Repeated-dose liver micronucleus assay of mitomycin C in young adult rats

Authors: Shimada, Keisuke, Yamamoto, Mika, Takashima, Miyuki, Wako, Yumi, Kawasako, Kazufumi, Aoki, Yoshinobu, Seki, Jiro, Miyamae, Yoichi, Wakata, Akihiro

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis March 2015 780-781:85-89

Effect of tacrolimus on the cauda epididymis in rats: Analysis of epididymal biochemical markers or antioxidant defense enzymes

Authors: Hisatomi, Akihiko, Sakuma, Shozo, Fujiwara, Michio, Seki, Jiro

Source: In Toxicology 2008 243(1):23-30

Ameliorating effect of FK614, a novel nonthiazolidinedione peroxisome proliferator-activated receptor γ agonist, on insulin resistance in Zucker fatty rat

Authors: Minoura, Hideaki, Takeshita, Shigeru, Yamamoto, Tadashi, Mabuchi, Miyuki, Hirosumi, Jiro, Takakura, Shoji, Kawamura, Ikuo, Seki, Jiro, Manda, Toshitaka, Ita, Makoto, Mutoh, Seitaro

Source: In European Journal of Pharmacology 5 September 2005 519(1-2):182-190

Design, synthesis, and structure–activity relationships of potent GPIIb/IIIa antagonists: discovery of FK419

Authors: Yamanaka, Toshio, Ohkubo, Mitsuru, Kuroda, Satoru, Nakamura, Hideko, Takahashi, Fumie, Aoki, Toshiaki, Mihara, Kayoko, Seki, Jiro, Kato, Masayuki

Source: In Bioorganic & Medicinal Chemistry 2005 13(13):4343-4352

Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig

Authors: Kato, Yasuko ^*, Kita, Yasuhiro, Hirasawa-Taniyama, Yoshimi, Nishio, Mie, Mihara, Kayoko, Ito, Kiyotaka, Yamanaka, Toshio, Seki, Jiro, Miyata, Susumu, Mutoh, Seitaro

Source: In European Journal of Pharmacology 25 July 2003 473(2-3):163-169

Vascular hypertrophy inhibitor

Synthesis and Biological Activity of 1-Phenylsulfonyl-4-Phenylsulfonylaminopyrrolidine Derivatives as Thromboxane A2 Receptor Antagonists

Authors: Marusawa, Hiroshi, Setoi, Hiroyuki, Sawada, Akihiko, Kuroda, Akio, Seki, Jiro, Motoyama, Yukio, Tanaka, Hirokazu

Source: In Bioorganic & Medicinal Chemistry May 2002 10(5):1399-1415

Amelioration of insulin resistance in diabetic ob/ob mice by a new type of orally active insulin–mimetic vanadyl complex: Bis(1-oxy-2-pyridinethiolato)oxovanadium(IV) with VO(S 2O 2) coordination mode

Authors: Takeshita, Shigeru, Kawamura, Ikuo ^*, Yasuno, Tohru, Kimura, Chiaki, Yamamoto, Tadashi, Seki, Jiro, Tamura, Asuka, Sakurai, Hiromu, Goto, Toshio

Source: In Journal of Inorganic Biochemistry 2001 85(2):179-186

The effects of zenarestat, an aldose reductase inhibitor, on minimal F-wave latency and nerve blood flow in streptozotocin-induced diabetic rats

Authors: Yamamoto, Tadashi, Takakura, Shoji ^*, Kawamura, Ikuo, Seki, Jiro, Goto, Toshio

Source: In Life Sciences 2001 68(12):1439-1448

Protective Effect of FR183998, a Na+H+ Exchange Inhibitor, Against Postischemic Injury After Normothermic and Prolonged Hypothermic Ischemia in Isolated Perfused Rat Hearts

Authors: Ohara, Fumihiro, Yamamoto, Nobuhiro, Maeda, Kazuhiro, Ozaki, Toru, Seki, Jiro, Goto, Toshio

