.cn

Source: Spectroscopy Letters. 2024, Vol. 57 Issue 2, p103-114. 12p.

Subject Terms: *SHIKONIN, *MOLECULAR docking, *VAN der Waals forces, *ALPHA-glucosidases, *BINDING constant

Inhibitory Effects of Shikonin Dispersion, an Extract of Lithospermum erythrorhizon Encapsulated in β-1,3-1,6 Glucan, on Streptococcus mutans and Non-Mutans Streptococci.

Authors: Nomura, Ryota^1,2,3 (AUTHOR) rnomura@hiroshima-u.ac.jp, Suehiro, Yuto¹ (AUTHOR) u181758a@ecs.osaka-u.ac.jp, Tojo, Fumikazu¹ (AUTHOR) matayoshi.saaya.dent@osaka-u.ac.jp, Matayoshi, Saaya¹ (AUTHOR) okawa.rena.dent@osaka-u.ac.jp, Okawa, Rena^1,2 (AUTHOR) nakano.kazuhiko.dent@osaka-u.ac.jp, Hamada, Masakazu⁴ (AUTHOR) hamada.masakazu.dent@osaka-u.ac.jp, Naka, Shuhei⁵ (AUTHOR) nshuhei@okayama-u.ac.jp, Matsumoto-Nakano, Michiyo⁵ (AUTHOR) mnakano@cc.okayama-u.ac.jp, Unesaki, Rika⁶ (AUTHOR) unerika15@gmail.com, Koumoto, Kazuya⁶ (AUTHOR) koumoto@konan-u.ac.jp, Kawauchi, Keiko⁶ (AUTHOR) kawauchi@konan-u.ac.jp, Nishikata, Takahito⁶ (AUTHOR) nisikata@konan-u.ac.jp, Akitomo, Tatsuya³ (AUTHOR) chiekom@hiroshima-u.ac.jp, Mitsuhata, Chieko³ (AUTHOR), Yagi, Masatoshi^2,7 (AUTHOR) k_fujikawa@takeda-co.com, Mizoguchi, Toshiro^2,8 (AUTHOR) taniguchi@pharmacrea.com, Fujikawa, Koki^2,8 (AUTHOR), Taniguchi, Taizo^2,7 (AUTHOR), Nakano, Kazuhiko^1,2 (AUTHOR)

Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 2, p1075. 14p.

Subject Terms: *SHIKONIN, *STREPTOCOCCUS mutans, *DISPERSION (Chemistry), *GLUCANS, *PLANT extracts, *DENTAL caries, *STREPTOCOCCUS

Attenuation of PI3K-Akt-mTOR Pathway to Reduce Cancer Stemness on Chemoresistant Lung Cancer Cells by Shikonin and Synergy with BEZ235 Inhibitor.

Authors: Huang, Yen-Hsiang^1,2 (AUTHOR) waynehuang0622@gmail.com, Chiu, Ling-Yen¹ (AUTHOR) iang0810@gmail.com, Tseng, Jeng-Sen^1,2,3 (AUTHOR) tzeng64@gmail.com, Hsu, Kuo-Hsuan⁴ (AUTHOR) vghryan@gmail.com, Chen, Chang-Han^5,6 (AUTHOR) changhan155@hotmail.com, Sheu, Gwo-Tarng^7,8 (AUTHOR) gtsheu@csmu.edu.tw, Yang, Tsung-Ying^1,9 (AUTHOR) gtsheu@csmu.edu.tw

Source: International Journal of Molecular Sciences. Jan2024, Vol. 25 Issue 1, p616. 15p.

Subject Terms: *CANCER stem cells, *SHIKONIN, *LUNG cancer, *DRUG resistance in cancer cells, *CANCER cells, *NON-small-cell lung carcinoma

The PKM2 inhibitor shikonin enhances piceatannol‐induced apoptosis of glyoxalase I‐dependent cancer cells.

