Translocational attenuation mediated by the PERK-SRP14 axis is a protective mechanism of unfolded protein response

Authors: Yaofu Liu, Yuexi Gu, Ying Chen, Xuan Wang, Guangfeng Zhou, Jing Li, Mu Wang, Shengyun Fang, Yili Yang

Source: Cell Reports, Vol 43, Iss 7, Pp 114402- (2024)

Subject Terms: CP: Molecular biology, Biology (General), QH301-705.5

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Relation: http://www.sciencedirect.com/science/article/pii/S2211124724007307; https://doaj.org/toc/2211-1247

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Auranofin targets UBA1 and enhances UBA1 activity by facilitating ubiquitin trans-thioesterification to E2 ubiquitin-conjugating enzymes

Authors: Wenjing Yan, Yongwang Zhong, Xin Hu, Tuan Xu, Yinghua Zhang, Stephen Kales, Yanyan Qu, Daniel C. Talley, Bolormaa Baljinnyam, Christopher A. LeClair, Anton Simeonov, Brian M. Polster, Ruili Huang, Yihong Ye, Ganesha Rai, Mark J. Henderson, Dingyin Tao, Shengyun Fang

Source: Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f3f674c5f7b14cfbb5a8b35c4adc9a3f

BAF45D regulates spinal cord neural stem/progenitor cell fate through the SMAD-PAX6 axis

Authors: Xueying Chen, Xiujuan Hu, Jing Jiang, Jie Tao, Lihua Liu, Shengyun Fang, Yuxian Shen, Qingsong Hu, Chao Liu

Source: Genes and Diseases, Vol 10, Iss 2, Pp 366-369 (2023)

Subject Terms: Medicine (General), R5-920, Genetics, QH426-470

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Relation: http://www.sciencedirect.com/science/article/pii/S2352304222001416; https://doaj.org/toc/2352-3042

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Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects against Aβ toxicity via attenuating Aβ-induced endoplasmic reticulum stress

Authors: Shengchun Xu, Zemin Di, Yufeng He, Runjie Wang, Yuyang Ma, Rui Sun, Jing Li, Tao Wang, Yujun Shen, Shengyun Fang, Lijie Feng, Yuxian Shen

Source: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

Subject Terms: MANF, β-amyloid, Alzheimer’s disease, ER stress, Apoptosis, Neurology. Diseases of the nervous system, RC346-429

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12974-019-1429-0; https://doaj.org/toc/1742-2094

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Regulation of p27 (Kip1) by Ubiquitin E3 Ligase RNF6

Authors: Dhanraj Deshmukh, Jin Xu, Xi Yang, Hermela Shimelis, Shengyun Fang, Yun Qiu

Source: Pharmaceutics, Vol 14, Iss 4, p 802 (2022)

Subject Terms: RNF6, p27, cell cycle, prostate cancer, Pharmacy and materia medica, RS1-441

File Description: electronic resource

Relation: https://www.mdpi.com/1999-4923/14/4/802; https://doaj.org/toc/1999-4923

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Data in support of DPF2 regulates OCT4 protein level and nuclear distribution

Authors: Chao Liu, Dijuan Zhang, Yuxian Shen, Xiaofang Tao, Lihua Liu, Yongwang Zhong, Shengyun Fang

Source: Data in Brief, Vol 5, Iss C, Pp 599-604 (2015)

Subject Terms: Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390

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Relation: http://www.sciencedirect.com/science/article/pii/S2352340915002589; https://doaj.org/toc/2352-3409

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Nuclear export of misfolded SOD1 mediated by a normally buried NES-like sequence reduces proteotoxicity in the nucleus

Authors: Yongwang Zhong, Jiou Wang, Mark J Henderson, Peixin Yang, Brian M Hagen, Teepu Siddique, Bruce E Vogel, Han-Xiang Deng, Shengyun Fang

Source: eLife, Vol 6 (2017)

Subject Terms: SOD1, protein misfolding, ALS, cytotoxicity, nuclear export signal, C. elegans, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/23759; https://doaj.org/toc/2050-084X

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The Role of Crosstalk between AR3 and E2F1 in Drug Resistance in Prostate Cancer Cells

Authors: Jin Xu, Xi Yang, Dhanraj Deshmukh, Hegang Chen, Shengyun Fang, Yun Qiu

Source: Cells, Vol 9, Iss 5, p 1094 (2020)

Subject Terms: prostate cancer, combination therapy, drug resistance, androgen receptor splicing variants, E2F1, auranofin, Cytology, QH573-671

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4409/9/5/1094; https://doaj.org/toc/2073-4409

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Spatiotemporal expression of MANF in the developing rat brain.

Authors: Haiping Wang, Zunji Ke, Alexander Alimov, Mei Xu, Jacqueline A Frank, Shengyun Fang, Jia Luo

Source: PLoS ONE, Vol 9, Iss 2, p e90433 (2014)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0090433&type=printable; https://doaj.org/toc/1932-6203

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Correction: Ubiquitination-Induced Fluorescence Complementation (UiFC) for Detection of K48 Ubiquitin Chains and in Live Cells.

Authors: Zhiliang Chen, Yongwang Zhong, Yang Wang, Shan Xu, Zheng Liu, Ilia V. Baskakov, Mervyn J. Monteiro, Mariusz Karbowski, Yuxian Shen, Shengyun Fang

Source: PLoS ONE, Vol 8, Iss 9 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3781205; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/99f9a241993545ed986a0d2252d5ce56

Ubiquitination-induced fluorescence complementation (UiFC) for detection of K48 ubiquitin chains in vitro and in live cells.

