Progesterone receptor membrane component 1 (PGRMC1) binds and stabilizes cytochromes P450 through a heme-independent mechanism

Authors: McGuire, Meredith R., Mukhopadhyay, Debaditya, Myers, Stephanie L., Mosher, Eric P., Brookheart, Rita T., Kammers, Kai, Sehgal, Alfica, Selen, Ebru S., Wolfgang, Michael J., Bumpus, Namandjé N., Espenshade, Peter J.

Source: In Journal of Biological Chemistry November 2021 297(5)

Thrombin generation in plasma of patients with haemophilia A and B with inhibitors: Effects of bypassing agents and antithrombin reduction

Authors: Livnat, Tami, Sehgal, Alfica, Qian, Kun, Van Nguyen, Huy, Madigan, Kate, Sorensen, Benny, Kenet, Gili

Source: In Blood Cells, Molecules and Diseases May 2020 82

Knockdown of Anillin Actin Binding Protein Blocks Cytokinesis in Hepatocytes and Reduces Liver Tumor Development in Mice Without Affecting Regeneration

Authors: Zhang, Shuyuan, Nguyen, Liem H., Zhou, Kejin, Tu, Ho-Chou, Sehgal, Alfica, Nassour, Ibrahim, Li, Lin, Gopal, Purva, Goodman, Joshua, Singal, Amit G., Yopp, Adam, Zhang, Yu, Siegwart, Daniel J., Zhu, Hao

Source: In Gastroenterology April 2018 154(5):1421-1434

Advanced siRNA Designs Further Improve In Vivo Performance of GalNAc-siRNA Conjugates

Authors: Foster, Donald J., Brown, Christopher R., Shaikh, Sarfraz, Trapp, Casey, Schlegel, Mark K., Qian, Kun, Sehgal, Alfica, Rajeev, Kallanthottathil G., Jadhav, Vasant, Manoharan, Muthiah, Kuchimanchi, Satya, Maier, Martin A., Milstein, Stuart

Source: In Molecular Therapy 7 March 2018 26(3):708-717

The Polyploid State Plays a Tumor-Suppressive Role in the Liver

Authors: Zhang, Shuyuan, Zhou, Kejin, Luo, Xin, Li, Lin, Tu, Ho-Chou, Sehgal, Alfica, Nguyen, Liem H., Zhang, Yu, Gopal, Purva, Tarlow, Branden D., Siegwart, Daniel J., Zhu, Hao

Source: In Developmental Cell 26 February 2018 44(4):447-459

Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression

Authors: Willoughby, Jennifer L.S., Chan, Amy, Sehgal, Alfica, Butler, James S., Nair, Jayaprakash K., Racie, Tim, Shulga-Morskaya, Svetlana, Nguyen, Tuyen, Qian, Kun, Yucius, Kristina, Charisse, Klaus, van Berkel, Theo J.C., Manoharan, Muthiah, Rajeev, Kallanthottathil G., Maier, Martin A., Jadhav, Vasant, Zimmermann, Tracy S.

Source: In Molecular Therapy 3 January 2018 26(1):105-114

Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis

Authors: Chen, Pei-Yu, Qin, Lingfeng, Li, Guangxin, Wang, Zheng, Dahlman, James E., Malagon-Lopez, Jose, Gujja, Sharvari, Cilfone, Nicholas A., Kauffman, Kevin J., Sun, Lele, Sun, Hongye, Zhang, Xinbo, Aryal, Binod, Canfran-Duque, Alberto, Liu, Rebecca, Kusters, Pascal, Sehgal, Alfica, Jiao, Yang, Anderson, Daniel G., Gulcher, Jeffrey, Fernandez-Hernando, Carlos, Lutgens, Esther, Schwartz, Martin A., Pober, Jordan S., Chittenden, Thomas W., Tellides, George, Simons, Michael

Source: Nature metabolism. 1(9):912-926

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100125163603.0x000001&indx=1&recIds=ETOCvdc_100125163603.0x000001

Progranulin upregulation by antisense oligonucleotides targeting regRNAs for treatment of FTD‐GRN

Authors: Aydemir, Yeliz Yuva, Abdullatif, Ali Al, Ramaswami, Gokul, Golczer, Gabriel, Akerberg, Brynn, Weinstein, Jenna, Nishi, Yuichi, Pai, Rutuja, Cohick, Evan, Matthews, Bryan, Liu, Yuting, Giagtzoglou, Nikolaos, Bumcrot, David, Sehgal, Alfica

Source: Alzheimer's & dementia. 18(10)

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100176997762.0x000001&indx=1&recIds=ETOCvdc_100176997762.0x000001

Compositions and methods directed to treating liver fibrosis

Methods to Identify and Characterize siRNAs Targeting Serpin A1 In Vitro and In Vivo Using RNA Interference

Authors: Milstein, Stuart, Qian, Kun, Zhang, Linying, Sehgal, Alfica

Source: Methods in molecular biology. 1639:115-126

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN612416781&indx=1&recIds=ETOCRN612416781

Preclinical Development of a Subcutaneous ALAS1 RNAi Therapeutic for Treatment of Hepatic Porphyrias Using Circulating RNA Quantification

Authors: Chan, Amy, Liebow, Abigail, Yasuda, Makiko, Gan, Lin, Racie, Tim, Maier, Martin, Kuchimanchi, Satya, Foster, Don, Milstein, Stuart, Charisse, Klaus, Sehgal, Alfica, Manoharan, Muthiah, Meyers, Rachel, Fitzgerald, Kevin, Simon, Amy, Desnick, Robert J, Querbes, William

