Overcoming the barriers to identifying and managing treatment-resistant schizophrenia and to improving access to clozapine: A narrative review and recommendation for clinical practice

Authors: Agid, Ofer, Crespo-Facorro, Benedicto, de Bartolomeis, Andrea, Fagiolini, Andrea, Howes, Oliver D., Seppälä, Niko, Correll, Christoph U.

Source: In European Neuropsychopharmacology July 2024 84:35-47

Guía internacional para una dosificación más segura de la clozapina en adultos mediante el uso de 6 titulaciones personalizadas de dosis basados en la etnicidad, la proteína C reactiva y los niveles de clozapina

Alternate Title: An international adult guideline for making clozapine titration safer by using six ancestry-based personalized dosing titrations, CRP, and clozapine levels (English)

Authors: de Leon, Jose, Schoretsanitis, Georgios, Smith, Robert L., Molden, Espen, Solismaa, Anssi, Seppälä, Niko, Kopeček, Miloslav, Švancer, Patrik, Olmos, Ismael, Ricciardi, Carina, Iglesias-Garcia, Celso, Iglesias-Alonso, Ana, Spina, Edoardo, Ruan, Can-Jun, Wang, Chuan-Yue, Wang, Gang, Tang, Yi-Lang, Lin, Shih-Ku, Lane, Hsien-Yuan, Kim, Yong Sik, Kim, Se Hyun, Rajkumar, Anto P., González-Esquivel, Dinora F., Jung-Cook, Helgi, Baptista, Trino, Rohde, Christopher, Nielsen, Jimmi, Verdoux, Hélène, Quiles, Clelia, Sanz, Emilio J., De las Cuevas, Carlos, Cohen, Dan, Schulte, Peter F.J., Ertuğrul, Aygün, Anıl Yağcıoğlu, A. Elif, Chopra, Nitin, McCollum, Betsy, Shelton, Charles, Cotes, Robert O., Kaithi, Arun R., Kane, John M., Farooq, Saeed, Ng, Chee H., Bilbily, John, Hiemke, Christoph, López-Jaramillo, Carlos, McGrane, Ian, Lana, Fernando, Eap, Chin B., Arrojo-Romero, Manuel, Rădulescu, Flavian Ştefan, Seifritz, Erich, Every-Palmer, Susanna, Bousman, Chad A., Bebawi, Emmanuel, Bhattacharya, Rahul, Kelly, Deanna L., Otsuka, Yuji, Lazary, Judit, Torres, Rafael, Yecora, Agustin, Motuca, Mariano, Chan, Sherry Kit Wa, Zolezzi, Monica, Ouanes, Sami, De Berardis, Domenico, Grover, Sandeep, Procyshyn, Ric M., Adebayo, Richard A., Kirilochev, Oleg O., Soloviev, Andrey, Fountoulakis, Konstantinos N., Wilkowska, Alina, Cubała, Wiesław Jerzy, Ayub, Muhammad, Silva, Alzira, Bonelli, Raphael M., Villagrán-Moreno, José María, Crespo-Facorro, Benedicto, Temmingh, Henk, Decloedt, Eric, Pedro, Maria Rosel, Takeuchi, Hiroyoshi, Tsukahara, Masaru, Gründer, Gerhard, Sagud, Marina, Celofiga, Andreja, Ignjatovic Ristic, Dragana, Ortiz, Bruno Bertolucci, Elkis, Helio, Pacheco Palha, António José, Llerena, Adrián, Fernandez-Egea, Emilio, Siskind, Dan, Weizman, Abraham, Masmoudi, Rim, Mohd Saffian, Shamin, Leung, Jonathan G., Buckley, Peter F., Marder, Stephen R., Citrome, Leslie, Freudenreich, Oliver, Correll, Christoph U., Müller, Daniel J.

Source: In Psiquiatria Biologica September-December 2023 30(3)

An International Adult Guideline for Making Clozapine Titration Safer by Using Six Ancestry-Based Personalized Dosing Titrations, CRP, and Clozapine Levels

