Endometrial tumorigenesis involves epigenetic plasticity demarcating non-coding somatic mutations and 3D-genome alterations.

Authors: Gregoricchio, Sebastian, Kojic, Aleksandar, Hoogstraat, Marlous, Schuurman, Karianne, Stelloo, Suzan, Severson, Tesa M., O'Mara, Tracy A., Droog, Marjolein, Singh, Abhishek A., Glubb, Dylan M., Wessels, Lodewyk F. A., Vermeulen, Michiel, van Leeuwen, Flora E., Zwart, Wilbert

Source: Genome Biology; 5/9/2025, Vol. 26 Issue 1, p1-31, 31p

BRCA1-like signature in triple negative breast cancer: Molecular and clinical characterization reveals subgroups with therapeutic potential

Authors: Severson, Tesa M., Peeters, Justine, Majewski, Ian, Michaut, Magali, Bosma, Astrid, Schouten, Philip C., Chin, Suet-Feung, Pereira, Bernard, Goldgraben, Mae A., Bismeijer, Tycho, Kluin, Roelof J.C., Muris, Jettie J.F., Jirström, Karin, Kerkhoven, Ron M., Wessels, Lodewyk, Caldas, Carlos, Bernards, René, Simon, Iris M., Linn, Sabine

Source: In Molecular Oncology October 2015 9(8):1528-1538

Robust BRCA1-like classification of copy number profiles of samples repeated across different datasets and platforms

Authors: Schouten, Philip C., Grigoriadis, Anita, Kuilman, Thomas, Mirza, Hasan, Watkins, Johnathan A., Cooke, Saskia A., van Dyk, Ewald, Severson, Tesa M., Rueda, Oscar M., Hoogstraat, Marlous, Verhagen, Caroline V.M., Natrajan, Rachael, Chin, Suet-Feung, Lips, Esther H., Kruizinga, Janneke, Velds, Arno, Nieuwland, Marja, Kerkhoven, Ron M., Krijgsman, Oscar, Vens, Conchita, Peeper, Daniel, Nederlof, Petra M., Caldas, Carlos, Tutt, Andrew N., Wessels, Lodewyk F., Linn, Sabine C.

Source: In Molecular Oncology August 2015 9(7):1274-1286

Grade Group 1 Prostate Cancers Exhibit Tumor-defining Androgen Receptor–driven Programs

Authors: Linder, Simon, Severson, Tesa M., van der Mijn, Koen J.C., Nevedomskaya, Ekaterina, Siefert, Joseph C., Stelloo, Suzan, Pomerantz, Mark M., Freedman, Matthew L., van der Poel, Henk, Jerónimo, Carmen, Henrique, Rui, Bergman, Andries M., Zwart, Wilbert

Source: In European Urology November 2023 84(5):455-460

PAXIP1 and STAG2 converge to maintain 3D genome architecture and facilitate promoter/enhancer contacts to enable stress hormone-dependent transcription.

Authors: Mayayo-Peralta, Isabel, Gregoricchio, Sebastian, Schuurman, Karianne, Yavuz, Selçuk, Zaalberg, Anniek, Kojic, Aleksandar, Abbott, Nina, Geverts, Bart, Beerthuijzen, Suzanne, Siefert, Joseph, Severson, Tesa M, van Baalen, Martijn, Hoekman, Liesbeth, Lieftink, Cor, Altelaar, Maarten, Beijersbergen, Roderick L, Houtsmuller, Adriaan B, Prekovic, Stefan, Zwart, Wilbert

Source: Nucleic Acids Research; 10/13/2023, Vol. 51 Issue 18, p9576-9593, 18p

Extensive androgen receptor enhancer heterogeneity in primary prostate cancers underlies transcriptional diversity and metastatic potential.

Authors: Kneppers, Jeroen, Severson, Tesa M., Siefert, Joseph C., Schol, Pieter, Joosten, Stacey E. P., Yu, Ivan Pak Lok, Huang, Chia-Chi Flora, Morova, Tunç, Altıntaş, Umut Berkay, Giambartolomei, Claudia, Seo, Ji-Heui, Baca, Sylvan C., Carneiro, Isa, Emberly, Eldon, Pasaniuc, Bogdan, Jerónimo, Carmen, Henrique, Rui, Freedman, Matthew L., Wessels, Lodewyk F. A., Lack, Nathan A.

Source: Nature Communications; 11/30/2022, Vol. 13 Issue 1, p1-16, 16p

Subject Terms: PROSTATE cancer, SOMATIC mutation, ANDROGEN receptors, HETEROGENEITY, PROSTATE, GENE expression, PROSTATE tumors

Double-strand break toxicity is chromatin context independent.

