The lipopolysaccharide-TLR4 axis regulates hepatic glutaminase 1 expression promoting liver ammonia build-up as steatotic liver disease progresses to steatohepatitis

Authors: Mercado-Gómez, Maria, Goikoetxea-Usandizaga, Naroa, Kerbert, Annarein J.C., Gracianteparaluceta, Leire Uraga, Serrano-Maciá, Marina, Lachiondo-Ortega, Sofia, Rodriguez-Agudo, Rubén, Gil-Pitarch, Clàudia, Simón, Jorge, González-Recio, Irene, Fondevila, Marcos F., Santamarina-Ojeda, Pablo, Fraga, Mario F., Nogueiras, Rubén, Heras, Javier de las, Jalan, Rajiv, Martínez-Chantar, María Luz, Delgado, Teresa C.

Source: In Metabolism September 2024 158

SUMOylation controls Hu antigen R posttranscriptional activity in liver cancer

Authors: Lachiondo-Ortega, Sofia ^{1, 30}, Rejano-Gordillo, Claudia M. ^{1, 2, 3, 30}, Simon, Jorge ^{1, 4}, Lopitz-Otsoa, Fernando ¹, C. Delgado, Teresa ¹, Mazan-Mamczarz, Krystyna ⁵, Goikoetxea-Usandizaga, Naroa ¹, Zapata-Pavas, L. Estefanía ¹, García-del Río, Ana ⁶, Guerra, Pietro ⁷, Peña-Sanfélix, Patricia ¹, Hermán-Sánchez, Natalia ⁸, Al-Abdulla, Ruba ^{9, 10}, Fernandez-Rodríguez, Carmen ¹, Azkargorta, Mikel ^{4, 11}, Velázquez-Cruz, Alejandro ¹², Guyon, Joris ^{13, 14}, Martín, César ³, Zalamea, Juan Diego ¹⁵, Egia-Mendikute, Leire ⁶, Sanz-Parra, Arantza ¹, Serrano-Maciá, Marina ¹, González-Recio, Irene ¹, Gonzalez-Lopez, Monika ¹⁶, Martínez-Cruz, Luis Alfonso ¹, Pontisso, Patrizia ⁷, Aransay, Ana M. ¹⁶, Barrio, Rosa ¹⁷, Sutherland, James D. ¹⁷, Abrescia, Nicola G.A. ^{15, 18}, Elortza, Félix ^{4, 11}, Lujambio, Amaia ^{19, 20, 21, 22}, Banales, Jesus M. ^{4, 18, 23, 24}, Luque, Raúl M. ⁸, Gahete, Manuel D. ⁸, Palazón, Asís ^{6, 18}, Avila, Matias A. ^{4, 25, 26}, G. Marin, Jose J. ^{4, 27}, De, Supriyo ⁵, Daubon, Thomas ²⁸, Díaz-Quintana, Antonio ¹², Díaz-Moreno, Irene ¹², Gorospe, Myriam ⁵, Rodríguez, Manuel S. ²⁹, Martínez-Chantar, María Luz ^{1, 4, 31, ∗}

Source: In Cell Reports 26 March 2024 43(3)

Anti-miR-873-5p improves alcohol-related liver disease by enhancing hepatic deacetylation via SIRT1

Authors: Rodríguez-Agudo, Rubén, González-Recio, Irene, Serrano-Maciá, Marina, Bravo, Miren, Petrov, Petar, Blaya, Delia, Herranz, Jose María, Mercado-Gómez, María, Rejano-Gordillo, Claudia María, Lachiondo-Ortega, Sofía, Gil-Pitarch, Clàudia, Azkargorta, Mikel, Van Liempd, Sebastiaan Martijn, Martinez-Cruz, Luis Alfonso, Simão, A.L., Elortza, Félix, Martín, César, Nevzorova, Yulia A., Cubero, Francisco Javier, Delgado, Teresa C., Argemi, Josepmaria, Bataller, Ramón, Schoonjans, Kristina, Banales, Jesús M., Castro, Rui E., Sancho-Bru, Pau, Avila, Matías A., Julve, Josep, Jover, Ramiro, Mabe, Jon, Simon, Jorge, Goikoetxea-Usandizaga, Naroa, Martínez-Chantar, María L.

