Sequence, structure prediction, and epitope analysis of the polymorphic membrane protein family in Chlamydia trachomatis.

Authors: Cervantes, Patrick W.¹ (AUTHOR), Segelke, Brent W.¹ (AUTHOR), Lau, Edmond Y.¹ (AUTHOR), Robinson, Beverly V.¹ (AUTHOR), Abisoye-Ogunniyan, Abisola¹ (AUTHOR), Pal, Sukumar² (AUTHOR), de la Maza, Luis M.² (AUTHOR), Coleman, Matthew A.¹ (AUTHOR), D'haeseleer, Patrik¹ (AUTHOR) dhaeseleer2@llnl.gov

Source: PLoS ONE. 6/11/2024, Vol. 19 Issue 6, p1-22. 22p.

Subject Terms: *CHLAMYDIA trachomatis, *MEMBRANE proteins, *PROTEIN structure prediction, *B cells, *CELL adhesion, *PROTEIN analysis

Functional Annotation from Structural Homology

Authors: Segelke, Brent W.

Source: Methods in molecular biology. 2349:215-258

Availability: http://explore.bl.uk/primo_library/libweb/action/display.do?tabs=detailsTab&gathStatTab=true&ct=display&fn=search&doc=ETOCRN627966695&indx=1&recIds=ETOCRN627966695

Computationally restoring the potency of a clinical antibody against Omicron

Authors: Desautels, Thomas A., Arrildt, Kathryn T., Zemla, Adam T., Lau, Edmond Y., Zhu, Fangqiang, Ricci, Dante, Cronin, Stephanie, Zost, Seth J., Binshtein, Elad, Scheaffer, Suzanne M., Dadonaite, Bernadeta, Petersen, Brenden K., Engdahl, Taylor B., Chen, Elaine, Handal, Laura S., Hall, Lynn, Goforth, John W., Vashchenko, Denis, Nguyen, Sam, Weilhammer, Dina R., Lo, Jacky Kai-Yin, Rubinfeld, Bonnee, Saada, Edwin A., Weisenberger, Tracy, Lee, Tek-Hyung, Whitener, Bradley, Case, James B., Ladd, Alexander, Silva, Mary S., Haluska, Rebecca M., Grzesiak, Emilia A., Earnhart, Christopher G., Hopkins, Svetlana, Bates, Thomas W., Thackray, Larissa B., Segelke, Brent W., Lillo, Antonietta Maria, Sundaram, Shivshankar, Bloom, Jesse D., Diamond, Michael S., Crowe, James E., Carnahan, Robert H., Faissol, Daniel M.

Source: Nature; May 2024, Vol. 629 Issue: 8013 p878-885, 8p

Differential laboratory passaging of SARS-CoV-2 viral stocks impacts the in vitro assessment of neutralizing antibodies.

Authors: Avila-Herrera, Aram, Kimbrel, Jeffrey A., Manuel Martí, Jose, Thissen, James, Saada, Edwin A., Weisenberger, Tracy, Arrildt, Kathryn T., Segelke, Brent W., Allen, Jonathan E., Zemla, Adam, Borucki, Monica K.

Source: PLoS ONE; 1/25/2024, Vol. 19 Issue 1, p1-19, 19p

Subject Terms: MONOCLONAL antibodies, VIRAL antibodies, IMMUNOGLOBULINS, SARS-CoV-2, IMMUNE serums, SARS-CoV-2 Omicron variant, RECOMBINANT viruses

Structure and Function of REP34 Implicates Carboxypeptidase Activity in Francisella tularensis Host Cell Invasion

Authors: Feld, Geoffrey K., El-Etr, Sahar, Corzett, Michele H., Hunter, Mark S., Belhocine, Kamila, Monack, Denise M., Frank, Matthias, Segelke, Brent W., Rasley, Amy

Source: In Journal of Biological Chemistry 31 October 2014 289(44):30668-30679

Practical applications of structural genomics technologies for mutagen research

Authors: Zemla, Adam, Segelke, Brent W.

Source: In Mut.Res.-Genetic Toxicology and Environmental Mutagenesis 2011 722(2):165-170

Amino acid and structural variability of Yersinia pestis LcrV protein

Authors: Anisimov, Andrey P., Dentovskaya, Svetlana V., Panfertsev, Evgeniy A., Svetoch, Tat’yana E., Kopylov, Pavel Kh., Segelke, Brent W., Zemla, Adam, Telepnev, Maxim V., Motin, Vladimir L.

Source: In Infection, Genetics and Evolution 2010 10(1):137-145

Atomic force microscopy differentiates discrete size distributions between membrane protein containing and empty nanolipoprotein particles

Authors: Blanchette, Craig D., Cappuccio, Jenny A., Kuhn, Edward A., Segelke, Brent W., Benner, W. Henry, Chromy, Brett A., Coleman, Matthew A., Bench, Graham, Hoeprich, Paul D., Sulchek, Todd A.

Source: In BBA - Biomembranes 2009 1788(3):724-731

Cell-free Co-expression of Functional Membrane Proteins and Apolipoprotein, Forming Soluble Nanolipoprotein Particles

Authors: Cappuccio, Jenny A. ^{‡, §}, Blanchette, Craig D. ^{‡, §}, Sulchek, Todd A. ^‡, Arroyo, Erin S. ^‡, Kralj, Joel M. ^¶, Hinz, Angela K. ^‡, Kuhn, Edward A. ^‡, Chromy, Brett A. ^‡, Segelke, Brent W. ^‡, Rothschild, Kenneth J. ^¶, Fletcher, Julia E. ^‖, Katzen, Federico ^‖, Peterson, Todd C. ^‖, Kudlicki, Wieslaw A. ^‖, Bench, Graham ^‡, Hoeprich, Paul D. ^{‡, **}, Coleman, Matthew A. ^{‡, ‡‡}

Source: In Molecular & Cellular Proteomics November 2008 7(11):2246-2253

Quantifying size distributions of nanolipoprotein particles with single-particle analysis and molecular dynamic simulations

Authors: Blanchette, Craig D., Law, Richard, Benner, W. Henry, Pesavento, Joseph B., Cappuccio, Jenny A., Walsworth, Vicki, Kuhn, Edward A., Corzett, Michele, Chromy, Brett A., Segelke, Brent W., Coleman, Matthew A., Bench, Graham, Hoeprich, Paul D., Sulchek, Todd A.

Source: In Journal of Lipid Research July 2008 49(7):1420-1430

METHODS AND SYSTEMS FOR PRODUCING NANOLIPOPROTEIN PARTICLES

High throughput protein production screening

Large-scale application of free energy perturbation calculations for antibody design.

Authors: Zhu, Fangqiang, Bourguet, Feliza A., Bennett, William F. D., Lau, Edmond Y., Arrildt, Kathryn T., Segelke, Brent W., Zemla, Adam T., Desautels, Thomas A., Faissol, Daniel M.

Source: Scientific Reports; 7/21/2022, Vol. 12 Issue 1, p1-14, 14p

Subject Terms: STATISTICAL errors, CHEMICAL systems, STRUCTURAL stability, INTEGRATED software, SARS virus

Robotic CCD microscope for enhanced crystal recognition

Protein crystallography prescreen kit

Relational database management system for automated random crystallization screening

Robotic CCD microscope for enhanced crystal recognition

Labware for high-throughput free-interface diffusion crystallization

Liquid class predictor for liquid handling of complex mixtures

Protein crystallography prescreen kit