Proteo-metabolomics and patient tumor slice experiments point to amino acid centrality for rewired mitochondria in fibrolamellar carcinoma

Authors: Long, Donald, Jr., Chan, Marina, Han, Mingqi, Kamdar, Zeal, Ma, Rosanna K., Tsai, Pei-Yin, Francisco, Adam B., Barrow, Joeva, Shackelford, David B., Yarchoan, Mark, McBride, Matthew J., Orre, Lukas M., Vacanti, Nathaniel M., Gujral, Taranjit S., Sethupathy, Praveen

Source: In Cell Reports Medicine 17 September 2024 5(9)

Inhibition of glucose transport synergizes with chemical or genetic disruption of mitochondrial metabolism and suppresses TCA cycle-deficient tumors

Authors: Olszewski, Kellen, Barsotti, Anthony, Feng, Xiao-Jiang, Momcilovic, Milica, Liu, Kevin G., Kim, Ji-In, Morris, Koi, Lamarque, Christophe, Gaffney, Jack, Yu, Xuemei, Patel, Jeegar P., Rabinowitz, Joshua D., Shackelford, David B., Poyurovsky, Masha V.

Source: In Cell Chemical Biology 17 March 2022 29(3):423-435

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

Authors: Krall, Abigail S., Mullen, Peter J., Surjono, Felicia, Momcilovic, Milica, Schmid, Ernst W., Halbrook, Christopher J., Thambundit, Apisadaporn, Mittelman, Steven D., Lyssiotis, Costas A., Shackelford, David B., Knott, Simon R.V., Christofk, Heather R.

Source: In Cell Metabolism 4 May 2021 33(5):1013-1026

Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design

Authors: Riess, Jonathan W., Frankel, Paul, Shackelford, David, Dunphy, Mark, Badawi, Ramsey D., Nardo, Lorenzo, Cherry, Simon R., Lanza, Ian, Reid, Joel, Gonsalves, Wilson I., Kunos, Charles, Gandara, David R., Lara, Primo N., Newman, Edward, Paik, Paul K.

Source: Clinical lung cancer. 22(1):67-70

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100134862199.0x000001&indx=1&recIds=ETOCvdc_100134862199.0x000001

Multiple Particle Tracking Detects Changes in Brain Extracellular Matrix and Predicts Neurodevelopmental Age

Authors: McKenna, Michael, Shackelford, David, Pontes, Hugo Ferreira, Ball, Brendan, Nance, Elizabeth

Source: ACS nano. 15(5):8559-8573

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626800395&indx=1&recIds=ETOCRN626800395

PGC-1α drives small cell neuroendocrine cancer progression toward an ASCL1-expressing subtype with increased mitochondrial capacity.

Authors: Varuzhanyan, Grigor, Chia-Chun Chen, Freeland, Jack, Tian He, Tran, Wendy, Kai Song, Liang Wang, Donghui Cheng, Shili Xu, Dibernardo, Gabriella A., Esedebe, Favour N., Bhatia, Vipul, Mingqi Han, Abt, Evan R., Jung Wook Park, Memarzadeh, Sanaz, Shackelford, David B., Lee, John K., Graeber, Thomas G., Shirihai, Orian S.

Source: Proceedings of the National Academy of Sciences of the United States of America; 12/3/2024, Vol. 121 Issue 49, p1-29, 53p

Subject Terms: POSITRON emission tomography, NEUROENDOCRINE cells, OXIDATIVE phosphorylation, PROSTATE tumors, CANCER cells

p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Authors: Hsieh, Meng-Hsiung, Choe, Joshua H., Gadhvi, Jashkaran, Kim, Yoon Jung, Arguez, Marcus A., Palmer, Madison, Gerold, Haleigh, Nowak, Chance, Do, Hung, Mazambani, Simbarashe, Knighton, Jordan K., Cha, Matthew, Goodwin, Justin, Kang, Min Kyu, Jeong, Ji Yun, Lee, Shin Yup, Faubert, Brandon, Xuan, Zhenyu, Abel, E. Dale, Scafoglio, Claudio, Shackelford, David B., Minna, John D., Singh, Pankaj K., Shulaev, Vladimir, Bleris, Leonidas, Hoyt, Kenneth, Kim, James, Inoue, Masahiro, DeBerardinis, Ralph J., Kim, Tae Hoon, Kim, Jung-whan

Source: In Cell Reports 13 August 2019 28(7):1860-1878

Targeting Asparagine Metabolism in Well-Differentiated/Dedifferentiated Liposarcoma.

Authors: Klingbeil, Kyle D., Wilde, Blake R., Graham, Danielle S., Lofftus, Serena, McCaw, Tyler, Matulionis, Nedas, Dry, Sarah M., Crompton, Joseph G., Eilber, Fritz C., Graeber, Thomas G., Shackelford, David B., Christofk, Heather R., Kadera, Brian E.

Source: Cancers; Sep2024, Vol. 16 Issue 17, p3031, 21p

Subject Terms: ASPARAGINE, BIOLOGICAL models, CANCER invasiveness, RESEARCH funding, RARE diseases, CELL proliferation, CELLULAR signal transduction, XENOGRAFTS, IN vivo studies, LIPOSARCOMA, CELL lines, GENE expression, AMINO acids, MTOR inhibitors, ANIMAL experimentation, METABOLOMICS

Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol.

Authors: Krieger, Matthew R., Abrahamian, Melania, He, Kevin L., Atamdede, Sean, Hakimjavadi, Hesamedin, Momcilovic, Milica, Ostrow, Dejerianne, Maggo, Simran D. S., Yik Pui Tsang, Xiaowu Gai, Chanfreau, Guillaume F., Shackelford, David B., Teitell, Michael A., Koehler, Carla M.

