Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia

Authors: Kunrong Cheng, Ahmed Chahdi, Shannon M. Larabee, Mazen Tolaymat, Margaret H. Sundel, Cinthia B. Drachenberg, Min Zhan, Shien Hu, Anan H. Said, Aaron C. Shang, Guofeng Xie, Madeline Alizadeh, Natalia Sampaio Moura, Andrea C. Bafford, Richelle T. Williams, Nader N. Hanna, Jean-Pierre Raufman

Source: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://doaj.org/toc/2045-2322

Access URL: https://doaj.org/article/70b4da240da844c3a6164a3fb1096cf6

Muscarinic receptor activation in colon cancer selectively augments pro-proliferative microRNA-21, microRNA-221 and microRNA-222 expression

Authors: Shannon M. Larabee, Kunrong Cheng, Jean-Pierre Raufman, Shien Hu

Source: PLoS ONE, Vol 17, Iss 6 (2022)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9165902/?tool=EBI; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/f28beed2fbcb4cbba6c54b6963f57f48

The microbe-derived short chain fatty acid butyrate targets miRNA-dependent p21 gene expression in human colon cancer.

Authors: Shien Hu, Tien Sy Dong, Sushila R Dalal, Feng Wu, Marc Bissonnette, John H Kwon, Eugene B Chang

Source: PLoS ONE, Vol 6, Iss 1, p e16221 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3024403?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/218a7a8a1c52418298ae8a0da71bd4c7

Butyrate inhibits pro-proliferative miR-92a by diminishing c-Myc-induced miR-17-92a cluster transcription in human colon cancer cells.

Authors: Shien Hu¹, Lan Liu², Eugene B. Chang³, Jian-Ying Wang², Raufman, Jean-Pierre¹ jraufman@medicine.umaryland.edu

Source: Molecular Cancer. 10/13/2015, Vol. 14 Issue 1, p1-15. 15p. 1 Diagram, 8 Graphs.

Subject Terms: *BUTYRATES, *HISTONE deacetylase inhibitors, *COLON cancer risk factors, *CANCER cells, *CELLULAR control mechanisms, *PROLIFERATIVE vitreoretinopathy, *GENETICS

Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, bPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice.

Authors: Kunrong Cheng, Larabee, Shannon M., Tolaymat, Mazen, Hanscom, Marie, Shang, Aaron C., Schledwitz, Alyssa, Shien Hu, Drachenberg, Cinthia B., Min Zhan, Chahdi, Ahmed, Raufman, Jean-Pierre

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology; Apr2021, Vol. 320 Issue 4, pG627-G643, 17p, 7 Graphs

Photosensitive gold-nanoparticle-embedded dielectric nanowires.

Authors: Ming-Shien Hu^1,2, Hsin-Li Chen^3,4, Ching-Hsing Shen⁴, Lu-Sheng Hong¹, Bohr-Ran Huang³, Kuei-Hsien Chen^2,4, Li-Chyong Chen⁴ chenlc@ccms.ntu.edu.tw

Source: Nature Materials. Feb2006, Vol. 5 Issue 2, p102-106. 5p. 4 Black and White Photographs, 1 Diagram, 4 Graphs.

Subject Terms: *NANOPARTICLES, *NANOWIRES, *ELECTRIC wire, *SURFACE plasmon resonance, *PLASMONS (Physics), *MICROREACTORS

Interacting post-muscarinic receptor signaling pathways potentiate matrix metalloproteinase-1 expression and invasion of human colon cancer cells.

Authors: Said, Anan H.¹, Shien Hu¹, Abutaleb, Ameer¹, Watkins, Tonya¹, Kunrong Cheng^1,2, Chahdi, Ahmed¹, Kuppusamy, Panjamurthy¹, Saxena, Neeraj¹, Guofeng Xie^1,2, Raufman, Jean-Pierre^1,2,3 jraufman@medicine.umaryland.edu

Source: Biochemical Journal. 3/1/2017, Vol. 474 Issue 5, p647-665. 19p.

Subject Terms: *MUSCARINIC receptors, *CELLULAR signal transduction, *MATRIX metalloproteinases, *CANCER invasiveness, *COLON cancer treatment, *CANCER cells

Slc10α2-null mice uncover colon cancer-promoting actions of endogenous fecal bile acids.