Source: In JHEP Reports January 2024 6(1)

Neddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism

Authors: Gonzalez-Rellan, María J., Fernández, Uxía, Parracho, Tamara, Novoa, Eva, Fondevila, Marcos F., da Silva Lima, Natalia, Ramos, Lucía, Rodríguez, Amaia, Serrano-Maciá, Marina, Perez-Mejias, Gonzalo, Chantada-Vazquez, Pilar, Riobello, Cristina, Veyrat-Durebex, Christelle, Tovar, Sulay, Coppari, Roberto, Woodhoo, Ashwin, Schwaninger, Markus, Prevot, Vincent, Delgado, Teresa C., Lopez, Miguel, Diaz-Quintana, Antonio, Dieguez, Carlos, Guallar, Diana, Frühbeck, Gema, Diaz-Moreno, Irene, Bravo, Susana B., Martinez-Chantar, Maria L., Nogueiras, Ruben

Source: In Cell Metabolism 5 September 2023 35(9):1630-1645

Hepatic levels of S-adenosylmethionine regulate the adaptive response to fasting

Authors: Capelo-Diz, Alba, Lachiondo-Ortega, Sofía, Fernández-Ramos, David, Cañas-Martín, Jorge, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, González-Rellan, Maria J., Mosca, Laura, Blazquez-Vicens, Joan, Tinahones-Ruano, Alberto, Fondevila, Marcos F., Buyan, Mason, Delgado, Teresa C., Gutierrez de Juan, Virginia, Ayuso-García, Paula, Sánchez-Rueda, Alejandro, Velasco-Avilés, Sergio, Fernández-Susavila, Héctor, Riobello-Suárez, Cristina, Dziechciarz, Bartlomiej, Montiel-Duarte, Cristina, Lopitz-Otsoa, Fernando, Bizkarguenaga, Maider, Bilbao-García, Jon, Bernardo-Seisdedos, Ganeko, Senra, Ana, Soriano-Navarro, Mario, Millet, Oscar, Díaz-Lagares, Ángel, Crujeiras, Ana B., Bao-Caamano, Aida, Cabrera, Diana, van Liempd, Sebastiaan, Tamayo-Caro, Miguel, Borzacchiello, Luigi, Gomez-Santos, Beatriz, Buqué, Xabier, Sáenz de Urturi, Diego, González-Romero, Francisco, Simon, Jorge, Rodríguez-Agudo, Rubén, Ruiz, Asier, Matute, Carlos, Beiroa, Daniel, Falcon-Perez, Juan M., Aspichueta, Patricia, Rodríguez-Cuesta, Juan, Porcelli, Marina, Pajares, María A., Ameneiro, Cristina, Fidalgo, Miguel, Aransay, Ana M., Lama-Díaz, Tomas, Blanco, Miguel G., López, Miguel, Villa-Bellosta, Ricardo, Müller, Timo D., Nogueiras, Rubén, Woodhoo, Ashwin, Martínez-Chantar, María Luz, Varela-Rey, Marta

Source: In Cell Metabolism 8 August 2023 35(8):1373-1389

Targeting NAE1-mediated protein hyper-NEDDylation halts cholangiocarcinogenesis and impacts on tumor-stroma crosstalk in experimental models

Authors: Olaizola, Paula, Lee-Law, Pui Yuen, Fernandez-Barrena, Maite G., Alvarez, Laura, Cadamuro, Massimiliano, Azkargorta, Mikel, O’Rourke, Colm J., Caballero-Camino, Francisco J., Olaizola, Irene, Macias, Rocio I.R., Marin, Jose J.G., Serrano-Maciá, Marina, Martinez-Chantar, Maria L., Avila, Matias A., Aspichueta, Patricia, Calvisi, Diego F., Evert, Matthias, Fabris, Luca, Castro, Rui E., Elortza, Felix, Andersen, Jesper B., Bujanda, Luis, Rodrigues, Pedro M., Perugorria, Maria J., Banales, Jesus M.

