Molecular markers of proliferation, DNA repair, and immune infiltration defines high-risk subset of resectable retroperitoneal sarcomas

Authors: Seligson, Nathan D., Asmann, Yan W., Almerey, Tariq, Zayas, Yaquelin Coll, Edgar, Mark A., Attia, Steven, Knutson, Keith L., Bagaria, Sanjay P.

Source: In Surgical Oncology October 2024 56

Comparison of variants in TPMT and NUDT15 between sequencing and genotyping methods in a multistate pediatric institution

Authors: Cook, Kelsey J., Grusauskas, Victoria, Gloe, Lucy, Duong, Benjamin Q., Gresh, Renee C., Kolb, E. Anders, Bansal, Manisha, Bechtel, Allison S., Nagasubramanian, Ramamoorthy, Kirwin, Susan M., Blake, Kathryn V., Seligson, Nathan D.

Source: Clinical and translational science. 16(8):1352-1358

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100192970729.0x000001&indx=1&recIds=ETOCvdc_100192970729.0x000001

CDK4/6 and autophagy inhibitors synergize to suppress the growth of human head and neck squamous cell carcinomas

Authors: Duah, Ernest, Seligson, Nathan D., Persaud, Avinash K., Dam, Quynh, Pabla, Navjot, Rocco, James W., Li, Junan, Poi, Ming

Source: Molecular carcinogenesis. 62(8):1201-1212

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Gene partners of the EWSR1 fusion may represent molecularly distinct entities

Authors: Walker, Victoria, Jin, Dexter X., Millis, Sherri Z., Nasri, Elham, Corao-Uribe, Diana A., Tan, Aik Choon, Fridley, Brooke L., Chen, James L., Seligson, Nathan D.

Source: In Translational Oncology December 2023 38

Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML

Authors: Nguyen, Nam H. K., Rafiee, Roya, Tagmount, Abderrahmane, Sobh, Amin, Loguinov, Alex, de Jesus Sosa, Angelica K., Elsayed, Abdelrahman H., Gbadamosi, Mohammed, Seligson, Nathan, Cogle, Christopher R., Rubnitz, Jeffery, Ribeiro, Raul, Downing, James, Cao, Xueyuan, Pounds, Stanley B., Vulpe, Christopher D., Lamba, Jatinder K.

Source: In Blood Advances 9 May 2023 7(9):1769-1783

Dabrafenib Versus Dabrafenib + Trametinib in BRAF-Mutated Radioactive Iodine Refractory Differentiated Thyroid Cancer: Results of a Randomized, Phase 2, Open-Label Multicenter Trial

Authors: Busaidy, Naifa L., Konda, Bhavana, Wei, Lai, Wirth, Lori J., Devine, Catherine, Daniels, Gregory A., DeSouza, Jonas A., Poi, Ming, Seligson, Nathan D., Cabanillas, Maria E., Sipos, Jennifer A., Ringel, Matthew D., Eisfeld, Ann-Kathrin, Timmers, Cynthia, Shah, Manisha H.

Source: Thyroid. 32(10):1184-1192

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Key Considerations for Selecting a Genomic Decision Support Platform for Implementing Pharmacogenomics

Authors: Cook, Kelsey J., Duong, Benjamin Q., Seligson, Nathan D., Arn, Pamela, Funanage, Vicky L., Gripp, Karen W., Kirwin, Susan M., Lawless, Stephen T., Lee, Mary M., Robbins, Katherine M., West, David, Blake, Kathryn V.

Source: Clinical pharmacology & therapeutics. 110(3):555-558

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Developing Drugs for Tissue‐Agnostic Indications: A Paradigm Shift in Leveraging Cancer Biology for Precision Medicine

Authors: Seligson, Nathan D., Knepper, Todd C., Ragg, Susanne, Walko, Christine M.

Source: Clinical pharmacology & therapeutics. 109(2):334-342

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100113511514.0x000001&indx=1&recIds=ETOCvdc_100113511514.0x000001

Sacituzumab Govitecan-hziy: An Antibody-Drug Conjugate for the Treatment of Refractory, Metastatic, Triple-Negative Breast Cancer

Authors: Seligson, John M., Patron, Alexandra M., Berger, Michael J., Harvey, R. Donald, Seligson, Nathan D.

Source: Annals of pharmacotherapy. 55(7):921-931

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN626741045&indx=1&recIds=ETOCRN626741045

Correction: Nelson et al. UGT1A1 Guided Cancer Therapy: Review of the Evidence and Considerations for Clinical Implementation. Cancers 2021, 13 , 1566.

Authors: Nelson, Ryan S.^1,2 (AUTHOR) alex.delcueto@moffitt.org, Seligson, Nathan D.^3,4 (AUTHOR) nseligson@cop.ufl.edu, Bottiglieri, Sal⁵ (AUTHOR) salvatore.bottiglieri@moffitt.org, Carballido, Estrella^6,7 (AUTHOR) estrella.carballido@moffitt.org, Cueto, Alex Del² (AUTHOR), Imanirad, Iman^6,7 (AUTHOR) iman.imanirad@moffitt.org, Levine, Richard^6,8 (AUTHOR) richard.levine@moffitt.org, Parker, Alexander S.⁹ (AUTHOR) alexander.parker@jax.ufl.edu, Swain, Sandra M.¹⁰ (AUTHOR) sandra.swain@georgetown.edu, Tillman, Emma M.¹¹ (AUTHOR) emtillma@iu.edu, Hicks, J. Kevin^2,6 (AUTHOR) james.hicks@moffitt.org

Source: Cancers. Nov2024, Vol. 16 Issue 21, p3595. 2p.

