Natural killer cell engagers for cancer immunotherapy

Authors: Shahryar Khoshtinat Nikkhoi, Geng Li, Arash Hatefi

Source: Frontiers in Oncology, Vol 14 (2025)

Subject Terms: NKCE platform technologies, NK activating receptors, bispecific trispecific multispecific antibodies, CD16a NKG2D NKG2C NKp30 NKp46, cancer immunotherapy, natural killer cells (NK cells), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2024.1483884/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/e81c3652217642b99ad0cb9319d5538d

A Novel Tetravalent Bispecific Immune Cell Engager Activates Natural Killer Cells to Kill Cancer Cells without Mediating Fratricide

Authors: Ge Yang, Shahryar Khoshtinat Nikkhoi, Hajar Owji, Geng Li, Mohammad Massumi, Jessica Cervelli, Venu Gopal Vandavasi, Arash Hatefi

Source: Antibodies, Vol 13, Iss 3, p 75 (2024)

Subject Terms: multi-paratope antibody, BiKE, immune cell engager, VHH, tetravalent bispecific antibody, fratricide, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.mdpi.com/2073-4468/13/3/75; https://doaj.org/toc/2073-4468

Access URL: https://doaj.org/article/981b54c6cdbc4aadaae0bcc6fd76e634

Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG mice

Authors: Ge Yang, Mohammad Massumi, Shahryar Khoshtinat Nikkhoi, Hajar Owji, Mayara Grizotte-Lake, Rick I Cohen, Lazaro Gil Gonzalez, Arash Hatefi

Source: Journal for ImmunoTherapy of Cancer, Vol 12, Iss 3 (2024)

Subject Terms: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://jitc.bmj.com/content/12/3/e008295.full; https://doaj.org/toc/2051-1426

Access URL: https://doaj.org/article/155b517c70c74416a35702828b6d5b6c

Bispecific killer cell engager with high affinity and specificity toward CD16a on NK cells for cancer immunotherapy

Authors: Shahryar Khoshtinat Nikkhoi, Geng Li, Suha Eleya, Ge Yang, Venu Gopal Vandavasi, Arash Hatefi

Source: Frontiers in Immunology, Vol 13 (2023)

Subject Terms: bispecific killer cell engager, BiKE, NK92 cells, CD16a, VHH nanobody, cancer immunotherapy, Immunologic diseases. Allergy, RC581-607

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fimmu.2022.1039969/full; https://doaj.org/toc/1664-3224

Access URL: https://doaj.org/article/4e03b9d20b4344a290532fab562b5b8d

Strategies for Dodging the Obstacles in CAR T Cell Therapy

Authors: Pooria Safarzadeh Kozani, Pouya Safarzadeh Kozani, Fatemeh Rahbarizadeh, Shahryar Khoshtinat Nikkhoi

Source: Frontiers in Oncology, Vol 11 (2021)

Subject Terms: chimeric antigen receptor, immunotherapy, tumor microenvironment, toxicities, adoptive cell therapy, solid tumors, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

File Description: electronic resource

Relation: https://www.frontiersin.org/articles/10.3389/fonc.2021.627549/full; https://doaj.org/toc/2234-943X

Access URL: https://doaj.org/article/5ccb41937ea849e6b13379377d759270