Source: In Journal of Hepatology July 2022 77(1):177-190

Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis

Authors: Serrano-Maciá, Marina, Simón, Jorge, González-Rellan, Maria J., Azkargorta, Mikel, Goikoetxea-Usandizaga, Naroa, Lopitz-Otsoa, Fernando, De Urturi, Diego Saenz, Rodríguez-Agudo, Rubén, Lachiondo-Ortega, Sofia, Mercado-Gomez, Maria, Gutiérrez de Juan, Virginia, Bizkarguenaga, Maider, Fernández-Ramos, David, Buque, Xabier, Baselli, Guido A., Valenti, Luca V.C., Iruzubieta, Paula, Crespo, Javier, Villa, Erica, Banales, Jesus M., Avila, Matias A., Marin, Jose J.G., Aspichueta, Patricia, Sutherland, James, Barrio, Rosa, Mayor, Ugo, Elortza, Félix, Xirodimas, Dimitris P., Nogueiras, Rubén, Delgado, Teresa C., Martínez-Chantar, María Luz

Source: In Molecular Metabolism November 2021 53

Magnesium accumulation upon cyclin M4 silencing activates microsomal triglyceride transfer protein improving NASH

Authors: Simón, Jorge, Goikoetxea-Usandizaga, Naroa, Serrano-Maciá, Marina, Fernández-Ramos, David, Sáenz de Urturi, Diego, Gruskos, Jessica J., Fernández-Tussy, Pablo, Lachiondo-Ortega, Sofía, González-Recio, Irene, Rodríguez-Agudo, Rubén, Gutiérrez-de-Juan, Virginia, Rodríguez-Iruretagoyena, Begoña, Varela-Rey, Marta, Gimenez-Mascarell, Paula, Mercado-Gomez, María, Gómez-Santos, Beatriz, Fernandez-Rodriguez, Carmen, Lopitz-Otsoa, Fernando, Bizkarguenaga, Maider, Dames, Sibylle, Schaeper, Ute, Martin, Franz, Sabio, Guadalupe, Iruzubieta, Paula, Crespo, Javier, Aspichueta, Patricia, Chu, Kevan H.-Y., Buccella, Daniela, Martín, César, Delgado, Teresa Cardoso, Martínez-Cruz, Luis Alfonso, Martínez-Chantar, María Luz

Source: In Journal of Hepatology July 2021 75(1):34-45

Boosting mitochondria activity by silencing MCJ overcomes cholestasis-induced liver injury

Authors: Iruzubieta, Paula, Goikoetxea-Usandizaga, Naroa, Barbier-Torres, Lucía, Serrano-Maciá, Marina, Fernández-Ramos, David, Fernández-Tussy, Pablo, Gutiérrez-de-Juan, Virginia, Lachiondo-Ortega, Sofia, Simon, Jorge, Bravo, Miren, Lopitz-Otsoa, Fernando, Robles, Mercedes, Ferre-Aracil, Carlos, Varela-Rey, Marta, Elguezabal, Natalia, Calleja, José Luis, Lu, Shelly C., Milkiewicz, Malgorzata, Milkiewicz, Piotr, Anguita, Juan, Monte, María J., Marin, José J.G., López-Hoyos, Marcos, Delgado, Teresa C., Rincón, Mercedes, Crespo, Javier, Martínez-Chantar, María Luz

Source: In JHEP Reports June 2021 3(3)

Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly

Authors: Simon, Jorge, Nuñez-García, Maitane, Fernández-Tussy, Pablo, Barbier-Torres, Lucía, Fernández-Ramos, David, Gómez-Santos, Beatriz, Buqué, Xabier, Lopitz-Otsoa, Fernando, Goikoetxea-Usandizaga, Naroa, Serrano-Macia, Marina, Rodriguez-Agudo, Rubén, Bizkarguenaga, Maider, Zubiete-Franco, Imanol, Gutiérrez-de Juan, Virginia, Cabrera, Diana, Alonso, Cristina, Iruzubieta, Paula, Romero-Gomez, Manuel, van Liempd, Sebastiaan, Castro, Azucena, Nogueiras, Ruben, Varela-Rey, Marta, Falcón-Pérez, Juan Manuel, Villa, Erica, Crespo, Javier, Lu, Shelly C., Mato, Jose M., Aspichueta, Patricia, Delgado, Teresa C., Martínez-Chantar, María Luz