Authors: de Leon, Jose, Schoretsanitis, Georgios, Smith, Robert, Molden, Espen, Solismaa, Anssi, Seppälä, Niko, Kopeček, Miloslav, Švancer, Patrik, Olmos, Ismael, Ricciardi, Carina, Iglesias-Garcia, Celso, Iglesias-Alonso, Ana, Spina, Edoardo, Ruan, Can-Jun, Wang, Chuan-Yue, Wang, Gang, Tang, Yi-Lang, Lin, Shih-Ku, Lane, Hsien-Yuan, Kim, Yong, Kim, Se, Rajkumar, Anto, González-Esquivel, Dinora, Jung-Cook, Helgi, Baptista, Trino, Rohde, Christopher, Nielsen, Jimmi, Verdoux, Hélène, Quiles, Clelia, Sanz, Emilio, De Las Cuevas, Carlos, Cohen, Dan, Schulte, Peter, Ertuğrul, Aygün, Anıl Yağcıoğlu, A., Chopra, Nitin, McCollum, Betsy, Shelton, Charles, Cotes, Robert, Kaithi, Arun, Kane, John, Farooq, Saeed, Ng, Chee, Bilbily, John, Hiemke, Christoph, López-Jaramillo, Carlos, McGrane, Ian, Lana, Fernando, Eap, Chin, Arrojo-Romero, Manuel, Rădulescu, Flavian, Seifritz, Erich, Every-Palmer, Susanna, Bousman, Chad, Bebawi, Emmanuel, Bhattacharya, Rahul, Kelly, Deanna, Otsuka, Yuji, Lazary, Judit, Torres, Rafael, Yecora, Agustin, Motuca, Mariano, Chan, Sherry, Zolezzi, Monica, Ouanes, Sami, De Berardis, Domenico, Grover, Sandeep, Procyshyn, Ric, Adebayo, Richard, Kirilochev, Oleg, Soloviev, Andrey, Fountoulakis, Konstantinos, Wilkowska, Alina, Cubała, Wiesław, Ayub, Muhammad, Silva, Alzira, Bonelli, Raphael, Villagrán-Moreno, José, Crespo-Facorro, Benedicto, Temmingh, Henk, Decloedt, Eric, Pedro, Maria, Takeuchi, Hiroyoshi, Tsukahara, Masaru, Gründer, Gerhard, Sagud, Marina, Celofiga, Andreja, Ignjatovic Ristic, Dragana, Ortiz, Bruno, Elkis, Helio, Pacheco Palha, António, LLerena, Adrián, Fernandez-Egea, Emilio, Siskind, Dan, Weizman, Abraham, Masmoudi, Rim, Mohd Saffian, Shamin, Leung, Jonathan, Buckley, Peter, Marder, Stephen, Citrome, Leslie, Freudenreich, Oliver, Correll, Christoph, Müller, Daniel

Source: Pharmacopsychiatry. 55(2):73-86

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Glucagon-like peptide-1 serum levels are associated with weight gain in patients treated with clozapine

Authors: Klemettilä, Jari-Pekka, Solismaa, Anssi, Seppälä, Niko, Hämäläinen, Mari, Moilanen, Eeva, Leinonen, Esa, Kampman, Olli

Source: In Psychiatry Research December 2021 306

A Survey of Electroconvulsive Therapy in Finland

Authors: Sumia, Petri, Seppälä, Niko, Ritschkoff, Jukka, Tammentie-Sarèn, Tarja, Leinonen, Esa, Järventausta, Kaija

Source: Journal of ECT. 37(1):36-39

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181555368.0x000001&indx=1&recIds=ETOCvdc_100181555368.0x000001

European Whites May Need Lower Minimum Therapeutic Clozapine Doses Than Those Customarily Proposed

Authors: Schoretsanitis, Georgios, Smith, Robert L., Molden, Espen, Solismaa, Anssi, Seppälä, Niko, Kopeček, Miloslav, Švancer, Patrik, Olmos, Ismael, Vázquez, Marta, Iglesias-Garcia, Celso, Iglesias-Alonso, Ana, Spina, Edoardo, de Leon, Jose

Source: Journal of clinical psychopharmacology. 41(2):140-147

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100181170934.0x000001&indx=1&recIds=ETOCvdc_100181170934.0x000001

Polymorphisms in ERBB4 and TACR1 associated with dry mouth in clozapine-treated patients.

Authors: Puolakka, Hanna, Solismaa, Anssi, Lyytikäinen, Leo-Pekka, Viikki, Merja, Seppälä, Niko, Mononen, Nina, Lehtimäki, Terho, Kampman, Olli

Source: Acta Neuropsychiatrica; Aug2024, Vol. 36 Issue 4, p218-223, 6p

Subject Terms: DROOLING, XEROSTOMIA, GENETIC variation, GENETIC polymorphisms, GENETIC regulation

Histaminergic gene polymorphisms associated with sedation in clozapine-treated patients

Authors: Solismaa, Anssi, Kampman, Olli, Lyytikäinen, Leo-Pekka, Seppälä, Niko, Viikki, Merja, Mononen, Nina, Lehtimäki, Terho, Leinonen, Esa

Source: In European Neuropsychopharmacology May 2017 27(5):442-449

Genetic Polymorphisms Associated With Constipation and Anticholinergic Symptoms in Patients Receiving Clozapine