Source: Life Science Alliance; Sep2024, Vol. 7 Issue 9, p1-19, 19p

Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models

Authors: Eichner, Lillian J., Brun, Sonja N., Herzig, Sébastien, Young, Nathan P., Curtis, Stephanie D., Shackelford, David B., Shokhirev, Maxim N., Leblanc, Mathias, Vera, Liliana I., Hutchins, Amanda, Ross, Debbie S., Shaw, Reuben J., Svensson, Robert U.

Source: In Cell Metabolism 5 February 2019 29(2):285-302

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

Authors: Sullivan, William J., Mullen, Peter J., Schmid, Ernst W., Flores, Aimee, Momcilovic, Milica, Sharpley, Mark S., Jelinek, David, Whiteley, Andrew E., Maxwell, Matthew B., Wilde, Blake R., Banerjee, Utpal, Coller, Hilary A., Shackelford, David B., Braas, Daniel, Ayer, Donald E., de Aguiar Vallim, Thomas Q., Lowry, William E., Christofk, Heather R.

Source: In Cell 20 September 2018 175(1):117-132

The Baltimore & Ohio Railroad in Maryland
Baltimore and Ohio Railroad in Maryland

Authors: Shackelford, David. Author

Availability: https://www.aspresolver.com/aspresolver.asp?LRHO;46712142

In vivo imaging of mitochondrial membrane potential in non-small-cell lung cancer

Authors: Momcilovic, Milica, Jones, Anthony, Bailey, Sean, Waldmann, Christopher, Li, Rui, Lee, Jason, Abdelhady, Gihad, Gomez, Adrian, Holloway, Travis, Schmid, Ernst, Stout, David, Fishbein, Michael, Stiles, Linsey, Dabir, Deepa, Dubinett, Steven, Christofk, Heather, Shirihai, Orian, Koehler, Carla, Sadeghi, Saman, Shackelford, David

Source: Nature. 575(7782):380-384

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190967806.0x000001&indx=1&recIds=ETOCvdc_100190967806.0x000001

Bioluminescent-based imaging and quantification of glucose uptake in vivo

Authors: Maric, Tamara, Mikhaylov, Georgy, Khodakivskyi, Pavlo, Bazhin, Arkadiy, Sinisi, Riccardo, Bonhoure, Nicolas, Yevtodiyenko, Aleksey, Jones, Anthony, Muhunthan, Vishaka, Abdelhady, Gihad, Shackelford, David, Goun, Elena

Source: Nature methods. 16(6):526-532

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100153462605.0x000001&indx=1&recIds=ETOCvdc_100153462605.0x000001

Imaging Cancer Metabolism

Authors: Momcilovic, Milica, Shackelford, David B.

Source: Biomolecules & therapeutics. 26(1):81-92

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN615297505&indx=1&recIds=ETOCRN615297505

Targeted Inhibition of EGFR and Glutaminase Induces Metabolic Crisis in EGFR Mutant Lung Cancer

Authors: Momcilovic, Milica, Bailey, Sean T., Lee, Jason T., Fishbein, Michael C., Magyar, Clara, Braas, Daniel, Graeber, Thomas, Jackson, Nicholas J., Czernin, Johannes, Emberley, Ethan, Gross, Matthew, Janes, Julie, Mackinnon, Andy, Pan, Alison, Rodriguez, Mirna, Works, Melissa, Zhang, Winter, Parlati, Francesco, Demo, Susan, Garon, Edward, Krysan, Kostyantyn, Walser, Tonya C., Dubinett, Steven M., Sadeghi, Saman, Christofk, Heather R., Shackelford, David B.

Source: Cell reports. 18(3):601-610

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100062392683.0x000001&indx=1&recIds=ETOCvdc_100062392683.0x000001

An Automated Multidose Synthesis of the Potentiometric PET Probe 4-[18F]Fluorobenzyl-Triphenylphosphonium ([18F]FBnTP)

Authors: Waldmann, Christopher M., Gomez, Adrian, Marchis, Phillip, Bailey, Sean T., Momcilovic, Milica, Jones, Anthony E., Shackelford, David B., Sadeghi, Saman

Source: Molecular imaging and biology. 20(2):205-212

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100127751975.0x000001&indx=1&recIds=ETOCvdc_100127751975.0x000001

PD17-02 UNIVERSAL LOSS OF COMPLEX I IN ONCOCYTOMA IS ASSOCIATED WITH DEFECTIVE MITOPHAGY VIA ALTERED GLUTATHIONE METABOLISM

Authors: Lin, Lin, Patel, Neal, Wilde, Blake, Fernandez-del-Rio, Lucia, Christodoulou, Eirini, Ohtake, Shinji, Caliliw, Randy, Shirihai, Orian, Gai, Xiaowu, Christofk, Heather, Shackelford, David, Shuch, Brian

Source: Journal of urology. 209(4):e495-e495

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100190184115.0x000001&indx=1&recIds=ETOCvdc_100190184115.0x000001

Teaching an Old Drug New Tricks

Authors: Momcilovic, Milica, Shackelford, David B.

Source: Cancer cell. 35(5):709-711

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100093369547.0x000001&indx=1&recIds=ETOCvdc_100093369547.0x000001

What is the current role of immunotherapy in EGFR mutant advanced NSCLC?

Authors: Velez, Maria A., Tsai, Hsin Hsiang Clarence, Shackelford, David B., Garon, Edward B., Lisberg, Aaron

Source: Lung cancer. 166:253-254

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100164542075.0x000001&indx=1&recIds=ETOCvdc_100164542075.0x000001