Source: In Cell Metabolism 3 March 2020 31(3):605-622

miR-873-5p targets mitochondrial GNMT-Complex II interface contributing to non-alcoholic fatty liver disease

Authors: Fernández-Tussy, Pablo, Fernández-Ramos, David, Lopitz-Otsoa, Fernando, Simón, Jorge, Barbier-Torres, Lucía, Gomez-Santos, Beatriz, Nuñez-Garcia, Maitane, Azkargorta, Mikel, Gutiérrez-de Juan, Virginia, Serrano-Macia, Marina, Rodríguez-Agudo, Rubén, Iruzubieta, Paula, Anguita, Juan, Castro, Rui E., Champagne, Devin, Rincón, Mercedes, Elortza, Felix, Arslanow, Anita, Krawczyk, Marcin, Lammert, Frank, Kirchmeyer, Mélanie, Behrmann, Iris, Crespo, Javier, Lu, Shelly C., Mato, José M., Varela-Rey, Marta, Aspichueta, Patricia, Delgado, Teresa C., Martínez-Chantar, María L.

Source: In Molecular Metabolism November 2019 29:40-54

The Balance between Mono- and NEDD8-Chains Controlled by NEDP1 upon DNA Damage Is a Regulatory Module of the HSP70 ATPase Activity

Authors: Bailly, Aymeric P., Perrin, Aurelien, Serrano-Macia, Marina, Maghames, Chantal, Leidecker, Orsolya, Trauchessec, Helene, Martinez-Chantar, M.L., Gartner, Anton, Xirodimas, Dimitris P.

Source: In Cell Reports 1 October 2019 29(1):212-224

In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring

Authors: Esteban, Javier, Serrano-Maciá, Marina, Sánchez-Pérez, Ismael, Alonso-Magdalena, Paloma, Pellín, María de la Cruz, García-Arévalo, Marta, Nadal, Ángel, Barril, Jose

Source: In Food and Chemical Toxicology April 2019 126:142-151

SUMOylation regulates LKB1 localization and its oncogenic activity in liver cancer

Authors: Zubiete-Franco, Imanol, García-Rodríguez, Juan L., Lopitz-Otsoa, Fernando, Serrano-Macia, Marina, Simon, Jorge, Fernández-Tussy, Pablo, Barbier-Torres, Lucía, Fernández-Ramos, David, Gutiérrez-de-Juan, Virginia, López de Davalillo, Sergio, Carlevaris, Onintza, Beguiristain Gómez, Adolfo, Villa, Erica, Calvisi, Diego, Martín, César, Berra, Edurne, Aspichueta, Patricia, Beraza, Naiara, Varela-Rey, Marta, Ávila, Matias, Rodríguez, Manuel S., Mato, José M., Díaz-Moreno, Irene, Díaz-Quintana, Antonio, Delgado, Teresa C., Martínez-Chantar, María L.

Source: In EBioMedicine February 2019 40:406-421

FRI-153 High prevalence of steatotic liver disease and systemic inflammation in hereditary fructose intolerance (HFI) patients independent of age, BMI and the presence of metabolic syndrome

Authors: Delgado, Teresa Cardoso, Cano, Ainara, Mercado-Gómez, Maria, Buque, Xabier, Alonso, Cristina, Serrano-Macia, Marina, Alcalde, Carlos, Belanger-Quintana, Amaya, Cañedo-Villarroya, Elvira, Hualde, Leticia Ceberia, Chumillas-Calzada, Silvia, Correcher, Patricia, García-Arenas, Dolores, Gómez, Igor, Hernández, Tomáz, Izquierdo-García, Elsa, Chicano, Dámaris Martínez, Morales, Montserrat, Pedrón-Giner, Consuelo, Jáuregui, Estrella Petrina, Peña, Luis, Sánchez-Pintos, Paula, Serrano-Nieto, Juliana, Suárez, Maria Unceta, Miñana, Isidro Vitoria, Larena, Jose Alejandro, Couce, María Luz, Martínez-Chantar, María Luz, Aspichueta, Patricia, de las Heras Montero, Javier

