Correlative cryo-soft X-ray tomography and cryo-structured illumination microscopy reveal changes to lysosomes in amyloid-β-treated neurons

Authors: Marshall, Karen E., Mengham, Kurtis, Spink, Matthew C., Vania, Lyra, Pollard, Hannah Jane, Darrow, Michele C., Duke, Elizabeth, Harkiolaki, Maria, Serpell, Louise C.

Source: In Structure 2 May 2024 32(5):585-593

Chiral Co~3Y Propeller-Shaped Chemosensory Platforms Based on ^1^9F-NMR

Authors: Audsley, Gabrielle, Carpenter, Harry, Essien, Nsikak B., Lai-Morrice, James, Al-Hilaly, Youssra, Serpell, Louise C., Akien, Geoffrey R., Tizzard, Graham J., Coles, Simon J., Ulldemolins, Cristina Pubill

Source: Inorganic chemistry. 62(6):2680-2693

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN631987824&indx=1&recIds=ETOCRN631987824

An Additive-Free Model for Tau Self-Assembly

Authors: Al-Hilaly, Youssra K., Marshall, Karen E., Lutter, Liisa, Biasetti, Luca, Mengham, Kurtis, Harrington, Charles R., Xue, Wei-Feng, Wischik, Claude M., Serpell, Louise C.

Source: Methods in molecular biology. 2551:163-188

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN630544372&indx=1&recIds=ETOCRN630544372

Dityrosine Cross-links are Present in Alzheimer’s Disease-derived Tau Oligomers and Paired Helical Filaments (PHF) which Promotes the Stability of the PHF-core Tau (297–391) In Vitro

Authors: Maina, Mahmoud B., Al-Hilaly, Youssra K., Oakley, Sebastian, Burra, Gunasekhar, Khanom, Tahmida, Biasetti, Luca, Mengham, Kurtis, Marshall, Karen, Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.

Source: In Journal of Molecular Biology 15 October 2022 434(19)

Charge screening wormlike micelles affects extensional relaxation time and noodle formationElectronic supplementary information (ESI) available. See DOI: https://doi.org/10.1039/d2cc03646k

Authors: Huang, Rui, McDowall, Daniel, Ng, Henry, Thomson, Lisa, Al-Hilaly, Youssra K., Doutch, James, Burholt, Sam, Serpell, Louise C., Poole, Robert J., Adams, Dave J.

Source: Chemical communications. 58(74):10388-10391

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100160908196.0x000001&indx=1&recIds=ETOCvdc_100160908196.0x000001

Structural Identification of Individual Helical Amyloid Filaments by Integration of Cryo-Electron Microscopy-Derived Maps in Comparative Morphometric Atomic Force Microscopy Image Analysis

Authors: Lutter, Liisa, Al-Hilaly, Youssra K., Serpell, Christopher J., Tuite, Mick F., Wischik, Claude M., Serpell, Louise C., Xue, Wei-Feng

Source: In Journal of Molecular Biology 15 April 2022 434(7)

Nucleation-dependent Aggregation Kinetics of Yeast Sup35 Fragment GNNQQNY

Authors: Burra, Gunasekhar, Maina, Mahmoud B., Serpell, Louise C., Thakur, Ashwani K.

Source: In Journal of Molecular Biology 5 February 2021 433(3)

Salpyran: A Cu(II) Selective Chelator with Therapeutic Potential

Authors: Devonport, Jack, Bodnár, Nikolett, McGown, Andrew, Maina, Mahmoud Bukar, Serpell, Louise C., Kállay, Csilla, Spencer, John, Kostakis, George E.

Source: Inorganic chemistry. 60(20):15310-15320

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Metal- and UV- Catalyzed Oxidation Results in Trapped Amyloid-β Intermediates Revealing that Self-Assembly Is Required for Aβ-Induced Cytotoxicity

Authors: Maina, Mahmoud B., Burra, Gunasekhar, Al-Hilaly, Youssra K., Mengham, Kurtis, Fennell, Kate, Serpell, Louise C.

Source: In iScience 23 October 2020 23(10)

Paired Helical Filament-Forming Region of Tau (297–391) Influences Endogenous Tau Protein and Accumulates in Acidic Compartments in Human Neuronal Cells

Authors: Pollack, Saskia J., Trigg, Jasmine, Khanom, Tahmida, Biasetti, Luca, Marshall, Karen E., Al-Hilaly, Youssra K., Rickard, Janet E., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.

