Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

Authors: Takaaki Akaike, Tomoaki Ida, Fan-Yan Wei, Motohiro Nishida, Yoshito Kumagai, Md. Morshedul Alam, Hideshi Ihara, Tomohiro Sawa, Tetsuro Matsunaga, Shingo Kasamatsu, Akiyuki Nishimura, Masanobu Morita, Kazuhito Tomizawa, Akira Nishimura, Satoshi Watanabe, Kenji Inaba, Hiroshi Shima, Nobuhiro Tanuma, Minkyung Jung, Shigemoto Fujii, Yasuo Watanabe, Masaki Ohmuraya, Péter Nagy, Martin Feelisch, Jon M. Fukuto, Hozumi Motohashi

Source: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/59355d393d744dc18b1812f57d180eae

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis

Authors: Hisyam Abdul Hamid, Akira Tanaka, Tomoaki Ida, Akira Nishimura, Tetsuro Matsunaga, Shigemoto Fujii, Masanobu Morita, Tomohiro Sawa, Jon M. Fukuto, Péter Nagy, Ryouhei Tsutsumi, Hozumi Motohashi, Hideshi Ihara, Takaaki Akaike

Source: Redox Biology, Vol 21, Iss , Pp - (2019)

Subject Terms: Medicine (General), R5-920, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2213231718308553; https://doaj.org/toc/2213-2317

Access URL: https://doaj.org/article/1b2dc593936b4f80bbebc2b8ff87d3c1

Important Role of Endothelial Caveolin-1 in the Protective Role of Endothelium-dependent Hyperpolarization Against Nitric Oxide-Mediated Nitrative Stress in Microcirculation in Mice.

Authors: Hiroki Saito, Shigeo Godo, Saori Sato, Akiyo Ito, Yosuke Ikumi, Shuhei Tanaka, Tomoaki Ida, Shigemoto Fujii, Takaaki Akaike, Hiroaki Shimokawa

Source: Journal of Cardiovascular Pharmacology; Feb2018, Vol. 71 Issue 2, p113-126, 14p

Production of reactive persulfide species in chronic obstructive pulmonary disease.

Authors: Tadahisa Numakura, Hisatoshi Sugiura, Takaaki Akaike, Tomoaki Ida, Shigemoto Fujii, Akira Koarai, Mitsuhiro Yamada, Katsuhiro Onodera, Yuichiro Hashimoto, Rie Tanaka, Kei Sato, Yutaka Shishikura, Taizou Hirano, Satoru Yanagisawa, Naoya Fujino, Tatsuma Okazaki, Tsutomu Tamada, Yasushi Hoshikawa, Yoshinori Okada, Masakazu Ichinose

Source: Thorax; Dec2017, Vol. 72 Issue 12, p1074-1083, 10p

Subject Terms: PERSULFATES, POLYSULFIDES, BIOSYNTHESIS, OBSTRUCTIVE lung diseases, ANTIOXIDANTS, CYSTEINE metabolism, REACTIVE oxygen species, CELL culture, CHEMOKINES, CYTOKINES, GLUTATHIONE, INFLAMMATORY mediators, LUNGS, RESPIRATORY measurements, SMOKING, SPUTUM, SULFIDES, SULFUR compounds, OXIDATIVE stress, VITAL capacity (Respiration), CYSTEINE

Exposure to Electrophiles Impairs Reactive Persulfide-Dependent Redox Signaling in Neuronal Cells.

Authors: Hideshi Ihara, Shingo Kasamatsu, Atsushi Kitamura, Akira Nishimura, Hiroyasu Tsutsuki, Tomoaki Ida, Kento Ishizaki, Takashi Toyama, Eiko Yoshida, Abdul Hamid, Hisyam, Minkyung Jung, Tetsuro Matsunaga, Shigemoto Fujii, Tomohiro Sawa, Motohiro Nishida, Yoshito Kumagai, Takaaki Akaike

Source: Chemical Research in Toxicology; Sep2017, Vol. 30 Issue 9, p1673-1684, 12p

Persistent Activation of cGMP-Dependent Protein Kinase by a Nitrated Cyclic Nucleotide via Site Specific Protein S-Guanylation.

