Identification of polycystin 2 missense mutants targeted for endoplasmic reticulum-associated degradation.

Authors: Guerriero, Christopher J., Carattino, Marcelo D., Sharp, Katherine G., Kantz, Luke J., Gresko, Nikolay P., Caplan, Michael J., Brodsky, Jeffrey L.

Source: American Journal of Physiology: Cell Physiology; Feb2025, Vol. 328 Issue 2, pC483-C499, 17p

Subject Terms: POLYCYSTIC kidney disease, CHRONIC kidney failure, MISSENSE mutation, CHANNELS (Hydraulic engineering), PROTEOLYSIS, ANIMAL rescue

A transcriptional network required for bradyzoite development in Toxoplasma gondii is dispensable for recrudescent disease.

Authors: Sokol-Borrelli, Sarah L., Reilly, Sarah M., Holmes, Michael J., Orchanian, Stephanie B., Massmann, Mackenzie D., Sharp, Katherine G., Cabo, Leah F., Alrubaye, Hisham S., Martorelli Di Genova, Bruno, Lodoen, Melissa B., Sullivan Jr., William J., Boyle, Jon P.

Source: Nature Communications; 9/28/2023, Vol. 14 Issue 1, p1-20, 20p

Subject Terms: TOXOPLASMA gondii, GENE regulatory networks, RNA-binding proteins

Phospholipase C is activated through a novel mechanism during the fast block to polyspermy in Xenopus laevis

Authors: Komondor, Kayla M., Sharp, Katherine G., Carlson, Anne E.

Source: In Biophysical Journal 8 February 2024 123(3) Supplement 1:518a-518a

TMEM16A activation for the fast block to polyspermy in the African clawed frog does not require conventional activation of egg PLCs.

Authors: Komondor, Kayla M.¹, Bainbridge, Rachel E.¹, Sharp, Katherine G.¹, Iyer, Anuradha R.¹, Rosenbaum, Joel C.¹, Carlson, Anne E.¹ acarlson@pitt.edu

Source: Journal of General Physiology. Oct2023, Vol. 155 Issue 10, p1-S3. 12p.

Subject Terms: *XENOPUS, *PHOSPHOLIPASE C, *XENOPUS laevis, *EGGS, *SEA urchins

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Large RNP granules in Caenorhabditis elegans oocytes have distinct phases of RNA-binding proteins.

Authors: Elaswad, Mohamed T.^1,2, Watkins, Brooklynne M.^1,2, Sharp, Katherine G.^2,3, Munderloh, Chloe^2,4, Schisa, Jennifer A.^1,2 schis1j@cmich.edu

Source: G3: Genes | Genomes | Genetics. Sep2022, Vol. 12 Issue 9, p1-10. 10p.

Subject Terms: *RNA-binding proteins, *CAENORHABDITIS elegans, *OVUM, *PHASE transitions, *OOGENESIS, *RNA metabolism

Imaging-associated stress causes divergent phase transitions of RNA-binding proteins in the Caenorhabditis elegans germ line.

Authors: Elaswad, Mohamed T.^1,2, Munderloh, Chloe^2,3, Watkins, Brooklynne M.^1,2, Sharp, Katherine G.^2,4, Breton, Elizabeth^2,5, Schisa, Jennifer A.^1,2 schis1j@cmich.edu

Source: G3: Genes | Genomes | Genetics. Sep2022, Vol. 12 Issue 9, p1-9. 9p.

Subject Terms: *RNA-binding proteins, *PHASE transitions, *CAENORHABDITIS elegans, *ORGANELLE formation, *HEAT shock proteins, *CYTOPLASMIC granules