Dynamics of the mammalian pyruvate dehydrogenase complex revealed by in-situ structural analysis

Authors: Chen Wang, Cheng Ma, Yuanyou Xu, Shenghai Chang, Hangjun Wu, Chunlan Yan, Jinghua Chen, Yongping Wu, Shaoya An, Jiaqi Xu, Qin Han, Yujie Jiang, Zhinong Jiang, Xiakun Chu, Haichun Gao, Xing Zhang, Yunjie Chang

Source: Nature Communications, Vol 16, Iss 1, Pp 1-15 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f2313de0377047058bebe39bf12e12a5

Structural insights into the activation mechanism of the human zinc-activated channel

Authors: Xuhang Lu, Dongmei Li, Yaojie Wang, Gaohua Zhang, Tianlei Wen, Yue Lu, Nan Jia, Xuedi Wang, Shenghai Chang, Xing Zhang, Jianping Lin, Yu-hang Chen, Xue Yang, Yuequan Shen

Source: Nature Communications, Vol 16, Iss 1, Pp 1-12 (2025)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f9230a11f2304c78918c83c5b568f45c

Deciphering the molecular basis of lipoprotein recognition and transport by LolCDE

Authors: Wen Qiao, Chongrong Shen, Yujiao Chen, Shenghai Chang, Xin Wang, Lili Yang, Jie Pang, Qinghua Luo, Zhibo Zhang, Yingxin Xiang, Chao Zhao, Guangwen Lu, Bi-Sen Ding, Binwu Ying, Xiaodi Tang, Haohao Dong

Source: Signal Transduction and Targeted Therapy, Vol 9, Iss 1, Pp 1-12 (2024)

Subject Terms: Medicine, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/2059-3635

Access URL: https://doaj.org/article/b66c6b0810f74304bf3894a88112c39c

Structural insights into the mechanotransducing mechanism of FtsEX in cell division

Authors: Yuejia Chen, Du Guo, Xin Wang, Changbin Zhang, Yatian Chen, Qinghua Luo, Yujiao Chen, Lili Yang, Zhibo Zhang, Tian Hong, Zhengyu Zhang, Haohao Dong, Shenghai Chang, Jianping Hu, Xiaodi Tang

Source: MedComm, Vol 5, Iss 11, Pp n/a-n/a (2024)

Subject Terms: ABC transporter, cell division, EnvC, FtsEX, mechanotransmission, Medicine

File Description: electronic resource

Relation: https://doaj.org/toc/2688-2663

Access URL: https://doaj.org/article/1217d081d0d04c89b4fa30fb5ecf0160

Structural insights into the activation of the divisome complex FtsWIQLB

Authors: Lili Yang, Yujiao Chen, Shenghai Chang, Chongrong Shen, Xin Wang, Changbin Zhang, Zhibo Zhang, Bi-Sen Ding, Zhaoming Su, Haohao Dong, Xiaodi Tang

Source: Cell Discovery, Vol 10, Iss 1, Pp 1-4 (2024)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2056-5968

Access URL: https://doaj.org/article/ca1549239e954489b63533e1395dc614

Molecular basis of Mg2+ permeation through the human mitochondrial Mrs2 channel

Authors: Ming Li, Yang Li, Yue Lu, Jianhui Li, Xuhang Lu, Yue Ren, Tianlei Wen, Yaojie Wang, Shenghai Chang, Xing Zhang, Xue Yang, Yuequan Shen

Source: Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/f0da641f058c4958b961818bb7a655f2

Structural basis of ligand activation and inhibition in a mammalian TRPV4 ion channel

Authors: Wenxuan Zhen, Zhijun Zhao, Shenghai Chang, Xiaoying Chen, Yangzhuoqun Wan, Fan Yang

Source: Cell Discovery, Vol 9, Iss 1, Pp 1-4 (2023)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: https://doaj.org/toc/2056-5968

Access URL: https://doaj.org/article/f93e68f5717649319e3edee197a3198b

Structures of the human Wilson disease copper transporter ATP7B

Authors: Guo-Min Yang, Lingyi Xu, Rou-Min Wang, Xin Tao, Zi-Wei Zheng, Shenghai Chang, Demin Ma, Cheng Zhao, Yi Dong, Shan Wu, Jiangtao Guo, Zhi-Ying Wu

Source: Cell Reports, Vol 42, Iss 5, Pp 112417- (2023)

Subject Terms: CP: Molecular biology, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S221112472300428X; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/e29daa0be93d41c7b0b4f82ddf3eac23

Cooperative transport mechanism of human monocarboxylate transporter 2

Authors: Bo Zhang, Qiuheng Jin, Lizhen Xu, Ningning Li, Ying Meng, Shenghai Chang, Xiang Zheng, Jiangqin Wang, Yuan Chen, Dante Neculai, Ning Gao, Xiaokang Zhang, Fan Yang, Jiangtao Guo, Sheng Ye

Source: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/d0c087436b35421cba015b279372e1cf

Cryo-EM structures of lipopolysaccharide transporter LptB2FGC in lipopolysaccharide or AMP-PNP-bound states reveal its transport mechanism

Authors: Xiaodi Tang, Shenghai Chang, Qinghua Luo, Zhengyu Zhang, Wen Qiao, Caihuang Xu, Changbin Zhang, Yang Niu, Wenxian Yang, Ting Wang, Zhibo Zhang, Xiaofeng Zhu, Xiawei Wei, Changjiang Dong, Xing Zhang, Haohao Dong

