Targeting Bfl-1 via acute CDK9 inhibition overcomes intrinsic BH3-mimetic resistance in lymphomas

Authors: Boiko, Scott, Proia, Theresa, San Martin, Maryann, Gregory, Gareth P., Wu, Michelle Min, Aryal, Neeraj, Hattersley, Maureen, Shao, Wenlin, Saeh, Jamal C., Fawell, Stephen E., Johnstone, Ricky W., Drew, Lisa, Cidado, Justin ^*

Source: In Blood 27 May 2021 137(21):2947-2957

Discovery of (2R,4R)‑4-((S)‑2-Amino-3-methylbutanamido)-2-(4-boronobutyl)pyrrolidine-2-carboxylic Acid (AZD0011), an Actively Transported Prodrug of a Potent Arginase Inhibitor to Treat Cancer.

Authors: Mlynarski, Scott N., Aquila, Brian M., Cantin, Susan, Cook, Steve, Doshi, Aatman, Finlay, M. Raymond V., Gangl, Eric T., Grebe, Tyler, Gu, Chungang, Kawatkar, Sameer P., Petersen, Jens, Pop-Damkov, Petar, Schuller, Alwin G., Shao, Wenlin, Shields, Jason D., Simpson, Iain, Tavakoli, Siavash, Tentarelli, Sharon, Throner, Scott, Wang, Haixia

Source: Journal of Medicinal Chemistry; 12/12/2024, Vol. 67 Issue 23, p20827-20841, 15p

Coactivator AIB1 Links Estrogen Receptor Transcriptional Activity and Stability

Authors: Shao, Wenlin, Keeton, Erika Krasnickas, McDonnell, Donald P., Brown, Myles, Eisenman, Robert N.

Source: Proceedings of the National Academy of Sciences of the United States of America, 2004 Aug 01. 101(32), 11599-11604.

Access URL: https://www.jstor.org/stable/3372936

Optimization of a series of potent, selective and orally bioavailable SYK inhibitors

Authors: Grimster, Neil P., Gingipalli, Lakshmaiah, Barlaam, Bernard, Su, Qibin, Zheng, XiaoLan, Watson, David, Wang, Haixia, Simpson, Iain, Pike, Andy, Balazs, Amber, Boiko, Scott, Ikeda, Timothy P., Impastato, Anna C., Jones, Natalie H., Kawatkar, Sameer, Kemmitt, Paul, Lamont, Scott, Patel, Joe, Read, Jon, Sarkar, Ujjal, Sha, Li, Tomlinson, Ronald C., Wang, Haiyun, Wilson, David M., Zehnder, Troy E., Wang, Lianghe, Wang, Peng, Goldberg, Frederick W., Shao, Wenlin, Fawell, Stephen, Dry, Hannah, Dowling, James E., Edmondson, Scott D.

Source: Bioorganic & medicinal chemistry letters. 30(19)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100120775988.0x000001&indx=1&recIds=ETOCvdc_100120775988.0x000001

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

Authors: Whitehead, Lewis, Dobler, Markus R., Radetich, Branko, Zhu, Yanyi, Atadja, Peter W., Claiborne, Tavina, Grob, Jonathan E., McRiner, Andrew, Pancost, Margaret R., Patnaik, Anup, Shao, Wenlin, Shultz, Michael, Tichkule, Ritesh, Tommasi, Ruben A., Vash, Brian, Wang, Ping, Stams, Travis

Source: In Bioorganic & Medicinal Chemistry 2011 19(15):4626-4634

USE OF HDAC INHIBITORS FOR THE TREATMENT OF BONE DESTRUCTION

USE OF HDAC INHIBITORS FOR THE TREATMENT OF LYMPHOMAS

Use of HDAC Inhibitors for the Treatment of Bone Destruction

COMBINATION OF LBH589 WITH OTHER THERAPEUTIC AGENTS FOR TREATING CANCER

USE OF HDAC INHIBITORS FOR THE TREATMENT OF LYMPHOMAS

Chromosome-Wide Mapping of Estrogen Receptor Binding Reveals Long-Range Regulation Requiring the Forkhead Protein FoxA1

Authors: Carroll, Jason S., Liu, X. Shirley, Brodsky, Alexander S., Li, Wei, Meyer, Clifford A., Szary, Anna J., Eeckhoute, Jerome, Shao, Wenlin, Hestermann, Eli V., Geistlinger, Timothy R., Fox, Edward A., Silver, Pamela A., Brown, Myles ^*

Source: In Cell 2005 122(1):33-43

Selective coactivation of estrogen-dependent transcription by CITED1 CBP/p300-binding protein.