Subject Terms: *DRUG toxicity, *IRINOTECAN, *HEPATOTOXICOLOGY, *ANTINEOPLASTIC agents, *GENETIC polymorphisms, *PHARMACOGENOMICS, *TUMORS, *INDIVIDUALIZED medicine, *NEUTROPENIA

XRCC1‐mediated DNA repair is associated with progression‐free survival of multiple myeloma patients after autologous stem cell transplant

Authors: Persaud, Avinash K., Li, Junan, Johnson, Jasmine A., Seligson, Nathan, Sborov, Douglas W., Duah, Ernest, Cho, Yu Kyoung, Wang, Danxin, Phelps, Mitch A., Hofmeister, Craig C., Poi, Ming J.

Source: Molecular carcinogenesis. 58(12):2327-2339

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Degree of MDM2 Amplification Affects Clinical Outcomes in Dedifferentiated Liposarcoma

Authors: Bill, Kate Lynn J., Seligson, Nathan D., Hays, John L., Awasthi, Achal, Demoret, Bryce, Stets, Colin W., Duggan, Megan C., Bupathi, Manojkumar, Brock, Guy N., Millis, Sherri Z., Shakya, Reena, Timmers, Cynthia D., Wakely, Paul E., Pollock, Raphael E., Chen, James L.

Source: Oncologist. 24(7):989-996

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085237015.0x000001&indx=1&recIds=ETOCvdc_100085237015.0x000001

BRCA1/2 Functional Loss Defines a Targetable Subset in Leiomyosarcoma

Authors: Seligson, Nathan D., Kautto, Esko A., Passen, Edward N., Stets, Colin, Toland, Amanda E., Millis, Sherri Z., Meyer, Christian F., Hays, John L., Chen, James L.

Source: Oncologist. 24(7):973-979

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100085236707.0x000001&indx=1&recIds=ETOCvdc_100085236707.0x000001

Clinical Utility of CDK4/6 Inhibitors in Sarcoma: Successes and Future Challenges

Authors: Hsu, Jocelyn Y., Seligson, Nathan D., Hays, John L., Miles, Wayne O., Chen, James L.

Source: JCO precision oncology. 6

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100152759701.0x000001&indx=1&recIds=ETOCvdc_100152759701.0x000001

SO006 / #839 - M2 MACROPHAGE INFILTRATION IN RETROPERITONEAL SARCOMAS: IS THERE A ROLE FOR HEAVY PARTICLE THERAPY?

Authors: Rutenberg, Michael, May, Byron, Asmann, Yan, Knutson, Keith, Seligson, Nathan

Source: In International Journal of Particle Therapy June 2024 12 Supplement

Atezolizumab as the First Systemic Therapy Approved for Alveolar Soft Part Sarcoma.

Authors: Bergsma, Emilie J., Elgawly, Mariam, Mancuso, David, Orr, Roger, Vuskovich, Theresa, Seligson, Nathan D.

Source: Annals of Pharmacotherapy; Apr2024, Vol. 58 Issue 4, p407-415, 9p

Subject Terms: ATEZOLIZUMAB, SARCOMA, THERAPEUTICS, CHILD patients, MUSCULOSKELETAL pain

Company/Entity: UNITED States. Food & Drug Administration

Evaluating the Impact of the Addition of Cladribine to Standard Acute Myeloid Leukemia Induction Therapy

Authors: Seligson, Nathan D., Hobbs, Athena L. V., Leonard, Joanna M., Mills, Elizabeth L., Evans, Amy G., Goorha, Salil

Source: Annals of pharmacotherapy. 52(5):439-445

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CYP3A5 influences oral tacrolimus pharmacokinetics and timing of acute kidney injury following allogeneic hematopoietic stem cell transplantation.

Authors: Seligson, Nathan D., Xunjie Zhang, Zemanek, Mark C., Johnson, Jasmine A., VanGundy, Zachary, Danxin Wang, Phelps, Mitch A., Roddy, Julianna, Hofmeister, Craig C., Junan Li, Poi, Ming J.

Source: Frontiers in Pharmacology; 2024, p1-10, 10p

Subject Terms: HEMATOPOIETIC stem cell transplantation, ACUTE kidney failure, CYTOCHROME P-450 CYP3A, TACROLIMUS, STEM cell transplantation

Evaluation of the timing of MRSA PCR nasal screening: How long can a negative assay be used to rule out MRSA-positive respiratory cultures?

Authors: Turner, Stephen C¹, Seligson, Nathan D², Parag, Bhavyata³, Shea, Katherine M⁴, Hobbs, Athena L V⁵ Athena.hobbs@bmhcc.org

Source: American Journal of Health-System Pharmacy. 2021 Supplement, Vol. 78, pS57-S61. 5p. 1 Chart.

Subject Terms: *RESPIRATORY organs, *PNEUMONIA, *CONFIDENCE intervals, *METHICILLIN-resistant staphylococcus aureus, *MEDICAL screening, *DESCRIPTIVE statistics, *POLYMERASE chain reaction, *PREDICTIVE validity

Convergence of therapy-induced senescence (TIS) and EMT in multistep carcinogenesis: current opinions and emerging perspectives

Authors: Faheem, Mir Mohd, Seligson, Nathan D., Ahmad, Syed Mudabir, Rasool, Reyaz Ur, Gandhi, Sumit G., Bhagat, Madhulika, Goswami, Anindya

Source: Cell death discovery. 6(1)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100174644734.0x000001&indx=1&recIds=ETOCvdc_100174644734.0x000001