Authors: Friskes, Anoek, Koob, Lisa, Krenning, Lenno, Severson, Tesa M, Koeleman, Emma S, Vergara, Xabier, Schubert, Michael, van den Berg, Jeroen, Evers, Bastiaan, Manjón, Anna G, Joosten, Stacey, Kim, Yongsoo, Zwart, Wilbert, Medema, René H

Source: Nucleic Acids Research; 9/23/2022, Vol. 50 Issue 17, p9930-9947, 18p

Hypomorphic Temperature-Sensitive Alleles of NSDHL Cause CK Syndrome.

Authors: McLarren, Keith W., Severson, Tesa M., Du Souich, Christèle

Source: American Journal of Human Genetics; December 10 2010, Vol. 87 Issue 6, p905-914, 10p

Opposing transcriptional programs of KLF5 and AR emerge during therapy for advanced prostate cancer.

Authors: Che, Meixia, Chaturvedi, Aashi, Munro, Sarah A., Pitzen, Samuel P., Ling, Alex, Zhang, Weijie, Mentzer, Josh, Ku, Sheng-Yu, Puca, Loredana, Zhu, Yanyun, Bergman, Andries M., Severson, Tesa M., Forster, Colleen, Liu, Yuzhen, Hildebrand, Jacob, Daniel, Mark, Wang, Ting-You, Selth, Luke A., Hickey, Theresa, Zoubeidi, Amina

Source: Nature Communications; 11/4/2021, Vol. 12 Issue 1, p1-15, 15p

Subject Terms: ANDROGEN receptors, PROSTATE cancer, CASTRATION-resistant prostate cancer, STEM cell factor, PHENOTYPES, TRANSCRIPTION factors

Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastases.

Authors: Severson, Tesa M., Zhu, Yanyun, De Marzo, Angelo M., Jones, Tracy, Simons, Jonathan W., Nelson, William G., Yegnasubramanian, Srinivasan, Freedman, Matthew L., Wessels, Lodewyk, Bergman, Andries M., Haffner, Michael C., Zwart, Wilbert

Source: Molecular Oncology; Jul2021, Vol. 15 Issue 7, p1942-1955, 14p

The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair.

Authors: Shafi, Ayesha A., McNair, Chris M., McCann, Jennifer J., Alshalalfa, Mohammed, Shostak, Anton, Severson, Tesa M., Zhu, Yanyun, Bergman, Andre, Gordon, Nicolas, Mandigo, Amy C., Chand, Saswati N., Gallagher, Peter, Dylgjeri, Emanuela, Laufer, Talya S., Vasilevskaya, Irina A., Schiewer, Matthew J., Brunner, Michael, Feng, Felix Y., Zwart, Wilbert, Knudsen, Karen E.

Source: Nature Communications; 1/15/2021, Vol. 12 Issue 1, p1-15, 15p

Subject Terms: CRYPTOCHROMES, DNA repair, CIRCADIAN rhythms, DNA damage

The MSP‐RON axis stimulates cancer cell growth in models of triple negative breast cancer.

Authors: Millar, Rhona, Kilbey, Anna, Remak, Sarah‐Jane, Severson, Tesa M., Dhayade, Sandeep, Sandilands, Emma, Foster, Kyla, Bryant, David M., Blyth, Karen, Coffelt, Seth B.

Source: Molecular Oncology; Aug2020, Vol. 14 Issue 8, p1868-1880, 13p

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin.

Authors: Morin, Ryan D., Johnson, Nathalie A., Severson, Tesa M.

Source: Nature Genetics; February 2010, Vol. 42 Issue 2, p181-185, 5p

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Noncoding mutations target cis-regulatory elements of the FOXA1 plexus in prostate cancer.

Authors: Zhou, Stanley, Hawley, James R., Soares, Fraser, Grillo, Giacomo, Teng, Mona, Madani Tonekaboni, Seyed Ali, Hua, Junjie Tony, Kron, Ken J., Mazrooei, Parisa, Ahmed, Musaddeque, Arlidge, Christopher, Yun, Hwa Young, Livingstone, Julie, Huang, Vincent, Yamaguchi, Takafumi N., Espiritu, Shadrielle M. G., Zhu, Yanyun, Severson, Tesa M., Murison, Alex, Cameron, Sarina

Source: Nature Communications; 1/23/2020, Vol. 11 Issue 1, p1-13, 13p

Subject Terms: PROSTATE cancer, PROSTATE tumors, CANCER cell growth, TRANSCRIPTION factors

CD4⁺ T cell help creates memory CD8⁺ T cells with innate and help-independent recall capacities.

Authors: Ahrends, Tomasz, Busselaar, Julia, Severson, Tesa M., Bąbała, Nikolina, de Vries, Evert, Bovens, Astrid, Wessels, Lodewyk, van Leeuwen, Fred, Borst, Jannie

Source: Nature Communications; 12/4/2019, Vol. 10 Issue 1, p1-13, 13p, 6 Graphs

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