Authors: Zhiliang Chen, Yongwang Zhong, Yang Wang, Shan Xu, Zheng Liu, Ilia V Baskakov, Mervyn J Monteiro, Mariusz Karbowski, Yuxian Shen, Shengyun Fang

Source: PLoS ONE, Vol 8, Iss 9, p e73482 (2013)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3764048?pdf=render; https://doaj.org/toc/1932-6203

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SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.

Authors: Yang Wang, Petek Ballar, Yongwang Zhong, Xuebao Zhang, Chao Liu, Ying-Jiu Zhang, Mervyn J Monteiro, Jun Li, Shengyun Fang

Source: PLoS ONE, Vol 6, Iss 8, p e24478 (2011)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3164199?pdf=render; https://doaj.org/toc/1932-6203

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Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP.

Authors: Hui Yang, Chao Liu, Yongwang Zhong, Shouqing Luo, Mervyn J Monteiro, Shengyun Fang

Source: PLoS ONE, Vol 5, Iss 1, p e8905 (2010)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC2811200?pdf=render; https://doaj.org/toc/1932-6203

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1α,25-Dihydroxyvitamin D3 up-regulates IL-34 expression in SH-SY5Y neural cells.

Authors: Dong Zhang, Miaomiao Li, Yang Dong, Xinhui Zhang, Xingyun Liu, Zhangming Chen, Yongji Zhu, Huiming Wang, Xuwen Liu, Jialiang Zhu, Yujun Shen, Korner, Heinrich, Songcheng Ying, Shengyun Fang, Yuxian Shen

Source: Innate Immunity; Oct2017, Vol. 23 Issue 7, p584-591, 8p

Subject Terms: GENE expression, IMMUNE response, ALZHEIMER'S disease, CELL lines, SENILE dementia

Androgen Receptor Regulates the Growth of Neuroblastoma Cells in vitro and in vivo.

Authors: Junyan Sun, Dongmei Wang, Lianying Guo, Shengyun Fang, Yang Wang, Rong Xing

Source: Frontiers in Neuroscience; 3/7/2017, Vol. 11, p1-11, 11p

Subject Terms: NEUROBLASTOMA, ANDROGEN receptors, CANCER cell growth, PHYSIOLOGY

High Glucose-Repressed CITED2 Expression Through miR-200b Triggers the Unfolded Protein Response and Endoplasmic Reticulum Stress.

Authors: Hui Gu, Jingwen Yu, Daoyin Dong, Qun Zhou, Jian-Ying Wang, Shengyun Fang, Peixin Yang, Gu, Hui, Yu, Jingwen, Dong, Daoyin, Zhou, Qun, Wang, Jian-Ying, Fang, Shengyun, Yang, Peixin

Source: Diabetes; Jan2016, Vol. 65 Issue 1, p149-163, 15p, 8 Graphs

Subject Terms: ENDOPLASMIC reticulum, PROTEINS, GLUCOSE, NEURAL tube defects, MICRORNA, GENE expression, GENETIC overexpression, SUPEROXIDE dismutase, PROTEIN metabolism, RNA metabolism, ANIMAL experimentation, APOPTOSIS, BLOOD sugar, DIABETES, GENETIC techniques, IMMUNOBLOTTING, MICE, RESEARCH funding, RNA, STEM cells, EMBRYOS, CARBOCYCLIC acids, IN vitro studies

Ask1 Gene Deletion Blocks Maternal Diabetes-Induced Endoplasmic Reticulum Stress in the Developing Embryo by Disrupting the Unfolded Protein Response Signalosome.

Authors: Fang Wang, Yanqing Wu, Hui Gu, Reece, E. Albert, Shengyun Fang, Gabbay-Benziv, Rinat, Aberdeen, Graham, Peixin Yang

Source: Diabetes; Mar2015, Vol. 64 Issue 3, p973-988, 16p, 1 Black and White Photograph, 1 Diagram, 3 Charts, 6 Graphs

Subject Terms: APOPTOSIS, PROTEIN kinases, ENDOPLASMIC reticulum, PHOSPHORYLATION, INOSITOL, PROTEIN binding

Live Cell Imaging of Protein Dislocation from the Endoplasmic Reticulum.

Authors: Yongwang Zhong¹, Shengyun Fang^1,2 sfang@umaryland.edu

Source: Journal of Biological Chemistry. 8/10/2012, Vol. 287 Issue 33, p28057-28066. 10p.

Subject Terms: *ENDOPLASMIC reticulum, *CYTOPLASM, *ANTITOXINS, *BACTERIAL toxins, *BACTERIAL antigens

Upregulation of mesencephalic astrocyte-derived neurotrophic factor in glial cells is associated with ischemia-induced glial activation.

Authors: Yujun Shen, Aimin Sun, Yunhong Wang, Daqin Cha, Haiping Wang, Facai Wang, Lijie Feng, Shengyun Fang, Yuxian Shen

Source: Journal of Neuroinflammation; 2012, Vol. 9 Issue 1, p1-13, 13p

Subject Terms: NEUROTROPHINS, ANIMAL models of cerebral ischemia, NEUROGLIA, ENDOPLASMIC reticulum, PROPIDIUM iodide

The ubiquitin ligase Hrd1 promotes degradation of the Z variant alpha 1-antitrypsin and increases its solubility.

Authors: Haiping Wang, Qi Li, Yujun Shen, Aimin Sun, Xiaoguang Zhu, Shengyun Fang, Yuxian Shen

Source: Molecular & Cellular Biochemistry; Jan2011, Vol. 346 Issue 1/2, p137-145, 9p