Authors: Inoue, Manami¹ (AUTHOR), Nakagawa, Yuki¹ (AUTHOR), Azuma, Miku¹ (AUTHOR), Akahane, Haruka¹ (AUTHOR), Chimori, Ryusei¹ (AUTHOR), Mano, Yasunari¹ (AUTHOR), Takasawa, Ryoko¹ (AUTHOR) takasawa@rs.tus.ac.jp

Source: Genes to Cells. Jan2024, Vol. 29 Issue 1, p52-62. 11p.

Subject Terms: *SHIKONIN, *CANCER cells, *GLYOXALASE, *PYRUVATE kinase, *NON-small-cell lung carcinoma

Structural Basis for the Inhibition of SARS-CoV-2 M pro D48N Mutant by Shikonin and PF-07321332.

Authors: Zhao, Zhenyu¹ (AUTHOR) 15729159685@163.com, Zhu, Qinyao² (AUTHOR) zhuqinyao0815@163.com, Zhou, Xuelan¹ (AUTHOR) zhouxuelan0125@163.com, Li, Wenwen¹ (AUTHOR) l18679629911@163.com, Yin, Xiushan² (AUTHOR) xiushanyin@gmail.com, Li, Jian¹ (AUTHOR) xiushanyin@gmail.com

Source: Viruses (1999-4915). Jan2024, Vol. 16 Issue 1, p65. 11p.

Subject Terms: *COVID-19 treatment, *SHIKONIN, *SARS-CoV-2, *DRUG development, *CORONAVIRUSES

Shikonin hastens diabetic wound healing by inhibiting M1 macrophage polarisation through the MAPK signaling pathway.

Authors: Luo, Banxin¹ (AUTHOR), Ding, Xiaofeng^1,2 (AUTHOR), Hu, Yue^1,3 (AUTHOR), Tian, Meng⁴ (AUTHOR), Wu, Junchao² (AUTHOR), Shi, Huan² (AUTHOR), Lu, Xizi⁵ (AUTHOR), Xia, Xuefeng¹ (AUTHOR) danielxuefeng@hotmail.com, Guan, Wenxian¹ (AUTHOR) guanwx2021@126.com, Jiang, Wencheng^1,2 (AUTHOR) jwc3307@163.com

Source: Molecular Immunology. Jan2025, Vol. 177, p73-84. 12p.

Subject Terms: *LABORATORY rats, *SHIKONIN, *WOUND healing, *DIABETES complications, *CELLULAR signal transduction

Pharmacological Effects of Shikonin and Its Potential in Skin Repair: A Review.

Authors: Song, Yanping¹ (AUTHOR) 15083339965@163.com, Ding, Qiteng² (AUTHOR) ding152778@163.com, Hao, Yuewen³ (AUTHOR) w2023@163.com, Cui, Bing³ (AUTHOR) cb1369@126.com, Ding, Chuanbo^1,4 (AUTHOR) chuanboding0506@163.com, Gao, Feng¹ (AUTHOR) chuanboding0506@163.com

Source: Molecules. Dec2023, Vol. 28 Issue 24, p7950. 16p.

Subject Terms: *SHIKONIN, *CHINESE medicine, *REPAIRING, *NAPHTHOQUINONE, *SKIN injuries, *QUINAZOLINONES, *PATHOGENIC bacteria

Zn-Shik-PEG nanoparticles alleviate inflammation and multi-organ damage in sepsis.

Authors: Guo, Jie¹ (AUTHOR), Miao, Yuqing¹ (AUTHOR) miaoyq@sntcm.edu.cn, Nie, Fayi¹ (AUTHOR), Gao, Fei¹ (AUTHOR), Li, Hua¹ (AUTHOR), Wang, Yuan² (AUTHOR), Liu, Qi² (AUTHOR), Zhang, Tingbin³ (AUTHOR), Yang, Xiaohang¹ (AUTHOR), Liu, Li¹ (AUTHOR), Fan, Haiming⁴ (AUTHOR), Wang, Qiang² (AUTHOR) 1511002@sntcm.edu.cn, Qiao, Haifa^1,2 (AUTHOR) 1511006@sntcm.edu.cn

Source: Journal of Nanobiotechnology. 11/25/2023, Vol. 21 Issue 1, p1-13. 13p.

