RNA-binding protein RBM5 plays an essential role in acute myeloid leukemia by activating the oncogenic protein HOXA9

Authors: Mengli Zhang, Judith Hyle, Xiaowen Chen, Ye Xin, Yingcai Jin, Jianxiang Zhang, Xue Yang, Xinfeng Chen, Shaela Wright, Zhenling Liu, Wojciech Rosikiewicz, Beisi Xu, Liusheng He, Hong Liu, Nana Ping, Depei Wu, Feiqiu Wen, Chunliang Li, Peng Xu

Source: Genome Biology, Vol 25, Iss 1, Pp 1-29 (2024)

Subject Terms: CRISPR screen, Genome editing, RBM5, HOXA9, Acute myeloid leukemia, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/26d5519bd45f4d089483909374e268f8

Systematic characterization of the HOXA9 downstream targets in MLL-r leukemia by noncoding CRISPR screens

Authors: Shaela Wright, Xujie Zhao, Wojciech Rosikiewicz, Shelby Mryncza, Judith Hyle, Wenjie Qi, Zhenling Liu, Siqi Yi, Yong Cheng, Beisi Xu, Chunliang Li

Source: Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)

Subject Terms: Science

File Description: electronic resource

Relation: https://doaj.org/toc/2041-1723

Access URL: https://doaj.org/article/471e2ddbee5c446b898b4a5cbf5a07c6

Auxin-inducible degron 2 system deciphers functions of CTCF domains in transcriptional regulation

Authors: Judith Hyle, Mohamed Nadhir Djekidel, Justin Williams, Shaela Wright, Ying Shao, Beisi Xu, Chunliang Li

Source: Genome Biology, Vol 24, Iss 1, Pp 1-30 (2023)

Subject Terms: CTCF, Transcription, Auxin-inducible degron, CRISPR, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/653df8a9744f4e94aef44191fad0d353

Acute depletion of CTCF rewires genome-wide chromatin accessibility

Authors: Beisi Xu, Hong Wang, Shaela Wright, Judith Hyle, Yang Zhang, Ying Shao, Mingming Niu, Yiping Fan, Wojciech Rosikiewicz, Mohamed Nadhir Djekidel, Junmin Peng, Rui Lu, Chunliang Li

Source: Genome Biology, Vol 22, Iss 1, Pp 1-25 (2021)

Subject Terms: ATAC-seq, Auxin-induced degron, Chromatin accessibility, CTCF, Transcription factor, Proteomics, Biology (General), QH301-705.5, Genetics, QH426-470

File Description: electronic resource

Relation: https://doaj.org/toc/1474-760X

Access URL: https://doaj.org/article/3af666db8ed9486ba062ca3e3c397961

Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen

Authors: Hao Zhang, Yang Zhang, Xinyue Zhou, Shaela Wright, Judith Hyle, Lianzhong Zhao, Jie An, Xujie Zhao, Ying Shao, Beisi Xu, Hyeong-Min Lee, Taosheng Chen, Yang Zhou, Xiang Chen, Rui Lu, Chunliang Li

Source: eLife, Vol 9 (2020)

Subject Terms: knock-in, CRISPR screen, HOXA9, transcriptional regulation, mll-rearranged leukemia, Medicine, Science, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://elifesciences.org/articles/57858; https://doaj.org/toc/2050-084X

Access URL: https://doaj.org/article/c05bb78898d24b23a12ae92b7e92ebae

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

Authors: BaoHan T. Vo, Chunliang Li, Marc A. Morgan, Ilan Theurillat, David Finkelstein, Shaela Wright, Judith Hyle, Stephanie M.C. Smith, Yiping Fan, Yong-Dong Wang, Gang Wu, Brent A. Orr, Paul A. Northcott, Ali Shilatifard, Charles J. Sherr, Martine F. Roussel

Source: Cell Reports, Vol 18, Iss 12, Pp 2907-2917 (2017)

Subject Terms: group 3 medulloblastoma, MYC, polycomb-repressive complex 2, PRC2, enhancer of zeste homology 2, EZH2, suppressor of zeste 12 homolog, SUZ12, growth factor independent 1, GFI1, histone H3 modification, Hox genes, epigenetic repression, Biology (General), QH301-705.5

File Description: electronic resource

Relation: http://www.sciencedirect.com/science/article/pii/S2211124717302917; https://doaj.org/toc/2211-1247

Access URL: https://doaj.org/article/8cdc8a025d034ff08042a4e43e4b4c04