Authors: Soichiro Akashi¹, Ahmed, Khandaker Ahtesham², Tomohiro Sawa^2,3, sawat@kumamoto-u.ac.jp, Katsuhiko Ono², Hiroyasu Tsutsuki², Burgoyne, Joseph R.⁴, Tomoaki Ida¹, Eiji Horio⁵, Prysyazhna, Oleksandra⁴, Yuichi Oike⁵, Rahaman, Mizanur Md.¹, Eaton, Philip⁴, Shigemoto Fujii¹, Takaaki Akaike¹

Source: Biochemistry; 2/9/2016, Vol. 55 Issue 5, p751-761, 11p

Reactive cysteine persulfides and S-polythiolation regulate oxidative stress and redox signaling.

Authors: Tomoaki Ida, Tomohiro Sawa, Hideshi Ihara, Yukihiro Tsuchiya, Yasuo Watanabe, Yoshito Kumagai, Makoto Suematsu, Hozumi Motohashi, Shigemoto Fujii, Tetsuro Matsunaga, Masayuki Yamamoto, Katsuhiko Ono, Devarie-Baez, Nelmi O., Ming Xian, Fukuto, Jon M., Takaaki Akaike

Source: Proceedings of the National Academy of Sciences of the United States of America; 5/27/2014, Vol. 111 Issue 21, p7606-7611, 6p

Subject Terms: CYSTEINE, MAMMAL physiology, OXIDATIVE stress, OXIDATION-reduction reaction, POLYSULFIDES, SMALL molecules, CYSTATHIONINE beta-synthase, CYSTATHIONINE gamma-lyase

Promotion of atherosclerosis by Helicobacter cinaedi infection that involves macrophage-driven proinflammatory responses.

Authors: Khan, Shahzada, Ashiqur Rahman, H. N., Tatsuya Okamoto, Tetsuro Matsunaga, Yukio Fujiwara, Tomohiro Sawa, Jun Yoshitake, Katsuhiko Ono, Ahmed, Khandaker Ahtesham, Rahaman, Md Mizanur, Oyama, Kohta, Motohiro Takeya, Tomoaki Ida, Yoshiaki Kawamura, Shigemoto Fujii, Takaaki Akaike

Source: Scientific Reports; 4/18/2014, p1-12, 12p

Subject Terms: ATHEROSCLEROSIS, HELICOBACTER, MACROPHAGES, HYPERLIPIDEMIA, LABORATORY mice

8-Nitroguanosines as chemical probes of the protein S-guanylationElectronic supplementary information (ESI) available: Preparative procedures for compounds, stability experiments of compounds 7and 8, crystal structure of 7, procedures for the reaction of 8with cell lysate, and for detection of heme oxygenase-1 induction by compounds 1, 2, 7and 8in cells. CCDC 692937. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/b810771h

Authors: Yohei Saito, Hirobumi Taguchi, Shigemoto Fujii, Tomohiro Sawa, Eriko Kida, Chizuko Kabuto, Takaaki Akaike, Hirokazu Arimoto

Source: Chemical Communications; Nov2008, Vol. 2008 Issue 45, p5984-5986, 3p

Subject Terms: NITRO compounds, PROTEIN S, NUCLEOSIDES, CHEMISTRY, CHEMISTRY experiments, CHEMICAL structure, INFORMATION services

Mice Deficient in Angiopoietin-like Protein 2 (Angptl2) Gene Show Increased Susceptibility to Bacterial Infection Due to Attenuated Macrophage Activity.

Authors: Masaki Yugami^1,2, Haruki Odagiri^1,2, Motoyoshi Endo¹ enmoto@gpo.kumamoto-u.ac.jp, Hiroyasu Tsutsuki³, Shigemoto Fujii⁴, Tsuyoshi Kadomatsu¹, Tetsuro Masuda^1,2, Keishi Miyata¹, Kazutoyo Terada¹, Hironori Tanoue^1,2, Hitoshi Ito^1,2, Jun Morinaga¹, Haruki Horiguchi¹, Taichi Sugizaki¹, Takaaki Akaike⁴, Tomomi Gotoh¹, Toshiyuki Takai⁵, Tomohiro Sawa³, Hiroshi Mizuta¹, Yuichi Oike^1,6 oike@gpo.kumamoto-u.ac.jp

Source: Journal of Biological Chemistry. 9/2/2016, Vol. 291 Issue 36, p18843-18852. 10p.

Subject Terms: *ANGIOPOIETIN-like proteins, *BACTERIAL diseases, *MACROPHAGES, *RHEUMATOID arthritis, *LABORATORY mice