Source: In Molecular Therapy - Nucleic Acids 2015 4

Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles

Authors: Nakayama, Tomoko, Butler, James S, Sehgal, Alfica, Severgnini, Mariano, Racie, Tim, Sharman, Jennifer, Ding, Feng, Morskaya, Svetlana Shulga, Brodsky, Joshua, Tchangov, Lubomir, Kosovrasti, Verbena, Meys, Mike, Nechev, Lubomir, Wang, Gang, Peng, Chang Geng, Fang, Yupang, Maier, Martin, Rajeev, Kallanthottathil G, Li, Robert, Hettinger, Julia, Barros, Scott, Clausen, Valerie, Zhang, Xuemei, Wang, Qianfan, Hutabarat, Renta, Dokholyan, Nikolay V, Wolfrum, Christian, Manoharan, Muthiah, Kotelianski, Victor, Stoffel, Markus, Sah, Dinah WY

Source: In Molecular Therapy August 2012 20(8):1582-1589

Compositions and method for inhibiting hepcidin antimicrobial peptide (HAMP) or HAMP-related gene expression

Liver as a target for oligonucleotide therapeutics

Authors: Sehgal, Alfica, Vaishnaw, Akshay, Fitzgerald, Kevin

Source: Journal of hepatology. 59(6):1354-1359

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCvdc_100059227201.0x000001&indx=1&recIds=ETOCvdc_100059227201.0x000001

Targeted Delivery of Small Interfering RNA (siRNA) to Proximal Tubule Cells in the Kidneys

Authors: Ding, Shiying, Long, Kimberly R., Cunniff, Jeremy, Lucas, Johnny, Rong, Haojing, Belanger, Adam, Zhang, Hongmei, Lawrence, Jonathan F., Rbaibi, Youssef, Weisz, Ora A., Sehgal, Alfica

Source: Journal of the American Society of Nephrology; October 2024, Vol. 35 Issue: 10, Number 10 Supplement 10

An RNAi therapeutic targeting antithrombin to rebalance the coagulation system and promote hemostasis in hemophilia.

Authors: Sehgal, Alfica¹, Barros, Scott¹, Ivanciu, Lacramioara², Cooley, Brian³, Qin, June¹, Racie, Tim¹, Hettinger, Julia¹, Carioto, Mary¹, Jiang, Yongfeng¹, Brodsky, Josh¹, Prabhala, Harsha¹, Zhang, Xuemei¹, Attarwala, Husain¹, Hutabarat, Renta¹, Foster, Don¹, Milstein, Stuart¹, Charisse, Klaus¹, Kuchimanchi, Satya¹, Maier, Martin A¹, Nechev, Lubo¹

Source: Nature Medicine. May2015, Vol. 21 Issue 5, p492-497. 6p. 4 Graphs.

Subject Terms: *HEMOPHILIA, *RNA interference, *PHENOTYPES, *THROMBIN, *HEMOSTASIS

Translocation of ribosomal protein P0 onto the Toxoplasma gondii tachyzoite surface

Authors: Sehgal, Alfica, Kumar, Nirbhay, Carruthers, Vern B., Sharma, Shobhona ^∗

Source: In International Journal for Parasitology 2003 33(14):1589-1594

Opportunities and challenges for innovative and equitable healthcare

Authors: Ecker, David J., Aiello, Clarice D., Arron, Joseph R., Bennett, C. Frank, Bernard, Amy, Breakefield, Xandra O., Broderick, Timothy J., Callier, Shawneequa L., Canton, Barry, Chen, Janice S., Fishburn, C. Simone, Garrett, Banning, Hecht, Sidney M., Janowitz, Tobias, Kliegman, Melinda, Krainer, Adrian, Louis, Chrystal U., Lowe, Christopher, Sehgal, Alfica, Tozan, Yesim, Tracey, Kevin J., Urnov, Fyodor, Wattendorf, Daniel, Williams, Thomas W., Zhao, Xuanhe, Hayden, Michael R.

Source: Nature Reviews Drug Discovery; May 2024, Vol. 23 Issue: 5 p321-322, 2p

SREBP Controls Oxygen-Dependent Mobilization of Retrotransposons in Fission Yeast.

Authors: Sehgal, Alfica¹, Lee, Chih-Yung S.¹, Espenshade, Peter J.¹ peter.espenshade@jhmi.edu

Source: PLoS Genetics. Aug2007, Vol. 3 Issue 8, p1389-1396. 8p. 7 Black and White Photographs, 2 Diagrams, 1 Chart, 4 Graphs.

Subject Terms: *SCHIZOSACCHAROMYCES, *YEAST, *RNA, *NUCLEOTIDE sequence, *OXYGEN

Author Correction: Transcriptional characterization of iPSC-derived microglia as a model for therapeutic development in neurodegeneration.

Authors: Ramaswami, Gokul, Yuva-Aydemir, Yeliz, Akerberg, Brynn, Matthews, Bryan, Williams, Jenna, Golczer, Gabriel, Huang, Jiaqi, Al Abdullatif, Ali, Huh, Dann, Burkly, Linda C., Engle, Sandra J., Grossman, Iris, Sehgal, Alfica, Sigova, Alla A., Fremeau Jr., Robert T., Liu, Yuting, Bumcrot, David

Source: Scientific Reports; 4/23/2024, Vol. 14 Issue 1, p1-1, 1p

Subject Terms: MICROGLIA, NEURODEGENERATION, EMPLOYEE ownership, EQUITY stake