RAS-RAF-miR-296-3p signaling axis increases Rad18 expression to augment radioresistance in pancreatic and thyroid cancers

Authors: Wolfe, Adam R., Feng, Haihua, Zuniga, Oscar, Rodrigues, Henrique, Eldridge, Daniel E., Yang, Linlin, Shen, Changxian, Williams, Terence M.

Source: In Cancer Letters 1 June 2024 591

Inhibition of RRM2 radiosensitizes glioblastoma and uncovers synthetic lethality in combination with targeting CHK1

Authors: Corrales-Guerrero, Sergio, Cui, Tiantian, Castro-Aceituno, Veronica, Yang, Linlin, Nair, Sindhu, Feng, Haihua, Venere, Monica, Yoon, Stephanie, DeWees, Todd, Shen, Changxian, Williams, Terence M.

Source: In Cancer Letters 28 August 2023 570

Regulation of DNA duplication by the mTOR signaling pathway

Authors: He, Zhengfu, Houghton, Peter J., Williams, Terence M., Shen, Changxian

Source: Cell cycle. 20(8):742-751

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100121042415.0x000001&indx=1&recIds=ETOCvdc_100121042415.0x000001

MTOR Signaling Upregulates CDC6 via Suppressing miR-3178 and Promotes the Loading of DNA Replication Helicase

Authors: Wu, Xianjin, Li, Shenghua, Hu, Xing, Xiang, Xiaoliang, Halloran, Megan, Yang, Linlin, Williams, Terence, Houghton, Peter, Shen, Changxian, He, Zhengfu

Source: Scientific reports. 9(1):1-8

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100184294517.0x000001&indx=1&recIds=ETOCvdc_100184294517.0x000001

Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia

Authors: Papaioannou, Dimitrios, Shen, Changxian, Nicolet, Deedra, McNeil, Betina, Bill, Marius, Karunasiri, Malith, Burke, Matthew H., Ozer, Hatice Gulcin, Yilmaz, Selen A., Zitzer, Nina, Behbehani, Gregory K., Oakes, Christopher C., Steiner, Damian J., Marcucci, Guido, Powell, Bayard L., Kolitz, Jonathan E., Carter, Thomas H., Wang, Eunice S., Mrózek, Krzysztof, Croce, Carlo M., Caligiuri, Michael A., Bloomfield, Clara D., Garzon, Ramiro, Dorrance, Adrienne M.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2017 Jun 01. 114(23), E4641-E4647.

Access URL: https://www.jstor.org/stable/26484170

Regulation of CHK1 by mTOR contributes to the evasion of DNA damage barrier of cancer cells

Authors: Zhou, Xinhui, Liu, Weijin, Hu, Xing, Dorrance, Adrienne, Garzon, Ramiro, Houghton, Peter, Shen, Changxian

Source: Scientific reports. 7(1):1-13

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174092383.0x000001&indx=1&recIds=ETOCvdc_100174092383.0x000001

A PI3K gene expression signature predicts for recurrence in early‐stage non–small cell lung cancer treated with stereotactic body radiation therapy.

Authors: Sebastian, Nikhil T., Webb, Amy, Shilo, Konstantin, Robb, Ryan, Xu‐Welliver, Meng, Haglund, Karl, Brownstein, Jeremy, DeNicola, Gina M., Shen, Changxian, Williams, Terence M.

Source: Cancer (0008543X); 12/15/2023, Vol. 129 Issue 24, p3971-3977, 7p

Subject Terms: STEREOTACTIC radiotherapy, NON-small-cell lung carcinoma, CANCER relapse, PHOSPHATIDYLINOSITOL 3-kinases, GENE expression, DISEASE risk factors

The mTOR pathway negatively controls ATM by up-regulating miRNAs

Authors: Shen, Changxian, Houghton, Peter J.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2013 Jul . 110(29), 11869-11874.

Access URL: https://www.jstor.org/stable/42712494

Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo

Authors: Caserta, Enrico, Egriboz, Onur, Wang, Hui, Martin, Chelsea, Koivisto, Christopher, Pecót, Thierry, Kladney, Raleigh D., Shen, Changxian, Shim, Kang-Sup, Pham, Thac

Source: Genes & development. 29(16):1707-1720

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN602682972&indx=1&recIds=ETOCRN602682972

Molecular imaging of proliferation in vivo: Positron emission tomography with [ 18F]fluorothymidine

Authors: Buck, Andreas K., Herrmann, Ken, Shen, Changxian, Dechow, Tobias, Schwaiger, Markus, Wester, Hans-Jürgen

Source: In Methods 2009 48(2):205-215

Gene silencing by adenovirus-delivered siRNA

Authors: Shen, Changxian, Buck, Andreas K, Liu, Xiangwei, Winkler, Michael, Reske, Sven N

Source: In FEBS Letters 2003 539(1):111-114

Oncogenic KRAS drives radioresistance through upregulation of NRF2-53BP1-mediated non-homologous end-joining repair.

Authors: Yang, Linlin, Shen, Changxian, Estrada-Bernal, Adriana, Robb, Ryan, Chatterjee, Moumita, Sebastian, Nikhil, Webb, Amy, Mo, Xiaokui, Chen, Wei, Krishnan, Sunil, Williams, Terence M

Source: Nucleic Acids Research; 11/8/2021, Vol. 49 Issue 19, p11067-11082, 16p

Triplex-forming oligodeoxynucleotides targeting survivin inhibit proliferation and induce apoptosis of human lung carcinoma cells.

Authors: Shen, Changxian, Buck, Andreas, Polat, Bulent, Schmid-Kotsas, Alexandra, Matuschek, Christiane, Gross, Hans-Juergen, Bachem, Max, Reske, Sven N

Source: Cancer Gene Therapy. Mar2003, Vol. 10 Issue 5, p403. 8p.

Subject Terms: *NUCLEOTIDES, *LUNG cancer, *APOPTOSIS

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EGFL7 Antagonizes NOTCH Signaling and Represents a Novel Therapeutic Target in Acute Myeloid Leukemia (AML)

Authors: Bill, Marius ^*, Pathmanathan, Aparna ^*, Karunasiri, Malith ^*, Shen, Changxian ^*, Burke, Matthew ^*, Ranganathan, Parvathi, Papaioannou, Dimitrios ^*, Zitzer, Nina C. ^*, Snyder, Katiri ^*, LaRocco, Allison ^*, Walker, Allison ^*, Brannan, Zachary ^*, Nalin, Ansel P. ^*, Freud, Aharon G., Dikov, Mikhail ^*, Zhang, Xiaoli ^*, Bloomfield, Clara D., Garzon, Ramiro, Dorrance, Adrienne M.

Source: In Blood 13 November 2019 134 Supplement 1:2546-2546

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