Outer membrane protein assembly mediated by BAM-SurA complexes

Authors: Katherine L. Fenn, Jim E. Horne, Joel A. Crossley, Nils Böhringer, Romany J. Horne, Till F. Schäberle, Antonio N. Calabrese, Sheena E. Radford, Neil A. Ranson

Source: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Dual client binding sites in the ATP-independent chaperone SurA

Authors: Bob Schiffrin, Joel A. Crossley, Martin Walko, Jonathan M. Machin, G. Nasir Khan, Iain W. Manfield, Andrew J. Wilson, David J. Brockwell, Tomas Fessl, Antonio N. Calabrese, Sheena E. Radford, Anastasia Zhuravleva

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Single molecule delivery into living cells

Authors: Chalmers C. Chau, Christopher M. Maffeo, Aleksei Aksimentiev, Sheena E. Radford, Eric W. Hewitt, Paolo Actis

Source: Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Local structural preferences in shaping tau amyloid polymorphism

Authors: Nikolaos Louros, Martin Wilkinson, Grigoria Tsaka, Meine Ramakers, Chiara Morelli, Teresa Garcia, Rodrigo Gallardo, Sam D’Haeyer, Vera Goossens, Dominique Audenaert, Dietmar Rudolf Thal, Ian R. Mackenzie, Rosa Rademakers, Neil A. Ranson, Sheena E. Radford, Frederic Rousseau, Joost Schymkowitz

Source: Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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The in-tissue molecular architecture of β-amyloid pathology in the mammalian brain

Authors: Conny Leistner, Martin Wilkinson, Ailidh Burgess, Megan Lovatt, Stanley Goodbody, Yong Xu, Susan Deuchars, Sheena E. Radford, Neil A. Ranson, René A. W. Frank

Source: Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Disease-relevant β2-microglobulin variants share a common amyloid fold

Authors: Martin Wilkinson, Rodrigo U. Gallardo, Roberto Maya Martinez, Nicolas Guthertz, Masatomo So, Liam D. Aubrey, Sheena E. Radford, Neil A. Ranson

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein

Authors: Sabine M. Ulamec, Roberto Maya-Martinez, Emily J. Byrd, Katherine M. Dewison, Yong Xu, Leon F. Willis, Frank Sobott, George R. Heath, Patricija van Oosten Hawle, Vladimir L. Buchman, Sheena E. Radford, David J. Brockwell

Source: Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/795dea3b15b941688aa5f281361c1332

Trigger factor both holds and folds its client proteins

Authors: Kevin Wu, Thomas C. Minshull, Sheena E. Radford, Antonio N. Calabrese, James C. A. Bardwell

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Dynamic interplay between the periplasmic chaperone SurA and the BAM complex in outer membrane protein folding

Authors: Bob Schiffrin, Jonathan M. Machin, Theodoros K. Karamanos, Anastasia Zhuravleva, David J. Brockwell, Sheena E. Radford, Antonio N. Calabrese

Source: Communications Biology, Vol 5, Iss 1, Pp 1-15 (2022)

Subject Terms: Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/2399-3642

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Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

Authors: Yong Xu, Roberto Maya-Martinez, Nicolas Guthertz, George R. Heath, Iain W. Manfield, Alexander L. Breeze, Frank Sobott, Richard Foster, Sheena E. Radford

Source: Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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The role of membrane destabilisation and protein dynamics in BAM catalysed OMP folding

Authors: Paul White, Samuel F. Haysom, Matthew G. Iadanza, Anna J. Higgins, Jonathan M. Machin, James M. Whitehouse, Jim E. Horne, Bob Schiffrin, Charlotte Carpenter-Platt, Antonio N. Calabrese, Kelly M. Storek, Steven T. Rutherford, David J. Brockwell, Neil A. Ranson, Sheena E. Radford

Source: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Distortion of the bilayer and dynamics of the BAM complex in lipid nanodiscs

Authors: Matthew G. Iadanza, Bob Schiffrin, Paul White, Matthew A. Watson, Jim E. Horne, Anna J. Higgins, Antonio N. Calabrese, David J. Brockwell, Roman Tuma, Antreas C. Kalli, Sheena E. Radford, Neil A. Ranson

