The complement system as a regulator of tumor-promoting activities mediated by myeloid-derived suppressor cells

Authors: Senent, Yaiza, Tavira, Beatriz, Pio, Ruben, Ajona, Daniel

Source: In Cancer Letters 28 November 2022 549

Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis

Authors: Ortiz-Espinosa, Sergio, Morales, Xabier, Senent, Yaiza, Alignani, Diego, Tavira, Beatriz, Macaya, Irati, Ruiz, Borja, Moreno, Haritz, Remírez, Ana, Sainz, Cristina, Rodriguez-Pena, Alejandro, Oyarbide, Alvaro, Ariz, Mikel, Andueza, Maria P., Valencia, Karmele, Teijeira, Alvaro, Hoehlig, Kai, Vater, Axel, Rolfe, Barbara, Woodruff, Trent M., Lopez-Picazo, Jose Maria, Vicent, Silvestre, Kochan, Grazyna, Escors, David, Gil-Bazo, Ignacio, Perez-Gracia, Jose Luis, Montuenga, Luis M., Lambris, John D., Ortiz de Solorzano, Carlos, Lecanda, Fernando, Ajona, Daniel, Pio, Ruben

Source: In Cancer Letters 31 March 2022 529:70-84

G9a/DNMT1 co-targeting inhibits non-small cell lung cancer growth and reprograms tumor cells to respond to cancer-drugs through SCARA5 and AOX1.

Authors: Exposito, Francisco, Redrado, Miriam, Serrano, Diego, Calabuig-Fariñas, Silvia, Bao-Caamano, Aida, Gallach, Sandra, Jantus-Lewintre, Eloisa, Diaz-Lagares, Angel, Rodriguez-Casanova, Aitor, Sandoval, Juan, San Jose-Eneriz, Edurne, Garcia, Javier, Redin, Esther, Senent, Yaiza, Leon, Sergio, Pio, Ruben, Lopez, Rafael, Oyarzabal, Julen, Pineda-Lucena, Antonio, Agirre, Xabier

Source: Cell Death & Disease; Nov2024, Vol. 15 Issue 11, p1-16, 16p

Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade

Authors: Ajona, Daniel, Ortiz-Espinosa, Sergio, Lozano, Teresa, Exposito, Francisco, Calvo, Alfonso, Valencia, Karmele, Redrado, Miriam, Remírez, Ana, Lecanda, Fernando, Alignani, Diego, Lasarte, Juan J., Macaya, Irati, Senent, Yaiza, Bértolo, Cristina, Sainz, Cristina, Gil-Bazo, Ignacio, Eguren-Santamaría, Iñaki, Lopez-Picazo, Jose M., Gonzalez, Alvaro, Perez-Gracia, Jose L., de Andrea, Carlos E., Vicent, Silvestre, Sanmamed, Miguel F., Montuenga, Luis M., Pio, Ruben

Source: Nature cancer. 1(1):75-85

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125036625.0x000001&indx=1&recIds=ETOCvdc_100125036625.0x000001

Chapter Three - A mouse model to assess immunotherapy-related colitis

Authors: Senent, Yaiza ^{a, b, c}, Remírez, Ana ^{a, c, d}, Tavira, Beatriz ^{a, c, e}, Ajona, Daniel ^{a, b, c, d, ⁎}

Source: In Methods in Cell Biology 2025 192:33-38

Gemcitabine-mediated depletion of immunosuppressive dendritic cells enhances the efficacy of therapeutic vaccination.

Authors: Repáraz, David, Ruiz, Marta, Silva, Leyre, Aparicio, Belén, Egea, Josune, Guruceaga, Elizabeth, Ajona, Daniel, Senent, Yaiza, Conde, Enrique, Navarro, Flor, Barace, Sergio, Alignani, Diego, Hervás-Stubbs, Sandra, Lasarte, Juan José, Llopiz, Diana, Sarobe, Pablo

Source: Frontiers in Immunology; 10/10/2022, Vol. 13, p1-15, 15p

Subject Terms: DENDRITIC cells, GENE expression profiling, TREATMENT effectiveness, IMMUNE checkpoint inhibitors, COMBINED vaccines

C5a elevation in convalescents from severe COVID-19 is not associated with early complement activation markers C3bBbP or C4d.

Authors: Kowalska, Daria, Kuźniewska, Alicja, Senent, Yaiza, Tavira, Beatriz, Inogés, Susana, López-Díaz de Cerio, Ascensión, Pio, Ruben, Okrój, Marcin, Yuste, José Ramón

Source: Frontiers in Immunology; 8/24/2022, Vol. 13, p01-06, 6p

Subject Terms: COMPLEMENT activation, COMPLEMENT (Immunology), COVID-19, HOSPITAL admission & discharge, DISEASE risk factors

Persistence of High Levels of Serum Complement C5a in Severe COVID-19 Cases After Hospital Discharge.

Authors: Senent, Yaiza, Inogés, Susana, López-Díaz de Cerio, Ascensión, Blanco, Andres, Campo, Arantxa, Carmona-Torre, Francisco, Sunsundegui, Patricia, González-Martín, Antonio, Ajona, Daniel, Okrój, Marcin, Prósper, Felipe, Pio, Ruben, Yuste, José Ramón, Tavira, Beatriz

Source: Frontiers in Immunology; 11/18/2021, Vol. 12, p1-9, 9p

Subject Terms: COVID-19 pandemic, COMPLEMENT (Immunology), HOSPITAL admission & discharge, COVID-19, SARS-CoV-2

The Complement System in Ovarian Cancer: An Underexplored Old Path.

Authors: Senent, Yaiza^1,2,3 (AUTHOR) ysenent@alumni.unav.es, Ajona, Daniel^1,2,3,4 (AUTHOR) agonzalezma@unav.es, González-Martín, Antonio^1,5 (AUTHOR) rpio@unav.es, Pio, Ruben^1,2,3,4 (AUTHOR) btavirai@unav.es, Tavira, Beatriz^1,3,6 (AUTHOR)

Source: Cancers. Aug2021, Vol. 13 Issue 15, p3806-3806. 1p.

Subject Terms: *DISEASE progression, *OVARIAN tumors, *COMPLEMENT (Immunology), *NEOVASCULARIZATION inhibitors, *IMMUNOSUPPRESSION, *CELLULAR signal transduction, *CELLULAR immunity, *COMBINED modality therapy, *T cells, *IMMUNOTHERAPY

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