Source: In Journal of Hepatology June 2024 80 Supplement 1:S693-S694

FRI-466-YI Implications and therapeutic potential of neddylation for pediatric liver cancer: hepatoblastoma

Authors: Zapata-Pavas, Leidy Estefanía, Serrano-Macía, Marina, Rodrigo, Miguel Angel Merlos, Peña-Sanfelix, Patricia, Gil-Pitarch, Claudia, Goikoetxea-Usandizaga, Naroa, Michalkova, Hana, Heger, Zbynek, del Río-Álvarez, Alvaro, Royo, Laura, Rejano-Gordillo, Claudia M., Barrenechea-Barrenechea, Jon Ander, Mercado-Gómez, Maria, Lachiondo-Ortega, Sofia, Delgado, Teresa C., Xirodimas, Dimitris, Marin, Jose J.G., Fernandez-Barrena, Maite G., Avila, Matías A., Armengol, Carolina, Martínez-Chantar, María Luz

Source: In Journal of Hepatology June 2024 80 Supplement 1:S417-S417

WED-113 Histological, molecular, and neuromotor alterations of the liverbrain axis in an aged model of experimental cirrhosis

Authors: Juanola, Oriol, Martinez, Sebastian, Serrano-Macía, Marina, Angel, Enrique, Gómez-Hurtado, Isabel, Boix, Paula, Navarrete Rueda, Francisco, Salud García Gutierrez, Maria, Caparrós, Esther, Francés, Rubén

Source: In Journal of Hepatology June 2024 80 Supplement 1:S194-S194

Corrigendum to “In utero exposure to bisphenol-A disrupts key elements of retinoid system in male mice offspring”

Authors: Esteban, Javier, Serrano-Maciá, Marina, Sánchez-Perez, Ismael, Alonso-Magdalena, Paloma, Pellín, María de la Cruz, García-Arévalo, Marta, Nadal, Ángel, Barril, Jose

Source: In Food and Chemical Toxicology December 2021 158

SAT-247 - Pediatric liver cancer: Hepatoblastoma and Neddylation post-translational modification

Authors: Zapata-Pavas, Leidy Estefanía, Serrano-Macia, Marina, Merlos Rodrigo, Miguel Angel, Felix, Patricia Peña-San, Gil-Pitarch, Claudia, Goikoetxea, Naroa, Michalkova, Hana, Heger, Zbynek, del Rio, Alvaro, Domingo-Sàbat, Montserrat, Royo, Laura, Barrenechea-Barrenechea, Jon Ander, Mercado-Gómez, Maria, Lachiondo-Ortega, Sofia, Delgado, Teresa Cardoso, Xirodimas, Dimitris, Marin, Jose, Fernandez-Barrena, Maite G, Avila, Matías A, Armengol, Carolina, Martínez-Chantar, María Luz

Source: In Journal of Hepatology June 2023 78 Supplement 1:S546-S546

SAT-244 - Silencing CNNM4 in cholangiocarcinoma inhibits tumoral progression by means of non-canonical ferroptosis

Authors: Mercado-Gómez, Maria, Giné, Alvaro Eguilero, Bravo, Miren, Azkargorta, Mikel, Serrano-Macia, Marina, Goikoetxea, Naroa, González-Recio, Irene, Lachiondo-Ortega, Sofia, Gil-Pitarch, Claudia, Romero, Marta, Omella, Judit Domenech, Agudo, Rubén Rodríguez, Zapata-Pavas, Leidy Estefanía, Felix, Patricia Peña-San, Olaizola, Paula, Rodrigues, Pedro Miguel, Martinez-Cruz, Luis Alfonso, Lamarca, Angela, Moreno, Victor, Banales, Jesus Maria, Delgado, Teresa Cardoso, Elortza, Felix, Avila, Matías A, Cubero, Francisco Javier, Martín, Cesar Augusto, Merlos Rodrigo, Miguel Angel, Calvisi, Diego, Marin, Jose, Martínez-Chantar, María Luz

Source: In Journal of Hepatology June 2023 78 Supplement 1:S544-S545