Source: In The Japanese Journal of Pharmacology 2001 87(2):110-116

Effect of FR194738, a potent inhibitor of squalene epoxidase, on cholesterol metabolism in HepG2 cells

Authors: Sawada, Masae ^*, Matsuo, Masahiko, Hagihara, Hiroyuki, Tenda, Noriko, Nagayoshi, Akira, Okumura, Hiroyuki, Washizuka, Ken-ichi, Seki, Jiro, Goto, Toshio

Source: In European Journal of Pharmacology 2001 431(1):11-16

FR226807: a potent and selective phosphodiesterase type 5 inhibitor

Authors: Hosogai, Naomi ^*, Hamada, Kaori, Tomita, Masayuki, Nagashima, Akira, Takahashi, Tokiko, Sekizawa, Toshihiro, Mizutani, Tsuyoshi, Urano, Yasuharu, Kuroda, Akio, Sawada, Kozo, Ozaki, Tohru, Seki, Jiro, Goto, Toshio

Source: In European Journal of Pharmacology 2001 428(2):295-302

Induction of choleresis by immunosuppressant FK506 through stimulation of insulin-like growth factor-I production in the liver of rats

Authors: Kawamura, Ikuo ^*, Takeshita, Shigeru, Fushimi, Mariko, Mabuchi, Miyuki, Seki, Jiro, Goto, Toshio

Source: In European Journal of Pharmacology 2001 419(1):99-105

The effects of zenarestat, an aldose reductase inhibitor, on peripheral neuropathy in Zucker diabetic fatty rats

Authors: Shimoshige, Yukinori, Ikuma, Kyoko, Yamamoto, Tadashi, Takakura, Shoji, Kawamura, Ikuo, Seki, Jiro, Mutoh, Seitaro, Goto, Toshio ¹

Source: In Metabolism November 2000 49(11):1395-1399

synthesis and biological activity of 4-methyl-3,5-dioxane derivatives as thromboxane a2 receptor antagonists

Authors: Marusawa, Hiroshi, Setoi, Hiroyuki ^*, Kuroda, Akio, Sawada, Akihiko, Seki, Jiro, Motoyama, Yukio, Tanaka, Hirokazu

Source: In Bioorganic & Medicinal Chemistry November 1999 7(11):2635-2645

Protective Effect of FR168888, a New Na+/H+ Exchange Inhibitor, on Ischemia and Reperfusion-Induced Arrhythmia and Myocardial Infarction in Rats: In Comparison With Other Cardioprotective Compounds

Authors: Ohara, Fumihiro ¹, Sugimoto, Toshiko ¹, Yamamoto, Nobuhiro ¹, Ohkubo, Kazumi ¹, Ozaki, Tohru ¹, Maeda, Kazuhiro ¹, Seki, Jiro ¹, Goto, Toshio ¹

Source: In Japanese Journal of Pharmacology 1999 80(4):295-302

In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist

Authors: Kato, Yasuko ^*, Kita, Yasuhiro, Nishio, Mie, Hirasawa, Yoshimi, Ito, Kiyotaka, Yamanaka, Toshio, Motoyama, Yukio, Seki, Jiro

Source: In European Journal of Pharmacology 1999 384(2):197-202

Prolonged rest period enables the detection of micronucleated hepatocytes in the liver of young adult rats after a single dose of diethylnitrosamine or mitomycin C

Authors: Shimada, Keisuke, Yamamoto, Mika, Takashima, Miyuki, Seki, Jiro, Miyamae, Yoichi, Wakata, Akihiro

Source: In Mutation Research - Genetic Toxicology and Environmental Mutagenesis September 2015 791:38-41

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Drug-induced phospholipidosis is caused by blockade of mannose 6-phosphate receptor-mediated targeting of lysosomal enzymes

Authors: Ikeda, Kazuhiko, Hirayama, Masahiro, Hirota, Yuko, Asa, Erika, Seki, Jiro, Tanaka, Yoshitaka

Source: In Biochemical and Biophysical Research Communications 2008 377(1):268-274