Source: In Journal of Molecular Biology 7 August 2020 432(17):4891-4907

Three-dimensional reconstruction of individual helical nano-filament structures from atomic force microscopy topographs

Authors: Lutter Liisa, Serpell Christopher J., Tuite Mick F., Serpell Louise C., Xue Wei-Feng

Source: Biomolecular Concepts, Vol 11, Iss 1, Pp 102-115 (2020)

Subject Terms: atomic force microscopy, tip-sample convolution, amyloid fibril structure, image analysis, Biology (General), QH301-705.5

File Description: electronic resource

Relation: https://doaj.org/toc/1868-5021; https://doaj.org/toc/1868-503X

Access URL: https://doaj.org/article/3b776a2fce5544cd87bd1a4e5113153a

Internalisation and toxicity of amyloid‐β 1‐42 are influenced by its conformation and assembly state rather than size

Authors: Vadukul, Devkee M., Maina, Mahmoud, Franklin, Hannah, Nardecchia, Astrid, Serpell, Louise C., Marshall, Karen E.

Source: FEBS letters. 594(21):3490-3503

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Half a century of amyloids: past, present and futureThis article is dedicated to the memory of our dear colleague Sir Christopher Dobson. Chris was an exceptional scientist, scholar, and a true pioneer of the field of amyloid studies as well as a wonderful mentor to his colleagues and students. He has inspired a whole generation of scientists and enriched the lives of so many people. He was widely admired and will always be remembered for his formidable contributions to the field of Chemistry, his sharp wit, and also his kindness and generosity.

Authors: Ke, Pu Chun, Zhou, Ruhong, Serpell, Louise C., Riek, Roland, Knowles, Tuomas P. J., Lashuel, Hilal A., Gazit, Ehud, Hamley, Ian W., Davis, Thomas P., Fändrich, Marcus, Otzen, Daniel Erik, Chapman, Matthew R., Dobson, Christopher M., Eisenberg, David S., Mezzenga, Raffaele

Source: Chemical Society reviews. 49(15):5473-5509

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100108077701.0x000001&indx=1&recIds=ETOCvdc_100108077701.0x000001

Tau (297‐391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

Authors: Al‐Hilaly, Youssra K., Foster, Bronwen E., Biasetti, Luca, Lutter, Liisa, Pollack, Saskia J., Rickard, Janet E., Storey, John M. D., Harrington, Charles R., Xue, Wei‐Feng, Wischik, Claude M., Serpell, Louise C.

Source: FEBS letters. 594(5):944-950

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Misfolded amyloid-β-42 impairs the endosomal–lysosomal pathway

Authors: Marshall, Karen E., Vadukul, Devkee M., Staras, Kevin, Serpell, Louise C.

Source: Cellular and molecular life sciences. 77(23):5031-5043

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100186549647.0x000001&indx=1&recIds=ETOCvdc_100186549647.0x000001

Tau‐mediated synaptic dysfunction is coupled with HCN channelopathy.

Authors: Goniotaki, Despoina, Tamagnini, Francesco, Biasetti, Luca, Rumpf, Svenja‐Lotta, Troakes, Claire, Pollack, Saskia J., Ukwesa, Shalom, Sun, Haoyue, Kraev, Igor, Serpell, Louise C., Noble, Wendy, Staras, Kevin, Hanger, Diane P.

Source: Alzheimer's & Dementia: The Journal of the Alzheimer's Association; Aug2024, Vol. 20 Issue 8, p5629-5646, 18p

Cysteine-Independent Inhibition of Alzheimer's Disease-like Paired Helical Filament Assembly by Leuco-Methylthioninium (LMT)

Authors: Al-Hilaly, Youssra K., Pollack, Saskia J., Rickard, Janet E., Simpson, Michael, Raulin, Ana-Caroline, Baddeley, Thomas, Schellenberger, Pascale, Storey, John M.D., Harrington, Charles R., Wischik, Claude M., Serpell, Louise C.

Source: In Journal of Molecular Biology 19 October 2018 430(21):4119-4131

Prions: Protein Rebels with a Cause!

Authors: Marshall, Karen E., Serpell, Louise C.

Source: School Science Review. Sep 2017 99(366):51-56.

Peer Reviewed: Y

Page Count: 6

Descriptors: Diseases, Biology, Pathology, Symptoms (Individual Disorders), Molecular Structure, Scientific Concepts

Access URL: https://www.ase.org.uk/journals/school-science-review/2017/10/366/

Molecular Basis for Amyloid Fibril Formation and Stability

Authors: Makin, O. Sumner, Atkins, Edward, Sikorski, Pawel, Johansson, Jan, Serpell, Louise C., Rich, Alexander

Source: Proceedings of the National Academy of Sciences of the United States of America, 2005 Jan 01. 102(2), 315-320.

Access URL: https://www.jstor.org/stable/3374242

Zinc–dysprosium functionalized amyloid fibrilsElectronic supplementary information (ESI) available. See DOI: 10.1039/c9dt01134j

Authors: SampaniThese authors contributed equally to this work., Stavroula I., Al-Hilaly, Youssra K., Malik, Sharali, Serpell, Louise C., Kostakis, George E.

Source: Dalton transactions. 48(41):15371-15375

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100091075576.0x000001&indx=1&recIds=ETOCvdc_100091075576.0x000001