Source: Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/b2966fc978dc4035a64b64637481ce2f

Structural basis of Q-dependent transcription antitermination

Authors: Jing Shi, Xiang Gao, Tongguan Tian, Zhaoyang Yu, Bo Gao, Aijia Wen, Linlin You, Shenghai Chang, Xing Zhang, Yu Zhang, Yu Feng

Source: Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/7e9689354b724ad5a73fd6c510dd9e7b

Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Authors: Demeng Sun, Sanling Liu, Siyu Li, Mengge Zhang, Fan Yang, Ming Wen, Pan Shi, Tao Wang, Man Pan, Shenghai Chang, Xing Zhang, Longhua Zhang, Changlin Tian, Lei Liu

Source: eLife, Vol 9 (2020)

Subject Terms: acid-sensing ion channel, snake toxin, cryo-EM structure, inhibition, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/57096; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/2800ac3a272d42a5ad5196853cf4e158

Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors

Authors: Jin-Bao Zhang, Shenghai Chang, Pan Xu, Miao Miao, Hangjun Wu, Youyi Zhang, Tongtong Zhang, Han Wang, Jilin Zhang, Chun Xie, Nan Song, Cheng Luo, Xing Zhang, Shujia Zhu

Source: Cell Reports, Vol 25, Iss 13, Pp 3582-3590.e4 (2018)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124718318473; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/a565a9a6302a48e2aa920e3aff00d2fb

Screen anti-influenza lead compounds that target the PA(C) subunit of H5N1 viral RNA polymerase.

Authors: Lin Li, Shenghai Chang, Junfeng Xiang, Qian Li, Huanhuan Liang, Yalin Tang, Yingfang Liu

Source: PLoS ONE, Vol 7, Iss 8, p e35234 (2012)

Subject Terms: Medicine, Science

File Description: electronic resource

Relation: http://europepmc.org/articles/PMC3427309?pdf=render; https://doaj.org/toc/1932-6203

Access URL: https://doaj.org/article/7aea93506e3a499bb4312b1a9a3cec38

Structures and an activation mechanism of human potassium-chloride cotransporters.

Authors: Yuan Xie¹, Shenghai Chang^1,2, Cheng Zhao¹, Feng Wang³, Si Liu⁴, Jin Wang⁵, Delpire, Eric⁶ eric.delpire@vanderbilt.edu, Sheng Ye^4,7 sye@tju.edu.cn, Jiangtao Guo^1,8 jiangtaoguo@zju.edu.cn

Source: Science Advances. 12/9/2020, Vol. 6 Issue 50, p1-10. 10p.

Subject Terms: *LABORATORY management, *GLYCINE, *GLYCINE receptors, *TYROSINE, *FLUORESCENCE resonance energy transfer

Cryo-EM structures of the human cation-chloride cotransporter KCC1.

Authors: Si Liu^1,2, Shenghai Chang^1,3, Binming Han⁴, Lingyi Xu^1,5, Mingfeng Zhang⁶, Cheng Zhao^1,6, Wei Yang⁶, Feng Wang⁷, Jingyuan Li⁴ jiangtaoguo@zju.edu.cn, Delpire, Eric⁸ eric.delpire@vanderbilt.edu, Sheng Ye^2,5 sye@tju.edu.cn, Xiao-chen Bai⁹ xiaochen.bai@utsouthwestern.edu, Jiangtao Guo^1,6 jingyuanli@zju.edu.cn

Source: Science. 10/25/2019, Vol. 366 Issue 6464, p505-508. 4p. 4 Diagrams.

Subject Terms: *CRYOELECTRONICS, *MEMBRANE transport proteins, *POTASSIUM chloride, *DIMERIZATION, *HYPOTONIC solutions

Structure of a C2S2M2N2-type PSII-LHCII supercomplex from the green alga Chlamydomonas reinhardtii.

Authors: Liangliang Shen^1,2, Zihui Huang^3,4,5, Shenghai Chang^3,4,5, Wenda Wang¹, Jingfen Wang⁶, Tingyun Kuang¹, Guangye Han¹, hanguangye@ibcas.ac.cn, Jian-Ren Shen^1,7,8, shen@cc.okayama-u.ac.jp, Xing Zhang^3,4,5,6, xzhang1999@zju.edu.cn

Source: Proceedings of the National Academy of Sciences of the United States of America; Oct2019, Vol. 116 Issue 42, p21246-21255, 10p

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Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase.

Authors: Lin Li, Shenghai Chang, Junfeng Xiang, Qian Li, Huanhuan Liang, Yalin Tang, Yingfang Liu, Liu, Jun

Source: PLoS ONE; Aug2012, Vol. 7 Issue 8, Special section p1-7, 7p

Subject Terms: AVIAN influenza, POLYMERASES, CHLOROGENIC acid, RNA polymerases, INFLUENZA, COMMUNICABLE diseases

Cryo-EM structure of the heptameric calcium homeostasis modulator 1 channel.

Authors: Yue Ren¹, Yang Li¹, Yaojie Wang¹, Tianlei Wen¹, Xuhang Lu¹, Shenghai Chang^2,3,4, Xing Zhang^2,3,4, Yuequan Shen¹ yshen@nankai.edu.cn, Xue Yang⁵ yangxue@nankai.edu.cn

Source: Journal of Biological Chemistry. May2022, Vol. 298 Issue 5, p1-10. 10p.

Subject Terms: *MOLECULAR dynamics, *HOMEOSTASIS, *ZEBRA danio, *CALCIUM, *MOLECULAR size