Authors: Yahata, Tetsuro, Shao, Wenlin, Endoh, Hideaki

Source: Genes & Development; October 1 2001, Vol. 15 Issue 19, p2598-2612, 15p

The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins

Authors: Shao Wenlin, Elliott Nathan A, Farrell Timothy, Kolpak Adrianne, Durand Mathieu, Brown Myles, Volkert Michael R

Source: BMC Cell Biology, Vol 8, Iss 1, p 13 (2007)

Subject Terms: Cytology, QH573-671

File Description: electronic resource

Relation: http://www.biomedcentral.com/1471-2121/8/13; https://doaj.org/toc/1471-2121

Access URL: https://doaj.org/article/9a766ff4cc6f43f8a6d6a35f3ee24dee

Ligand-inducible interaction of the DRIP/TRAP coactivator complex with retinoid receptors in retinoic acid–sensitive and –resistant acute promyelocytic leukemia cells

Authors: Shao, Wenlin, Rosenauer, Angelika, Mann, Koren, Chang, Chao-Pei Betty, Rachez, Christophe, Freedman, Leonard P., Miller, Wilson H., Jr

Source: In Blood 15 September 2000 96(6):2233-2239

Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model.

Authors: Voronova, Veronika, Peskov, Kirill, Kosinsky, Yuri, Helmlinger, Gabriel, Chu, Lulu, Borodovsky, Alexandra, Woessner, Richard, Sachsenmeier, Kris, Shao, Wenlin, Kumar, Rakesh, Pouliot, Gayle, Merchant, Melinda, Kimko, Holly, Mugundu, Ganesh

Source: Frontiers in Immunology; 3/2/2021, pN.PAG-N.PAG, 12p

Subject Terms: ADENOSINES, TUMOR microenvironment, T cell differentiation, PHARMACOLOGY, ORDINARY differential equations, LYSIS

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Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies

Authors: Barlaam, Bernard, Casella, Robert, Cidado, Justin, Cook, Calum, De Savi, Chris, Dishington, Allan, Donald, Craig S., Drew, Lisa, Ferguson, Andrew D., Ferguson, Douglas, Glossop, Steve, Grebe, Tyler, Gu, Chungang, Hande, Sudhir, Hawkins, Janet, Hird, Alexander W., Holmes, Jane, Horstick, James, Jiang, Yun, Lamb, Michelle L., McGuire, Thomas M., Moore, Jane E., O’Connell, Nichole, Pike, Andy, Pike, Kurt G., Proia, Theresa, Roberts, Bryan, San Martin, Maryann, Sarkar, Ujjal, Shao, Wenlin, Stead, Darren, Sumner, Neil, Thakur, Kumar, Vasbinder, Melissa M., Varnes, Jeffrey G., Wang, Jianyan, Wang, Lei, Wu, Dedong, Wu, Liangwei, Yang, Bin, Yao, Tieguang

Source: Journal of Medicinal Chemistry; December 2020, Vol. 63 Issue: 24 p15564-15590, 27p

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Discovery and pharmacological characterization of AZD3229, a potent KIT/PDGFRα inhibitor for treatment of gastrointestinal stromal tumors.

Authors: Banks, Erica, Grondine, Michael, Bhavsar, Deepa, Barry, Evan, Kettle, Jason G., Reddy, Venkatesh Pilla, Brown, Crystal, Wang, Haiyun, Mettetal, Jerome T., Collins, Teresa, Adeyemi, Oladipupo, Overman, Ross, Lawson, Deborah, Harmer, Alexander R., Reimer, Corinne, Drew, Lisa, Packer, Martin J., Cosulich, Sabina, Jones, Rhys DO., Shao, Wenlin

Source: Science Translational Medicine; 4/29/2020, Vol. 12 Issue 541, p1-13, 13p

Subject Terms: GASTROINTESTINAL stromal tumors, VASCULAR endothelial growth factor receptors, PLATELET-derived growth factor, TREATMENT effectiveness, DRUG resistance in cancer cells

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