Authors: Solismaa, Anssi, Kampman, Olli, Lyytikäinen, Leo-Pekka, Seppälä, Niko, Viikki, Merja, Mononen, Nina, Lehtimäki, Terho, Leinonen, Esa

Source: Journal of clinical psychopharmacology. 38(3):193-199

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100057963947.0x000001&indx=1&recIds=ETOCvdc_100057963947.0x000001

Resistin as an inflammatory marker in patients with schizophrenia treated with clozapine

Authors: Klemettilä, Jari-Pekka, Kampman, Olli, Seppälä, Niko, Viikki, Merja, Hämäläinen, Mari, Moilanen, Eeva, Leinonen, Esa

Source: Nordic journal of psychiatry. 71(2):89-95

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105250392.0x000001&indx=1&recIds=ETOCvdc_100105250392.0x000001

Cytokine and adipokine alterations in patients with schizophrenia treated with clozapine

Authors: Klemettilä, Jari-Pekka, Kampman, Olli, Seppälä, Niko, Viikki, Merja, Hämäläinen, Mari, Moilanen, Eeva, Leinonen, Esa

Source: In Psychiatry Research 30 August 2014 218(3):277-283

INSIG2 polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine

Authors: Koskinen, Suvi, Kampman, Olli, Solismaa, Anssi, Lyytikäinen, Leo-Pekka, Seppälä, Niko, Viikki, Merja, Hämäläinen, Mari, Moilanen, Eeva, Mononen, Nina, Lehtimäki, Terho, Leinonen, Esa

Source: Pharmacogenomics. 17(18):1987-1997

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100139392188.0x000001&indx=1&recIds=ETOCvdc_100139392188.0x000001

Factors associated with subjective side-effects during clozapine treatment

Authors: Seppälä, Niko, Leinonen, Esa, Viikki, Merja, Solismaa, Anssi, Nuolivirta, Timo, Kampman, Olli

Source: Nordic journal of psychiatry. 69(3):161-166

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105249629.0x000001&indx=1&recIds=ETOCvdc_100105249629.0x000001

Smoking and weight among patients using clozapine

Authors: Seppälä, Niko, Leinonen, Esa, Viikki, Merja, Kampman, Olli

Source: Nordic journal of psychiatry. 68(8):620-625

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100105333126.0x000001&indx=1&recIds=ETOCvdc_100105333126.0x000001

A Guideline and Checklist for Initiating and Managing Clozapine Treatment in Patients with Treatment-Resistant Schizophrenia.

Authors: Correll, C. U., Agid, Ofer, Crespo-Facorro, Benedicto, de Bartolomeis, Andrea, Fagiolini, Andrea, Seppälä, Niko, Howes, Oliver D.

Source: CNS Drugs; Jul2022, Vol. 36 Issue 7, p659-679, 21p

Subject Terms: CLOZAPINE, PEOPLE with schizophrenia, SURGERY safety measures

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Effect of anticholinergics in preventing acute deterioration in patients undergoing abrupt clozapine withdrawal.

Authors: Seppälä, Niko¹ niko.seppala@satshp.fi, Kovio, Carita², Leinonen, Esa^2,3, Seppälä, Niko⁴ (AUTHOR)

Source: CNS Drugs. 2005, Vol. 19 Issue 12, p1049-1055. 7p. 2 Charts.

Subject Terms: *CLOZAPINE, *ANTIPSYCHOTIC agents, *PSYCHIATRIC drugs, *DRUG side effects, *PHARMACOKINETICS, *PSYCHOSES, *PSYCHOTHERAPY patients, *PARASYMPATHOLYTIC agents, *PARASYMPATHOMIMETIC agents, *COMBINATION drug therapy, *COMPARATIVE studies, *DRUG withdrawal symptoms, *RESEARCH methodology, *MEDICAL cooperation, *PSYCHOLOGICAL tests, *PSYCHOLOGY, *RESEARCH, *SCHIZOPHRENIA, *EVALUATION research, *TREATMENT effectiveness, *RETROSPECTIVE studies, *THERAPEUTICS, DRUG therapy for schizophrenia

Geographic Terms: FINLAND

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INSIG2polymorphism and weight gain, dyslipidemia and serum adiponectin in Finnish patients with schizophrenia treated with clozapine

Authors: Koskinen, Suvi, Kampman, Olli, Solismaa, Anssi, Lyytikäinen, Leo-Pekka, Seppälä, Niko, Viikki, Merja, Hämäläinen, Mari, Moilanen, Eeva, Mononen, Nina, Lehtimäki, Terho, Leinonen, Esa

Source: Pharmacogenomics; December 2016, Vol. 17 Issue: 18 p1987-1997, 11p