Authors: Raufman, Jean-Pierre, Dawson, Paul A., Rao, Anuradha, Drachenberg, Cinthia B., Heath, Jonathon, Shang, Aaron C., Shien Hu, Min Zhan, Polli, James E., Kunrong Cheng

Source: Carcinogenesis; Oct2015, Vol. 36 Issue 10, p1193-1200, 8p

Subject Terms: LABORATORY mice, COLON cancer, BILE acids, EPIDEMIOLOGY, PROMOTERS (Genetics)

Regional differences in colonic mucosa-associated microbiota determine the physiological expression of host heat shock proteins.

Authors: Shien Hu¹, Yunwei Wang¹, Lichtenstein, Lev², Yun Tao¹, Musch, Mark W.¹, Jabri, Bana¹, Antonopoulos, Dionysios³, Claud, Erika C.¹, Chang, Eugene B.¹ echang@medicine.bsd.uchicago.edu

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology. Dec2010, Vol. 299, pG1266-G1275. 10p. 9 Color Photographs, 7 Black and White Photographs, 7 Graphs.

Subject Terms: *HEAT shock proteins, *HOMEOSTASIS, *MESSENGER RNA, *INFLAMMATORY bowel diseases, *BACTERIA

Stress granule formation mediates the inhibition of colonic Hsp70 translation by interferon-γ and tumor necrosis factor-α.

Authors: Shien Hu¹, Claud, Erika C.¹, Musch, Mark W.¹, Chang, Eugene B.¹ echang@rnedicine.bsd.uchicago.edu

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology. Apr2010, Vol. 298, pG481-G492. 12p.

Subject Terms: *INFLAMMATORY bowel diseases, *EPITHELIAL cells, *CYTOKINES, *INTERFERONS, *TUMOR necrosis factors, *CYTOPLASMIC granules, *HEAT shock proteins, *PROTEIN kinases, *CELL physiology

Inflammation-induced, 3′UTR-dependent translational inhibition of Hsp70 mRNA impairs intestinal homeostasis.

Authors: Shien Hu¹, Xiaorong Zhu¹, Triggs, Joseph R.¹, Yun Tao¹, Yunwei Wang¹, Lichtenstein, Lev^1,2, Bissonnette, Marc¹, Musch, Mark W.¹, Chang, Eugene B.¹

Source: American Journal of Physiology: Gastrointestinal & Liver Physiology. May2009, Vol. 296, pG1003-G1011. 9p. 1 Color Photograph, 2 Graphs.

Subject Terms: *INFLAMMATION, *RESPONSE inhibition, *MESSENGER RNA, *HOMEOSTASIS, *COLITIS

Anisotropic surface plasmon excitation in Au/silica nanowire.

Authors: Chien-Ting Wu, Ming-Wen Chu, Sheng-Bo Wang, Ming-Shien Hu, Kuei-Hsien Chen, Li-Chyong Chen, Chun-Wei Chen, Cheng-Hsuan Chen

Source: Applied Physics Letters; 6/28/2010, Vol. 96 Issue 26, p263106, 3p, 4 Graphs

Subject Terms: ANISOTROPY, PLASMONS (Physics), GOLD, SILICA, NANOWIRES, SCANNING transmission electron microscopy

Selective-hydrogen sensing at room temperature with Pt-coated InN nanobelts.

Authors: Wantae Lim, Wright, J. S., Gila, B. P., Pearton, S. J., Ren, F., Wei-Ta Lai, Li-Chyong aChen, Ming-Shien Hu, Chen, Kuei-Hsien

Source: Applied Physics Letters; 11/17/2008, Vol. 93 Issue 20, p202109, 3p, 4 Graphs

Subject Terms: HYDROGEN, SOLUTION (Chemistry), SEMICONDUCTOR doping, SEPARATION (Technology), INDUSTRIAL chemistry

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Inducible heat shock protein 70 prevents multifocal flat dysplastic lesions and invasive tumors in an inflammatory model of colon cancer.

Authors: Yun Tao, John Hart, Lev Lichtenstein, Loren J. Joseph, Mae J. Ciancio, Shien Hu, Eugene B. Chang, Marc Bissonnette

Source: Carcinogenesis; Jan2009, Vol. 30 Issue 1, p175-175, 1p

Subject Terms: HEAT shock proteins, GENETICS of colon cancer, DYSPLASIA, CANCER invasiveness, INFLAMMATORY bowel diseases, PROTEIN synthesis, CYCLOOXYGENASE 2, LABORATORY mice, THERAPEUTICS

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