Source: Communications Biology, Vol 3, Iss 1, Pp 1-14 (2020)

Subject Terms: Biology (General), QH301-705.5

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Relation: https://doaj.org/toc/2399-3642

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Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients

Authors: Antonio N. Calabrese, Bob Schiffrin, Matthew Watson, Theodoros K. Karamanos, Martin Walko, Julia R. Humes, Jim E. Horne, Paul White, Andrew J. Wilson, Antreas C. Kalli, Roman Tuma, Alison E. Ashcroft, David J. Brockwell, Sheena E. Radford

Source: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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An in vivo platform to select and evolve aggregation-resistant proteins

Authors: Jessica S. Ebo, Janet C. Saunders, Paul W. A. Devine, Alice M. Gordon, Amy S. Warwick, Bob Schiffrin, Stacey E. Chin, Elizabeth England, James D. Button, Christopher Lloyd, Nicholas J. Bond, Alison E. Ashcroft, Sheena E. Radford, David C. Lowe, David J. Brockwell

Source: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Generating Ensembles of Dynamic Misfolding Proteins

Authors: Theodoros K. Karamanos, Arnout P. Kalverda, Sheena E. Radford

Source: Frontiers in Neuroscience, Vol 16 (2022)

Subject Terms: ensemble calculations, protein misfolding, machine learning, intrinsic disorder, oligomerization, NMR spectroscopy, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: https://www.frontiersin.org/articles/10.3389/fnins.2022.881534/full; https://doaj.org/toc/1662-453X

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Looking Beyond the Core: The Role of Flanking Regions in the Aggregation of Amyloidogenic Peptides and Proteins

Authors: Sabine M. Ulamec, David J. Brockwell, Sheena E. Radford

Source: Frontiers in Neuroscience, Vol 14 (2020)

Subject Terms: flanking region, amyloid, synuclein, fuzzy coat, aggregation, Tau, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: https://www.frontiersin.org/articles/10.3389/fnins.2020.611285/full; https://doaj.org/toc/1662-453X

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Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection

Authors: Madeleine R. Brown, Sheena E. Radford, Eric W. Hewitt

Source: Frontiers in Molecular Neuroscience, Vol 13 (2020)

Subject Terms: β-amyloid, Aβ, amyloid fibril, amyloid plaques, Alzheimer’s disease, infection, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

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Relation: https://www.frontiersin.org/articles/10.3389/fnmol.2020.609073/full; https://doaj.org/toc/1662-5099

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The uniqueness of flow in probing the aggregation behavior of clinically relevant antibodies

Authors: Leon F. Willis, Amit Kumar, Tushar Jain, Isabelle Caffry, Yingda Xu, Sheena E. Radford, Nikil Kapur, Maximiliano Vásquez, David J. Brockwell

Source: Engineering Reports, Vol 2, Iss 5, Pp n/a-n/a (2020)

Subject Terms: aggregation, developability, extensional flow, monoclonal antibody, shear flow, Engineering (General). Civil engineering (General), TA1-2040, Electronic computers. Computer science, QA75.5-76.95

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Relation: https://doaj.org/toc/2577-8196

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The structure of a β2-microglobulin fibril suggests a molecular basis for its amyloid polymorphism

Authors: Matthew G. Iadanza, Robert Silvers, Joshua Boardman, Hugh I. Smith, Theodoros K. Karamanos, Galia T. Debelouchina, Yongchao Su, Robert G. Griffin, Neil A. Ranson, Sheena E. Radford

Source: Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)

Subject Terms: Science

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Relation: https://doaj.org/toc/2041-1723

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Outer membrane protein folding from an energy landscape perspective

Authors: Bob Schiffrin, David J. Brockwell, Sheena E. Radford

Source: BMC Biology, Vol 15, Iss 1, Pp 1-16 (2017)

Subject Terms: Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://link.springer.com/article/10.1186/s12915-017-0464-5; https://doaj.org/toc/1741-7007

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