Subject Terms: *SEPSIS, *SHIKONIN, *REACTIVE oxygen species, *NANOPARTICLES

The Biological Assessment of Shikonin and β,β-dimethylacrylshikonin Using a Cellular Myxofibrosarcoma Tumor Heterogeneity Model.

Authors: Lohberger, Birgit¹ (AUTHOR) birgit.lohberger@medunigraz.at, Kaltenegger, Heike¹ (AUTHOR) nicole.eck@medunigraz.at, Eck, Nicole¹ (AUTHOR) dietmar.glaenzer@medunigraz.at, Glänzer, Dietmar¹ (AUTHOR) andreas.leithner@medunigraz.at, Leithner, Andreas¹ (AUTHOR), Kretschmer, Nadine² (AUTHOR)

Source: International Journal of Molecular Sciences. Nov2023, Vol. 24 Issue 21, p15910. 14p.

Subject Terms: *SHIKONIN, *DNA repair, *HETEROGENEITY, *SARCOMA, *CONNECTIVE tissues

Shikonin Suppresses High Glucose-Induced Cardiomyocyte Damage by Down-Regulating circ_0000491.

Authors: LE ZHOU¹ 18018501521@163.com, XIAOHONG GENG¹, QIAN HU¹, JIANI GU¹, YI CHEN¹

Source: Indian Journal of Pharmaceutical Sciences. Nov/Dec2023, Vol. 85 Issue 6, p1725-1730. 6p.

Subject Terms: *SHIKONIN, *REVERSE transcriptase polymerase chain reaction

Shikonin Causes an Apoptotic Effect on Human Kidney Cancer Cells through Ras/MAPK and PI3K/AKT Pathways.

Authors: Király, József¹ (AUTHOR) kiraly.jozsef@pharm.unideb.hu, Szabó, Erzsébet^2,3 (AUTHOR) erzsebet.szabo@med.unideb.hu, Fodor, Petra¹ (AUTHOR) fodor.petra@pharm.unideb.hu, Fejes, Zsolt⁴ (AUTHOR) fejes.zsolt@med.unideb.hu, Nagy Jr., Béla⁴ (AUTHOR) nagy.bela@med.unideb.hu, Juhász, Éva⁵ (AUTHOR) juhasze@med.unideb.hu, Vass, Anna¹ (AUTHOR) vass.anna@pharm.unideb.hu, Choudhury, Mahua⁶ (AUTHOR) mchoudhury@tamu.edu, Kónya, Gábor¹ (AUTHOR) konya.gabor@pharm.unideb.hu, Halmos, Gábor¹ (AUTHOR) halmos.gabor@pharm.unideb.hu, Szabó, Zsuzsanna¹ (AUTHOR) szabo.zsuzsanna@pharm.unideb.hu

Source: Molecules. Sep2023, Vol. 28 Issue 18, p6725. 22p.

Subject Terms: *SHIKONIN, *PI3K/AKT pathway, *RAS oncogenes, *RENAL cancer, *MITOGEN-activated protein kinases, *RAS proteins, *APOPTOSIS, *CANCER cells

Ionic liquid treated cellulose-based intelligent pH-responsive color indicator film, with excellent anti-ultraviolet function.

Authors: An, Nan¹ (AUTHOR), Hu, Jingwan¹ (AUTHOR), Ding, Yun¹ (AUTHOR) dingyun@mail.buct.edu.cn, Sheng, Pinghou² (AUTHOR), Zhang, Zhicheng¹ (AUTHOR), Guo, Xiangrui¹ (AUTHOR)

Source: Journal of Polymer Research. Sep2023, Vol. 30 Issue 9, p1-12. 12p.

Subject Terms: *SHIKONIN, *FOOD packaging, *COLOR, *FREE radicals, *THERMAL stability, *IONIC liquids, *CHROMOGENIC compounds